The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Dirk Rades - One of the best experts on this subject based on the ideXlab platform.

Daniel M Sciubba - One of the best experts on this subject based on the ideXlab platform.

  • extramedullary hematopoiesis causing Spinal Cord Compression
    World Neurosurgery, 2021
    Co-Authors: Brendan F Judy, Yike Jin, Daniel M Sciubba
    Abstract:

    Spinal Cord Compression due to extramedullary hematopoiesis is a rare neurosurgical problem that is successfully treated with urgent deCompression. Here we report the case of a young man with hemoglobin Lepore disease and beta thalassemia who presented with 1 month of lower extremity weakness and urinary retention. The patient underwent urgent thoracic laminectomies and recovered fully. This pathology can be treated with multiple modalities; however, deCompression must remain in the neurosurgeon's armamentarium in the acute setting.

  • extramedullary hematopoiesis causing Spinal Cord Compression
    World Neurosurgery, 2021
    Co-Authors: Brendan F Judy, Yike Jin, Daniel M Sciubba
    Abstract:

    Abstract Spinal Cord Compression due to extramedullary hematopoiesis is a rare neurosurgical problem that is successfully treated with urgent deCompression. Here we report the case of a young man with hemoglobin Lepore disease and beta thalassemia who presented with one month of lower extremity weakness and urinary retention. The patient underwent urgent thoracic laminectomies and recovered fully. This pathology can be treated with multiple modalities however deCompression must remain in the neurosurgeon’s armamentarium in the acute setting.

  • metastatic Spinal Cord Compression and steroid treatment
    Journal of Spinal Disorders & Techniques, 2017
    Co-Authors: Abhishek Kumar, Michael H Weber, Ziya L Gokaslan, Jean Paul Wolinsky, Meic H Schmidt, Laurence D Rhines, Michael G Fehlings, Ilya Laufer, Daniel M Sciubba, Michelle J Clarke
    Abstract:

    Study Design:Systematic review.Objectives:We conducted a systematic review of the literature to answer the following questions regarding the use of steroid therapy in metastatic Spinal Cord Compression (MSCC): 1. In cases of MSCC, what is the effect of steroid administration before definitive radiot

  • metastatic Spinal Cord Compression and steroid treatment a systematic review
    Clinical spine surgery, 2017
    Co-Authors: Abhishek Kumar, Michael H Weber, Ziya L Gokaslan, Jean Paul Wolinsky, Meic H Schmidt, Laurence D Rhines, Michael G Fehlings, Ilya Laufer, Daniel M Sciubba, Michelle J Clarke
    Abstract:

    Study Design:Systematic review.Objectives:We conducted a systematic review of the literature to answer the following questions regarding the use of steroid therapy in metastatic Spinal Cord Compression (MSCC): 1. In cases of MSCC, what is the effect of steroid administration before definitive radiot

Ilya Laufer - One of the best experts on this subject based on the ideXlab platform.

  • surgical deCompression of high grade Spinal Cord Compression from hormone refractory metastatic prostate cancer
    Neurosurgery, 2018
    Co-Authors: Muhammad Omar Chohan, Mark H Bilsky, Ilya Laufer, Sweena Kahn, Gustav Y Cederquist, Anne S Reiner, Joseph H Schwab
    Abstract:

    Background Spine and nonspine skeletal metastases occur in more than 80% of patients with prostate cancer. Objective To examine the characteristics of the patient population undergoing surgery for the treatment of prostate cancer metastatic to the spine. Methods A retrospective chart review was performed on all patients treated at our institution from June 1993 to August 2014 for surgical management of metastatic spine disease from prostate cancer. Results During the study period, 139 patients with 157 surgical lesions underwent surgery for metastatic spine disease. DeCompression for high-grade epidural Spinal Cord Compression was required for 126 patients with 143 lesions. Preoperatively, 69% had a motor deficit and 21% were nonambulatory, with 32% due to motor weakness. At surgery, 87% of patients had hormone-refractory prostate cancer (HRPC) and 61% failed prior radiation. Median overall survival for HRPC patients was 6.6 mo (95% confidence interval [CI]: 5.6-8.6) while the median overall survival for hormone-sensitive patients was 16.3 mo (95% CI: 4.0-26.6). Conclusion The majority of patients undergoing surgery for prostate cancer metastases to the spine were refractory to hormone therapy, indicating that patients with hormone-sensitive prostate cancer are unlikely to develop symptomatic Spinal Cord Compression or Spinal instability. A significant number of HRPC patients presented with neurological deficits attributable to Spinal Cord Compression. Vigilant monitoring for the development of signs and symptoms of epidural Spinal Cord Compression and Spinal instability in hormone-refractory patients is recommended. Surgical decision making may be affected by the much shorter postoperative survival for HRPC patients as compared to patients with hormone-sensitive cancer.

  • modern approaches to the management of metastatic epidural Spinal Cord Compression
    CNS oncology, 2017
    Co-Authors: Zain A Husain, Charles G Fisher, Eric L Chang, Charlotte Dai Kubicky, Arjun Sahgal, Pejman Jabehdar Maralani, Kristin J Redmond, Ilya Laufer
    Abstract:

    Metastatic epidural Spinal Cord Compression (MESCC) is an oncologic emergency requiring prompt treatment to maximize neurologic function, ambulatory function and local control. Traditionally, options for MESCC included external beam radiation therapy with or without surgery. Surgery has usually been reserved for the patient with optimal performance status, single level MESCC or mechanical instability. Advances in external beam radiation therapy such as the development of stereotactic body radiation therapy have allowed for the delivery of high-dose radiation, allowing for both long-term pain and local control. Surgical advances, such as separation surgery, minimal access spine surgery and percutaneous instrumentation, have decreased surgical morbidity. This review summarizes the latest advances and evidence in MESCC to enable modern management.

  • metastatic Spinal Cord Compression and steroid treatment
    Journal of Spinal Disorders & Techniques, 2017
    Co-Authors: Abhishek Kumar, Michael H Weber, Ziya L Gokaslan, Jean Paul Wolinsky, Meic H Schmidt, Laurence D Rhines, Michael G Fehlings, Ilya Laufer, Daniel M Sciubba, Michelle J Clarke
    Abstract:

    Study Design:Systematic review.Objectives:We conducted a systematic review of the literature to answer the following questions regarding the use of steroid therapy in metastatic Spinal Cord Compression (MSCC): 1. In cases of MSCC, what is the effect of steroid administration before definitive radiot

  • metastatic Spinal Cord Compression and steroid treatment a systematic review
    Clinical spine surgery, 2017
    Co-Authors: Abhishek Kumar, Michael H Weber, Ziya L Gokaslan, Jean Paul Wolinsky, Meic H Schmidt, Laurence D Rhines, Michael G Fehlings, Ilya Laufer, Daniel M Sciubba, Michelle J Clarke
    Abstract:

    Study Design:Systematic review.Objectives:We conducted a systematic review of the literature to answer the following questions regarding the use of steroid therapy in metastatic Spinal Cord Compression (MSCC): 1. In cases of MSCC, what is the effect of steroid administration before definitive radiot

  • reliability analysis of the epidural Spinal Cord Compression scale
    Journal of Neurosurgery, 2010
    Co-Authors: Mark H Bilsky, Meic H Schmidt, Ilya Laufer, Daryl R Fourney, Michael W Groff, Peter Paul Varga, Frank D Vrionis, Yoshiya Yamada, Peter C Gerszten, Timothy R Kuklo
    Abstract:

    Objective The evolution of imaging techniques, along with highly effective radiation options has changed the way metastatic epidural tumors are treated. While high-grade epidural Spinal Cord Compression (ESCC) frequently serves as an indication for surgical deCompression, no consensus exists in the literature about the precise definition of this term. The advancement of the treatment paradigms in patients with metastatic tumors for the spine requires a clear grading scheme of ESCC. The degree of ESCC often serves as a major determinant in the decision to operate or irradiate. The purpose of this study was to determine the reliability and validity of a 6-point, MR imaging–based grading system for ESCC. Methods To determine the reliability of the grading scale, a survey was distributed to 7 spine surgeons who participate in the Spine Oncology Study Group. The MR images of 25 cervical or thoracic Spinal tumors were distributed consisting of 1 sagittal image and 3 axial images at the identical level including...

Mark H Bilsky - One of the best experts on this subject based on the ideXlab platform.

  • surgical deCompression of high grade Spinal Cord Compression from hormone refractory metastatic prostate cancer
    Neurosurgery, 2018
    Co-Authors: Muhammad Omar Chohan, Mark H Bilsky, Ilya Laufer, Sweena Kahn, Gustav Y Cederquist, Anne S Reiner, Joseph H Schwab
    Abstract:

    Background Spine and nonspine skeletal metastases occur in more than 80% of patients with prostate cancer. Objective To examine the characteristics of the patient population undergoing surgery for the treatment of prostate cancer metastatic to the spine. Methods A retrospective chart review was performed on all patients treated at our institution from June 1993 to August 2014 for surgical management of metastatic spine disease from prostate cancer. Results During the study period, 139 patients with 157 surgical lesions underwent surgery for metastatic spine disease. DeCompression for high-grade epidural Spinal Cord Compression was required for 126 patients with 143 lesions. Preoperatively, 69% had a motor deficit and 21% were nonambulatory, with 32% due to motor weakness. At surgery, 87% of patients had hormone-refractory prostate cancer (HRPC) and 61% failed prior radiation. Median overall survival for HRPC patients was 6.6 mo (95% confidence interval [CI]: 5.6-8.6) while the median overall survival for hormone-sensitive patients was 16.3 mo (95% CI: 4.0-26.6). Conclusion The majority of patients undergoing surgery for prostate cancer metastases to the spine were refractory to hormone therapy, indicating that patients with hormone-sensitive prostate cancer are unlikely to develop symptomatic Spinal Cord Compression or Spinal instability. A significant number of HRPC patients presented with neurological deficits attributable to Spinal Cord Compression. Vigilant monitoring for the development of signs and symptoms of epidural Spinal Cord Compression and Spinal instability in hormone-refractory patients is recommended. Surgical decision making may be affected by the much shorter postoperative survival for HRPC patients as compared to patients with hormone-sensitive cancer.

  • reliability analysis of the epidural Spinal Cord Compression scale
    Journal of Neurosurgery, 2010
    Co-Authors: Mark H Bilsky, Meic H Schmidt, Ilya Laufer, Daryl R Fourney, Michael W Groff, Peter Paul Varga, Frank D Vrionis, Yoshiya Yamada, Peter C Gerszten, Timothy R Kuklo
    Abstract:

    Objective The evolution of imaging techniques, along with highly effective radiation options has changed the way metastatic epidural tumors are treated. While high-grade epidural Spinal Cord Compression (ESCC) frequently serves as an indication for surgical deCompression, no consensus exists in the literature about the precise definition of this term. The advancement of the treatment paradigms in patients with metastatic tumors for the spine requires a clear grading scheme of ESCC. The degree of ESCC often serves as a major determinant in the decision to operate or irradiate. The purpose of this study was to determine the reliability and validity of a 6-point, MR imaging–based grading system for ESCC. Methods To determine the reliability of the grading scale, a survey was distributed to 7 spine surgeons who participate in the Spine Oncology Study Group. The MR images of 25 cervical or thoracic Spinal tumors were distributed consisting of 1 sagittal image and 3 axial images at the identical level including...

  • surgical approach to epidural Spinal Cord Compression
    Hematology-oncology Clinics of North America, 2006
    Co-Authors: Mark H Bilsky, Michelle K Smith
    Abstract:

    NOMS provides a framework to make decisions regarding surgery or radiation in the face of changing technology. NOMS reflects the most important decision points including neurologic, oncologic, mechanical stability, and systemic disease. Currently, patients who have high-grade epidural Spinal Cord Compression (N) from radioresistant disease (O) or demonstrate mechanical instability (M) are offered surgery if they can tolerate it from a systemic (S) standpoint. Patients with radiosensitive tumors (O) are offered external beam radiation regardless of the degree of Spinal Cord Compression (N). Patients with radioresistant tumors (O) who do not have significant Spinal Cord Compression (N) are now offered IGIMRT as the best chance of controlling local tumor and avoiding an operation.

Brendan F Judy - One of the best experts on this subject based on the ideXlab platform.

  • extramedullary hematopoiesis causing Spinal Cord Compression
    World Neurosurgery, 2021
    Co-Authors: Brendan F Judy, Yike Jin, Daniel M Sciubba
    Abstract:

    Abstract Spinal Cord Compression due to extramedullary hematopoiesis is a rare neurosurgical problem that is successfully treated with urgent deCompression. Here we report the case of a young man with hemoglobin Lepore disease and beta thalassemia who presented with one month of lower extremity weakness and urinary retention. The patient underwent urgent thoracic laminectomies and recovered fully. This pathology can be treated with multiple modalities however deCompression must remain in the neurosurgeon’s armamentarium in the acute setting.

  • extramedullary hematopoiesis causing Spinal Cord Compression
    World Neurosurgery, 2021
    Co-Authors: Brendan F Judy, Yike Jin, Daniel M Sciubba
    Abstract:

    Spinal Cord Compression due to extramedullary hematopoiesis is a rare neurosurgical problem that is successfully treated with urgent deCompression. Here we report the case of a young man with hemoglobin Lepore disease and beta thalassemia who presented with 1 month of lower extremity weakness and urinary retention. The patient underwent urgent thoracic laminectomies and recovered fully. This pathology can be treated with multiple modalities; however, deCompression must remain in the neurosurgeon's armamentarium in the acute setting.