The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
Weijian Zhu - One of the best experts on this subject based on the ideXlab platform.
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Primary thyroid Spindle Cell tumors: Spindle Cell variant of papillary thyroid carcinoma?
International journal of clinical and experimental pathology, 2015Co-Authors: Chunyan Xia, Huimin Liu, Weijian ZhuAbstract:Primary thyroid Spindle Cell tumors or Spindle Cell component in the thyroid tumors are very rare. The Spindle tumor Cells were positive for thyroid papillary carcinoma markers. So these tumors were diagnosed as Spindle Cell variant of papillary thyroid carcinoma (PTC). To further delineate clinico-pathological features of primary thyroid Spindle Cell tumors and discuss differential diagnosis, we reported a 67-year-old man with a mass in the right thyroid without clinical symptom. Microscopy revealed that an encapsulated tumor with lot criss Spindle Cells arranged in bundles. Nuclear grooves were easy to see and rare displayed pseudoinclusions. Immunohistochemical studied showed that the Spindle Cells were all strong positive for TTF-1, Pax-8, thyroglobulin. Rare follicular were seen in the periphery of the tumor near the thyroid tissue. The Cells formed follicular but the Spindle tumor Cells were positive for pan-keratins. The pathological diagnosis was primary thyroid Spindle Cell tumors, suspected Spindle Cell variant of PTC. Primary thyroid Spindle Cell tumors were presence and without the unified name. The further reports and more discussion were need about these tumors.
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Case Report Primary thyroid Spindle Cell tumors: Spindle Cell variant of papillary thyroid carcinoma?
2015Co-Authors: Chunyan Xia, Huimin Liu, Weijian ZhuAbstract:Primary thyroid Spindle Cell tumors or Spindle Cell component in the thyroid tumors are very rare. The spin- dle tumor Cells were positive for thyroid papillary carcinoma markers. So these tumors were diagnosed as Spindle Cell variant of papillary thyroid carcinoma (PTC). To further delineate clinico-pathological features of primary thyroid Spindle Cell tumors and discuss differential diagnosis, we reported a 67-year-old man with a mass in the right thy- roid without clinical symptom. Microscopy revealed that an encapsulated tumor with lot criss Spindle Cells arranged in bundles. Nuclear grooves were easy to see and rare displayed pseudoinclusions. Immunohistochemical studied showed that the Spindle Cells were all strong positive for TTF-1, Pax-8, thyroglobulin. Rare follicular were seen in the periphery of the tumor near the thyroid tissue. The Cells formed follicular but the Spindle tumor Cells were positive for pan-keratins. The pathological diagnosis was primary thyroid Spindle Cell tumors, suspected Spindle Cell variant of PTC. Primary thyroid Spindle Cell tumors were presence and without the unified name. The further reports and more discussion were need about these tumors.
Chandrika Sreekantaiah - One of the best experts on this subject based on the ideXlab platform.
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recurrent ncoa2 gene rearrangements in congenital infantile Spindle Cell rhabdomyosarcoma
Genes Chromosomes and Cancer, 2013Co-Authors: Juan Miguel Mosquera, Andrea Sboner, Lei Zhang, Naoki Kitabayashi, Chunliang Chen, Yun Shao Sung, Leonard H Wexler, Michael P Laquaglia, Morris Edelman, Chandrika SreekantaiahAbstract:Spindle Cell rhabdomyosarcoma (RMS) is a rare form of RMS with different clinical characteristics between children and adult patients. Its genetic hallmark remains unknown and it remains debatable if there is pathogenetic relationship between the Spindle Cell and the so-called sclerosing RMS. We studied two pediatric and one adult Spindle Cell RMS by next generation RNA sequencing and FusionSeq data analysis to detect novel fusions. An SRF-NCOA2 fusion was detected in a Spindle Cell RMS from the posterior neck in a 7-month-old child. The fusion matched the tumor karyotype and was confirmed by FISH and RT-PCR, which showed fusion of SRF exon 6 to NCOA2 exon 12. Additional 14 Spindle Cell (from 8 children and 6 adults) and 4 sclerosing (from 2 children and 2 adults) RMS were tested by FISH for the presence of abnormalities in NCOA2, SRF, as well as for PAX3 and NCOA1. NCOA2 rearrangements were found in two additional Spindle Cell RMS from a 3-month-old and a 4-week-old child. In the latter tumor, TEAD1 was identified by rapid amplification of cDNA ends (RACE) to be the NCOA2 gene fusion partner. None of the adult tumors were positive for NCOA2 rearrangement. Despite similar histomorphology in adults and young children, these results suggest that Spindle Cell RMS is a heterogeneous disease genetically as well as clinically. Our findings also support a relationship between NCOA2-rearranged Spindle Cell RMS occurring in young childhood and the so-called congenital RMS, which often displays rearrangements at 8q13 locus (NCOA2).
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recurrent ncoa2 gene rearrangements in congenital infantile Spindle Cell rhabdomyosarcoma
Genes Chromosomes and Cancer, 2013Co-Authors: Juan Miguel Mosquera, Andrea Sboner, Lei Zhang, Naoki Kitabayashi, Chunliang Chen, Yun Shao Sung, Leonard H Wexler, Michael P Laquaglia, Morris Edelman, Chandrika SreekantaiahAbstract:Spindle Cell rhabdomyosarcoma (RMS) is a rare form of RMS with different clinical characteristics and behavior between children and adult patients. Its genetic hallmark remains unknown and it remains debatable if there is pathogenetic relationship between the Spindle Cell and the so-called sclerosing RMS. We studied two pediatric and one adult Spindle Cell RMS by next generation RNA sequencing and used FusionSeq for data analysis to detect novel fusions. An SRF-NCOA2 gene fusion was detected in a Spindle Cell RMS from the posterior neck in a 7 month-old child. The fusion matched the tumor karyotype and was further confirmed by fluorescence in situ hybridization (FISH) and by RT-PCR, which showed fusion of SRF exon 6 to NCOA2 exon 12. Additional 14 Spindle Cell (from 8 children and 6 adults) and 4 sclerosing (from 2 children and 2 adults) RMS were tested by FISH for the presence of abnormalities in NCOA2, SRF, as well as for PAX3 and NCOA1, identifying NCOA2 rearrangements in two additional Spindle Cell RMS from a 3 month-old and a 4 week-old child, both arising in the chest wall. In the latter tumor, TEAD1 was identified by rapid amplification of cDNA ends (RACE) to be the NCOA2 gene fusion partner. None of the adult tumors were positive for NCOA2 rearrangement. Despite similar histomorphology in adults and young children, these results suggest that Spindle Cell RMS is a heterogeneous disease genetically as well as clinically. Our findings also support a relationship between NCOA2-rearranged Spindle Cell RMS occurring in young childhood and the so-called congenital RMS, which often displays rearrangements at 8q13 locus (NCOA2).
Chunyan Xia - One of the best experts on this subject based on the ideXlab platform.
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Primary thyroid Spindle Cell tumors: Spindle Cell variant of papillary thyroid carcinoma?
International journal of clinical and experimental pathology, 2015Co-Authors: Chunyan Xia, Huimin Liu, Weijian ZhuAbstract:Primary thyroid Spindle Cell tumors or Spindle Cell component in the thyroid tumors are very rare. The Spindle tumor Cells were positive for thyroid papillary carcinoma markers. So these tumors were diagnosed as Spindle Cell variant of papillary thyroid carcinoma (PTC). To further delineate clinico-pathological features of primary thyroid Spindle Cell tumors and discuss differential diagnosis, we reported a 67-year-old man with a mass in the right thyroid without clinical symptom. Microscopy revealed that an encapsulated tumor with lot criss Spindle Cells arranged in bundles. Nuclear grooves were easy to see and rare displayed pseudoinclusions. Immunohistochemical studied showed that the Spindle Cells were all strong positive for TTF-1, Pax-8, thyroglobulin. Rare follicular were seen in the periphery of the tumor near the thyroid tissue. The Cells formed follicular but the Spindle tumor Cells were positive for pan-keratins. The pathological diagnosis was primary thyroid Spindle Cell tumors, suspected Spindle Cell variant of PTC. Primary thyroid Spindle Cell tumors were presence and without the unified name. The further reports and more discussion were need about these tumors.
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Case Report Primary thyroid Spindle Cell tumors: Spindle Cell variant of papillary thyroid carcinoma?
2015Co-Authors: Chunyan Xia, Huimin Liu, Weijian ZhuAbstract:Primary thyroid Spindle Cell tumors or Spindle Cell component in the thyroid tumors are very rare. The spin- dle tumor Cells were positive for thyroid papillary carcinoma markers. So these tumors were diagnosed as Spindle Cell variant of papillary thyroid carcinoma (PTC). To further delineate clinico-pathological features of primary thyroid Spindle Cell tumors and discuss differential diagnosis, we reported a 67-year-old man with a mass in the right thy- roid without clinical symptom. Microscopy revealed that an encapsulated tumor with lot criss Spindle Cells arranged in bundles. Nuclear grooves were easy to see and rare displayed pseudoinclusions. Immunohistochemical studied showed that the Spindle Cells were all strong positive for TTF-1, Pax-8, thyroglobulin. Rare follicular were seen in the periphery of the tumor near the thyroid tissue. The Cells formed follicular but the Spindle tumor Cells were positive for pan-keratins. The pathological diagnosis was primary thyroid Spindle Cell tumors, suspected Spindle Cell variant of PTC. Primary thyroid Spindle Cell tumors were presence and without the unified name. The further reports and more discussion were need about these tumors.
Juan Miguel Mosquera - One of the best experts on this subject based on the ideXlab platform.
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recurrent ncoa2 gene rearrangements in congenital infantile Spindle Cell rhabdomyosarcoma
Genes Chromosomes and Cancer, 2013Co-Authors: Juan Miguel Mosquera, Andrea Sboner, Lei Zhang, Naoki Kitabayashi, Chunliang Chen, Yun Shao Sung, Leonard H Wexler, Michael P Laquaglia, Morris Edelman, Chandrika SreekantaiahAbstract:Spindle Cell rhabdomyosarcoma (RMS) is a rare form of RMS with different clinical characteristics between children and adult patients. Its genetic hallmark remains unknown and it remains debatable if there is pathogenetic relationship between the Spindle Cell and the so-called sclerosing RMS. We studied two pediatric and one adult Spindle Cell RMS by next generation RNA sequencing and FusionSeq data analysis to detect novel fusions. An SRF-NCOA2 fusion was detected in a Spindle Cell RMS from the posterior neck in a 7-month-old child. The fusion matched the tumor karyotype and was confirmed by FISH and RT-PCR, which showed fusion of SRF exon 6 to NCOA2 exon 12. Additional 14 Spindle Cell (from 8 children and 6 adults) and 4 sclerosing (from 2 children and 2 adults) RMS were tested by FISH for the presence of abnormalities in NCOA2, SRF, as well as for PAX3 and NCOA1. NCOA2 rearrangements were found in two additional Spindle Cell RMS from a 3-month-old and a 4-week-old child. In the latter tumor, TEAD1 was identified by rapid amplification of cDNA ends (RACE) to be the NCOA2 gene fusion partner. None of the adult tumors were positive for NCOA2 rearrangement. Despite similar histomorphology in adults and young children, these results suggest that Spindle Cell RMS is a heterogeneous disease genetically as well as clinically. Our findings also support a relationship between NCOA2-rearranged Spindle Cell RMS occurring in young childhood and the so-called congenital RMS, which often displays rearrangements at 8q13 locus (NCOA2).
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recurrent ncoa2 gene rearrangements in congenital infantile Spindle Cell rhabdomyosarcoma
Genes Chromosomes and Cancer, 2013Co-Authors: Juan Miguel Mosquera, Andrea Sboner, Lei Zhang, Naoki Kitabayashi, Chunliang Chen, Yun Shao Sung, Leonard H Wexler, Michael P Laquaglia, Morris Edelman, Chandrika SreekantaiahAbstract:Spindle Cell rhabdomyosarcoma (RMS) is a rare form of RMS with different clinical characteristics and behavior between children and adult patients. Its genetic hallmark remains unknown and it remains debatable if there is pathogenetic relationship between the Spindle Cell and the so-called sclerosing RMS. We studied two pediatric and one adult Spindle Cell RMS by next generation RNA sequencing and used FusionSeq for data analysis to detect novel fusions. An SRF-NCOA2 gene fusion was detected in a Spindle Cell RMS from the posterior neck in a 7 month-old child. The fusion matched the tumor karyotype and was further confirmed by fluorescence in situ hybridization (FISH) and by RT-PCR, which showed fusion of SRF exon 6 to NCOA2 exon 12. Additional 14 Spindle Cell (from 8 children and 6 adults) and 4 sclerosing (from 2 children and 2 adults) RMS were tested by FISH for the presence of abnormalities in NCOA2, SRF, as well as for PAX3 and NCOA1, identifying NCOA2 rearrangements in two additional Spindle Cell RMS from a 3 month-old and a 4 week-old child, both arising in the chest wall. In the latter tumor, TEAD1 was identified by rapid amplification of cDNA ends (RACE) to be the NCOA2 gene fusion partner. None of the adult tumors were positive for NCOA2 rearrangement. Despite similar histomorphology in adults and young children, these results suggest that Spindle Cell RMS is a heterogeneous disease genetically as well as clinically. Our findings also support a relationship between NCOA2-rearranged Spindle Cell RMS occurring in young childhood and the so-called congenital RMS, which often displays rearrangements at 8q13 locus (NCOA2).
Huimin Liu - One of the best experts on this subject based on the ideXlab platform.
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Primary thyroid Spindle Cell tumors: Spindle Cell variant of papillary thyroid carcinoma?
International journal of clinical and experimental pathology, 2015Co-Authors: Chunyan Xia, Huimin Liu, Weijian ZhuAbstract:Primary thyroid Spindle Cell tumors or Spindle Cell component in the thyroid tumors are very rare. The Spindle tumor Cells were positive for thyroid papillary carcinoma markers. So these tumors were diagnosed as Spindle Cell variant of papillary thyroid carcinoma (PTC). To further delineate clinico-pathological features of primary thyroid Spindle Cell tumors and discuss differential diagnosis, we reported a 67-year-old man with a mass in the right thyroid without clinical symptom. Microscopy revealed that an encapsulated tumor with lot criss Spindle Cells arranged in bundles. Nuclear grooves were easy to see and rare displayed pseudoinclusions. Immunohistochemical studied showed that the Spindle Cells were all strong positive for TTF-1, Pax-8, thyroglobulin. Rare follicular were seen in the periphery of the tumor near the thyroid tissue. The Cells formed follicular but the Spindle tumor Cells were positive for pan-keratins. The pathological diagnosis was primary thyroid Spindle Cell tumors, suspected Spindle Cell variant of PTC. Primary thyroid Spindle Cell tumors were presence and without the unified name. The further reports and more discussion were need about these tumors.
-
Case Report Primary thyroid Spindle Cell tumors: Spindle Cell variant of papillary thyroid carcinoma?
2015Co-Authors: Chunyan Xia, Huimin Liu, Weijian ZhuAbstract:Primary thyroid Spindle Cell tumors or Spindle Cell component in the thyroid tumors are very rare. The spin- dle tumor Cells were positive for thyroid papillary carcinoma markers. So these tumors were diagnosed as Spindle Cell variant of papillary thyroid carcinoma (PTC). To further delineate clinico-pathological features of primary thyroid Spindle Cell tumors and discuss differential diagnosis, we reported a 67-year-old man with a mass in the right thy- roid without clinical symptom. Microscopy revealed that an encapsulated tumor with lot criss Spindle Cells arranged in bundles. Nuclear grooves were easy to see and rare displayed pseudoinclusions. Immunohistochemical studied showed that the Spindle Cells were all strong positive for TTF-1, Pax-8, thyroglobulin. Rare follicular were seen in the periphery of the tumor near the thyroid tissue. The Cells formed follicular but the Spindle tumor Cells were positive for pan-keratins. The pathological diagnosis was primary thyroid Spindle Cell tumors, suspected Spindle Cell variant of PTC. Primary thyroid Spindle Cell tumors were presence and without the unified name. The further reports and more discussion were need about these tumors.
