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Ruta Gupta - One of the best experts on this subject based on the ideXlab platform.

  • Regional Metastasis in Head and Neck Cutaneous Squamous Cell Carcinoma: An Update on the Significance of Extra-Nodal Extension and Soft Tissue Metastasis
    Annals of Surgical Oncology, 2020
    Co-Authors: Shaheen Hasmat, Craig Mooney, Carsten E. Palme, Ardalan Ebrahimi, Sydney Ch’ng, Ruta Gupta, Jonathan Clark
    Abstract:

    Background Soft Tissue metastases (STMs) are reported to predict worse prognosis than extra-nodal extension (ENE) in metastatic head and neck cutaneous squamous cell carcinoma. This study aimed to update the authors’ previous analysis of STM in a larger series. Methods The study analyzed 535 cases of consecutive cSCC metastatic to the parotid and/or neck treated by primary surgical resection between 1987 and 2007. A Cox proportional hazard model was used to determine the effect of STM, with adjustment for other relevant prognostic factors. Overall survival (OS) and disease-specific survival (DSS) were the primary end points. Results Of the 535 patients, 275 (51.4%) had STM. After adjustment for the effects of age, tumor location, number of metastatic deposits, and adjuvant radiotherapy, both STM (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.08–2.22; p  = 0.018) and ENE (HR, 1.56; 95% CI 1.10–2.22; p  = 0.013) were shown to be independent predictors of reduced OS, with similar size of effect. Conclusion In metastatic cSCC of the head and neck, STM is an independent predictor of reduced survival and has an impact on survival similar to that of ENE.

  • regional Metastasis in head and neck cutaneous squamous cell carcinoma an update on the significance of extra nodal extension and Soft Tissue Metastasis
    Annals of Surgical Oncology, 2020
    Co-Authors: Shaheen Hasmat, Carsten E. Palme, Ardalan Ebrahimi, Ruta Gupta, Craig P Mooney, Kan Gao, Sydney Chng, Tsuhui Low, Jonathan R Clark
    Abstract:

    Soft Tissue metastases (STMs) are reported to predict worse prognosis than extra-nodal extension (ENE) in metastatic head and neck cutaneous squamous cell carcinoma. This study aimed to update the authors’ previous analysis of STM in a larger series. The study analyzed 535 cases of consecutive cSCC metastatic to the parotid and/or neck treated by primary surgical resection between 1987 and 2007. A Cox proportional hazard model was used to determine the effect of STM, with adjustment for other relevant prognostic factors. Overall survival (OS) and disease-specific survival (DSS) were the primary end points. Of the 535 patients, 275 (51.4%) had STM. After adjustment for the effects of age, tumor location, number of metastatic deposits, and adjuvant radiotherapy, both STM (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.08–2.22; p = 0.018) and ENE (HR, 1.56; 95% CI 1.10–2.22; p = 0.013) were shown to be independent predictors of reduced OS, with similar size of effect. In metastatic cSCC of the head and neck, STM is an independent predictor of reduced survival and has an impact on survival similar to that of ENE.

Shaheen Hasmat - One of the best experts on this subject based on the ideXlab platform.

  • Regional Metastasis in Head and Neck Cutaneous Squamous Cell Carcinoma: An Update on the Significance of Extra-Nodal Extension and Soft Tissue Metastasis
    Annals of Surgical Oncology, 2020
    Co-Authors: Shaheen Hasmat, Craig Mooney, Carsten E. Palme, Ardalan Ebrahimi, Sydney Ch’ng, Ruta Gupta, Jonathan Clark
    Abstract:

    Background Soft Tissue metastases (STMs) are reported to predict worse prognosis than extra-nodal extension (ENE) in metastatic head and neck cutaneous squamous cell carcinoma. This study aimed to update the authors’ previous analysis of STM in a larger series. Methods The study analyzed 535 cases of consecutive cSCC metastatic to the parotid and/or neck treated by primary surgical resection between 1987 and 2007. A Cox proportional hazard model was used to determine the effect of STM, with adjustment for other relevant prognostic factors. Overall survival (OS) and disease-specific survival (DSS) were the primary end points. Results Of the 535 patients, 275 (51.4%) had STM. After adjustment for the effects of age, tumor location, number of metastatic deposits, and adjuvant radiotherapy, both STM (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.08–2.22; p  = 0.018) and ENE (HR, 1.56; 95% CI 1.10–2.22; p  = 0.013) were shown to be independent predictors of reduced OS, with similar size of effect. Conclusion In metastatic cSCC of the head and neck, STM is an independent predictor of reduced survival and has an impact on survival similar to that of ENE.

  • regional Metastasis in head and neck cutaneous squamous cell carcinoma an update on the significance of extra nodal extension and Soft Tissue Metastasis
    Annals of Surgical Oncology, 2020
    Co-Authors: Shaheen Hasmat, Carsten E. Palme, Ardalan Ebrahimi, Ruta Gupta, Craig P Mooney, Kan Gao, Sydney Chng, Tsuhui Low, Jonathan R Clark
    Abstract:

    Soft Tissue metastases (STMs) are reported to predict worse prognosis than extra-nodal extension (ENE) in metastatic head and neck cutaneous squamous cell carcinoma. This study aimed to update the authors’ previous analysis of STM in a larger series. The study analyzed 535 cases of consecutive cSCC metastatic to the parotid and/or neck treated by primary surgical resection between 1987 and 2007. A Cox proportional hazard model was used to determine the effect of STM, with adjustment for other relevant prognostic factors. Overall survival (OS) and disease-specific survival (DSS) were the primary end points. Of the 535 patients, 275 (51.4%) had STM. After adjustment for the effects of age, tumor location, number of metastatic deposits, and adjuvant radiotherapy, both STM (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.08–2.22; p = 0.018) and ENE (HR, 1.56; 95% CI 1.10–2.22; p = 0.013) were shown to be independent predictors of reduced OS, with similar size of effect. In metastatic cSCC of the head and neck, STM is an independent predictor of reduced survival and has an impact on survival similar to that of ENE.

Bulent Mizrak - One of the best experts on this subject based on the ideXlab platform.

  • follicular thyroid cancer presenting initially with Soft Tissue Metastasis
    Japanese Journal of Clinical Oncology, 2000
    Co-Authors: Alper Sevinc, Suleyman Buyukberber, Ramazan Sari, Tamer Baysal, Bulent Mizrak
    Abstract:

    Follicular thyroid cancer rarely manifests itself as a distant metastatic lesion. We report a case of an otherwise asymptomatic 58-year-old woman with follicular thyroid cancer who initially presented with a Soft Tissue mass on the right scapular region. An incisional biopsy specimen of Soft Tissue Metastasis showed thyroid follicular neoplasm. Upon this diagnosis, the thyroid gland was re-evaluated by ultrasound, which demonstrated a solitary, hypoechoic nodule in the right lobe. Ultrasonography guided fine-needle aspiration biopsy of the thyroid nodule confirmed follicular neoplasm and the diagnosis of metastatic follicular thyroid cancer was established. The patient refused any type of treatment and left hospital against medical advice. 2.5 years later the patient was admitted to the hospital with giant, sarcoma-like multiple Soft Tissue masses. On this admission, the serum thyroglobulin level was extremely elevated (3500 ng/ml) and she only accepted to receive chemotherapy. Epirubicin and cyclophosphamide were administered. She received three courses of chemotherapy and is alive with a stable disease after 3 months of follow-up. This case of follicular thyroid cancer is reported because of its uncommon initial presentation with Soft Tissue Metastasis which spread to multiple areas as giant Soft Tissue masses during follow-up.

Jonathan R Clark - One of the best experts on this subject based on the ideXlab platform.

  • regional Metastasis in head and neck cutaneous squamous cell carcinoma an update on the significance of extra nodal extension and Soft Tissue Metastasis
    Annals of Surgical Oncology, 2020
    Co-Authors: Shaheen Hasmat, Carsten E. Palme, Ardalan Ebrahimi, Ruta Gupta, Craig P Mooney, Kan Gao, Sydney Chng, Tsuhui Low, Jonathan R Clark
    Abstract:

    Soft Tissue metastases (STMs) are reported to predict worse prognosis than extra-nodal extension (ENE) in metastatic head and neck cutaneous squamous cell carcinoma. This study aimed to update the authors’ previous analysis of STM in a larger series. The study analyzed 535 cases of consecutive cSCC metastatic to the parotid and/or neck treated by primary surgical resection between 1987 and 2007. A Cox proportional hazard model was used to determine the effect of STM, with adjustment for other relevant prognostic factors. Overall survival (OS) and disease-specific survival (DSS) were the primary end points. Of the 535 patients, 275 (51.4%) had STM. After adjustment for the effects of age, tumor location, number of metastatic deposits, and adjuvant radiotherapy, both STM (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.08–2.22; p = 0.018) and ENE (HR, 1.56; 95% CI 1.10–2.22; p = 0.013) were shown to be independent predictors of reduced OS, with similar size of effect. In metastatic cSCC of the head and neck, STM is an independent predictor of reduced survival and has an impact on survival similar to that of ENE.

Jonathan Clark - One of the best experts on this subject based on the ideXlab platform.

  • Regional Metastasis in Head and Neck Cutaneous Squamous Cell Carcinoma: An Update on the Significance of Extra-Nodal Extension and Soft Tissue Metastasis
    Annals of Surgical Oncology, 2020
    Co-Authors: Shaheen Hasmat, Craig Mooney, Carsten E. Palme, Ardalan Ebrahimi, Sydney Ch’ng, Ruta Gupta, Jonathan Clark
    Abstract:

    Background Soft Tissue metastases (STMs) are reported to predict worse prognosis than extra-nodal extension (ENE) in metastatic head and neck cutaneous squamous cell carcinoma. This study aimed to update the authors’ previous analysis of STM in a larger series. Methods The study analyzed 535 cases of consecutive cSCC metastatic to the parotid and/or neck treated by primary surgical resection between 1987 and 2007. A Cox proportional hazard model was used to determine the effect of STM, with adjustment for other relevant prognostic factors. Overall survival (OS) and disease-specific survival (DSS) were the primary end points. Results Of the 535 patients, 275 (51.4%) had STM. After adjustment for the effects of age, tumor location, number of metastatic deposits, and adjuvant radiotherapy, both STM (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.08–2.22; p  = 0.018) and ENE (HR, 1.56; 95% CI 1.10–2.22; p  = 0.013) were shown to be independent predictors of reduced OS, with similar size of effect. Conclusion In metastatic cSCC of the head and neck, STM is an independent predictor of reduced survival and has an impact on survival similar to that of ENE.