The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform
Jiangnan Yu - One of the best experts on this subject based on the ideXlab platform.
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preparation and in vitro evaluation of povidone Sodium Cholate phospholipid mixed micelles for the solubilization of poorly soluble drugs
Archives of Pharmacal Research, 2010Co-Authors: Shanshan Tong, Jiangnan Yu, Min Peng, Li Wang, Ximing XuAbstract:Mixed micelles made of polyvinylpyrrolidone (PVP), Sodium Cholate, and phospholipids were prepared to improve the solubility of poorly water-soluble drugs. Sylibin, a drug used in treating liver diseases, was incorporated into the mixed micelles. The formulation of sylibin containing PVP-Sodium Cholate-phospholipid mixed micelles with an optimized composition (PVP/Sodium Cholate/phospholipid/silybin = 3:3:4:1∼2 by weight) was obtained based on the study of pseudoternary phase diagrams. The critical micelle concentration was used to evaluate the micellar stability towards dilution. The results showed that addition of PVP to Sodium-Cholate-phospholipid mixed micelles increased stability. The solubility of sylibin in PVP-Sodium Cholate-phospholipid mixed micelles was higher than that in pure water or in Sodium Cholate-phospholipid mixed micelles. In a stability study, we found that PVP-Sodium Cholate-phospholipid mixed micelles showed good stability. After 3 months storage at 40°C, just 2.6% sylibin was lost with only minor changes of the particle size when compared to a reference formulation containing Sodium Cholate and phospholipid mixed micelles. In addition, the developed formulation significantly improved in vitro drug release. The time required to release 50% sylibin (t50%) from Sodium Cholate and phospholipid mixed micelles was 326 h, while the t50% from PVP-Sodium Cholate-phospholipid mixed micelles was only 51.1 h. Our results suggest that these mixed micelles might have significant potential application to the biomedical field.
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enhancement of oral bioavailability of the poorly water soluble drug silybin by Sodium Cholate phospholipid mixed micelles
Acta Pharmacologica Sinica, 2010Co-Authors: Shanshan Tong, Jiangnan Yu, Min Peng, Li Wang, Ximing XuAbstract:Enhancement of oral bioavailability of the poorly water-soluble drug silybin by Sodium Cholate/phospholipid-mixed micelles
Min Peng - One of the best experts on this subject based on the ideXlab platform.
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preparation and in vitro evaluation of povidone Sodium Cholate phospholipid mixed micelles for the solubilization of poorly soluble drugs
Archives of Pharmacal Research, 2010Co-Authors: Shanshan Tong, Jiangnan Yu, Min Peng, Li Wang, Ximing XuAbstract:Mixed micelles made of polyvinylpyrrolidone (PVP), Sodium Cholate, and phospholipids were prepared to improve the solubility of poorly water-soluble drugs. Sylibin, a drug used in treating liver diseases, was incorporated into the mixed micelles. The formulation of sylibin containing PVP-Sodium Cholate-phospholipid mixed micelles with an optimized composition (PVP/Sodium Cholate/phospholipid/silybin = 3:3:4:1∼2 by weight) was obtained based on the study of pseudoternary phase diagrams. The critical micelle concentration was used to evaluate the micellar stability towards dilution. The results showed that addition of PVP to Sodium-Cholate-phospholipid mixed micelles increased stability. The solubility of sylibin in PVP-Sodium Cholate-phospholipid mixed micelles was higher than that in pure water or in Sodium Cholate-phospholipid mixed micelles. In a stability study, we found that PVP-Sodium Cholate-phospholipid mixed micelles showed good stability. After 3 months storage at 40°C, just 2.6% sylibin was lost with only minor changes of the particle size when compared to a reference formulation containing Sodium Cholate and phospholipid mixed micelles. In addition, the developed formulation significantly improved in vitro drug release. The time required to release 50% sylibin (t50%) from Sodium Cholate and phospholipid mixed micelles was 326 h, while the t50% from PVP-Sodium Cholate-phospholipid mixed micelles was only 51.1 h. Our results suggest that these mixed micelles might have significant potential application to the biomedical field.
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Enhancement of oral bioavailability of the poorly water-soluble drug silybin by Sodium Cholate/phospholipid-mixed micelles
Acta pharmacologica Sinica, 2010Co-Authors: Yuan Zhu, Shanshan Tong, Min Peng, Li Wang, Xia Cao, Hui QiuAbstract:Enhancement of oral bioavailability of the poorly water-soluble drug silybin by Sodium Cholate/phospholipid-mixed micelles
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enhancement of oral bioavailability of the poorly water soluble drug silybin by Sodium Cholate phospholipid mixed micelles
Acta Pharmacologica Sinica, 2010Co-Authors: Shanshan Tong, Jiangnan Yu, Min Peng, Li Wang, Ximing XuAbstract:Enhancement of oral bioavailability of the poorly water-soluble drug silybin by Sodium Cholate/phospholipid-mixed micelles
Ximing Xu - One of the best experts on this subject based on the ideXlab platform.
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preparation and in vitro evaluation of povidone Sodium Cholate phospholipid mixed micelles for the solubilization of poorly soluble drugs
Archives of Pharmacal Research, 2010Co-Authors: Shanshan Tong, Jiangnan Yu, Min Peng, Li Wang, Ximing XuAbstract:Mixed micelles made of polyvinylpyrrolidone (PVP), Sodium Cholate, and phospholipids were prepared to improve the solubility of poorly water-soluble drugs. Sylibin, a drug used in treating liver diseases, was incorporated into the mixed micelles. The formulation of sylibin containing PVP-Sodium Cholate-phospholipid mixed micelles with an optimized composition (PVP/Sodium Cholate/phospholipid/silybin = 3:3:4:1∼2 by weight) was obtained based on the study of pseudoternary phase diagrams. The critical micelle concentration was used to evaluate the micellar stability towards dilution. The results showed that addition of PVP to Sodium-Cholate-phospholipid mixed micelles increased stability. The solubility of sylibin in PVP-Sodium Cholate-phospholipid mixed micelles was higher than that in pure water or in Sodium Cholate-phospholipid mixed micelles. In a stability study, we found that PVP-Sodium Cholate-phospholipid mixed micelles showed good stability. After 3 months storage at 40°C, just 2.6% sylibin was lost with only minor changes of the particle size when compared to a reference formulation containing Sodium Cholate and phospholipid mixed micelles. In addition, the developed formulation significantly improved in vitro drug release. The time required to release 50% sylibin (t50%) from Sodium Cholate and phospholipid mixed micelles was 326 h, while the t50% from PVP-Sodium Cholate-phospholipid mixed micelles was only 51.1 h. Our results suggest that these mixed micelles might have significant potential application to the biomedical field.
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enhancement of oral bioavailability of the poorly water soluble drug silybin by Sodium Cholate phospholipid mixed micelles
Acta Pharmacologica Sinica, 2010Co-Authors: Shanshan Tong, Jiangnan Yu, Min Peng, Li Wang, Ximing XuAbstract:Enhancement of oral bioavailability of the poorly water-soluble drug silybin by Sodium Cholate/phospholipid-mixed micelles
I. Smit - One of the best experts on this subject based on the ideXlab platform.
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Interactions in Aqueous Systems Containing Sodium Cholate/Calcium Chloride Mixtures
Journal of Colloid and Interface Science, 1996Co-Authors: Nada Filipović-vinceković, Vesna Babić-ivančić, I. SmitAbstract:Abstract A systematic examination was made of the effects of Sodium Cholate and calcium chloride concentrations on the phases formed at 298 K. The phase diagram is a rather complex one, showing regions in which a single phase and a mixture of several phases coexist. At lower concentrations, Cholate anions may exist as monomers or may be incorporated into an equimolar complex with calcium. Inside the precipitation region the appearance of various solid crystalline phases and of a liquid crystalline phase as well as of their mixtures can be observed. In the micellar region, calcium Cholate (CaC2) coexists with Cholate micelles, while in the region where a gel-like phase is formed the coexistence of CaC2, as solid crystalline phase, and of Sodium Cholate (NaC), as liquid crystalline phase, has been confirmed. The Krafft point for CaC2as determined from specific conductivity measurements is 316 K.
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interactions in aqueous systems containing Sodium Cholate calcium chloride mixtures
Journal of Colloid and Interface Science, 1996Co-Authors: N Filipovicvincekovic, V Babicivancic, I. SmitAbstract:Abstract A systematic examination was made of the effects of Sodium Cholate and calcium chloride concentrations on the phases formed at 298 K. The phase diagram is a rather complex one, showing regions in which a single phase and a mixture of several phases coexist. At lower concentrations, Cholate anions may exist as monomers or may be incorporated into an equimolar complex with calcium. Inside the precipitation region the appearance of various solid crystalline phases and of a liquid crystalline phase as well as of their mixtures can be observed. In the micellar region, calcium Cholate (CaC 2 ) coexists with Cholate micelles, while in the region where a gel-like phase is formed the coexistence of CaC 2 , as solid crystalline phase, and of Sodium Cholate (NaC), as liquid crystalline phase, has been confirmed. The Krafft point for CaC 2 as determined from specific conductivity measurements is 316 K.
G. Mangiapia - One of the best experts on this subject based on the ideXlab platform.
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a diffusion study on the ternary system Sodium Cholate Sodium deoxyCholate water
Journal of Molecular Liquids, 2010Co-Authors: Vincenzo Vitagliano, Roberto Sartorio, Ornella Ortona, Luigi Paduano, Fabio Capuano, Gerardino Derrico, G. MangiapiaAbstract:Abstract The mutual diffusion coefficients, Dij, of the ternary system Sodium Cholate (NaC, component 1) + Sodium deoxyCholate (NadC, component 2) + water have been determined at five average compositions (c1, c2) keeping c1 constant and varying c2. The possibility to obtain expressions for the four diffusion coefficients in term of the micellization parameters and of the diffusivity of the species in solution is discussed. Data have been qualitatively interpreted. Results for the main term diffusion coefficients have been used in the much more difficult analysis of the cross term diffusion coefficients.
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A diffusion study on the ternary system, Sodium Cholate–Sodium deoxyCholate–water
Journal of Molecular Liquids, 2010Co-Authors: Vincenzo Vitagliano, Roberto Sartorio, Ornella Ortona, Luigi Paduano, Gerardino D'errico, Fabio Capuano, G. MangiapiaAbstract:Abstract The mutual diffusion coefficients, Dij, of the ternary system Sodium Cholate (NaC, component 1) + Sodium deoxyCholate (NadC, component 2) + water have been determined at five average compositions (c1, c2) keeping c1 constant and varying c2. The possibility to obtain expressions for the four diffusion coefficients in term of the micellization parameters and of the diffusivity of the species in solution is discussed. Data have been qualitatively interpreted. Results for the main term diffusion coefficients have been used in the much more difficult analysis of the cross term diffusion coefficients.
