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Hamid Zafarpour - One of the best experts on this subject based on the ideXlab platform.
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seizure duration and hemodynamic state during electroconvulsive therapy Sodium Thiopental versus propofol
Global Journal of Health Science, 2015Co-Authors: Hashem Jarineshin, Saeed Kashani, Fereydoon Fekrat, Majid Vatankhah, Javad Golmirzaei, Esmaeel Alimolaee, Hamid ZafarpourAbstract:INTRODUCTION: General anesthesia is required for Electroconvulsive Therapy (ECT) and it is usually provided by a hypnotic agent. The seizure duration is important for the treatment, and it is usually accompanied by severe hemodynamic changes. The aim of this study was to compare the effects of Sodium Thiopental versus Propofol on seizure duration and hemodynamic variables during ECT. METHODS: A number of 100 patient-sessions of ECT were included in this randomized clinical trial. The initial hemodynamic state of each patient was recorded. Anesthesia was induced by Sodium Thiopental in the 1 st group and with Propofol in 2 nd group. All the patients received the muscle relaxant succinylcholine. The hemodynamic variables after seizure and seizure duration were recorded. The data were analyzed through SPSS 20 and independent t-test. P<0.05 was considered significant. RESULTS: The mean duration of seizure in the Sodium Thiopental group was significantly longer than the Propofol group (40.3±16.6 sec versus 32±11.3 sec) (P=0.001). There was no statistically significant difference between the mean energy level applied in the two groups (20.5±3.81 joules in the Sodium Thiopental versus 20.2±3.49 joules in the Propofol group). The mean systolic and diastolic blood pressure at all times after seizure and mean heart rate at 3 and 5 minutes after seizure were significantly lower in Propofol than Sodium Thiopental groups. DISCUSSION & CONCLUSION: Propofol provides a more stable hemodynamic state for the ECT procedures, and its use is highly preferred over Sodium Thiopental in patients with cardiovascular disease.
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Seizure Duration and Hemodynamic State During Electroconvulsive Therapy: Sodium Thiopental Versus Propofol.
Global Journal of Health Science, 2015Co-Authors: Hashem Jarineshin, Saeed Kashani, Fereydoon Fekrat, Majid Vatankhah, Javad Golmirzaei, Esmaeel Alimolaee, Hamid ZafarpourAbstract:INTRODUCTION: General anesthesia is required for Electroconvulsive Therapy (ECT) and it is usually provided by a hypnotic agent. The seizure duration is important for the treatment, and it is usually accompanied by severe hemodynamic changes. The aim of this study was to compare the effects of Sodium Thiopental versus Propofol on seizure duration and hemodynamic variables during ECT. METHODS: A number of 100 patient-sessions of ECT were included in this randomized clinical trial. The initial hemodynamic state of each patient was recorded. Anesthesia was induced by Sodium Thiopental in the 1 st group and with Propofol in 2 nd group. All the patients received the muscle relaxant succinylcholine. The hemodynamic variables after seizure and seizure duration were recorded. The data were analyzed through SPSS 20 and independent t-test. P
John W Olney - One of the best experts on this subject based on the ideXlab platform.
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propofol and Sodium Thiopental protect against mk 801 induced neuronal necrosis in the posterior cingulate retrosplenial cortex
Brain Research, 2001Co-Authors: Vesna Jevtovictodorovic, David F Wozniak, Sarah Powell, John W OlneyAbstract:Abstract N -Methyl- d -aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents — propofol and Sodium Thiopental — protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801.
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Propofol and Sodium Thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex.
Brain Research, 2001Co-Authors: Vesna Jevtovic-todorovic, David F Wozniak, Sarah Powell, John W OlneyAbstract:Abstract N -Methyl- d -aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents — propofol and Sodium Thiopental — protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801.
Ebrahim Espahbodi - One of the best experts on this subject based on the ideXlab platform.
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paediatric sedation during upper gastrointestinal endoscopy comparison of propofol ketamine vs Sodium Thiopental fentanyl
Electronic Journal of General Medicine, 2018Co-Authors: Alireza Takzare, Mehrdad Goudarzi, Anahid Maleki, Alireza Ebrahim Soltani, Fariba Kaheh, Sagar Arab, Ebrahim EspahbodiAbstract:Background:Different drug regimens can be used for management of anxiety before endoscopy. This study aimed to compare the sedation effects of propofol+ketamine (PK) and Sodium Thiopental+fentanyl (TF) in children during upper gastrointestinal (UGI) endoscopy.Methods:A triple-blind clinical trial was conducted on 88 children aged 2-12 years who were candidate for UGI endoscopy at Children’s Medical Centre, Tehran, Iran, during 2012-2013. It was administered propofol (2.1 mg/kg) + ketamine (1 mg/kg) and 100% oxygen in PK group, and Thiopental (5 mg/kg) + fentanyl (1 mg/kg) in TF group. The haemodynamic status and degree of sedation by Ramsay’s criteria were measured.Results:The mean age in PK and TF groups was 92.2±38.2 and 98.6±49.5 months, respectively. The systolic blood pressure and heart rate significantly increased and decreased in PK and TF groups during the procedure, respectively. The frequency of Ramsay's Sedation Scales of 5 and 6 were respectively 72.7% and 27.3% for PF, and 54.5% and 45.5% for TF group (p=0.076).Conclusion:Although both groups were similar in the degree of sedation, PK can be a more appropriate choice for sedation in children with special diseases undergoing endoscopy due to small changes in haemodynamic parameters and, consequently, their higher stability.
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Paediatric sedation during upper gastrointestinal endoscopy: Comparison of propofol + ketamine vs Sodium Thiopental + fentanyl
Electronic Journal of General Medicine, 2018Co-Authors: Alireza Takzare, Mehrdad Goudarzi, Anahid Maleki, Alireza Ebrahim Soltani, Fariba Kaheh, Sagar Arab, Ebrahim EspahbodiAbstract:Background:Different drug regimens can be used for management of anxiety before endoscopy. This study aimed to compare the sedation effects of propofol+ketamine (PK) and Sodium Thiopental+fentanyl (TF) in children during upper gastrointestinal (UGI) endoscopy.Methods:A triple-blind clinical trial was conducted on 88 children aged 2-12 years who were candidate for UGI endoscopy at Children’s Medical Centre, Tehran, Iran, during 2012-2013. It was administered propofol (2.1 mg/kg) + ketamine (1 mg/kg) and 100% oxygen in PK group, and Thiopental (5 mg/kg) + fentanyl (1 mg/kg) in TF group. The haemodynamic status and degree of sedation by Ramsay’s criteria were measured.Results:The mean age in PK and TF groups was 92.2±38.2 and 98.6±49.5 months, respectively. The systolic blood pressure and heart rate significantly increased and decreased in PK and TF groups during the procedure, respectively. The frequency of Ramsay's Sedation Scales of 5 and 6 were respectively 72.7% and 27.3% for PF, and 54.5% and 45.5% for TF group (p=0.076).Conclusion:Although both groups were similar in the degree of sedation, PK can be a more appropriate choice for sedation in children with special diseases undergoing endoscopy due to small changes in haemodynamic parameters and, consequently, their higher stability.
Hashem Jarineshin - One of the best experts on this subject based on the ideXlab platform.
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seizure duration and hemodynamic state during electroconvulsive therapy Sodium Thiopental versus propofol
Global Journal of Health Science, 2015Co-Authors: Hashem Jarineshin, Saeed Kashani, Fereydoon Fekrat, Majid Vatankhah, Javad Golmirzaei, Esmaeel Alimolaee, Hamid ZafarpourAbstract:INTRODUCTION: General anesthesia is required for Electroconvulsive Therapy (ECT) and it is usually provided by a hypnotic agent. The seizure duration is important for the treatment, and it is usually accompanied by severe hemodynamic changes. The aim of this study was to compare the effects of Sodium Thiopental versus Propofol on seizure duration and hemodynamic variables during ECT. METHODS: A number of 100 patient-sessions of ECT were included in this randomized clinical trial. The initial hemodynamic state of each patient was recorded. Anesthesia was induced by Sodium Thiopental in the 1 st group and with Propofol in 2 nd group. All the patients received the muscle relaxant succinylcholine. The hemodynamic variables after seizure and seizure duration were recorded. The data were analyzed through SPSS 20 and independent t-test. P<0.05 was considered significant. RESULTS: The mean duration of seizure in the Sodium Thiopental group was significantly longer than the Propofol group (40.3±16.6 sec versus 32±11.3 sec) (P=0.001). There was no statistically significant difference between the mean energy level applied in the two groups (20.5±3.81 joules in the Sodium Thiopental versus 20.2±3.49 joules in the Propofol group). The mean systolic and diastolic blood pressure at all times after seizure and mean heart rate at 3 and 5 minutes after seizure were significantly lower in Propofol than Sodium Thiopental groups. DISCUSSION & CONCLUSION: Propofol provides a more stable hemodynamic state for the ECT procedures, and its use is highly preferred over Sodium Thiopental in patients with cardiovascular disease.
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Seizure Duration and Hemodynamic State During Electroconvulsive Therapy: Sodium Thiopental Versus Propofol.
Global Journal of Health Science, 2015Co-Authors: Hashem Jarineshin, Saeed Kashani, Fereydoon Fekrat, Majid Vatankhah, Javad Golmirzaei, Esmaeel Alimolaee, Hamid ZafarpourAbstract:INTRODUCTION: General anesthesia is required for Electroconvulsive Therapy (ECT) and it is usually provided by a hypnotic agent. The seizure duration is important for the treatment, and it is usually accompanied by severe hemodynamic changes. The aim of this study was to compare the effects of Sodium Thiopental versus Propofol on seizure duration and hemodynamic variables during ECT. METHODS: A number of 100 patient-sessions of ECT were included in this randomized clinical trial. The initial hemodynamic state of each patient was recorded. Anesthesia was induced by Sodium Thiopental in the 1 st group and with Propofol in 2 nd group. All the patients received the muscle relaxant succinylcholine. The hemodynamic variables after seizure and seizure duration were recorded. The data were analyzed through SPSS 20 and independent t-test. P
Stephane Legriel - One of the best experts on this subject based on the ideXlab platform.
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comparison of etomidate and Sodium Thiopental for induction during rapid sequence intubation in convulsive status epilepticus a retrospective single center study
Seizure-european Journal of Epilepsy, 2018Co-Authors: Francois Perier, Annelaure Chateauneuf, Gwenaelle Jacq, Mathilde Holleville, David Schnell, Sybille Merceron, Sebastien Cavelot, Olivier Richard, Stephane LegrielAbstract:Abstract Purpose Few outcome data are available about morbidity associated with endotracheal intubation modalities in critically ill patients with convulsive status epilepticus. We compared etomidate versus Sodium Thiopental for emergency rapid sequence intubation in patients with out-of-hospital convulsive status epilepticus. Methods Patients admitted to our intensive care unit in 2006–2015 were studied retrospectively. The main outcome measure was seizure and/or status epilepticus recurrence within 12 h after rapid sequence intubation. Results We included 97 patients (60% male; median age, 59 years [IQR, 48–70]). Median time from seizure onset to first antiepileptic drug was 60 min [IQR, 35–90]. Reasons for intubation were coma in 95 (98%), acute respiratory distress in 18 (19%), refractory convulsive status epilepticus in 9 (9%), and shock in 6 (6%) patients; 50 (52%) patients had more than one reason. The hypnotic drugs used were etomidate in 54 (56%) and Sodium Thiopental in 43 (44%) patients. Seizure and/or status epilepticus recurred in 13 (56%) patients in the etomidate group and 11 patients (44%) in the Sodium Thiopental group (adjusted common odds ratio [aOR], 0.98; 95%CI, 0.36–2.63; P = 0.97). The two groups were not significantly different for proportions of patients with hemodynamic instability after intubation (aOR, 0.60; 95%CI, 0.23–1.58; P = 0.30) or with difficult endotracheal intubation (OR, 1.28; 95% CI 0.23 to 7.21; P=0.77). Conclusions Our findings argue against a difference in seizure and/or status epilepticus recurrences rates between critically ill patients with convulsive status epilepticus given etomidate vs. Sodium Thiopental as the induction agent for emergency intubation.