The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform

Ramon Bernabeu - One of the best experts on this subject based on the ideXlab platform.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on pentylenetetrazol induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    : Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based on previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms, and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on ptz induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based in previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of PTZ-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration. This article is protected by copyright. All rights reserved.

Antonella Piserafuster - One of the best experts on this subject based on the ideXlab platform.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on pentylenetetrazol induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    : Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based on previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms, and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on ptz induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based in previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of PTZ-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration. This article is protected by copyright. All rights reserved.

Luis E Brunoblanch - One of the best experts on this subject based on the ideXlab platform.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on pentylenetetrazol induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    : Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based on previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms, and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on ptz induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based in previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of PTZ-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration. This article is protected by copyright. All rights reserved.

Alan Talevi - One of the best experts on this subject based on the ideXlab platform.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on pentylenetetrazol induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    : Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based on previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms, and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on ptz induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based in previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of PTZ-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration. This article is protected by copyright. All rights reserved.

Sofia Otero - One of the best experts on this subject based on the ideXlab platform.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on pentylenetetrazol induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    : Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based on previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms, and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.

  • anticonvulsant effect of Sodium Cyclamate and propylparaben on ptz induced seizures in zebrafish
    Synapse, 2017
    Co-Authors: Antonella Piserafuster, Sofia Otero, Alan Talevi, Luis E Brunoblanch, Ramon Bernabeu
    Abstract:

    Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based in previous results in rodents, we have here examined the effects of artificial sweetener Sodium Cyclamate and antimicrobial agent Sodium propylparaben on a model of PTZ-induced seizures in zebrafish. Sodium Cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration. This article is protected by copyright. All rights reserved.