The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform
Fusako Maehira - One of the best experts on this subject based on the ideXlab platform.
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Basic nutritional investigation Effects of calcium sources and Soluble Silicate on bone metabolism and the related gene expression in mice
2020Co-Authors: Fusako Maehira, Ikuko Miyagi, Yukinori EguchiAbstract:Objective: The effects of five calcium (Ca) sources were compared for bone biochemical and mechanical properties and the related gene expression using mice, from the viewpoint of their Soluble silicon (Si) content. Methods: Weanling male mice were fed diets containing 1% Ca supplemented with CaCO3 as the control (CT), coral sand (CS), fossil stony coral (FSC), fish bone (FC) and eggshell (EC) powders, and 50 ppm of Si in the CT diet for 6 mo. The mRNA expressions related to bone remodeling were quantified by real-time polymerase chain reaction. Results: Soluble Si content was 9.83, 7.17, 2.48, 0.29, and 0.20 ppm for the CS, FC, FSC, EC, and Ca-deficient basal diets, respectively. Si, CS, and FSC, in order, significantly increased dry and ash weights, Ca and hydroxyproline contents, and alkaline phosphatase and decreased tartrate-resistant acid phosphatase and urinary excretion of hydroxyproline compared with the CT group. Si signif- icantly increased and FC decreased femoral strength and stiffness. In the mRNA expression related to osteoblastogenesis, Si and CS significantly increased runt-related transcription factor 2. Si, CS, and FSC, in order, significantly decreased and FC and EC increased peroxisome proliferator- activated receptor-. In the mRNA expression related to osteoclastogenesis, Si and CS significantly increased and FC and EC decreased the osteoprotegerin/receptor activator of nuclear factor-B ligand ratio, whereas Si and CS decreased transforming growth factor-. Conclusion: The results indicated that Soluble Silicate and CS, with the highest Si content among Ca sources, improved bone biochemical and mechanical properties through stimulation of gene expression related to osteoblastogenesis and suppression of that related to osteoclastogenesis. © 2009 Published by Elsevier Inc.
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effects of calcium sources and Soluble Silicate on bone metabolism and the related gene expression in mice
Nutrition, 2009Co-Authors: Fusako Maehira, Ikuko Miyagi, Yukinori EguchiAbstract:Abstract Objective The effects of five calcium (Ca) sources were compared for bone biochemical and mechanical properties and the related gene expression using mice, from the viewpoint of their Soluble silicon (Si) content. Methods Weanling male mice were fed diets containing 1% Ca supplemented with CaCO 3 as the control (CT), coral sand (CS), fossil stony coral (FSC), fish bone (FC) and eggshell (EC) powders, and 50 ppm of Si in the CT diet for 6 mo. The mRNA expressions related to bone remodeling were quantified by real-time polymerase chain reaction. Results Soluble Si content was 9.83, 7.17, 2.48, 0.29, and 0.20 ppm for the CS, FC, FSC, EC, and Ca-deficient basal diets, respectively. Si, CS, and FSC, in order, significantly increased dry and ash weights, Ca and hydroxyproline contents, and alkaline phosphatase and decreased tartrate-resistant acid phosphatase and urinary excretion of hydroxyproline compared with the CT group. Si significantly increased and FC decreased femoral strength and stiffness. In the mRNA expression related to osteoblastogenesis, Si and CS significantly increased runt-related transcription factor 2. Si, CS, and FSC, in order, significantly decreased and FC and EC increased peroxisome proliferator-activated receptor-γ. In the mRNA expression related to osteoclastogenesis, Si and CS significantly increased and FC and EC decreased the osteoprotegerin/receptor activator of nuclear factor-κB ligand ratio, whereas Si and CS decreased transforming growth factor-β. Conclusion The results indicated that Soluble Silicate and CS, with the highest Si content among Ca sources, improved bone biochemical and mechanical properties through stimulation of gene expression related to osteoblastogenesis and suppression of that related to osteoclastogenesis.
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Effects of Soluble silicon compound and deep-sea water on biochemical and mechanical properties of bone and the related gene expression in mice
Journal of Bone and Mineral Metabolism, 2008Co-Authors: Fusako Maehira, Ikuko Miyagi, Yukinori Eguchi, Yoshirou Iinuma, Shoei TeruyaAbstract:Silicon has been known as an essential element for bone formation. The silicon contents of sea water increase with increasing of depth: 1.8 ppm Si in deep-sea water (DW) at 612 m in depth versus 0.06 ppm in surface sea water (SW). The effects of Soluble silicon (Si) and DW from which NaCl was eliminated were studied in comparison with tap water (TW) and SW in cell cultures and in animal experiments using the control strain of senescence accelerated mouse, SAMR1. Si at 10 ppm as sodium metaSilicate or 10% DW in the α-MEM medium stimulated cellular viability, marker enzymes of osteoblast and osteoclast cell lines, and the ^45CaCl_2 uptake in those cells in comparison with the medium control. After weanling SAMR1 were maintained for 6 months on a diet containing 200 ppm Si and 39% of DW and SW, DW and Si improved bone biochemical indices such as femoral weight, mineral and collagen content, and marker enzymes of bone formation and resorption as well as mechanical properties as compared to TW. In the femoral bone marrow of SAMR1, the mRNA expression of bone morphogenetic protein-2 (BMP-2), interleukin-11 (IL-11), and runt-related transcription factor 2 (Runx 2), which stimulate osteoblast development as well as type I procollagen (COL1A1) mRNA, were significantly increased in both DW and Si groups. The expressions of both osteoprotegerin (OPG) and receptor activator of NF-κB ligand (RANKL) were also elevated, resulting in distinct increases of the OPG/RANKL ratio in both DW and Si groups. The results indicated that a Soluble Silicate and deep-sea water as its natural material stimulated cell growth in both osteoblasts and osteoclasts in cell culture and promoted bone metabolic turnover in favor of bone formation through stimulation of the related mRNA expression in animal experiments.
Shoei Teruya - One of the best experts on this subject based on the ideXlab platform.
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Effects of Soluble silicon compound and deep-sea water on biochemical and mechanical properties of bone and the related gene expression in mice
Journal of Bone and Mineral Metabolism, 2008Co-Authors: Fusako Maehira, Ikuko Miyagi, Yukinori Eguchi, Yoshirou Iinuma, Shoei TeruyaAbstract:Silicon has been known as an essential element for bone formation. The silicon contents of sea water increase with increasing of depth: 1.8 ppm Si in deep-sea water (DW) at 612 m in depth versus 0.06 ppm in surface sea water (SW). The effects of Soluble silicon (Si) and DW from which NaCl was eliminated were studied in comparison with tap water (TW) and SW in cell cultures and in animal experiments using the control strain of senescence accelerated mouse, SAMR1. Si at 10 ppm as sodium metaSilicate or 10% DW in the α-MEM medium stimulated cellular viability, marker enzymes of osteoblast and osteoclast cell lines, and the ^45CaCl_2 uptake in those cells in comparison with the medium control. After weanling SAMR1 were maintained for 6 months on a diet containing 200 ppm Si and 39% of DW and SW, DW and Si improved bone biochemical indices such as femoral weight, mineral and collagen content, and marker enzymes of bone formation and resorption as well as mechanical properties as compared to TW. In the femoral bone marrow of SAMR1, the mRNA expression of bone morphogenetic protein-2 (BMP-2), interleukin-11 (IL-11), and runt-related transcription factor 2 (Runx 2), which stimulate osteoblast development as well as type I procollagen (COL1A1) mRNA, were significantly increased in both DW and Si groups. The expressions of both osteoprotegerin (OPG) and receptor activator of NF-κB ligand (RANKL) were also elevated, resulting in distinct increases of the OPG/RANKL ratio in both DW and Si groups. The results indicated that a Soluble Silicate and deep-sea water as its natural material stimulated cell growth in both osteoblasts and osteoclasts in cell culture and promoted bone metabolic turnover in favor of bone formation through stimulation of the related mRNA expression in animal experiments.
Thomas J. Pinnavaia - One of the best experts on this subject based on the ideXlab platform.
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A low cost route to hexagonal mesostructured carbon molecular sieves
Chemical Communications, 2001Co-Authors: Thomas J. PinnavaiaAbstract:A mesoporous carbon molecular sieve with a hexagonal framework structure (denoted C-MSU-H) has been prepared using a MSU-H silica template that can be assembled from a low cost Soluble Silicate precursor at near-neutral pH conditions.
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Non-ionic surfactant assembly of ordered, very large pore molecular sieve silicas from water Soluble Silicates
Chemical Communications, 2000Co-Authors: Thomas R. Pauly, Thomas J. PinnavaiaAbstract:Very large pore hexagonal and cellular foam-like molecular sieve silicas with well cross-linked framework walls (denoted MSU-H and MSU-F, respectively), have been prepared from Soluble Silicate precursors under neutral pH conditions.
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Non-ionic surfactant assembly of wormhole silica molecular sieves from water Soluble Silicates
Chemical Communications, 2000Co-Authors: Thomas R. Pauly, Thomas J. PinnavaiaAbstract:Thermally stable mesoporous silica molecular sieves with wormhole framework structures, previously obtainable only from silicon alkoxides, have been prepared from low cost Soluble Silicate precursors in the presence of non-ionic surfactants as structure directors.
Yukinori Eguchi - One of the best experts on this subject based on the ideXlab platform.
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Basic nutritional investigation Effects of calcium sources and Soluble Silicate on bone metabolism and the related gene expression in mice
2020Co-Authors: Fusako Maehira, Ikuko Miyagi, Yukinori EguchiAbstract:Objective: The effects of five calcium (Ca) sources were compared for bone biochemical and mechanical properties and the related gene expression using mice, from the viewpoint of their Soluble silicon (Si) content. Methods: Weanling male mice were fed diets containing 1% Ca supplemented with CaCO3 as the control (CT), coral sand (CS), fossil stony coral (FSC), fish bone (FC) and eggshell (EC) powders, and 50 ppm of Si in the CT diet for 6 mo. The mRNA expressions related to bone remodeling were quantified by real-time polymerase chain reaction. Results: Soluble Si content was 9.83, 7.17, 2.48, 0.29, and 0.20 ppm for the CS, FC, FSC, EC, and Ca-deficient basal diets, respectively. Si, CS, and FSC, in order, significantly increased dry and ash weights, Ca and hydroxyproline contents, and alkaline phosphatase and decreased tartrate-resistant acid phosphatase and urinary excretion of hydroxyproline compared with the CT group. Si signif- icantly increased and FC decreased femoral strength and stiffness. In the mRNA expression related to osteoblastogenesis, Si and CS significantly increased runt-related transcription factor 2. Si, CS, and FSC, in order, significantly decreased and FC and EC increased peroxisome proliferator- activated receptor-. In the mRNA expression related to osteoclastogenesis, Si and CS significantly increased and FC and EC decreased the osteoprotegerin/receptor activator of nuclear factor-B ligand ratio, whereas Si and CS decreased transforming growth factor-. Conclusion: The results indicated that Soluble Silicate and CS, with the highest Si content among Ca sources, improved bone biochemical and mechanical properties through stimulation of gene expression related to osteoblastogenesis and suppression of that related to osteoclastogenesis. © 2009 Published by Elsevier Inc.
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effects of calcium sources and Soluble Silicate on bone metabolism and the related gene expression in mice
Nutrition, 2009Co-Authors: Fusako Maehira, Ikuko Miyagi, Yukinori EguchiAbstract:Abstract Objective The effects of five calcium (Ca) sources were compared for bone biochemical and mechanical properties and the related gene expression using mice, from the viewpoint of their Soluble silicon (Si) content. Methods Weanling male mice were fed diets containing 1% Ca supplemented with CaCO 3 as the control (CT), coral sand (CS), fossil stony coral (FSC), fish bone (FC) and eggshell (EC) powders, and 50 ppm of Si in the CT diet for 6 mo. The mRNA expressions related to bone remodeling were quantified by real-time polymerase chain reaction. Results Soluble Si content was 9.83, 7.17, 2.48, 0.29, and 0.20 ppm for the CS, FC, FSC, EC, and Ca-deficient basal diets, respectively. Si, CS, and FSC, in order, significantly increased dry and ash weights, Ca and hydroxyproline contents, and alkaline phosphatase and decreased tartrate-resistant acid phosphatase and urinary excretion of hydroxyproline compared with the CT group. Si significantly increased and FC decreased femoral strength and stiffness. In the mRNA expression related to osteoblastogenesis, Si and CS significantly increased runt-related transcription factor 2. Si, CS, and FSC, in order, significantly decreased and FC and EC increased peroxisome proliferator-activated receptor-γ. In the mRNA expression related to osteoclastogenesis, Si and CS significantly increased and FC and EC decreased the osteoprotegerin/receptor activator of nuclear factor-κB ligand ratio, whereas Si and CS decreased transforming growth factor-β. Conclusion The results indicated that Soluble Silicate and CS, with the highest Si content among Ca sources, improved bone biochemical and mechanical properties through stimulation of gene expression related to osteoblastogenesis and suppression of that related to osteoclastogenesis.
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Effects of Soluble silicon compound and deep-sea water on biochemical and mechanical properties of bone and the related gene expression in mice
Journal of Bone and Mineral Metabolism, 2008Co-Authors: Fusako Maehira, Ikuko Miyagi, Yukinori Eguchi, Yoshirou Iinuma, Shoei TeruyaAbstract:Silicon has been known as an essential element for bone formation. The silicon contents of sea water increase with increasing of depth: 1.8 ppm Si in deep-sea water (DW) at 612 m in depth versus 0.06 ppm in surface sea water (SW). The effects of Soluble silicon (Si) and DW from which NaCl was eliminated were studied in comparison with tap water (TW) and SW in cell cultures and in animal experiments using the control strain of senescence accelerated mouse, SAMR1. Si at 10 ppm as sodium metaSilicate or 10% DW in the α-MEM medium stimulated cellular viability, marker enzymes of osteoblast and osteoclast cell lines, and the ^45CaCl_2 uptake in those cells in comparison with the medium control. After weanling SAMR1 were maintained for 6 months on a diet containing 200 ppm Si and 39% of DW and SW, DW and Si improved bone biochemical indices such as femoral weight, mineral and collagen content, and marker enzymes of bone formation and resorption as well as mechanical properties as compared to TW. In the femoral bone marrow of SAMR1, the mRNA expression of bone morphogenetic protein-2 (BMP-2), interleukin-11 (IL-11), and runt-related transcription factor 2 (Runx 2), which stimulate osteoblast development as well as type I procollagen (COL1A1) mRNA, were significantly increased in both DW and Si groups. The expressions of both osteoprotegerin (OPG) and receptor activator of NF-κB ligand (RANKL) were also elevated, resulting in distinct increases of the OPG/RANKL ratio in both DW and Si groups. The results indicated that a Soluble Silicate and deep-sea water as its natural material stimulated cell growth in both osteoblasts and osteoclasts in cell culture and promoted bone metabolic turnover in favor of bone formation through stimulation of the related mRNA expression in animal experiments.
J.s.j. Van Deventer - One of the best experts on this subject based on the ideXlab platform.
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Chemical interactions between siliceous aggregates and low-Ca alkali-activated cements
Cement and Concrete Research, 2007Co-Authors: J.s.j. Van DeventerAbstract:Abstract The chemical interactions between natural siliceous aggregates and a low-Ca alkali-activated cement (geopolymer) were studied. By leaching ideal aluminoSilicate minerals such as kaolinite and albite in various alkaline solutions with or without Soluble Silicates, it was found that addition of 0.5 M SiO 2 to a highly alkaline activating solution ([OH − ] 0 = 5 to 10 M) was responsible for the formation of an Al-enriched aluminoSilicate surface through the initial non-stoichiometric and Si preferential dissolution of the parent aluminoSilicates. This then facilitated Soluble Silicate deposition from the activating solutions onto the Al-rich surfaces, which resulted in the formation of a dense deposited aluminoSilicate gel interfacial layer. This aluminoSilicate interface formed during albite leaching ([OH − ] 0 = 5 to 10 M and [SiO 2 ] 0 = 0.5 M) was found to possess a similar Si/Al ratio to the real interface between a siliceous aggregate slice (basalt or siltstone) and a low-Ca fly ash/kaolinite geopolymer, activated with an activating solution of [OH − ] 0 = 10 M and [SiO 2 ] 0 = 2.5 M. Due to the similarities between the activating solutions used and the interfaces formed, it is postulated that a similar formation mechanism is shared between the deposited aluminoSilicate interface formed from leaching and a ‘real’ geopolymer concrete synthesis. Without Soluble Silicate addition, or if a solution of low alkalinity ([OH − ] 0 = 0.6 M and [SiO 2 ] 0 = 0 and 0.5 M) was used, the Al-enriched reacting surface was not formed, and no deposited aluminoSilicate interface was observed in these systems.
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Effect of Alkali Cations on Aluminum Incorporation in Geopolymeric Gels
Industrial & Engineering Chemistry Research, 2005Co-Authors: Peter Duxson, Grant C. Lukey, And F. Separovic, J.s.j. Van DeventerAbstract:In geopolymeric gels, aluminum is known to have tetrahedral coordination and to be associated with an alkali cation to satisfy electronic neutrality. However, the mechanism of aluminum incorporation and the effects of different synthesis parameters are not well understood. 2H, 27Al, and 23Na MAS NMR techniques have been used to elucidate the structural properties and mechanism of aluminum incorporation in metakaolin-based geopolymers. Na+(aq) and Al(OH)4-(aq) species were detected in the pore solution of geopolymers with Si/Al ratios of ≤1.40 and found to be directly related to the concentration of Soluble Silicate in the activating solution used for synthesis. The relative concentration of Na+(aq) in sodium and mixed-alkali geopolymers indicated a preferential incorporation of potassium into geopolymeric gels during curing. This work demonstrates a direct link between the composition of the Silicate activator and aluminum incorporation in geopolymeric gels.
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structural reorganisation of class f fly ash in alkaline Silicate solutions
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2002Co-Authors: J.s.j. Van DeventerAbstract:Abstract Class F fly ash was leached in alkaline solutions (pH∼13.95) of varying concentrations of Soluble Silicates at 20 °C. The elemental compositions of the leached solutions were studied by inductively coupled plasma with optical emission spectroscopy (ICP–OES). X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) were used to examine the bulk properties of the leached solids. The surface morphology and compositions were characterised by scanning electron microscopy (SEM) coupled with an energy dispersive spectrometer (EDS). It was found that when the Soluble Silicate dosage was low ( ∼200 mM). The greatly enhanced aluminoSilicate dissolution followed by the subsequent precipitation was found to be responsible for the formation of a new aluminoSilicate gel phase as observed from the ICP–OES analysis, FTIR study and SEM micrographs.