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Jianfeng Gong - One of the best experts on this subject based on the ideXlab platform.

  • long term follow up of the effects of fecal microbiota transplantation in combination with Soluble Dietary Fiber as a therapeutic regimen in slow transit constipation
    Science China-life Sciences, 2018
    Co-Authors: Xueying Zhang, Chao Ding, Hongliang Tian, Yongzhan Nie, Bo Yang, Jianfeng Gong
    Abstract:

    As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation (FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation (STC), we conducted a single-center, open-label trial to study the long-term effect of FMT combined with Soluble Dietary Fiber (pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and Soluble Dietary Fiber (pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0% (20/29) and 75.9% (22/29), respectively. At the end of the study, 48.3% (14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6% (17/29) of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with Soluble Dietary Fiber (pectin) had both short-term and long-term efficacy in treating STC.

  • Soluble Dietary Fiber ameliorates radiation induced intestinal epithelial to mesenchymal transition and fibrosis
    Journal of Parenteral and Enteral Nutrition, 2017
    Co-Authors: Jianbo Yang, Chao Ding, Jianfeng Gong, Xujie Dai, Tingbing Xie, Tenghui Zhang, Wen Gao, Weiming Zhu
    Abstract:

    BACKGROUND Intestinal fibrosis is a late complication of pelvic radiotherapy. Epithelial-to-mesenchymal transition (EMT) plays an important role in tissue fibrosis. The aim of this study was to examine the effect of Soluble Dietary Fiber on radiation-induced intestinal EMT and fibrosis in a mouse model. MATERIALS AND METHODS Apple pectin (4% wt/wt in drinking water) was administered to wild-type and pVillin-Cre-EGFP transgenic mice with intestinal fibrosis induced by a single dose of abdominal irradiation of 10 Gy. The effects of pectin on intestinal EMT and fibrosis, gut microbiota, and short-chain fatty acid (SCFA) concentration were evaluated. RESULTS Intestinal fibrosis in late radiation enteropathy showed increased submucosal thickness and subepithelial collagen deposition. Enhanced green fluorescent protein (EGFP)+/vimentin+ and EGFP+/α-smooth muscle actin (SMA)+ coexpressing cells were most clearly observed at 2 weeks after irradiation and gradually decreased at 4 and 12 weeks. Pectin significantly attenuated the thickness of submucosa and collagen deposition at 12 weeks (24.3 vs 27.6 µm in the pectin + radiation-treated group compared with radiation-alone group, respectively, P < .05; 69.0% vs 57.1%, P < .001) and ameliorated EMT at 2 and 4 weeks. Pectin also modulated the intestinal microbiota composition and increased the luminal SCFA concentration. CONCLUSION The Soluble Dietary Fiber pectin protected the terminal ileum against radiation-induced fibrosis. This effect might be mediated by altered SCFA concentration in the intestinal lumen and reduced EMT in the ileal epithelium.

  • Short-term efficacy on fecal microbiota transplantation combined with Soluble Dietary Fiber and probiotics in the treatment of slow transit constipation
    Chinese Journal of Gastrointestinal Surgery, 2016
    Co-Authors: Chao Ding, Jianfeng Gong, Hongliang Tian, Yao Wei, Qiyi Chen
    Abstract:

    Objective To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) combined with Soluble Dietary Fiber and probiotics for slow transit constipation (STC) . Methods Twenty-three patients with STC from Jinling Hospital, Medical School of Nanjing University were prospectively enrolled between April 2015 and January 2016. STC patients received FMT combined with Soluble Dietary Fiber and probiotics. Fresh stool (100 g) was immediately mixed in a blender with 500 ml of 0.9% sterile saline for several seconds, which was then filtered through a gauze pad and a decreasing number of gauze screen (2.0 to 0.5 mm) . The fecal bacteria suspension was stored frozen at - 20℃. The preparation time of FMT material was less than 1 hour. Total time of treatment was 9 days. An initial oral antibiotics (vancomycin 500 mg orally twice per day) was given for 3 consecutive days. Then the fecal microbiota (100 ml) was infused slowly (5 min) through nasojejunal tube for 6 consecutive days. After FMT, patients were recommended to receive Soluble Dietary Fiber (pectin, 8 g/d) and probiotics (bifid triple viable capsules, twice per day) for 4 weeks. Rates of clinical improvement and remission, adverse events, constipation-related symptoms (PAC-SYM scores) , bowel movements per week and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. This study was registered in the Clinical Trials.gov (NCT02016469) . Results Among 23 patients, 7 were male, 16 were female, the mean age was (49.6 ± 14.7) years, the body mass index was (21.2 ± 2.2) kg/m2, the duration of constipation was (8.3 ± 5.9) years, and the defecation frequency was 1.8 ± 0.7 per week. Compared with pre-treatment, PAC-SYM scores decreased significantly from 2.3 ± 0.5 to 1.3 ± 0.4 at week 12 (P < 0.01) , defecation frequency increased from 1.8 ± 0.7 per week to 4.8 ± 2.0 per week at week 12 (P < 0.01) , and patients felt satisfied with improved GIQLI score (from 78.5 ± 15.5 to 120.8 ± 21.3, P < 0.01) . During the follow-up, the clinical improvement and remission of STC patients reached 69.6% (16/23) and 52.2% (12/23) , respectively. No serious adverse events were observed. Conclusion FMT combined with Soluble Dietary Fiber and probiotics is safe and effective in treating slow transit constipation, which can improve the symptom and quality of life significantly. Key words: Slow transit constipation; Fecal microbiota transplantation; Soluble Dietary Fiber; Probiotics

  • fecal microbiota transplantation in combination with Soluble Dietary Fiber for treatment of slow transit constipation a pilot study
    Archives of Medical Research, 2016
    Co-Authors: Hongliang Tian, Chao Ding, Jianfeng Gong, Yao Wei, Weiming Zhu
    Abstract:

    Background and Aims Intestinal microbiota and Soluble Dietary Fiber play an important role in intestinal microecology, which is closely related to gut motility. Regulating intestinal microecology comprised of fecal microbiota transplantation (FMT) or Fiber supplementation is becoming a novel therapy for functional gastrointestinal disease. We launched this study to evaluate the efficacy and safety of FMT combined with Fiber for slow transit constipation (STC). Methods We performed a study of 21 patients with STC. Participants received FMT (via nasojejunal tubes) on 3 consecutive days. After FMT, they were recommended to receive Soluble Dietary Fiber for 4 weeks (8 g, twice daily). Rate of clinical improvement and remission, constipation-related symptoms (PAC-SYM scores), bowel movements per week, colonic transit time (CTT) and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. Results At the study end, clinical improvement and remission of constipated patients reached 66.7 and 42.9%, respectively. The patients showed an increased stool frequency from 1.7 ± 0.5 per week to 4.8 ± 2.1 per week (p Conclusion This is a pilot study confirming that FMT combined with Fiber may improve symptoms experienced by constipated patients by regulating intestinal microecology, without any serious adverse events.

Weiming Zhu - One of the best experts on this subject based on the ideXlab platform.

  • Soluble Dietary Fiber ameliorates radiation induced intestinal epithelial to mesenchymal transition and fibrosis
    Journal of Parenteral and Enteral Nutrition, 2017
    Co-Authors: Jianbo Yang, Chao Ding, Jianfeng Gong, Xujie Dai, Tingbing Xie, Tenghui Zhang, Wen Gao, Weiming Zhu
    Abstract:

    BACKGROUND Intestinal fibrosis is a late complication of pelvic radiotherapy. Epithelial-to-mesenchymal transition (EMT) plays an important role in tissue fibrosis. The aim of this study was to examine the effect of Soluble Dietary Fiber on radiation-induced intestinal EMT and fibrosis in a mouse model. MATERIALS AND METHODS Apple pectin (4% wt/wt in drinking water) was administered to wild-type and pVillin-Cre-EGFP transgenic mice with intestinal fibrosis induced by a single dose of abdominal irradiation of 10 Gy. The effects of pectin on intestinal EMT and fibrosis, gut microbiota, and short-chain fatty acid (SCFA) concentration were evaluated. RESULTS Intestinal fibrosis in late radiation enteropathy showed increased submucosal thickness and subepithelial collagen deposition. Enhanced green fluorescent protein (EGFP)+/vimentin+ and EGFP+/α-smooth muscle actin (SMA)+ coexpressing cells were most clearly observed at 2 weeks after irradiation and gradually decreased at 4 and 12 weeks. Pectin significantly attenuated the thickness of submucosa and collagen deposition at 12 weeks (24.3 vs 27.6 µm in the pectin + radiation-treated group compared with radiation-alone group, respectively, P < .05; 69.0% vs 57.1%, P < .001) and ameliorated EMT at 2 and 4 weeks. Pectin also modulated the intestinal microbiota composition and increased the luminal SCFA concentration. CONCLUSION The Soluble Dietary Fiber pectin protected the terminal ileum against radiation-induced fibrosis. This effect might be mediated by altered SCFA concentration in the intestinal lumen and reduced EMT in the ileal epithelium.

  • fecal microbiota transplantation in combination with Soluble Dietary Fiber for treatment of slow transit constipation a pilot study
    Archives of Medical Research, 2016
    Co-Authors: Hongliang Tian, Chao Ding, Jianfeng Gong, Yao Wei, Weiming Zhu
    Abstract:

    Background and Aims Intestinal microbiota and Soluble Dietary Fiber play an important role in intestinal microecology, which is closely related to gut motility. Regulating intestinal microecology comprised of fecal microbiota transplantation (FMT) or Fiber supplementation is becoming a novel therapy for functional gastrointestinal disease. We launched this study to evaluate the efficacy and safety of FMT combined with Fiber for slow transit constipation (STC). Methods We performed a study of 21 patients with STC. Participants received FMT (via nasojejunal tubes) on 3 consecutive days. After FMT, they were recommended to receive Soluble Dietary Fiber for 4 weeks (8 g, twice daily). Rate of clinical improvement and remission, constipation-related symptoms (PAC-SYM scores), bowel movements per week, colonic transit time (CTT) and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. Results At the study end, clinical improvement and remission of constipated patients reached 66.7 and 42.9%, respectively. The patients showed an increased stool frequency from 1.7 ± 0.5 per week to 4.8 ± 2.1 per week (p Conclusion This is a pilot study confirming that FMT combined with Fiber may improve symptoms experienced by constipated patients by regulating intestinal microecology, without any serious adverse events.

Chao Ding - One of the best experts on this subject based on the ideXlab platform.

  • long term follow up of the effects of fecal microbiota transplantation in combination with Soluble Dietary Fiber as a therapeutic regimen in slow transit constipation
    Science China-life Sciences, 2018
    Co-Authors: Xueying Zhang, Chao Ding, Hongliang Tian, Yongzhan Nie, Bo Yang, Jianfeng Gong
    Abstract:

    As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation (FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation (STC), we conducted a single-center, open-label trial to study the long-term effect of FMT combined with Soluble Dietary Fiber (pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and Soluble Dietary Fiber (pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0% (20/29) and 75.9% (22/29), respectively. At the end of the study, 48.3% (14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6% (17/29) of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with Soluble Dietary Fiber (pectin) had both short-term and long-term efficacy in treating STC.

  • Soluble Dietary Fiber ameliorates radiation induced intestinal epithelial to mesenchymal transition and fibrosis
    Journal of Parenteral and Enteral Nutrition, 2017
    Co-Authors: Jianbo Yang, Chao Ding, Jianfeng Gong, Xujie Dai, Tingbing Xie, Tenghui Zhang, Wen Gao, Weiming Zhu
    Abstract:

    BACKGROUND Intestinal fibrosis is a late complication of pelvic radiotherapy. Epithelial-to-mesenchymal transition (EMT) plays an important role in tissue fibrosis. The aim of this study was to examine the effect of Soluble Dietary Fiber on radiation-induced intestinal EMT and fibrosis in a mouse model. MATERIALS AND METHODS Apple pectin (4% wt/wt in drinking water) was administered to wild-type and pVillin-Cre-EGFP transgenic mice with intestinal fibrosis induced by a single dose of abdominal irradiation of 10 Gy. The effects of pectin on intestinal EMT and fibrosis, gut microbiota, and short-chain fatty acid (SCFA) concentration were evaluated. RESULTS Intestinal fibrosis in late radiation enteropathy showed increased submucosal thickness and subepithelial collagen deposition. Enhanced green fluorescent protein (EGFP)+/vimentin+ and EGFP+/α-smooth muscle actin (SMA)+ coexpressing cells were most clearly observed at 2 weeks after irradiation and gradually decreased at 4 and 12 weeks. Pectin significantly attenuated the thickness of submucosa and collagen deposition at 12 weeks (24.3 vs 27.6 µm in the pectin + radiation-treated group compared with radiation-alone group, respectively, P < .05; 69.0% vs 57.1%, P < .001) and ameliorated EMT at 2 and 4 weeks. Pectin also modulated the intestinal microbiota composition and increased the luminal SCFA concentration. CONCLUSION The Soluble Dietary Fiber pectin protected the terminal ileum against radiation-induced fibrosis. This effect might be mediated by altered SCFA concentration in the intestinal lumen and reduced EMT in the ileal epithelium.

  • Short-term efficacy on fecal microbiota transplantation combined with Soluble Dietary Fiber and probiotics in the treatment of slow transit constipation
    Chinese Journal of Gastrointestinal Surgery, 2016
    Co-Authors: Chao Ding, Jianfeng Gong, Hongliang Tian, Yao Wei, Qiyi Chen
    Abstract:

    Objective To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) combined with Soluble Dietary Fiber and probiotics for slow transit constipation (STC) . Methods Twenty-three patients with STC from Jinling Hospital, Medical School of Nanjing University were prospectively enrolled between April 2015 and January 2016. STC patients received FMT combined with Soluble Dietary Fiber and probiotics. Fresh stool (100 g) was immediately mixed in a blender with 500 ml of 0.9% sterile saline for several seconds, which was then filtered through a gauze pad and a decreasing number of gauze screen (2.0 to 0.5 mm) . The fecal bacteria suspension was stored frozen at - 20℃. The preparation time of FMT material was less than 1 hour. Total time of treatment was 9 days. An initial oral antibiotics (vancomycin 500 mg orally twice per day) was given for 3 consecutive days. Then the fecal microbiota (100 ml) was infused slowly (5 min) through nasojejunal tube for 6 consecutive days. After FMT, patients were recommended to receive Soluble Dietary Fiber (pectin, 8 g/d) and probiotics (bifid triple viable capsules, twice per day) for 4 weeks. Rates of clinical improvement and remission, adverse events, constipation-related symptoms (PAC-SYM scores) , bowel movements per week and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. This study was registered in the Clinical Trials.gov (NCT02016469) . Results Among 23 patients, 7 were male, 16 were female, the mean age was (49.6 ± 14.7) years, the body mass index was (21.2 ± 2.2) kg/m2, the duration of constipation was (8.3 ± 5.9) years, and the defecation frequency was 1.8 ± 0.7 per week. Compared with pre-treatment, PAC-SYM scores decreased significantly from 2.3 ± 0.5 to 1.3 ± 0.4 at week 12 (P < 0.01) , defecation frequency increased from 1.8 ± 0.7 per week to 4.8 ± 2.0 per week at week 12 (P < 0.01) , and patients felt satisfied with improved GIQLI score (from 78.5 ± 15.5 to 120.8 ± 21.3, P < 0.01) . During the follow-up, the clinical improvement and remission of STC patients reached 69.6% (16/23) and 52.2% (12/23) , respectively. No serious adverse events were observed. Conclusion FMT combined with Soluble Dietary Fiber and probiotics is safe and effective in treating slow transit constipation, which can improve the symptom and quality of life significantly. Key words: Slow transit constipation; Fecal microbiota transplantation; Soluble Dietary Fiber; Probiotics

  • fecal microbiota transplantation in combination with Soluble Dietary Fiber for treatment of slow transit constipation a pilot study
    Archives of Medical Research, 2016
    Co-Authors: Hongliang Tian, Chao Ding, Jianfeng Gong, Yao Wei, Weiming Zhu
    Abstract:

    Background and Aims Intestinal microbiota and Soluble Dietary Fiber play an important role in intestinal microecology, which is closely related to gut motility. Regulating intestinal microecology comprised of fecal microbiota transplantation (FMT) or Fiber supplementation is becoming a novel therapy for functional gastrointestinal disease. We launched this study to evaluate the efficacy and safety of FMT combined with Fiber for slow transit constipation (STC). Methods We performed a study of 21 patients with STC. Participants received FMT (via nasojejunal tubes) on 3 consecutive days. After FMT, they were recommended to receive Soluble Dietary Fiber for 4 weeks (8 g, twice daily). Rate of clinical improvement and remission, constipation-related symptoms (PAC-SYM scores), bowel movements per week, colonic transit time (CTT) and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. Results At the study end, clinical improvement and remission of constipated patients reached 66.7 and 42.9%, respectively. The patients showed an increased stool frequency from 1.7 ± 0.5 per week to 4.8 ± 2.1 per week (p Conclusion This is a pilot study confirming that FMT combined with Fiber may improve symptoms experienced by constipated patients by regulating intestinal microecology, without any serious adverse events.

Hongliang Tian - One of the best experts on this subject based on the ideXlab platform.

  • long term follow up of the effects of fecal microbiota transplantation in combination with Soluble Dietary Fiber as a therapeutic regimen in slow transit constipation
    Science China-life Sciences, 2018
    Co-Authors: Xueying Zhang, Chao Ding, Hongliang Tian, Yongzhan Nie, Bo Yang, Jianfeng Gong
    Abstract:

    As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation (FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation (STC), we conducted a single-center, open-label trial to study the long-term effect of FMT combined with Soluble Dietary Fiber (pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and Soluble Dietary Fiber (pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0% (20/29) and 75.9% (22/29), respectively. At the end of the study, 48.3% (14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6% (17/29) of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with Soluble Dietary Fiber (pectin) had both short-term and long-term efficacy in treating STC.

  • Short-term efficacy on fecal microbiota transplantation combined with Soluble Dietary Fiber and probiotics in the treatment of slow transit constipation
    Chinese Journal of Gastrointestinal Surgery, 2016
    Co-Authors: Chao Ding, Jianfeng Gong, Hongliang Tian, Yao Wei, Qiyi Chen
    Abstract:

    Objective To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) combined with Soluble Dietary Fiber and probiotics for slow transit constipation (STC) . Methods Twenty-three patients with STC from Jinling Hospital, Medical School of Nanjing University were prospectively enrolled between April 2015 and January 2016. STC patients received FMT combined with Soluble Dietary Fiber and probiotics. Fresh stool (100 g) was immediately mixed in a blender with 500 ml of 0.9% sterile saline for several seconds, which was then filtered through a gauze pad and a decreasing number of gauze screen (2.0 to 0.5 mm) . The fecal bacteria suspension was stored frozen at - 20℃. The preparation time of FMT material was less than 1 hour. Total time of treatment was 9 days. An initial oral antibiotics (vancomycin 500 mg orally twice per day) was given for 3 consecutive days. Then the fecal microbiota (100 ml) was infused slowly (5 min) through nasojejunal tube for 6 consecutive days. After FMT, patients were recommended to receive Soluble Dietary Fiber (pectin, 8 g/d) and probiotics (bifid triple viable capsules, twice per day) for 4 weeks. Rates of clinical improvement and remission, adverse events, constipation-related symptoms (PAC-SYM scores) , bowel movements per week and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. This study was registered in the Clinical Trials.gov (NCT02016469) . Results Among 23 patients, 7 were male, 16 were female, the mean age was (49.6 ± 14.7) years, the body mass index was (21.2 ± 2.2) kg/m2, the duration of constipation was (8.3 ± 5.9) years, and the defecation frequency was 1.8 ± 0.7 per week. Compared with pre-treatment, PAC-SYM scores decreased significantly from 2.3 ± 0.5 to 1.3 ± 0.4 at week 12 (P < 0.01) , defecation frequency increased from 1.8 ± 0.7 per week to 4.8 ± 2.0 per week at week 12 (P < 0.01) , and patients felt satisfied with improved GIQLI score (from 78.5 ± 15.5 to 120.8 ± 21.3, P < 0.01) . During the follow-up, the clinical improvement and remission of STC patients reached 69.6% (16/23) and 52.2% (12/23) , respectively. No serious adverse events were observed. Conclusion FMT combined with Soluble Dietary Fiber and probiotics is safe and effective in treating slow transit constipation, which can improve the symptom and quality of life significantly. Key words: Slow transit constipation; Fecal microbiota transplantation; Soluble Dietary Fiber; Probiotics

  • fecal microbiota transplantation in combination with Soluble Dietary Fiber for treatment of slow transit constipation a pilot study
    Archives of Medical Research, 2016
    Co-Authors: Hongliang Tian, Chao Ding, Jianfeng Gong, Yao Wei, Weiming Zhu
    Abstract:

    Background and Aims Intestinal microbiota and Soluble Dietary Fiber play an important role in intestinal microecology, which is closely related to gut motility. Regulating intestinal microecology comprised of fecal microbiota transplantation (FMT) or Fiber supplementation is becoming a novel therapy for functional gastrointestinal disease. We launched this study to evaluate the efficacy and safety of FMT combined with Fiber for slow transit constipation (STC). Methods We performed a study of 21 patients with STC. Participants received FMT (via nasojejunal tubes) on 3 consecutive days. After FMT, they were recommended to receive Soluble Dietary Fiber for 4 weeks (8 g, twice daily). Rate of clinical improvement and remission, constipation-related symptoms (PAC-SYM scores), bowel movements per week, colonic transit time (CTT) and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. Results At the study end, clinical improvement and remission of constipated patients reached 66.7 and 42.9%, respectively. The patients showed an increased stool frequency from 1.7 ± 0.5 per week to 4.8 ± 2.1 per week (p Conclusion This is a pilot study confirming that FMT combined with Fiber may improve symptoms experienced by constipated patients by regulating intestinal microecology, without any serious adverse events.

Ye Chen - One of the best experts on this subject based on the ideXlab platform.

  • intensifying Soluble Dietary Fiber production and properties of soybean curd residue via autoclaving treatment
    Bioresource Technology Reports, 2019
    Co-Authors: Guiyun Chen, Siqi Qiang, Dong Tang, Yue Chen, Zhenya Zhang, Zhongfang Lei, Ye Chen
    Abstract:

    Abstract Soybean curd residue (SCR) contains rich Dietary Fiber, but the low content of Soluble Dietary Fiber (SDF) limits its development and utilization. To fully utilize SCR, autoclaving treatment (AT) was used to enhance the yield and properties of SDF. The results indicated that when SCR was treated under the condition of 128 °C for 10 min and solid liquid ratio 1:3, the yield of SDF increased to 23.60% compared with the original 11.13%. Under the optimized condition, SDF degraded into low molecular mass products by AT. Meanwhile, referred to the glucose, monosaccharide molar ratios in ASDF were increased except mannose. ASDF has a viscosity of 23.6 Pa·S when the concentration was 35 mg/mL. When the temperature reaches to 90 °C, the solubility of ASDF is 9.24 g/100 mL. The results indicated that AT is a potential pathway to improve yield and properties of SDF in SCR.

  • novel blasting extrusion processing improved the physicochemical properties of Soluble Dietary Fiber from soybean residue and in vivo evaluation
    Journal of Food Engineering, 2014
    Co-Authors: Ye Chen, Luo Yin, Ning Zhang
    Abstract:

    Abstract Soluble Dietary Fiber is a carbohydrate-based polymer with significant health benefits that is enriched in whole grains, nuts, fruits, and vegetables. Soybean residues are generally discarded in food industries during the production of soybean milk and tofu. This study investigated the effect of blasting extrusion processing (BEP) on the increase in soybean residue SDF content under optimal conditions (170 °C and an extrusion screw speed of 150 r/min). Compared with the control, the content of Soluble Dietary Fiber from soybean residues treated by BEP (BEPSDF) was increased from 2.6 ± 0.3% to 30.1 ± 0.6%. In addition, BEPSDF showed improved water solubility, water retention capacity and swelling capacity. Furthermore, differential scanning calorimetry (DSC) experiments showed that SDF treated by BEP has a higher peak temperature (92.5 °C) than that of the control (86.6 °C). Scanning electron microscopy (SEM) images showed that the surface of BEPSDF was rough and collapsed. Moreover, in vivo experiment results indicated that BEPSDF significantly reduces the concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) while elevating the concentration of high-density lipoprotein cholesterol (HDL-C). This finding indicates that BEPSDF has beneficial physiological effects.