The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform

Dirk De Ridder - One of the best experts on this subject based on the ideXlab platform.

  • Comparison study of autonomous activity in bladders from normal and paraplegic rats.
    Neurourology and urodynamics, 2006
    Co-Authors: Thomas Gevaert, Dieter Ost, Dirk De Ridder
    Abstract:

    Aim To identify differences in the pattern of pressure generated by isolated bladders from normal and paraplegic rats. Materials and Methods Nine female Wister rats were made paraplegic by Spinal Cord Transsection at the vertebral level T8-T9 and sacrificed between D21 and D28. A further group (n = 9) was used as a control group. Each bladder was excised and placed in an organ bath where intravesical pressures were measured. Pressure changes were divided in two well-defined groups: macro-transients and spikes. The effects of intravesical volume load and muscarinic (M) agonists were studied. Results We demonstrated a higher frequency, a longer duration, and a higher variance of duration in macro-transients in the neurogenic group. Intravesical volume load influenced the amplitude and frequency of macro-transients in both groups similarly. The effects of the muscarinic (M2)-selective agonist arecaidine were different in neurogenic bladder; the effects of the non-selective muscarinic (M)-agonist carbachol were similar in both groups. Conclusion We showed that the pattern of autonomous activity was significantly different between normal and neurogenic rat bladders. We also found evidence for alterations in the muscarinic response of isolated neurogenic rat bladders. This model offers an exciting new research tool to evaluate the detrusor activity in neurogenic and normal conditions. Neurourol. Urodynam. © 2006 Wiley-Liss, Inc.

Thomas Gevaert - One of the best experts on this subject based on the ideXlab platform.

  • Comparison study of autonomous activity in bladders from normal and paraplegic rats.
    Neurourology and urodynamics, 2006
    Co-Authors: Thomas Gevaert, Dieter Ost, Dirk De Ridder
    Abstract:

    Aim To identify differences in the pattern of pressure generated by isolated bladders from normal and paraplegic rats. Materials and Methods Nine female Wister rats were made paraplegic by Spinal Cord Transsection at the vertebral level T8-T9 and sacrificed between D21 and D28. A further group (n = 9) was used as a control group. Each bladder was excised and placed in an organ bath where intravesical pressures were measured. Pressure changes were divided in two well-defined groups: macro-transients and spikes. The effects of intravesical volume load and muscarinic (M) agonists were studied. Results We demonstrated a higher frequency, a longer duration, and a higher variance of duration in macro-transients in the neurogenic group. Intravesical volume load influenced the amplitude and frequency of macro-transients in both groups similarly. The effects of the muscarinic (M2)-selective agonist arecaidine were different in neurogenic bladder; the effects of the non-selective muscarinic (M)-agonist carbachol were similar in both groups. Conclusion We showed that the pattern of autonomous activity was significantly different between normal and neurogenic rat bladders. We also found evidence for alterations in the muscarinic response of isolated neurogenic rat bladders. This model offers an exciting new research tool to evaluate the detrusor activity in neurogenic and normal conditions. Neurourol. Urodynam. © 2006 Wiley-Liss, Inc.

Klaus Bielefeldt - One of the best experts on this subject based on the ideXlab platform.

  • Pain without nociception
    European journal of gastroenterology & hepatology, 2012
    Co-Authors: David J. Levinthal, Klaus Bielefeldt
    Abstract:

    We describe a young woman with complete cervical Spinal Cord Transsection, who developed significant abdominal pain, triggered by gastric distension and deep abdominal palpation. On the basis of the nature of her Spinal Cord injury, her brain-gut axis was limited to vagal pathways. Studies in mammalian models of human visceral sensation consistently showed that the subdiaphragmatic vagus contains a homogeneous population of afferents that are activated by low-intensity stimuli, which are generally believed to be important in regulating autonomic function and perhaps contributing to visceral sensory experiences triggered by such low-intensity stimuli (e.g. fullness, nausea), but not pain, although many fibers encode stimuli well into the noxious range. In contrast, Spinal afferent pathways include fibers with high-activation thresholds that are thought to represent specialized nociceptors. This illustrative case argues against an exclusive role of specialized nociceptive pathways in visceral pain, but supports a concept of intensity coding with the composite of vagal and Spinal input contributing to conscious perception and pain.

Dieter Ost - One of the best experts on this subject based on the ideXlab platform.

  • Comparison study of autonomous activity in bladders from normal and paraplegic rats.
    Neurourology and urodynamics, 2006
    Co-Authors: Thomas Gevaert, Dieter Ost, Dirk De Ridder
    Abstract:

    Aim To identify differences in the pattern of pressure generated by isolated bladders from normal and paraplegic rats. Materials and Methods Nine female Wister rats were made paraplegic by Spinal Cord Transsection at the vertebral level T8-T9 and sacrificed between D21 and D28. A further group (n = 9) was used as a control group. Each bladder was excised and placed in an organ bath where intravesical pressures were measured. Pressure changes were divided in two well-defined groups: macro-transients and spikes. The effects of intravesical volume load and muscarinic (M) agonists were studied. Results We demonstrated a higher frequency, a longer duration, and a higher variance of duration in macro-transients in the neurogenic group. Intravesical volume load influenced the amplitude and frequency of macro-transients in both groups similarly. The effects of the muscarinic (M2)-selective agonist arecaidine were different in neurogenic bladder; the effects of the non-selective muscarinic (M)-agonist carbachol were similar in both groups. Conclusion We showed that the pattern of autonomous activity was significantly different between normal and neurogenic rat bladders. We also found evidence for alterations in the muscarinic response of isolated neurogenic rat bladders. This model offers an exciting new research tool to evaluate the detrusor activity in neurogenic and normal conditions. Neurourol. Urodynam. © 2006 Wiley-Liss, Inc.

David J. Levinthal - One of the best experts on this subject based on the ideXlab platform.

  • Pain without nociception
    European journal of gastroenterology & hepatology, 2012
    Co-Authors: David J. Levinthal, Klaus Bielefeldt
    Abstract:

    We describe a young woman with complete cervical Spinal Cord Transsection, who developed significant abdominal pain, triggered by gastric distension and deep abdominal palpation. On the basis of the nature of her Spinal Cord injury, her brain-gut axis was limited to vagal pathways. Studies in mammalian models of human visceral sensation consistently showed that the subdiaphragmatic vagus contains a homogeneous population of afferents that are activated by low-intensity stimuli, which are generally believed to be important in regulating autonomic function and perhaps contributing to visceral sensory experiences triggered by such low-intensity stimuli (e.g. fullness, nausea), but not pain, although many fibers encode stimuli well into the noxious range. In contrast, Spinal afferent pathways include fibers with high-activation thresholds that are thought to represent specialized nociceptors. This illustrative case argues against an exclusive role of specialized nociceptive pathways in visceral pain, but supports a concept of intensity coding with the composite of vagal and Spinal input contributing to conscious perception and pain.