The Experts below are selected from a list of 46584 Experts worldwide ranked by ideXlab platform
Naomi A Fineberg - One of the best experts on this subject based on the ideXlab platform.
-
obsessive compulsive disorder ocd practical strategies for pharmacological and Somatic Treatment in adults
Psychiatry Research-neuroimaging, 2015Co-Authors: Naomi A Fineberg, Samar Reghunandanan, Helen Blair Simpson, Katharine A Phillips, Margaret A Richter, Keith Matthews, Dan J Stein, Jitender SareenAbstract:This narrative review gathers together a range of international experts to critically appraise the existing trial-based evidence relating to the efficacy and tolerability of pharmacotherapy for obsessive compulsive disorder in adults. We discuss the diagnostic evaluation and clinical characteristics followed by Treatment options suitable for the clinician working from primary through to specialist psychiatric care. Robust data supports the effectiveness of Treatment with selective serotonin reuptake inhibitors (SSRIs) and clomipramine in the short-term and the longer-term Treatment and for relapse prevention. Owing to better tolerability, SSRIs are acknowledged as the first-line pharmacological Treatment of choice. For those patients for whom first line Treatments have been ineffective, evidence supports the use of adjunctive antipsychotic medication, and some evidence supports the use of high-dose SSRIs. Novel compounds are also the subject of active investigation. Neurosurgical Treatments, including ablative lesion neurosurgery and deep brain stimulation, are reserved for severely symptomatic individuals who have not experienced sustained response to both pharmacological and cognitive behavior therapies.
Jitender Sareen - One of the best experts on this subject based on the ideXlab platform.
-
obsessive compulsive disorder ocd practical strategies for pharmacological and Somatic Treatment in adults
Psychiatry Research-neuroimaging, 2015Co-Authors: Naomi A Fineberg, Samar Reghunandanan, Helen Blair Simpson, Katharine A Phillips, Margaret A Richter, Keith Matthews, Dan J Stein, Jitender SareenAbstract:This narrative review gathers together a range of international experts to critically appraise the existing trial-based evidence relating to the efficacy and tolerability of pharmacotherapy for obsessive compulsive disorder in adults. We discuss the diagnostic evaluation and clinical characteristics followed by Treatment options suitable for the clinician working from primary through to specialist psychiatric care. Robust data supports the effectiveness of Treatment with selective serotonin reuptake inhibitors (SSRIs) and clomipramine in the short-term and the longer-term Treatment and for relapse prevention. Owing to better tolerability, SSRIs are acknowledged as the first-line pharmacological Treatment of choice. For those patients for whom first line Treatments have been ineffective, evidence supports the use of adjunctive antipsychotic medication, and some evidence supports the use of high-dose SSRIs. Novel compounds are also the subject of active investigation. Neurosurgical Treatments, including ablative lesion neurosurgery and deep brain stimulation, are reserved for severely symptomatic individuals who have not experienced sustained response to both pharmacological and cognitive behavior therapies.
Ronald A Weller - One of the best experts on this subject based on the ideXlab platform.
-
Somatic Treatment of bipolar disorder in children and adolescents
Psychiatric Clinics of North America, 2004Co-Authors: Elizabeth B Weller, Arman K Danielyan, Ronald A WellerAbstract:The currently available data from randomized, controlled trials and a considerable amount of open clinical data suggest that adolescent-onset bipolar disorder probably responds to the same agents as adult-onset bipolar disorder. Research examining psychopharmacologic Treatment approaches in the early-onset bipolar disorder is limited, however. Methodologic problems include small sample sizes, lack of comparison groups, retrospective designs,and lack of standardized measures. In addition, sometimes no clear differentiation is made between mania and bipolar disorder, the latter term being used broadly in the literature. Often the studies show that symptoms improve because of Treatment, but the functioning of the patients does not improve significantly. More research is clearly needed in all aspects of this disorder but especially in examining the efficacy of various types of Treatment, its longitudinal course, and diagnostic issues. The indications for, and the overall duration of, long-term maintenance therapy need further study.Many adolescents and children with bipolar disorder do not respond to any of the first-line pharmacologic Treatments; therefore, studies with novel agents should be extended to patients in this age range. Furthermore, physicians will probably continue to use combination therapies when confronted by either lack of efficacy or delayed onset of efficacy with a single agent. Thus, such resultant drug-drug interactions also should also be systematically studied [97].
Samar Reghunandanan - One of the best experts on this subject based on the ideXlab platform.
-
obsessive compulsive disorder ocd practical strategies for pharmacological and Somatic Treatment in adults
Psychiatry Research-neuroimaging, 2015Co-Authors: Naomi A Fineberg, Samar Reghunandanan, Helen Blair Simpson, Katharine A Phillips, Margaret A Richter, Keith Matthews, Dan J Stein, Jitender SareenAbstract:This narrative review gathers together a range of international experts to critically appraise the existing trial-based evidence relating to the efficacy and tolerability of pharmacotherapy for obsessive compulsive disorder in adults. We discuss the diagnostic evaluation and clinical characteristics followed by Treatment options suitable for the clinician working from primary through to specialist psychiatric care. Robust data supports the effectiveness of Treatment with selective serotonin reuptake inhibitors (SSRIs) and clomipramine in the short-term and the longer-term Treatment and for relapse prevention. Owing to better tolerability, SSRIs are acknowledged as the first-line pharmacological Treatment of choice. For those patients for whom first line Treatments have been ineffective, evidence supports the use of adjunctive antipsychotic medication, and some evidence supports the use of high-dose SSRIs. Novel compounds are also the subject of active investigation. Neurosurgical Treatments, including ablative lesion neurosurgery and deep brain stimulation, are reserved for severely symptomatic individuals who have not experienced sustained response to both pharmacological and cognitive behavior therapies.
Helen Blair Simpson - One of the best experts on this subject based on the ideXlab platform.
-
obsessive compulsive disorder ocd practical strategies for pharmacological and Somatic Treatment in adults
Psychiatry Research-neuroimaging, 2015Co-Authors: Naomi A Fineberg, Samar Reghunandanan, Helen Blair Simpson, Katharine A Phillips, Margaret A Richter, Keith Matthews, Dan J Stein, Jitender SareenAbstract:This narrative review gathers together a range of international experts to critically appraise the existing trial-based evidence relating to the efficacy and tolerability of pharmacotherapy for obsessive compulsive disorder in adults. We discuss the diagnostic evaluation and clinical characteristics followed by Treatment options suitable for the clinician working from primary through to specialist psychiatric care. Robust data supports the effectiveness of Treatment with selective serotonin reuptake inhibitors (SSRIs) and clomipramine in the short-term and the longer-term Treatment and for relapse prevention. Owing to better tolerability, SSRIs are acknowledged as the first-line pharmacological Treatment of choice. For those patients for whom first line Treatments have been ineffective, evidence supports the use of adjunctive antipsychotic medication, and some evidence supports the use of high-dose SSRIs. Novel compounds are also the subject of active investigation. Neurosurgical Treatments, including ablative lesion neurosurgery and deep brain stimulation, are reserved for severely symptomatic individuals who have not experienced sustained response to both pharmacological and cognitive behavior therapies.