The Experts below are selected from a list of 65976 Experts worldwide ranked by ideXlab platform
Jia Zhou - One of the best experts on this subject based on the ideXlab platform.
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quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing Spondylitis
Genome Biology, 2017Co-Authors: Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Jia Zhou, Shunfeng CaiAbstract:The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing Spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing Spondylitis may be a microbiome-driven disease. To investigate the relationship between the gut microbiome and ankylosing Spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing Spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported cases with inflammatory bowel disease. Specifically, the ankylosing Spondylitis patients demonstrated increases in the abundance of Prevotella melaninogenica, Prevotella copri, and Prevotella sp. C561 and decreases in Bacteroides spp. It is noteworthy that the Bifidobacterium genus, which is commonly used in probiotics, accumulated in the ankylosing Spondylitis patients. Diagnostic algorithms were established using a subset of these gut microbial biomarkers. Alterations of the gut microbiome are associated with development of ankylosing Spondylitis. Our data suggest biomarkers identified in this study might participate in the pathogenesis or development process of ankylosing Spondylitis, providing new leads for the development of new diagnostic tools and potential treatments.
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Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing Spondylitis
Genome Biology, 2017Co-Authors: Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Emmanuelle Le Chatelier, Jia ZhouAbstract:Background: The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing Spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing Spondylitis may be a microbiome-driven disease. Results: To investigate the relationship between the gut microbiome and ankylosing Spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing Spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported cases with inflammatory bowel disease. Specifically, the ankylosing Spondylitis patients demonstrated increases in the abundance of Prevotella melaninogenica, Prevotella copri, and Prevotella sp. C561 and decreases in Bacteroides spp. It is noteworthy that the Bifidobacterium genus, which is commonly used in probiotics, accumulated in the ankylosing Spondylitis patients. Diagnostic algorithms were established using a subset of these gut microbial biomarkers. Conclusions: Alterations of the gut microbiome are associated with development of ankylosing Spondylitis. Our data suggest biomarkers identified in this study might participate in the pathogenesis or development process of ankylosing Spondylitis, providing new leads for the development of new diagnostic tools and potential treatments.
Chengping Wen - One of the best experts on this subject based on the ideXlab platform.
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quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing Spondylitis
Genome Biology, 2017Co-Authors: Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Jia Zhou, Shunfeng CaiAbstract:The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing Spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing Spondylitis may be a microbiome-driven disease. To investigate the relationship between the gut microbiome and ankylosing Spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing Spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported cases with inflammatory bowel disease. Specifically, the ankylosing Spondylitis patients demonstrated increases in the abundance of Prevotella melaninogenica, Prevotella copri, and Prevotella sp. C561 and decreases in Bacteroides spp. It is noteworthy that the Bifidobacterium genus, which is commonly used in probiotics, accumulated in the ankylosing Spondylitis patients. Diagnostic algorithms were established using a subset of these gut microbial biomarkers. Alterations of the gut microbiome are associated with development of ankylosing Spondylitis. Our data suggest biomarkers identified in this study might participate in the pathogenesis or development process of ankylosing Spondylitis, providing new leads for the development of new diagnostic tools and potential treatments.
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Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing Spondylitis
Genome Biology, 2017Co-Authors: Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Emmanuelle Le Chatelier, Jia ZhouAbstract:Background: The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing Spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing Spondylitis may be a microbiome-driven disease. Results: To investigate the relationship between the gut microbiome and ankylosing Spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing Spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported cases with inflammatory bowel disease. Specifically, the ankylosing Spondylitis patients demonstrated increases in the abundance of Prevotella melaninogenica, Prevotella copri, and Prevotella sp. C561 and decreases in Bacteroides spp. It is noteworthy that the Bifidobacterium genus, which is commonly used in probiotics, accumulated in the ankylosing Spondylitis patients. Diagnostic algorithms were established using a subset of these gut microbial biomarkers. Conclusions: Alterations of the gut microbiome are associated with development of ankylosing Spondylitis. Our data suggest biomarkers identified in this study might participate in the pathogenesis or development process of ankylosing Spondylitis, providing new leads for the development of new diagnostic tools and potential treatments.
Shunfeng Cai - One of the best experts on this subject based on the ideXlab platform.
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quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing Spondylitis
Genome Biology, 2017Co-Authors: Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Jia Zhou, Shunfeng CaiAbstract:The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing Spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing Spondylitis may be a microbiome-driven disease. To investigate the relationship between the gut microbiome and ankylosing Spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing Spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported cases with inflammatory bowel disease. Specifically, the ankylosing Spondylitis patients demonstrated increases in the abundance of Prevotella melaninogenica, Prevotella copri, and Prevotella sp. C561 and decreases in Bacteroides spp. It is noteworthy that the Bifidobacterium genus, which is commonly used in probiotics, accumulated in the ankylosing Spondylitis patients. Diagnostic algorithms were established using a subset of these gut microbial biomarkers. Alterations of the gut microbiome are associated with development of ankylosing Spondylitis. Our data suggest biomarkers identified in this study might participate in the pathogenesis or development process of ankylosing Spondylitis, providing new leads for the development of new diagnostic tools and potential treatments.
Zhijun Xie - One of the best experts on this subject based on the ideXlab platform.
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quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing Spondylitis
Genome Biology, 2017Co-Authors: Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Jia Zhou, Shunfeng CaiAbstract:The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing Spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing Spondylitis may be a microbiome-driven disease. To investigate the relationship between the gut microbiome and ankylosing Spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing Spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported cases with inflammatory bowel disease. Specifically, the ankylosing Spondylitis patients demonstrated increases in the abundance of Prevotella melaninogenica, Prevotella copri, and Prevotella sp. C561 and decreases in Bacteroides spp. It is noteworthy that the Bifidobacterium genus, which is commonly used in probiotics, accumulated in the ankylosing Spondylitis patients. Diagnostic algorithms were established using a subset of these gut microbial biomarkers. Alterations of the gut microbiome are associated with development of ankylosing Spondylitis. Our data suggest biomarkers identified in this study might participate in the pathogenesis or development process of ankylosing Spondylitis, providing new leads for the development of new diagnostic tools and potential treatments.
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Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing Spondylitis
Genome Biology, 2017Co-Authors: Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Emmanuelle Le Chatelier, Jia ZhouAbstract:Background: The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing Spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing Spondylitis may be a microbiome-driven disease. Results: To investigate the relationship between the gut microbiome and ankylosing Spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing Spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported cases with inflammatory bowel disease. Specifically, the ankylosing Spondylitis patients demonstrated increases in the abundance of Prevotella melaninogenica, Prevotella copri, and Prevotella sp. C561 and decreases in Bacteroides spp. It is noteworthy that the Bifidobacterium genus, which is commonly used in probiotics, accumulated in the ankylosing Spondylitis patients. Diagnostic algorithms were established using a subset of these gut microbial biomarkers. Conclusions: Alterations of the gut microbiome are associated with development of ankylosing Spondylitis. Our data suggest biomarkers identified in this study might participate in the pathogenesis or development process of ankylosing Spondylitis, providing new leads for the development of new diagnostic tools and potential treatments.
Linshuang Zhang - One of the best experts on this subject based on the ideXlab platform.
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quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing Spondylitis
Genome Biology, 2017Co-Authors: Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Jia Zhou, Shunfeng CaiAbstract:The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing Spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing Spondylitis may be a microbiome-driven disease. To investigate the relationship between the gut microbiome and ankylosing Spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing Spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported cases with inflammatory bowel disease. Specifically, the ankylosing Spondylitis patients demonstrated increases in the abundance of Prevotella melaninogenica, Prevotella copri, and Prevotella sp. C561 and decreases in Bacteroides spp. It is noteworthy that the Bifidobacterium genus, which is commonly used in probiotics, accumulated in the ankylosing Spondylitis patients. Diagnostic algorithms were established using a subset of these gut microbial biomarkers. Alterations of the gut microbiome are associated with development of ankylosing Spondylitis. Our data suggest biomarkers identified in this study might participate in the pathogenesis or development process of ankylosing Spondylitis, providing new leads for the development of new diagnostic tools and potential treatments.
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Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing Spondylitis
Genome Biology, 2017Co-Authors: Chengping Wen, Zhijun Zheng, Tiejuan Shao, Lin Liu, Zhijun Xie, Wendi Zhong, Yongsheng Fan, Linshuang Zhang, Emmanuelle Le Chatelier, Jia ZhouAbstract:Background: The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing Spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing Spondylitis may be a microbiome-driven disease. Results: To investigate the relationship between the gut microbiome and ankylosing Spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing Spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported cases with inflammatory bowel disease. Specifically, the ankylosing Spondylitis patients demonstrated increases in the abundance of Prevotella melaninogenica, Prevotella copri, and Prevotella sp. C561 and decreases in Bacteroides spp. It is noteworthy that the Bifidobacterium genus, which is commonly used in probiotics, accumulated in the ankylosing Spondylitis patients. Diagnostic algorithms were established using a subset of these gut microbial biomarkers. Conclusions: Alterations of the gut microbiome are associated with development of ankylosing Spondylitis. Our data suggest biomarkers identified in this study might participate in the pathogenesis or development process of ankylosing Spondylitis, providing new leads for the development of new diagnostic tools and potential treatments.
