The Experts below are selected from a list of 28053 Experts worldwide ranked by ideXlab platform
S Hoffmann - One of the best experts on this subject based on the ideXlab platform.
-
incision and drainage preceding definite Surgery achieves lower 20 year long term recurrence rate in 583 primary pilonidal sinus Surgery patients
Journal Der Deutschen Dermatologischen Gesellschaft, 2013Co-Authors: Dietrich Doll, Edouard Matevossian, Christian Hoenemann, S HoffmannAbstract:BACKGROUND: It has long been suspected that acute infection leads to less satisfactory results in Soft Tissue Surgery. Its influence on long-term recurrence rate in primary pilonidal sinus Surgery has not been investigated yet. PATIENTS AND METHODS: 583 patients (military cohort) were analyzed, comparing an incision and drainage (ID p = 0.009; log-rank-test). CONCLUSIONS: Early I&D treatment preceding definite Surgery for some weeks seem to give significant superior results compared to primary Surgery without I&D. The combination of early I&D and asymmetric excision and out of the midline closure is expected to give even further improved results compared to this cohort. The optimum interval between I&D and definite Surgery has still to be determined.
-
incision and drainage preceding definite Surgery achieves lower 20 year long term recurrence rate in 583 primary pilonidal sinus Surgery patients
Journal Der Deutschen Dermatologischen Gesellschaft, 2013Co-Authors: Dietrich Doll, Edouard Matevossian, Christian Hoenemann, S HoffmannAbstract:Summary Background: It has long been suspected that acute infection leads to less satisfactory results in Soft Tissue Surgery. Its influence on long-term recurrence rate in primary pilonidal sinus Surgery has not been investigated yet. Patients and Methods: 583 patients (military cohort) were analyzed, comparing an incision and drainage (I&D) group preceding Surgery (n = 286 pts) with a spontaneous abscess and empyema rupture group (n = 297 pts). Long-term recurrence rate up to 25 years following Surgery was determined. Results: The ID p = 0.009; log-rank-test). Conclusions: Early I&D treatment preceding definite Surgery for some weeks seem to give significant superior results compared to primary Surgery without I&D. The combination of early I&D and asymmetric excision and out of the midline closure is expected to give even further improved results compared to this cohort. The optimum interval between I&D and definite Surgery has still to be determined.
Jonathan N. King - One of the best experts on this subject based on the ideXlab platform.
-
Efficacy and safety of oral robenacoxib (tablet) for the treatment of pain associated with Soft Tissue Surgery in client-owned dogs
BMC Veterinary Research, 2017Co-Authors: Gabriele Friton, Stephen King, Caryn Marie Thompson, Daniela Karadzovska, Jonathan N. KingAbstract:Background Non-steroidal anti-inflammatory drugs (NSAIDs) have been proven to be effective in controlling peri-operative pain in dogs. Robenacoxib is an NSAID with high selectivity for the cyclooxygenase (COX)-2 isoform. The objective of this study was to assess the efficacy and safety of an oral tablet formulation of robenacoxib in client-owned dogs undergoing Soft Tissue Surgery. The study was a prospective, multi-center, randomized, masked, placebo-controlled, parallel-group clinical trial. A total of 239 dogs were included and randomly allocated in a 1:1 ratio to receive either robenacoxib or placebo. Each dog received an oral tablet administration of either robenacoxib, at a target dose of 2 mg/kg, or placebo once prior to Surgery and for two additional days post-operatively. All dogs also received a pre-anesthetic dose of 0.2 mg/kg butorphanol (intravenous or intramuscular). Pain assessments were performed using the short form of the Glasgow Composite Measure Pain Scale. Robenacoxib was compared to the placebo group on a success/failure basis. Treatment failure was defined as the need for rescue therapy to control post-operative pain. Results Significantly ( P = 0.019) more dogs administered robenacoxib were considered treatment successes (89 of 116, 76.72%) compared to dogs given placebo (74 of 115, 64.35%). The percentage of treatment failure was therefore 23.28% in the robenacoxib and 35.65% in the placebo group. The least squares mean total pain scores were significantly different between groups and in favor of robenacoxib at 3 and 5 hours ( P < 0.05) and 8 hours post-extubation ( P < 0.01). Pain at the Surgery sites (response to touch) was also significantly improved at 3, 5 and 8 hours post-extubation in dogs receiving robenacoxib versus placebo ( P < 0.01). In addition, a significant overall improvement in posture/activity was revealed with robenacoxib having lower scores versus placebo ( P < 0.01). No significant differences between the robenacoxib and placebo groups in the frequency of reported adverse events were observed. Conclusions Robenacoxib by oral (tablet) administration was effective and well tolerated in the control of peri-operative pain and inflammation associated with Soft Tissue Surgery in dogs.
-
efficacy and safety of oral robenacoxib tablet for the treatment of pain associated with Soft Tissue Surgery in client owned dogs
BMC Veterinary Research, 2017Co-Authors: Gabriele Friton, Stephen King, Caryn Marie Thompson, Daniela Karadzovska, Jonathan N. KingAbstract:Non-steroidal anti-inflammatory drugs (NSAIDs) have been proven to be effective in controlling peri-operative pain in dogs. Robenacoxib is an NSAID with high selectivity for the cyclooxygenase (COX)-2 isoform. The objective of this study was to assess the efficacy and safety of an oral tablet formulation of robenacoxib in client-owned dogs undergoing Soft Tissue Surgery. The study was a prospective, multi-center, randomized, masked, placebo-controlled, parallel-group clinical trial. A total of 239 dogs were included and randomly allocated in a 1:1 ratio to receive either robenacoxib or placebo. Each dog received an oral tablet administration of either robenacoxib, at a target dose of 2 mg/kg, or placebo once prior to Surgery and for two additional days post-operatively. All dogs also received a pre-anesthetic dose of 0.2 mg/kg butorphanol (intravenous or intramuscular). Pain assessments were performed using the short form of the Glasgow Composite Measure Pain Scale. Robenacoxib was compared to the placebo group on a success/failure basis. Treatment failure was defined as the need for rescue therapy to control post-operative pain. Significantly (P = 0.019) more dogs administered robenacoxib were considered treatment successes (89 of 116, 76.72%) compared to dogs given placebo (74 of 115, 64.35%). The percentage of treatment failure was therefore 23.28% in the robenacoxib and 35.65% in the placebo group. The least squares mean total pain scores were significantly different between groups and in favor of robenacoxib at 3 and 5 hours (P < 0.05) and 8 hours post-extubation (P < 0.01). Pain at the Surgery sites (response to touch) was also significantly improved at 3, 5 and 8 hours post-extubation in dogs receiving robenacoxib versus placebo (P < 0.01). In addition, a significant overall improvement in posture/activity was revealed with robenacoxib having lower scores versus placebo (P < 0.01). No significant differences between the robenacoxib and placebo groups in the frequency of reported adverse events were observed. Robenacoxib by oral (tablet) administration was effective and well tolerated in the control of peri-operative pain and inflammation associated with Soft Tissue Surgery in dogs.
-
efficacy and safety of injectable robenacoxib for the treatment of pain associated with Soft Tissue Surgery in dogs
Journal of Veterinary Internal Medicine, 2017Co-Authors: Gabriele Friton, Stephen King, Daniela Karadzovska, C Thompson, Jonathan N. KingAbstract:Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are used routinely to control pain and inflammation after Surgery in dogs. Robenacoxib is a cyclooxygenase-2 selective NSAID. Hypothesis/Objective Assess the clinical efficacy and safety of an injectable formulation of robenacoxib in dogs undergoing Surgery. Animals Three hundred and seventeen client-owned dogs (N = 159 robenacoxib or N = 158 placebo). Methods In this prospective, multicenter, randomized, masked, placebo-controlled, parallel-group study, dogs received a SC injection of either robenacoxib, at a target dose of 2.0 mg/kg, or placebo once prior to Surgery and for 2 additional days postoperatively. Pain assessments were performed using the short form of the Glasgow Composite Measure Pain Scale (CMPS-SF). The primary efficacy variable was treatment success/failure, with failure defined as the need for rescue therapy to control pain or withdrawal of the dog from the study due to an adverse event. Results Significantly (P = .006) more dogs administered robenacoxib were considered treatment successes (108 of 151, 73.7%) compared to dogs given placebo (85 of 152, 58.1%). Total pain scores (P < .01), pain at the Surgery sites (response to touch, P < .01), and posture/activity (P < .05) were significantly improved at 3, 5, and 8 hours postextubation in dogs receiving robenacoxib versus placebo. Conclusions and Clinical Importance Robenacoxib administered by SC injection prior to Surgery and for 2 additional days postoperatively was effective and well tolerated in the control of postoperative pain and inflammation associated with Soft Tissue Surgery in dogs.
-
evaluation of injectable robenacoxib for the treatment of post operative pain in cats results of a randomized masked placebo controlled clinical trial
BMC Veterinary Research, 2016Co-Authors: Stephen King, Elizabeth S. Roberts, Jonathan N. KingAbstract:Few pharmaceuticals are registered in cats for the management of post-operative pain and inflammation. The objective of this study was to assess the field efficacy and safety of an injectable formulation of the nonsteroidal anti-inflammatory drug robenacoxib in cats undergoing Surgery. The study was a multi-center, prospective, randomized, masked, parallel-group, placebo-controlled clinical trial. A total of 349 cats were enrolled and underwent Surgery comprising forelimb onychectomy, as an example of orthopedic Surgery, plus either ovariohysterectomy or castration. All cats received butorphanol prior to anesthesia and forelimb four-point regional nerve blocks with bupivacaine after induction of general anesthesia. Cats were randomized to receive daily subcutaneous (s.c.) injection of robenacoxib, at a target dosage of 2.0 mg/kg (n = 174), or placebo (n = 175) once prior to Surgery and for an additional two days post-operatively. Significantly (P = 0.037) fewer cats administered robenacoxib received additional analgesia rescue therapy (34 of 173, 19.7 %) compared to cats given placebo (73 of 175, 41.7 %). The percentage of treatment success was therefore 80.3 % with robenacoxib and 58.3 % with placebo. Behavior, posture, pain on palpation of the paw and Soft Tissue Surgery sites, and overall pain were significantly (P < 0.05) improved versus placebo at various time points within the first 8 h in cats receiving robenacoxib. The most frequently reported adverse events were incision site infection/dehiscence, bleeding, vomiting, decreased appetite and lethargy. Frequencies of reported adverse clinical signs, hematology, serum chemistry and urinalysis variables, and body weight changes were similar between groups. There were no significant changes from baseline with robenacoxib in hepatic, hematological or renal clinical pathology variables. Robenacoxib by s.c. injection was effective and well tolerated in the control of post-operative pain associated with orthopedic, ovariohysterectomy and castration Surgery in cats.
-
robenacoxib versus meloxicam for the management of pain and inflammation associated with Soft Tissue Surgery in dogs a randomized non inferiority clinical trial
BMC Veterinary Research, 2013Co-Authors: Philippe Gruet, Wolfgang Seewald, Jonathan N. KingAbstract:Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are used routinely to control pain and inflammation after Surgery in dogs. Robenacoxib is a new NSAID with high selectivity for the cyclo-oxygenase (COX)-2 isoform of COX. The objective of this study was to evaluate the efficacy and tolerability of robenacoxib for the management of peri-operative pain and inflammation associated with Soft Tissue Surgery in dogs. The study was a prospective, randomized, blinded, positive-controlled, non-inferiority, multi-center clinical trial. A total of 174 dogs undergoing major Soft Tissue Surgery were included and randomly allocated in a 2:1 ratio to receive either robenacoxib (n = 118) or the positive control, meloxicam (n = 56). Each dog received an initial dose subcutaneously prior to Surgery (robenacoxib 2 mg/kg, meloxicam 0.2 mg/kg), followed by daily oral doses (robenacoxib 1–2 mg/kg, meloxicam 0.1 mg/kg) for 12 days (range 10–14) after Surgery. Pain and inflammation were assessed subjectively using the Glasgow Composite Pain Scale (GCPS) by clinicians as the primary end point and additional evaluations by the clinicians and animal owners as secondary endpoints. Results: Both treatments provided similar pain control, with no significant differences between groups for any efficacy variable using non-parametric analyses (Mann–Whitney U test). In no dog was analgesic rescue therapy administered. Non-inferior efficacy of robenacoxib compared to meloxicam was demonstrated statistically for the primary and all secondary endpoints using parametric analysis of variance, although the data were not normally distributed even after log transformation. For the primary endpoint (reciprocal of the modified GCPS score), the relative efficacy of robenacoxib/meloxicam was 1.12 with a 95% confidence interval of 0.97-1.29. Both treatments were well tolerated and did not affect buccal mucosal bleeding time. Conclusion: A treatment regimen of robenacoxib by subcutaneous injection followed by oral tablets had good tolerability and non-inferior efficacy compared to meloxicam for the management of peri-operative pain and inflammation associated with Soft Tissue Surgery in dogs.
Dietrich Doll - One of the best experts on this subject based on the ideXlab platform.
-
incision and drainage preceding definite Surgery achieves lower 20 year long term recurrence rate in 583 primary pilonidal sinus Surgery patients
Journal Der Deutschen Dermatologischen Gesellschaft, 2013Co-Authors: Dietrich Doll, Edouard Matevossian, Christian Hoenemann, S HoffmannAbstract:BACKGROUND: It has long been suspected that acute infection leads to less satisfactory results in Soft Tissue Surgery. Its influence on long-term recurrence rate in primary pilonidal sinus Surgery has not been investigated yet. PATIENTS AND METHODS: 583 patients (military cohort) were analyzed, comparing an incision and drainage (ID p = 0.009; log-rank-test). CONCLUSIONS: Early I&D treatment preceding definite Surgery for some weeks seem to give significant superior results compared to primary Surgery without I&D. The combination of early I&D and asymmetric excision and out of the midline closure is expected to give even further improved results compared to this cohort. The optimum interval between I&D and definite Surgery has still to be determined.
-
incision and drainage preceding definite Surgery achieves lower 20 year long term recurrence rate in 583 primary pilonidal sinus Surgery patients
Journal Der Deutschen Dermatologischen Gesellschaft, 2013Co-Authors: Dietrich Doll, Edouard Matevossian, Christian Hoenemann, S HoffmannAbstract:Summary Background: It has long been suspected that acute infection leads to less satisfactory results in Soft Tissue Surgery. Its influence on long-term recurrence rate in primary pilonidal sinus Surgery has not been investigated yet. Patients and Methods: 583 patients (military cohort) were analyzed, comparing an incision and drainage (I&D) group preceding Surgery (n = 286 pts) with a spontaneous abscess and empyema rupture group (n = 297 pts). Long-term recurrence rate up to 25 years following Surgery was determined. Results: The ID p = 0.009; log-rank-test). Conclusions: Early I&D treatment preceding definite Surgery for some weeks seem to give significant superior results compared to primary Surgery without I&D. The combination of early I&D and asymmetric excision and out of the midline closure is expected to give even further improved results compared to this cohort. The optimum interval between I&D and definite Surgery has still to be determined.
Edouard Matevossian - One of the best experts on this subject based on the ideXlab platform.
-
incision and drainage preceding definite Surgery achieves lower 20 year long term recurrence rate in 583 primary pilonidal sinus Surgery patients
Journal Der Deutschen Dermatologischen Gesellschaft, 2013Co-Authors: Dietrich Doll, Edouard Matevossian, Christian Hoenemann, S HoffmannAbstract:BACKGROUND: It has long been suspected that acute infection leads to less satisfactory results in Soft Tissue Surgery. Its influence on long-term recurrence rate in primary pilonidal sinus Surgery has not been investigated yet. PATIENTS AND METHODS: 583 patients (military cohort) were analyzed, comparing an incision and drainage (ID p = 0.009; log-rank-test). CONCLUSIONS: Early I&D treatment preceding definite Surgery for some weeks seem to give significant superior results compared to primary Surgery without I&D. The combination of early I&D and asymmetric excision and out of the midline closure is expected to give even further improved results compared to this cohort. The optimum interval between I&D and definite Surgery has still to be determined.
-
incision and drainage preceding definite Surgery achieves lower 20 year long term recurrence rate in 583 primary pilonidal sinus Surgery patients
Journal Der Deutschen Dermatologischen Gesellschaft, 2013Co-Authors: Dietrich Doll, Edouard Matevossian, Christian Hoenemann, S HoffmannAbstract:Summary Background: It has long been suspected that acute infection leads to less satisfactory results in Soft Tissue Surgery. Its influence on long-term recurrence rate in primary pilonidal sinus Surgery has not been investigated yet. Patients and Methods: 583 patients (military cohort) were analyzed, comparing an incision and drainage (I&D) group preceding Surgery (n = 286 pts) with a spontaneous abscess and empyema rupture group (n = 297 pts). Long-term recurrence rate up to 25 years following Surgery was determined. Results: The ID p = 0.009; log-rank-test). Conclusions: Early I&D treatment preceding definite Surgery for some weeks seem to give significant superior results compared to primary Surgery without I&D. The combination of early I&D and asymmetric excision and out of the midline closure is expected to give even further improved results compared to this cohort. The optimum interval between I&D and definite Surgery has still to be determined.
Christian Hoenemann - One of the best experts on this subject based on the ideXlab platform.
-
incision and drainage preceding definite Surgery achieves lower 20 year long term recurrence rate in 583 primary pilonidal sinus Surgery patients
Journal Der Deutschen Dermatologischen Gesellschaft, 2013Co-Authors: Dietrich Doll, Edouard Matevossian, Christian Hoenemann, S HoffmannAbstract:BACKGROUND: It has long been suspected that acute infection leads to less satisfactory results in Soft Tissue Surgery. Its influence on long-term recurrence rate in primary pilonidal sinus Surgery has not been investigated yet. PATIENTS AND METHODS: 583 patients (military cohort) were analyzed, comparing an incision and drainage (ID p = 0.009; log-rank-test). CONCLUSIONS: Early I&D treatment preceding definite Surgery for some weeks seem to give significant superior results compared to primary Surgery without I&D. The combination of early I&D and asymmetric excision and out of the midline closure is expected to give even further improved results compared to this cohort. The optimum interval between I&D and definite Surgery has still to be determined.
-
incision and drainage preceding definite Surgery achieves lower 20 year long term recurrence rate in 583 primary pilonidal sinus Surgery patients
Journal Der Deutschen Dermatologischen Gesellschaft, 2013Co-Authors: Dietrich Doll, Edouard Matevossian, Christian Hoenemann, S HoffmannAbstract:Summary Background: It has long been suspected that acute infection leads to less satisfactory results in Soft Tissue Surgery. Its influence on long-term recurrence rate in primary pilonidal sinus Surgery has not been investigated yet. Patients and Methods: 583 patients (military cohort) were analyzed, comparing an incision and drainage (I&D) group preceding Surgery (n = 286 pts) with a spontaneous abscess and empyema rupture group (n = 297 pts). Long-term recurrence rate up to 25 years following Surgery was determined. Results: The ID p = 0.009; log-rank-test). Conclusions: Early I&D treatment preceding definite Surgery for some weeks seem to give significant superior results compared to primary Surgery without I&D. The combination of early I&D and asymmetric excision and out of the midline closure is expected to give even further improved results compared to this cohort. The optimum interval between I&D and definite Surgery has still to be determined.