The Experts below are selected from a list of 57 Experts worldwide ranked by ideXlab platform

Slavica Vučinić - One of the best experts on this subject based on the ideXlab platform.

  • The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine.
    Drug development and industrial pharmacy, 2007
    Co-Authors: Nada Vučinić-milanković, Snežana Savić, Gordana Vuleta, Slavica Vučinić
    Abstract:

    Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and Sorbitan Stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug - diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and rheological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.

Nada Vučinić-milanković - One of the best experts on this subject based on the ideXlab platform.

  • The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine.
    Drug development and industrial pharmacy, 2007
    Co-Authors: Nada Vučinić-milanković, Snežana Savić, Gordana Vuleta, Slavica Vučinić
    Abstract:

    Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and Sorbitan Stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug - diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and rheological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.

Snežana Savić - One of the best experts on this subject based on the ideXlab platform.

  • natural surfactant based emulsion vehicles a correlation between colloidal structure and in vitro release of diclofenac diethylamine
    Journal of Dispersion Science and Technology, 2010
    Co-Authors: Nada Vucinicmilankovic, Snežana Savić, Gordana Vuleta, Slavica Vucinic
    Abstract:

    The need for an official pharmaceutical vehicle or carrier of drug based on natural sugar emulsifiers that protect and regenerate natural barriers of the skin lipid layer is constantly increasing. This article studies the specific structures of emulsions and two manners of water binding that provide prolonged skin moisturization and delayed or prolonged release of drugs insoluble in water. Natural emulsifiers of an alkylpolyglucoside (cetearyl alcohol and cetearyl glycoside) and estar-type (Sorbitan Stearate and sucrose cocoate) are used for manufacturing vehicle/carriers of drugs (diclofenac diethylamine). Specific hydrofilic groups in emulsifiers, such as glycozide and ester, are capable of binding in different manners and variable quantities of water by hydrogen bonds within the cream, which is responsible for water distribution and prolonged skin moisturization. This lyotropic potential of natural emulsifiers—alkylpolyglucoside and estar type—may affect the physical stability of topical vehicles by de...

  • The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine.
    Drug development and industrial pharmacy, 2007
    Co-Authors: Nada Vučinić-milanković, Snežana Savić, Gordana Vuleta, Slavica Vučinić
    Abstract:

    Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and Sorbitan Stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug - diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and rheological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.

Gordana Vuleta - One of the best experts on this subject based on the ideXlab platform.

  • natural surfactant based emulsion vehicles a correlation between colloidal structure and in vitro release of diclofenac diethylamine
    Journal of Dispersion Science and Technology, 2010
    Co-Authors: Nada Vucinicmilankovic, Snežana Savić, Gordana Vuleta, Slavica Vucinic
    Abstract:

    The need for an official pharmaceutical vehicle or carrier of drug based on natural sugar emulsifiers that protect and regenerate natural barriers of the skin lipid layer is constantly increasing. This article studies the specific structures of emulsions and two manners of water binding that provide prolonged skin moisturization and delayed or prolonged release of drugs insoluble in water. Natural emulsifiers of an alkylpolyglucoside (cetearyl alcohol and cetearyl glycoside) and estar-type (Sorbitan Stearate and sucrose cocoate) are used for manufacturing vehicle/carriers of drugs (diclofenac diethylamine). Specific hydrofilic groups in emulsifiers, such as glycozide and ester, are capable of binding in different manners and variable quantities of water by hydrogen bonds within the cream, which is responsible for water distribution and prolonged skin moisturization. This lyotropic potential of natural emulsifiers—alkylpolyglucoside and estar type—may affect the physical stability of topical vehicles by de...

  • The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine.
    Drug development and industrial pharmacy, 2007
    Co-Authors: Nada Vučinić-milanković, Snežana Savić, Gordana Vuleta, Slavica Vučinić
    Abstract:

    Two sugar-based emulsifiers, cetearyl alcohol & cetearyl glycoside and Sorbitan Stearate & sucrose cocoate, known as potential promoters of lamellar liquid crystals/gel phases, were investigated in order to formulate an optimal vehicle for amphiphilic drug - diclofenac diethylamine (DDA). Physico-chemical characterization and study of vehicle's physical stability were performed. Then, the in vitro DDA liberation profile, dependent on the mode of drug incorporation to the system, and the in vivo, short-term effects of chosen samples on skin parameters were examined. Droplets size distribution and rheological behavior indicated satisfying physical stability of both types of vehicles. Unexpectedly, the manner of DDA incorporation to the system had no significant influence on DDA release. In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle.

Nilmoni Sarkar - One of the best experts on this subject based on the ideXlab platform.