The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
A M L Coenen - One of the best experts on this subject based on the ideXlab platform.
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effects of remacemide and its metabolite fpl 12495 on spike wave discharges electroencephalogram and behaviour in rats with absence epilepsy
Neuropharmacology, 1995Co-Authors: E L J M Van Luijtelaar, A M L CoenenAbstract:The effects of the anti-convulsant drug remacemide and one of its active metabolites FPL 12495 were examined in a genetic model for generalized absence epilepsy, the WAG/Rij strain of rats. Number, mean and total duration of spike-wave discharges were measured following oral administration of remacemide and FPL 12495, together with parameters of background electroencephalographic activity (EEG) and spontaneous behaviour in the recording cage. A decrease in the number of the spike-wave discharges was found after remacemide administration. At the highest dose there was near total suppression of the spike-wave discharges. There were no important effects on behaviour and on Spectral Content of the background EEG, suggesting that remacemide has little side effects. A decrease in the number of spike-wave discharges was also found after FPL 12495 gavage and there was a prolongation of the mean duration. Behavioural changes were only noticed after the highest dose. These were accompanied by changes in the Spectral Content and particularly by an increase in the amplitude of the delta and the high beta frequencies, together with a decrease in the spindle frequency range. FPL 12495 appeared to be more potent that remacemide in all its effects. The effects of mainly FPL 12495 are uncommon in the sense that so far no other investigated drug shows a decrease in the number together with an increase in the mean duration of the discharges. It seems that in contrast to other anti-epileptic drugs, FPL 12495 exerts a differential action on the two commonly distinguished mechanisms controlling number and duration.
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effects of remacemide and its metabolite fpl 12495 on spike wave discharges eeg and behavior in rats with absence epilepsy
Epilepsia, 1995Co-Authors: E L J M Van Luijtelaar, A M L CoenenAbstract:Anticonvulsant drugs may or may not be effective against generalized absence epilepsy. Carbamazepine and phenytoin aggravate spike-wave discharges (SWD) whereas valproate and benzodiazepines reduce SWD. The effects of the new anticonvulsant remacemide on SWD are unknown, which prompted us to investigate the effects of remacemide and its active metabolite FPL 12495 in a genetic rat model for absence epilepsy, the WAG/Rij strain. Number and mean duration of SWD, parameters of the background EEG and spontaneous behavior were measured after various oral doses of remacemide and FPL 12495. A decrease in the number of SWD was noted after remacemide administration. At the highest dose, SWD were almost completely suppressed and there were no important effects on behavior or on Spectral Content of the background EEG, suggesting that remacemide has few side effects and might be effective against absence epilepsy. A decrease in the number of SWD was also noted after FPL 12495 gavage, but mean duration was prolonged. Behavioral changes were apparent only after the highest dose, accompanied by changes in Spectral Content, suggesting that FPL 12495 has other central effects as well. FPL 12495 appeared to be more potent than remacemide in all its effects. The effects of FPL 12495 are unusual in that no other investigated drug has yet shown a decrease in number together with an increase in mean duration of discharges. FPL 12495 appears to exert a differential action on the two commonly distinguished mechanisms controling number and duration.
E L J M Van Luijtelaar - One of the best experts on this subject based on the ideXlab platform.
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effects of remacemide and its metabolite fpl 12495 on spike wave discharges electroencephalogram and behaviour in rats with absence epilepsy
Neuropharmacology, 1995Co-Authors: E L J M Van Luijtelaar, A M L CoenenAbstract:The effects of the anti-convulsant drug remacemide and one of its active metabolites FPL 12495 were examined in a genetic model for generalized absence epilepsy, the WAG/Rij strain of rats. Number, mean and total duration of spike-wave discharges were measured following oral administration of remacemide and FPL 12495, together with parameters of background electroencephalographic activity (EEG) and spontaneous behaviour in the recording cage. A decrease in the number of the spike-wave discharges was found after remacemide administration. At the highest dose there was near total suppression of the spike-wave discharges. There were no important effects on behaviour and on Spectral Content of the background EEG, suggesting that remacemide has little side effects. A decrease in the number of spike-wave discharges was also found after FPL 12495 gavage and there was a prolongation of the mean duration. Behavioural changes were only noticed after the highest dose. These were accompanied by changes in the Spectral Content and particularly by an increase in the amplitude of the delta and the high beta frequencies, together with a decrease in the spindle frequency range. FPL 12495 appeared to be more potent that remacemide in all its effects. The effects of mainly FPL 12495 are uncommon in the sense that so far no other investigated drug shows a decrease in the number together with an increase in the mean duration of the discharges. It seems that in contrast to other anti-epileptic drugs, FPL 12495 exerts a differential action on the two commonly distinguished mechanisms controlling number and duration.
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effects of remacemide and its metabolite fpl 12495 on spike wave discharges eeg and behavior in rats with absence epilepsy
Epilepsia, 1995Co-Authors: E L J M Van Luijtelaar, A M L CoenenAbstract:Anticonvulsant drugs may or may not be effective against generalized absence epilepsy. Carbamazepine and phenytoin aggravate spike-wave discharges (SWD) whereas valproate and benzodiazepines reduce SWD. The effects of the new anticonvulsant remacemide on SWD are unknown, which prompted us to investigate the effects of remacemide and its active metabolite FPL 12495 in a genetic rat model for absence epilepsy, the WAG/Rij strain. Number and mean duration of SWD, parameters of the background EEG and spontaneous behavior were measured after various oral doses of remacemide and FPL 12495. A decrease in the number of SWD was noted after remacemide administration. At the highest dose, SWD were almost completely suppressed and there were no important effects on behavior or on Spectral Content of the background EEG, suggesting that remacemide has few side effects and might be effective against absence epilepsy. A decrease in the number of SWD was also noted after FPL 12495 gavage, but mean duration was prolonged. Behavioral changes were apparent only after the highest dose, accompanied by changes in Spectral Content, suggesting that FPL 12495 has other central effects as well. FPL 12495 appeared to be more potent than remacemide in all its effects. The effects of FPL 12495 are unusual in that no other investigated drug has yet shown a decrease in number together with an increase in mean duration of discharges. FPL 12495 appears to exert a differential action on the two commonly distinguished mechanisms controling number and duration.
Esben Auken - One of the best experts on this subject based on the ideXlab platform.
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resolving Spectral information from time domain induced polarization data through 2 d inversion
Geophysical Journal International, 2013Co-Authors: Gianluca Fiandaca, James Ramm, Andrew Binley, A Gazoty, Anders Vest Christiansen, Esben AukenAbstract:SUMMARY Field-basedtimedomain(TD)inducedpolarization(IP)surveysareusuallymodelledbytaking into account only the integral chargeability, thus disregarding Spectral Content. Furthermore, the effect of the transmitted waveform is commonly neglected, biasing inversion results. Given these limitations of conventional approaches, a new 2-D inversion algorithm has been developed using the full voltage decay of the IP response, together with an accurate description of the transmitter waveform and receiver transfer function. This allows reconstruction of the Spectral information contained in the TD decay series. The inversion algorithm is based around a 2-D complex conductivity kernel that is computedoverarangeoffrequenciesandconvertedtotheTDthroughafastHankeltransform. Two key points in the implementation ensure that computation times are minimized. First, the speed of the Jacobian computation, time transformed from frequency domain through the same transformation adopted for the forward response is optimized. Secondly, the reduction of the number of frequencies where the forward response and Jacobian are calculated: cubic splines are used to interpolate the responses to the frequency sampling necessary in the fast Hankel transform. These features, together with parallel computation, ensure inversion times comparable with those of direct current algorithms. Thealgorithmhasbeendevelopedinalaterallyconstrainedinversionscheme,andhandles both smooth and layered inversions; the latter being helpful in sedimentary environments, where quasi-layered models often represent the actual geology more accurately than smooth minimum-structure models. In the layered inversion approach, a general method to derive the thickness derivative from the complex conductivity Jacobian is also proposed. One synthetic example of layered inversion and one field example of smooth inversion show the capability of the algorithm and illustrates a complete uncertainty analysis of the model parameters. With this new algorithm, in situ TD IP measurements give access to the Spectral Content of the polarization processes, opening up new applications in environmental and hydrogeophysical investigations.
Issa M S Panahi - One of the best experts on this subject based on the ideXlab platform.
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a new structure with spectrum tuning of residual noise for active noise control
International Conference on Acoustics Speech and Signal Processing, 2011Co-Authors: Hua Bao, Issa M S PanahiAbstract:Typical active noise control (ANC) system aims primarily at reducing the acoustic noise over the entire frequency band. Non-uniformity of human hearing response in frequency domain and diversity of individual preference for Spectral Content require tuning of the residual noise spectrum in ANC system. In this paper, we propose a new ANC structure featuring spectrum-tuning of the residual noise. Simulation results show good tuning performance and little influence on system adaptation for the proposed system.
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A novel feedforward active noise control structure with spectrum-tuning for residual noise
IEEE Transactions on Consumer Electronics, 2010Co-Authors: Issa M S PanahiAbstract:Active noise control (ANC) technology is becoming popular in consumer electronic products for audio applications. Typical ANC system aims primarily at reducing acoustic noise over the entire frequency band. However, human factors including diversity of individual listening preferences on Spectral Content and non-uniform characteristics of human hearing response in frequency domain require the capability of tuning the residual noise spectrum in ANC system. In this paper, we propose a new feedforward ANC structure featuring spectrum-tuning of the residual noise. Analysis shows that this new system has good tuning performance and little influence on system adaptation. Simulation results verify the effectiveness of the proposed system.
George A Mashour - One of the best experts on this subject based on the ideXlab platform.
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Genuine and Spurious Phase Synchronization Strengths during Consciousness and General Anesthesia
2012Co-Authors: Uncheol Lee, Heonsoo Lee, Gyu-jeong Noh, George A MashourAbstract:Spectral Content in a physiological dataset of finite size has the potential to produce spurious measures of coherence. This is especially true for electroencephalography (EEG) during general anesthesia because of the significant alteration of the power spectrum. In this study we quantitatively evaluated the genuine and spurious phase synchronization strength (PSS) of EEG during consciousness, general anesthesia, and recovery. A computational approach based on the randomized data method was used for evaluating genuine and spurious PSS. The validity of the method was tested with a simulated dataset. We applied this method to the EEG of normal subjects undergoing general anesthesia and investigated the finite size effects of EEG references, data length and Spectral Content on phase synchronization. The most influential factor for genuine PSS was the type of EEG reference; the most influential factor for spurious PSS was the Spectral Content. Genuine and spurious PSS showed characteristic temporal patterns for each frequency band across consciousness and anesthesia. Simultaneous measurement of both genuine and spurious PSS during general anesthesia is necessary in order to avoid incorrec
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Genuine and spurious phase synchronization strengths during consciousness and general anesthesia.
Public Library of Science (PLoS), 1Co-Authors: Uncheol Lee, Heonsoo Lee, Markus Müller, Gyu-jeong Noh, George A MashourAbstract:Spectral Content in a physiological dataset of finite size has the potential to produce spurious measures of coherence. This is especially true for electroencephalography (EEG) during general anesthesia because of the significant alteration of the power spectrum. In this study we quantitatively evaluated the genuine and spurious phase synchronization strength (PSS) of EEG during consciousness, general anesthesia, and recovery. A computational approach based on the randomized data method was used for evaluating genuine and spurious PSS. The validity of the method was tested with a simulated dataset. We applied this method to the EEG of normal subjects undergoing general anesthesia and investigated the finite size effects of EEG references, data length and Spectral Content on phase synchronization. The most influential factor for genuine PSS was the type of EEG reference; the most influential factor for spurious PSS was the Spectral Content. Genuine and spurious PSS showed characteristic temporal patterns for each frequency band across consciousness and anesthesia. Simultaneous measurement of both genuine and spurious PSS during general anesthesia is necessary in order to avoid incorrect interpretations regarding states of consciousness
