The Experts below are selected from a list of 123 Experts worldwide ranked by ideXlab platform
Stephen L Buchwald - One of the best experts on this subject based on the ideXlab platform.
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palladium catalyzed synthesis of n aryl carbamates
Organic Letters, 2013Co-Authors: Ekaterina V Vinogradova, Nathaniel H Park, Brett P Fors, Stephen L BuchwaldAbstract:An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with Sodium Cyanate. The use of aryl triflates as electrophilic components in this transformation allowed for an expanded substrate scope for direct synthesis of aryl isoCyanates. This methodology provides direct access to major carbamate protecting groups, S-thiocarbamates, and diisoCyanate precursors to polyurethane materials.
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Palladium-Catalyzed Synthesis of N‑Aryl Carbamates
2013Co-Authors: Ekaterina V Vinogradova, Nathaniel H Park, Brett P Fors, Stephen L BuchwaldAbstract:An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with Sodium Cyanate. The use of aryl triflates as electrophilic components in this transformation allowed for an expanded substrate scope for direct synthesis of aryl isoCyanates. This methodology provides direct access to major carbamate protecting groups, S-thiocarbamates, and diisoCyanate precursors to polyurethane materials
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palladium catalyzed cross coupling of aryl chlorides and triflates with Sodium Cyanate a practical synthesis of unsymmetrical ureas
ChemInform, 2012Co-Authors: Ekaterina V Vinogradova, Brett P Fors, Stephen L BuchwaldAbstract:An efficient one-pot protocol for the synthesis of unsymmetrical ureas such as (IV) or (VII) via palladium-catalyzed cross-coupling of aryl chlorides and triflates with Sodium Cyanate and amines is developed.
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palladium catalyzed cross coupling of aryl chlorides and triflates with Sodium Cyanate a practical synthesis of unsymmetrical ureas
Journal of the American Chemical Society, 2012Co-Authors: Ekaterina V Vinogradova, Brett P Fors, Stephen L BuchwaldAbstract:An efficient method for palladium-catalyzed cross-coupling of aryl chlorides and triflates with Sodium Cyanate is reported. The protocol allows for the synthesis of unsymmetrical N,N′-di- and N,N,N′-trisubstituted ureas in one pot and is tolerant of a wide range of functional groups. Insight into the mechanism of aryl isoCyanate formation was gleaned through studies of the transmetalation and reductive elimination steps of the reaction, including the first demonstration of reductive elimination from an arylpalladium isoCyanate complex to produce an aryl isoCyanate.
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Palladium-Catalyzed Cross-Coupling of Aryl Chlorides and Triflates with Sodium Cyanate: A Practical Synthesis of Unsymmetrical Ureas
2012Co-Authors: Ekaterina V. Vinogradova, Brett P Fors, Stephen L BuchwaldAbstract:An efficient method for palladium-catalyzed cross-coupling of aryl chlorides and triflates with Sodium Cyanate is reported. The protocol allows for the synthesis of unsymmetrical N,N′-di- and N,N,N′-trisubstituted ureas in one pot and is tolerant of a wide range of functional groups. Insight into the mechanism of aryl isoCyanate formation was gleaned through studies of the transmetalation and reductive elimination steps of the reaction, including the first demonstration of reductive elimination from an arylpalladium isoCyanate complex to produce an aryl isoCyanate
Mark Lautens - One of the best experts on this subject based on the ideXlab platform.
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expedient synthesis of chiral oxazolidinone scaffolds via rhodium catalyzed asymmetric ring opening with Sodium Cyanate
ChemInform, 2013Co-Authors: Gavin Chit Tsui, Nina M Ninnemann, Akihito Hosotani, Mark LautensAbstract:The synthesis of chiral oxazolidinone scaffolds from readily available oxabicyclic alkenes is described.
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expedient synthesis of chiral oxazolidinone scaffolds via rhodium catalyzed asymmetric ring opening with Sodium Cyanate
Organic Letters, 2013Co-Authors: Gavin Chit Tsui, Nina M Ninnemann, Akihito Hosotani, Mark LautensAbstract:A method for synthesizing chiral oxazolidinone scaffolds from readily available oxabicyclic alkenes is described. The reaction utilizes a domino sequence of Rh(I)-catalyzed asymmetric ring-opening (ARO) with Sodium Cyanate as a novel nucleophile followed by intramolecular cyclization to generate oxazolidinone products in excellent enantioselectivities (trans stereochemistry).
Ekaterina V Vinogradova - One of the best experts on this subject based on the ideXlab platform.
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palladium catalyzed synthesis of n aryl carbamates
Organic Letters, 2013Co-Authors: Ekaterina V Vinogradova, Nathaniel H Park, Brett P Fors, Stephen L BuchwaldAbstract:An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with Sodium Cyanate. The use of aryl triflates as electrophilic components in this transformation allowed for an expanded substrate scope for direct synthesis of aryl isoCyanates. This methodology provides direct access to major carbamate protecting groups, S-thiocarbamates, and diisoCyanate precursors to polyurethane materials.
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Palladium-Catalyzed Synthesis of N‑Aryl Carbamates
2013Co-Authors: Ekaterina V Vinogradova, Nathaniel H Park, Brett P Fors, Stephen L BuchwaldAbstract:An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with Sodium Cyanate. The use of aryl triflates as electrophilic components in this transformation allowed for an expanded substrate scope for direct synthesis of aryl isoCyanates. This methodology provides direct access to major carbamate protecting groups, S-thiocarbamates, and diisoCyanate precursors to polyurethane materials
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palladium catalyzed cross coupling of aryl chlorides and triflates with Sodium Cyanate a practical synthesis of unsymmetrical ureas
ChemInform, 2012Co-Authors: Ekaterina V Vinogradova, Brett P Fors, Stephen L BuchwaldAbstract:An efficient one-pot protocol for the synthesis of unsymmetrical ureas such as (IV) or (VII) via palladium-catalyzed cross-coupling of aryl chlorides and triflates with Sodium Cyanate and amines is developed.
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palladium catalyzed cross coupling of aryl chlorides and triflates with Sodium Cyanate a practical synthesis of unsymmetrical ureas
Journal of the American Chemical Society, 2012Co-Authors: Ekaterina V Vinogradova, Brett P Fors, Stephen L BuchwaldAbstract:An efficient method for palladium-catalyzed cross-coupling of aryl chlorides and triflates with Sodium Cyanate is reported. The protocol allows for the synthesis of unsymmetrical N,N′-di- and N,N,N′-trisubstituted ureas in one pot and is tolerant of a wide range of functional groups. Insight into the mechanism of aryl isoCyanate formation was gleaned through studies of the transmetalation and reductive elimination steps of the reaction, including the first demonstration of reductive elimination from an arylpalladium isoCyanate complex to produce an aryl isoCyanate.
Brett P Fors - One of the best experts on this subject based on the ideXlab platform.
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palladium catalyzed synthesis of n aryl carbamates
Organic Letters, 2013Co-Authors: Ekaterina V Vinogradova, Nathaniel H Park, Brett P Fors, Stephen L BuchwaldAbstract:An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with Sodium Cyanate. The use of aryl triflates as electrophilic components in this transformation allowed for an expanded substrate scope for direct synthesis of aryl isoCyanates. This methodology provides direct access to major carbamate protecting groups, S-thiocarbamates, and diisoCyanate precursors to polyurethane materials.
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Palladium-Catalyzed Synthesis of N‑Aryl Carbamates
2013Co-Authors: Ekaterina V Vinogradova, Nathaniel H Park, Brett P Fors, Stephen L BuchwaldAbstract:An efficient synthesis of aryl carbamates was achieved by introducing alcohols into the reaction of palladium-catalyzed cross-coupling of ArX (X = Cl, OTf) with Sodium Cyanate. The use of aryl triflates as electrophilic components in this transformation allowed for an expanded substrate scope for direct synthesis of aryl isoCyanates. This methodology provides direct access to major carbamate protecting groups, S-thiocarbamates, and diisoCyanate precursors to polyurethane materials
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palladium catalyzed cross coupling of aryl chlorides and triflates with Sodium Cyanate a practical synthesis of unsymmetrical ureas
ChemInform, 2012Co-Authors: Ekaterina V Vinogradova, Brett P Fors, Stephen L BuchwaldAbstract:An efficient one-pot protocol for the synthesis of unsymmetrical ureas such as (IV) or (VII) via palladium-catalyzed cross-coupling of aryl chlorides and triflates with Sodium Cyanate and amines is developed.
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palladium catalyzed cross coupling of aryl chlorides and triflates with Sodium Cyanate a practical synthesis of unsymmetrical ureas
Journal of the American Chemical Society, 2012Co-Authors: Ekaterina V Vinogradova, Brett P Fors, Stephen L BuchwaldAbstract:An efficient method for palladium-catalyzed cross-coupling of aryl chlorides and triflates with Sodium Cyanate is reported. The protocol allows for the synthesis of unsymmetrical N,N′-di- and N,N,N′-trisubstituted ureas in one pot and is tolerant of a wide range of functional groups. Insight into the mechanism of aryl isoCyanate formation was gleaned through studies of the transmetalation and reductive elimination steps of the reaction, including the first demonstration of reductive elimination from an arylpalladium isoCyanate complex to produce an aryl isoCyanate.
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Palladium-Catalyzed Cross-Coupling of Aryl Chlorides and Triflates with Sodium Cyanate: A Practical Synthesis of Unsymmetrical Ureas
2012Co-Authors: Ekaterina V. Vinogradova, Brett P Fors, Stephen L BuchwaldAbstract:An efficient method for palladium-catalyzed cross-coupling of aryl chlorides and triflates with Sodium Cyanate is reported. The protocol allows for the synthesis of unsymmetrical N,N′-di- and N,N,N′-trisubstituted ureas in one pot and is tolerant of a wide range of functional groups. Insight into the mechanism of aryl isoCyanate formation was gleaned through studies of the transmetalation and reductive elimination steps of the reaction, including the first demonstration of reductive elimination from an arylpalladium isoCyanate complex to produce an aryl isoCyanate
Gavin Chit Tsui - One of the best experts on this subject based on the ideXlab platform.
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expedient synthesis of chiral oxazolidinone scaffolds via rhodium catalyzed asymmetric ring opening with Sodium Cyanate
ChemInform, 2013Co-Authors: Gavin Chit Tsui, Nina M Ninnemann, Akihito Hosotani, Mark LautensAbstract:The synthesis of chiral oxazolidinone scaffolds from readily available oxabicyclic alkenes is described.
-
expedient synthesis of chiral oxazolidinone scaffolds via rhodium catalyzed asymmetric ring opening with Sodium Cyanate
Organic Letters, 2013Co-Authors: Gavin Chit Tsui, Nina M Ninnemann, Akihito Hosotani, Mark LautensAbstract:A method for synthesizing chiral oxazolidinone scaffolds from readily available oxabicyclic alkenes is described. The reaction utilizes a domino sequence of Rh(I)-catalyzed asymmetric ring-opening (ARO) with Sodium Cyanate as a novel nucleophile followed by intramolecular cyclization to generate oxazolidinone products in excellent enantioselectivities (trans stereochemistry).