The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Daniel Hipps - One of the best experts on this subject based on the ideXlab platform.
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Hip fracture—great steps forward but we still need better evidence. A commentary on NICE CG124 and QS16 on fractured neck of femur
Age and ageing, 2018Co-Authors: Roger H Jay, Daniel HippsAbstract:The National Institute for Health and Care Excellence (NICE) updated its Clinical Guideline and its Quality Standard on hip fracture in 2017. Three quality statements relate to the organisation of care-having a multidisciplinary hip fracture programme, and both operating and starting rehabilitation without delay-while three relate to surgical aspects, the most recent being the requirement to offer total hip replacement rather than hemiarthroplasty for those with displaced intracapsular fractures who could mobilise outdoors with a stick. Some evidence exists to support this, but the timely provision of this more complex and Specialised Operation presents a logistical challenge to many units. The evidence for many more general aspects of the care of hip fracture patients is still extrapolated from other populations, and more research is needed to guide the care of this specific group.
Roger H Jay - One of the best experts on this subject based on the ideXlab platform.
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Hip fracture—great steps forward but we still need better evidence. A commentary on NICE CG124 and QS16 on fractured neck of femur
Age and ageing, 2018Co-Authors: Roger H Jay, Daniel HippsAbstract:The National Institute for Health and Care Excellence (NICE) updated its Clinical Guideline and its Quality Standard on hip fracture in 2017. Three quality statements relate to the organisation of care-having a multidisciplinary hip fracture programme, and both operating and starting rehabilitation without delay-while three relate to surgical aspects, the most recent being the requirement to offer total hip replacement rather than hemiarthroplasty for those with displaced intracapsular fractures who could mobilise outdoors with a stick. Some evidence exists to support this, but the timely provision of this more complex and Specialised Operation presents a logistical challenge to many units. The evidence for many more general aspects of the care of hip fracture patients is still extrapolated from other populations, and more research is needed to guide the care of this specific group.
M. Rollinson - One of the best experts on this subject based on the ideXlab platform.
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Use of pyrolysis–g.c.–m.s. to assess the thermal degradation behaviour of polymers containing chlorineI. The limits of detection and measurement of HCl, deduced from a study of PVC pyrolysis
Polymer Degradation and Stability, 1999Co-Authors: N. Dadvand, Roy S. Lehrle, Ian W. Parsons, M. RollinsonAbstract:From measurements of the yields of hydrogen chloride evolved from the thermal degradation of PVC samples, it is deduced that the authors' pyrolysis–gas chromatography–mass spectrometry equipment can detect HCl down to at least 50 ng (1.4 nanomoles). The actual limit is almost certainly smaller, because the calculations assume that HCl is obtained in quantitative yield from PVC on prolonged pyrolysis at 250°C. (Additional sensitivity may also be available by more Specialised Operation of the mass spectrometer in single ion monitoring mode, but the present work relates to the normal scanning mode used in general analysis). The above measured detection limit is more than 4000 times better than that obtained using g.c. equipment incorporating packed columns and a thermal conductivity detector, because with the latter apparatus there is substantial loss of HCl, probably due to reaction with the column packing. The prolysis–g.c.–m.s. results also provide an absolute sensitivity calibration for HCl, and in addition, permit calculation of the rate constant (specific rate, k) for HCl evolution from PVC at 250°C. The value of k, as calculated from the initial rate, is found to be ca. 5×10−3 s−1 at 250°C, and is independent of sample size over the range 10–40 micrograms (corresponding to sample thickness 2.5–10 microns on the pyrolysis filament). For samples of 30–40 micrograms, the specific rate increases with conversion to a value in the final stages which is approximately double that of the initial value. This phenomenon is consistent with an autoaccelerative mechanism in which HCl production is promoted by HCl itself, with the residence time for HCl increasing with both the sample size and the degree of cross-linking of the residue.
N. Dadvand - One of the best experts on this subject based on the ideXlab platform.
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Use of pyrolysis–g.c.–m.s. to assess the thermal degradation behaviour of polymers containing chlorineI. The limits of detection and measurement of HCl, deduced from a study of PVC pyrolysis
Polymer Degradation and Stability, 1999Co-Authors: N. Dadvand, Roy S. Lehrle, Ian W. Parsons, M. RollinsonAbstract:From measurements of the yields of hydrogen chloride evolved from the thermal degradation of PVC samples, it is deduced that the authors' pyrolysis–gas chromatography–mass spectrometry equipment can detect HCl down to at least 50 ng (1.4 nanomoles). The actual limit is almost certainly smaller, because the calculations assume that HCl is obtained in quantitative yield from PVC on prolonged pyrolysis at 250°C. (Additional sensitivity may also be available by more Specialised Operation of the mass spectrometer in single ion monitoring mode, but the present work relates to the normal scanning mode used in general analysis). The above measured detection limit is more than 4000 times better than that obtained using g.c. equipment incorporating packed columns and a thermal conductivity detector, because with the latter apparatus there is substantial loss of HCl, probably due to reaction with the column packing. The prolysis–g.c.–m.s. results also provide an absolute sensitivity calibration for HCl, and in addition, permit calculation of the rate constant (specific rate, k) for HCl evolution from PVC at 250°C. The value of k, as calculated from the initial rate, is found to be ca. 5×10−3 s−1 at 250°C, and is independent of sample size over the range 10–40 micrograms (corresponding to sample thickness 2.5–10 microns on the pyrolysis filament). For samples of 30–40 micrograms, the specific rate increases with conversion to a value in the final stages which is approximately double that of the initial value. This phenomenon is consistent with an autoaccelerative mechanism in which HCl production is promoted by HCl itself, with the residence time for HCl increasing with both the sample size and the degree of cross-linking of the residue.
Roy S. Lehrle - One of the best experts on this subject based on the ideXlab platform.
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Use of pyrolysis–g.c.–m.s. to assess the thermal degradation behaviour of polymers containing chlorineI. The limits of detection and measurement of HCl, deduced from a study of PVC pyrolysis
Polymer Degradation and Stability, 1999Co-Authors: N. Dadvand, Roy S. Lehrle, Ian W. Parsons, M. RollinsonAbstract:From measurements of the yields of hydrogen chloride evolved from the thermal degradation of PVC samples, it is deduced that the authors' pyrolysis–gas chromatography–mass spectrometry equipment can detect HCl down to at least 50 ng (1.4 nanomoles). The actual limit is almost certainly smaller, because the calculations assume that HCl is obtained in quantitative yield from PVC on prolonged pyrolysis at 250°C. (Additional sensitivity may also be available by more Specialised Operation of the mass spectrometer in single ion monitoring mode, but the present work relates to the normal scanning mode used in general analysis). The above measured detection limit is more than 4000 times better than that obtained using g.c. equipment incorporating packed columns and a thermal conductivity detector, because with the latter apparatus there is substantial loss of HCl, probably due to reaction with the column packing. The prolysis–g.c.–m.s. results also provide an absolute sensitivity calibration for HCl, and in addition, permit calculation of the rate constant (specific rate, k) for HCl evolution from PVC at 250°C. The value of k, as calculated from the initial rate, is found to be ca. 5×10−3 s−1 at 250°C, and is independent of sample size over the range 10–40 micrograms (corresponding to sample thickness 2.5–10 microns on the pyrolysis filament). For samples of 30–40 micrograms, the specific rate increases with conversion to a value in the final stages which is approximately double that of the initial value. This phenomenon is consistent with an autoaccelerative mechanism in which HCl production is promoted by HCl itself, with the residence time for HCl increasing with both the sample size and the degree of cross-linking of the residue.