The Experts below are selected from a list of 93150 Experts worldwide ranked by ideXlab platform
Serena J Counsell - One of the best experts on this subject based on the ideXlab platform.
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prediction of neurodevelopmental outcome after hypoxic ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract based Spatial Statistics
Pediatric Research, 2012Co-Authors: Nora Tusor, Denis Azzopardi, Joanna M Allsop, David A. Edwards, Courtney J Wusthoff, Natalie Smee, Nazakat Merchant, Tomoki Arichi, F M Cowan, Serena J CounsellAbstract:Prediction of neurodevelopmental outcome after hypoxic–ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based Spatial Statistics
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an optimised tract based Spatial Statistics protocol for neonates applications to prematurity and chronic lung disease
NeuroImage, 2010Co-Authors: Gareth Ball, Serena J Counsell, Mustafa Anjari, Nazakat Merchant, Tomoki Arichi, Valentina Doria, Mary A RutherfordAbstract:Preterm birth is associated with altered white matter microstructure, defined by metrics derived from diffusion tensor imaging (DTI). Tract-based Spatial Statistics (TBSS) is a useful tool for investigating developing white matter using DTI, but standard TBSS protocols have limitations for neonatal studies. We describe an optimised TBSS protocol for neonatal DTI data, in which registration errors are reduced. As chronic lung disease (CLD) is an independent risk factor for abnormal white matter development, we investigate the effect of this condition on white matter anisotropy and diffusivity using the optimised protocol in a proof of principle experiment. DTI data were acquired from 93 preterm infants (48 male) with a median gestational age at birth of 28(+5) (23(+4)-35(+2))weeks at a median postmenstrual age at scan of 41(+4) (38(+1)-46(+6))weeks. Nineteen infants developed CLD, defined as requiring supplemental oxygen at 36weeks postmenstrual age. TBSS was modified to include an initial low degrees-of-freedom linear registration step and a second registration to a population-average FA map. The additional registration steps reduced global misalignment between neonatal fractional anisotropy (FA) maps. Infants with CLD had significantly increased radial diffusivity (RD) and significantly reduced FA within the centrum semiovale, corpus callosum and inferior longitudinal fasciculus (p<0.05) compared to their peers, controlling for degree of prematurity and age at scan. The optimised TBSS protocol improved reliability for neonatal DTI analysis. These data suggest that potentially modifiable respiratory morbidity is associated with widespread altered white matter microstructure in preterm infants at term-equivalent age.
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an optimised tract based Spatial Statistics protocol for neonates applications to prematurity and chronic lung disease
NeuroImage, 2010Co-Authors: Gareth Ball, Serena J Counsell, Mustafa Anjari, Nazakat Merchant, Tomoki Arichi, Valentina Doria, Mary A RutherfordAbstract:Abstract Preterm birth is associated with altered white matter microstructure, defined by metrics derived from diffusion tensor imaging (DTI). Tract-based Spatial Statistics (TBSS) is a useful tool for investigating developing white matter using DTI, but standard TBSS protocols have limitations for neonatal studies. We describe an optimised TBSS protocol for neonatal DTI data, in which registration errors are reduced. As chronic lung disease (CLD) is an independent risk factor for abnormal white matter development, we investigate the effect of this condition on white matter anisotropy and diffusivity using the optimised protocol in a proof of principle experiment. DTI data were acquired from 93 preterm infants (48 male) with a median gestational age at birth of 28+ 5 (23+ 4–35+ 2) weeks at a median postmenstrual age at scan of 41+ 4 (38+ 1–46+ 6) weeks. Nineteen infants developed CLD, defined as requiring supplemental oxygen at 36 weeks postmenstrual age. TBSS was modified to include an initial low degrees-of-freedom linear registration step and a second registration to a population-average FA map. The additional registration steps reduced global misalignment between neonatal fractional anisotropy (FA) maps. Infants with CLD had significantly increased radial diffusivity (RD) and significantly reduced FA within the centrum semiovale, corpus callosum and inferior longitudinal fasciculus (p The optimised TBSS protocol improved reliability for neonatal DTI analysis. These data suggest that potentially modifiable respiratory morbidity is associated with widespread altered white matter microstructure in preterm infants at term-equivalent age.
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tract based Spatial Statistics of magnetic resonance images to assess disease and treatment effects in perinatal asphyxial encephalopathy
Pediatric Research, 2010Co-Authors: E. Porter, Serena J Counsell, Joanna M Allsop, David A. Edwards, Denis AzzopardiAbstract:Tract-Based Spatial Statistics of Magnetic Resonance Images to Assess Disease and Treatment Effects in Perinatal Asphyxial Encephalopathy
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Tract-Based Spatial Statistics of Magnetic Resonance Images to Assess Disease and Treatment Effects in Perinatal Asphyxial Encephalopathy
Pediatric Research, 2010Co-Authors: Emma J Porter, Joanna M Allsop, Serena J Counsell, A David Edwards, Denis AzzopardiAbstract:Biomarkers are required for efficient trials of neuroprotective interventions after perinatal asphyxia. This study aimed to determine whether diffusion tensor imaging (DTI) analyzed by tract-based Spatial Statistics (TBSS) may be a suitable biomarker of disease and treatment effects after perinatal asphyxia in small groups of patients. We performed TBSS from DTI obtained at 3 T from eight healthy control infants, 10 untreated and 10 hypothermia-treated infants with neonatal encephalopathy. Median (range) postnatal age at scan was 1 d (1–21) in the healthy infants, 6 d (4–20) in the cooled, and 7 d (4–18) in noncooled infants. Compared with the control group, fractional anisotropy (FA) was significantly reduced not only in several white matter tracts in the noncooled infants but also in the internal capsule in the cooled group. Noncooled infants had significantly lower FA than the cooled treated infants, indicating more extensive damage, in the anterior and posterior limbs of the internal capsule, the corpus callosum, and optic radiations. We conclude that perinatal hypoxic ischemic encephalopathy is associated with widespread white matter abnormalities that are reduced by moderate hypothermia. DTI analyzed by TBSS detects this treatment effect and is therefore a qualified biomarker for the early evaluation of neuroprotective interventions.
Mary A Rutherford - One of the best experts on this subject based on the ideXlab platform.
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an optimised tract based Spatial Statistics protocol for neonates applications to prematurity and chronic lung disease
NeuroImage, 2010Co-Authors: Gareth Ball, Serena J Counsell, Mustafa Anjari, Nazakat Merchant, Tomoki Arichi, Valentina Doria, Mary A RutherfordAbstract:Preterm birth is associated with altered white matter microstructure, defined by metrics derived from diffusion tensor imaging (DTI). Tract-based Spatial Statistics (TBSS) is a useful tool for investigating developing white matter using DTI, but standard TBSS protocols have limitations for neonatal studies. We describe an optimised TBSS protocol for neonatal DTI data, in which registration errors are reduced. As chronic lung disease (CLD) is an independent risk factor for abnormal white matter development, we investigate the effect of this condition on white matter anisotropy and diffusivity using the optimised protocol in a proof of principle experiment. DTI data were acquired from 93 preterm infants (48 male) with a median gestational age at birth of 28(+5) (23(+4)-35(+2))weeks at a median postmenstrual age at scan of 41(+4) (38(+1)-46(+6))weeks. Nineteen infants developed CLD, defined as requiring supplemental oxygen at 36weeks postmenstrual age. TBSS was modified to include an initial low degrees-of-freedom linear registration step and a second registration to a population-average FA map. The additional registration steps reduced global misalignment between neonatal fractional anisotropy (FA) maps. Infants with CLD had significantly increased radial diffusivity (RD) and significantly reduced FA within the centrum semiovale, corpus callosum and inferior longitudinal fasciculus (p<0.05) compared to their peers, controlling for degree of prematurity and age at scan. The optimised TBSS protocol improved reliability for neonatal DTI analysis. These data suggest that potentially modifiable respiratory morbidity is associated with widespread altered white matter microstructure in preterm infants at term-equivalent age.
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an optimised tract based Spatial Statistics protocol for neonates applications to prematurity and chronic lung disease
NeuroImage, 2010Co-Authors: Gareth Ball, Serena J Counsell, Mustafa Anjari, Nazakat Merchant, Tomoki Arichi, Valentina Doria, Mary A RutherfordAbstract:Abstract Preterm birth is associated with altered white matter microstructure, defined by metrics derived from diffusion tensor imaging (DTI). Tract-based Spatial Statistics (TBSS) is a useful tool for investigating developing white matter using DTI, but standard TBSS protocols have limitations for neonatal studies. We describe an optimised TBSS protocol for neonatal DTI data, in which registration errors are reduced. As chronic lung disease (CLD) is an independent risk factor for abnormal white matter development, we investigate the effect of this condition on white matter anisotropy and diffusivity using the optimised protocol in a proof of principle experiment. DTI data were acquired from 93 preterm infants (48 male) with a median gestational age at birth of 28+ 5 (23+ 4–35+ 2) weeks at a median postmenstrual age at scan of 41+ 4 (38+ 1–46+ 6) weeks. Nineteen infants developed CLD, defined as requiring supplemental oxygen at 36 weeks postmenstrual age. TBSS was modified to include an initial low degrees-of-freedom linear registration step and a second registration to a population-average FA map. The additional registration steps reduced global misalignment between neonatal fractional anisotropy (FA) maps. Infants with CLD had significantly increased radial diffusivity (RD) and significantly reduced FA within the centrum semiovale, corpus callosum and inferior longitudinal fasciculus (p The optimised TBSS protocol improved reliability for neonatal DTI analysis. These data suggest that potentially modifiable respiratory morbidity is associated with widespread altered white matter microstructure in preterm infants at term-equivalent age.
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diffusion tensor imaging with tract based Spatial Statistics reveals local white matter abnormalities in preterm infants
NeuroImage, 2007Co-Authors: Mustafa Anjari, Joanna M Allsop, David A. Edwards, Mary A Rutherford, Latha Srinivasan, Joseph V Hajnal, Serena J CounsellAbstract:Infants born preterm have a high incidence of neurodevelopmental impairment in later childhood, often associated with poorly defined cerebral white matter abnormalities. Diffusion tensor imaging quantifies the diffusion of water within tissues and can assess microstructural abnormalities in the developing preterm brain. Tract-based Spatial Statistics (TBSS) is an automated observer-independent method of aligning fractional anisotropy (FA) images from multiple subjects to allow groupwise comparisons of diffusion tensor imaging data. We applied TBSS to test the hypothesis that preterm infants have reduced fractional anisotropy in specific regions of white matter compared to term-born controls. We studied 26 preterm infants with no evidence of focal lesions on conventional magnetic resonance imaging (MRI) at term equivalent age and 6 healthy term-born control infants. We found that the centrum semiovale, frontal white matter and the genu of the corpus callosum showed significantly lower FA in the preterm group. Infants born at less than or equal to 28 weeks gestational age (n=11) displayed additional reductions in FA in the external capsule, the posterior aspect of the posterior limb of the internal capsule and the isthmus and middle portion of the body of the corpus callosum. This study demonstrates that TBSS provides an observer-independent method of identifying white matter abnormalities in the preterm brain at term equivalent age in the absence of focal lesions.
Denis Azzopardi - One of the best experts on this subject based on the ideXlab platform.
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prediction of neurodevelopmental outcome after hypoxic ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract based Spatial Statistics
Pediatric Research, 2012Co-Authors: Nora Tusor, Denis Azzopardi, Joanna M Allsop, David A. Edwards, Courtney J Wusthoff, Natalie Smee, Nazakat Merchant, Tomoki Arichi, F M Cowan, Serena J CounsellAbstract:Prediction of neurodevelopmental outcome after hypoxic–ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based Spatial Statistics
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tract based Spatial Statistics of magnetic resonance images to assess disease and treatment effects in perinatal asphyxial encephalopathy
Pediatric Research, 2010Co-Authors: E. Porter, Serena J Counsell, Joanna M Allsop, David A. Edwards, Denis AzzopardiAbstract:Tract-Based Spatial Statistics of Magnetic Resonance Images to Assess Disease and Treatment Effects in Perinatal Asphyxial Encephalopathy
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Tract-Based Spatial Statistics of Magnetic Resonance Images to Assess Disease and Treatment Effects in Perinatal Asphyxial Encephalopathy
Pediatric Research, 2010Co-Authors: Emma J Porter, Joanna M Allsop, Serena J Counsell, A David Edwards, Denis AzzopardiAbstract:Biomarkers are required for efficient trials of neuroprotective interventions after perinatal asphyxia. This study aimed to determine whether diffusion tensor imaging (DTI) analyzed by tract-based Spatial Statistics (TBSS) may be a suitable biomarker of disease and treatment effects after perinatal asphyxia in small groups of patients. We performed TBSS from DTI obtained at 3 T from eight healthy control infants, 10 untreated and 10 hypothermia-treated infants with neonatal encephalopathy. Median (range) postnatal age at scan was 1 d (1–21) in the healthy infants, 6 d (4–20) in the cooled, and 7 d (4–18) in noncooled infants. Compared with the control group, fractional anisotropy (FA) was significantly reduced not only in several white matter tracts in the noncooled infants but also in the internal capsule in the cooled group. Noncooled infants had significantly lower FA than the cooled treated infants, indicating more extensive damage, in the anterior and posterior limbs of the internal capsule, the corpus callosum, and optic radiations. We conclude that perinatal hypoxic ischemic encephalopathy is associated with widespread white matter abnormalities that are reduced by moderate hypothermia. DTI analyzed by TBSS detects this treatment effect and is therefore a qualified biomarker for the early evaluation of neuroprotective interventions.
Joanna M Allsop - One of the best experts on this subject based on the ideXlab platform.
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prediction of neurodevelopmental outcome after hypoxic ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract based Spatial Statistics
Pediatric Research, 2012Co-Authors: Nora Tusor, Denis Azzopardi, Joanna M Allsop, David A. Edwards, Courtney J Wusthoff, Natalie Smee, Nazakat Merchant, Tomoki Arichi, F M Cowan, Serena J CounsellAbstract:Prediction of neurodevelopmental outcome after hypoxic–ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based Spatial Statistics
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tract based Spatial Statistics of magnetic resonance images to assess disease and treatment effects in perinatal asphyxial encephalopathy
Pediatric Research, 2010Co-Authors: E. Porter, Serena J Counsell, Joanna M Allsop, David A. Edwards, Denis AzzopardiAbstract:Tract-Based Spatial Statistics of Magnetic Resonance Images to Assess Disease and Treatment Effects in Perinatal Asphyxial Encephalopathy
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Tract-Based Spatial Statistics of Magnetic Resonance Images to Assess Disease and Treatment Effects in Perinatal Asphyxial Encephalopathy
Pediatric Research, 2010Co-Authors: Emma J Porter, Joanna M Allsop, Serena J Counsell, A David Edwards, Denis AzzopardiAbstract:Biomarkers are required for efficient trials of neuroprotective interventions after perinatal asphyxia. This study aimed to determine whether diffusion tensor imaging (DTI) analyzed by tract-based Spatial Statistics (TBSS) may be a suitable biomarker of disease and treatment effects after perinatal asphyxia in small groups of patients. We performed TBSS from DTI obtained at 3 T from eight healthy control infants, 10 untreated and 10 hypothermia-treated infants with neonatal encephalopathy. Median (range) postnatal age at scan was 1 d (1–21) in the healthy infants, 6 d (4–20) in the cooled, and 7 d (4–18) in noncooled infants. Compared with the control group, fractional anisotropy (FA) was significantly reduced not only in several white matter tracts in the noncooled infants but also in the internal capsule in the cooled group. Noncooled infants had significantly lower FA than the cooled treated infants, indicating more extensive damage, in the anterior and posterior limbs of the internal capsule, the corpus callosum, and optic radiations. We conclude that perinatal hypoxic ischemic encephalopathy is associated with widespread white matter abnormalities that are reduced by moderate hypothermia. DTI analyzed by TBSS detects this treatment effect and is therefore a qualified biomarker for the early evaluation of neuroprotective interventions.
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diffusion tensor imaging with tract based Spatial Statistics reveals local white matter abnormalities in preterm infants
NeuroImage, 2007Co-Authors: Mustafa Anjari, Joanna M Allsop, David A. Edwards, Mary A Rutherford, Latha Srinivasan, Joseph V Hajnal, Serena J CounsellAbstract:Infants born preterm have a high incidence of neurodevelopmental impairment in later childhood, often associated with poorly defined cerebral white matter abnormalities. Diffusion tensor imaging quantifies the diffusion of water within tissues and can assess microstructural abnormalities in the developing preterm brain. Tract-based Spatial Statistics (TBSS) is an automated observer-independent method of aligning fractional anisotropy (FA) images from multiple subjects to allow groupwise comparisons of diffusion tensor imaging data. We applied TBSS to test the hypothesis that preterm infants have reduced fractional anisotropy in specific regions of white matter compared to term-born controls. We studied 26 preterm infants with no evidence of focal lesions on conventional magnetic resonance imaging (MRI) at term equivalent age and 6 healthy term-born control infants. We found that the centrum semiovale, frontal white matter and the genu of the corpus callosum showed significantly lower FA in the preterm group. Infants born at less than or equal to 28 weeks gestational age (n=11) displayed additional reductions in FA in the external capsule, the posterior aspect of the posterior limb of the internal capsule and the isthmus and middle portion of the body of the corpus callosum. This study demonstrates that TBSS provides an observer-independent method of identifying white matter abnormalities in the preterm brain at term equivalent age in the absence of focal lesions.
Tomoki Arichi - One of the best experts on this subject based on the ideXlab platform.
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prediction of neurodevelopmental outcome after hypoxic ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract based Spatial Statistics
Pediatric Research, 2012Co-Authors: Nora Tusor, Denis Azzopardi, Joanna M Allsop, David A. Edwards, Courtney J Wusthoff, Natalie Smee, Nazakat Merchant, Tomoki Arichi, F M Cowan, Serena J CounsellAbstract:Prediction of neurodevelopmental outcome after hypoxic–ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based Spatial Statistics
-
an optimised tract based Spatial Statistics protocol for neonates applications to prematurity and chronic lung disease
NeuroImage, 2010Co-Authors: Gareth Ball, Serena J Counsell, Mustafa Anjari, Nazakat Merchant, Tomoki Arichi, Valentina Doria, Mary A RutherfordAbstract:Preterm birth is associated with altered white matter microstructure, defined by metrics derived from diffusion tensor imaging (DTI). Tract-based Spatial Statistics (TBSS) is a useful tool for investigating developing white matter using DTI, but standard TBSS protocols have limitations for neonatal studies. We describe an optimised TBSS protocol for neonatal DTI data, in which registration errors are reduced. As chronic lung disease (CLD) is an independent risk factor for abnormal white matter development, we investigate the effect of this condition on white matter anisotropy and diffusivity using the optimised protocol in a proof of principle experiment. DTI data were acquired from 93 preterm infants (48 male) with a median gestational age at birth of 28(+5) (23(+4)-35(+2))weeks at a median postmenstrual age at scan of 41(+4) (38(+1)-46(+6))weeks. Nineteen infants developed CLD, defined as requiring supplemental oxygen at 36weeks postmenstrual age. TBSS was modified to include an initial low degrees-of-freedom linear registration step and a second registration to a population-average FA map. The additional registration steps reduced global misalignment between neonatal fractional anisotropy (FA) maps. Infants with CLD had significantly increased radial diffusivity (RD) and significantly reduced FA within the centrum semiovale, corpus callosum and inferior longitudinal fasciculus (p<0.05) compared to their peers, controlling for degree of prematurity and age at scan. The optimised TBSS protocol improved reliability for neonatal DTI analysis. These data suggest that potentially modifiable respiratory morbidity is associated with widespread altered white matter microstructure in preterm infants at term-equivalent age.
-
an optimised tract based Spatial Statistics protocol for neonates applications to prematurity and chronic lung disease
NeuroImage, 2010Co-Authors: Gareth Ball, Serena J Counsell, Mustafa Anjari, Nazakat Merchant, Tomoki Arichi, Valentina Doria, Mary A RutherfordAbstract:Abstract Preterm birth is associated with altered white matter microstructure, defined by metrics derived from diffusion tensor imaging (DTI). Tract-based Spatial Statistics (TBSS) is a useful tool for investigating developing white matter using DTI, but standard TBSS protocols have limitations for neonatal studies. We describe an optimised TBSS protocol for neonatal DTI data, in which registration errors are reduced. As chronic lung disease (CLD) is an independent risk factor for abnormal white matter development, we investigate the effect of this condition on white matter anisotropy and diffusivity using the optimised protocol in a proof of principle experiment. DTI data were acquired from 93 preterm infants (48 male) with a median gestational age at birth of 28+ 5 (23+ 4–35+ 2) weeks at a median postmenstrual age at scan of 41+ 4 (38+ 1–46+ 6) weeks. Nineteen infants developed CLD, defined as requiring supplemental oxygen at 36 weeks postmenstrual age. TBSS was modified to include an initial low degrees-of-freedom linear registration step and a second registration to a population-average FA map. The additional registration steps reduced global misalignment between neonatal fractional anisotropy (FA) maps. Infants with CLD had significantly increased radial diffusivity (RD) and significantly reduced FA within the centrum semiovale, corpus callosum and inferior longitudinal fasciculus (p The optimised TBSS protocol improved reliability for neonatal DTI analysis. These data suggest that potentially modifiable respiratory morbidity is associated with widespread altered white matter microstructure in preterm infants at term-equivalent age.
