The Experts below are selected from a list of 2991 Experts worldwide ranked by ideXlab platform
Monica Passananti - One of the best experts on this subject based on the ideXlab platform.
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photochemical fate and eco genotoxicity assessment of the drug etodolac
Science of The Total Environment, 2015Co-Authors: Monica Passananti, Margherita Lavorgna, Maria Rosaria Iesce, Marina Dellagreca, Marcello Brigante, Emma Criscuolo, Flavio Cermola, Marina IsidoriAbstract:The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a Spiro Compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable Spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative.
Sang Hyun Sung - One of the best experts on this subject based on the ideXlab platform.
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isolation and structure elucidation of idescarparide a new Spiro Compound from idesia polycarpa
Tetrahedron Letters, 2014Co-Authors: Tae Bum Kim, Seung Hyun Kim, Hyeon Woo Kim, Mina Lee, Hyang Hwa Lee, Sung Kwon Kang, Sang Hyun SungAbstract:Abstract (−)-Idescarparide, a new Spiro Compound possessing a tetrahydrobenzodioxole structure from the fruit of Idesia polycarpa Maxim. was identified to be a dimer of (−)-idescarpin by spectroscopic analysis. The absolute configuration of (−)-idescarpin was firstly determined to be of S form by using single-crystal X-ray diffraction. The absolute configuration of (−)-idescarparide was confirmed by comparison with semi-synthetic (−)-idescarparide, achieved via triethylamine-catalyzed dimerization of (−)-idescarpin. (−)-Idescarparide significantly reduced lipid production in 3T3-L1 cells.
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Idesolide: A New Spiro Compound from Idesia polycarpa
Organic letters, 2005Co-Authors: Seung Hyun Kim, Sang Hyun Sung, Soo Young Choi, Young Keun Chung, Jinwoong Kim, Young Choong KimAbstract:Idesolide, a new Spiro Compound possessing tetrahydrobenzodioxole structure, was isolated from the fruits of Idesia polycarpa Maxim. Its structure was established by NMR and MS spectroscopic analysis with single-crystal X-ray experiments. Idesolide significantly reduced nitric oxide production induced by lipopolysaccharide in BV2 microglial cells.
Marina Isidori - One of the best experts on this subject based on the ideXlab platform.
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photochemical fate and eco genotoxicity assessment of the drug etodolac
Science of The Total Environment, 2015Co-Authors: Monica Passananti, Margherita Lavorgna, Maria Rosaria Iesce, Marina Dellagreca, Marcello Brigante, Emma Criscuolo, Flavio Cermola, Marina IsidoriAbstract:The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a Spiro Compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable Spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative.
Seung Hyun Kim - One of the best experts on this subject based on the ideXlab platform.
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isolation and structure elucidation of idescarparide a new Spiro Compound from idesia polycarpa
Tetrahedron Letters, 2014Co-Authors: Tae Bum Kim, Seung Hyun Kim, Hyeon Woo Kim, Mina Lee, Hyang Hwa Lee, Sung Kwon Kang, Sang Hyun SungAbstract:Abstract (−)-Idescarparide, a new Spiro Compound possessing a tetrahydrobenzodioxole structure from the fruit of Idesia polycarpa Maxim. was identified to be a dimer of (−)-idescarpin by spectroscopic analysis. The absolute configuration of (−)-idescarpin was firstly determined to be of S form by using single-crystal X-ray diffraction. The absolute configuration of (−)-idescarparide was confirmed by comparison with semi-synthetic (−)-idescarparide, achieved via triethylamine-catalyzed dimerization of (−)-idescarpin. (−)-Idescarparide significantly reduced lipid production in 3T3-L1 cells.
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Idesolide: A New Spiro Compound from Idesia polycarpa
Organic letters, 2005Co-Authors: Seung Hyun Kim, Sang Hyun Sung, Soo Young Choi, Young Keun Chung, Jinwoong Kim, Young Choong KimAbstract:Idesolide, a new Spiro Compound possessing tetrahydrobenzodioxole structure, was isolated from the fruits of Idesia polycarpa Maxim. Its structure was established by NMR and MS spectroscopic analysis with single-crystal X-ray experiments. Idesolide significantly reduced nitric oxide production induced by lipopolysaccharide in BV2 microglial cells.
Young Choong Kim - One of the best experts on this subject based on the ideXlab platform.
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Idesolide: A New Spiro Compound from Idesia polycarpa
Organic letters, 2005Co-Authors: Seung Hyun Kim, Sang Hyun Sung, Soo Young Choi, Young Keun Chung, Jinwoong Kim, Young Choong KimAbstract:Idesolide, a new Spiro Compound possessing tetrahydrobenzodioxole structure, was isolated from the fruits of Idesia polycarpa Maxim. Its structure was established by NMR and MS spectroscopic analysis with single-crystal X-ray experiments. Idesolide significantly reduced nitric oxide production induced by lipopolysaccharide in BV2 microglial cells.
