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Jean-jacques Dubost - One of the best experts on this subject based on the ideXlab platform.
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis
BMC Infectious Diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:BackgroundCoagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis.MethodsThis was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times.ResultPatients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis.
BMC infectious diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:Coagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis. This was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times. Patients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
Martin Soubrier - One of the best experts on this subject based on the ideXlab platform.
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis
BMC Infectious Diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:BackgroundCoagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis.MethodsThis was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times.ResultPatients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis.
BMC infectious diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:Coagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis. This was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times. Patients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
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axial calcium pyrophosphate dihydrate deposition disease revealed by recurrent sterile Spondylodiscitis and epidural abscess
Joint Bone Spine, 2014Co-Authors: V Grobost, Marielle Vayssade, Antoine Roche, Jeanlouis Kemeny, Martin SoubrierAbstract:Spondylodiscitis are frequent and clinical challenge for practionners. Axial calcium pyrophosphate dihydrate deposition disease (CPDD) is well known for cervical spine involvement with the crowned dens syndrome but other localisations are probably underdiagnosed in sterile Spondylodiscitis. We report a case of recurrent sterile Spondylodiscitis with epidural abscess related to CPDD proved by vertebral percutaneous needle biopsy with rapid favourable course under colchicine therapy. Axial CPDD could mimic septic Spondylodiscitis with epidural abscess on MRI. Sterile Spondylodiscitis are probably underdiagnosed forms of microcrystalline disease. Investigations of the presence of microcrystals should be systematically undertaken with tamponed formalin fixed biopsies. If axial CPDD is suspected, colchicine therapy could be a good therapeutic test and would avoid unnecessary antibiotic treatment.
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Spondylodiscitis caused by Fusobacterium nucleatum. Apropos of a case
Presse medicale (Paris France : 1983), 1995Co-Authors: Martin Soubrier, Z. Urosevic, Jean-michel RistoriAbstract:Spondylodiscitis is rarely caused by anaerobic germs and occurs mainly in patients weakened by another infection. We report a case of Fusobacterium nucleatum Spondylodiscitis in a 63-year-old man. This is the third such report and the second in a non-immunodepressed patient. The clinical presentation and laboratory findings in this type of Spondylodiscitis vary little from those produced by other germs. Magnetic resonance imaging is the most useful diagnostic tool for Spondylodiscitis. The germ is isolated from a discal puncture aspirate in 66% of the cases but can also be obtained from blood cultures. Anaerobic germs are usually sensitive to penicillin or cephalosporins.
Julien Lopez - One of the best experts on this subject based on the ideXlab platform.
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis
BMC Infectious Diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:BackgroundCoagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis.MethodsThis was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times.ResultPatients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis.
BMC infectious diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:Coagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis. This was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times. Patients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
Zuzana Tatar - One of the best experts on this subject based on the ideXlab platform.
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis
BMC Infectious Diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:BackgroundCoagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis.MethodsThis was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times.ResultPatients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis.
BMC infectious diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:Coagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis. This was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times. Patients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
Marion Couderc - One of the best experts on this subject based on the ideXlab platform.
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis
BMC Infectious Diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:BackgroundCoagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis.MethodsThis was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times.ResultPatients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
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Characteristics of spontaneous coagulase-negative staphylococcal Spondylodiscitis: a retrospective comparative study versus Staphylococcus aureus Spondylodiscitis.
BMC infectious diseases, 2017Co-Authors: Julien Lopez, Anne Tournadre, Marion Couderc, Zuzana Tatar, Martin Soubrier, Bruno Pereira, Jean-jacques DubostAbstract:Coagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of Spondylodiscitis, but there are no series of CoNS-Spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-Spondylodiscitis with those patients with Staphylococcus aureus (SA) Spondylodiscitis. This was a retrospective single center study involving 147 spontaneous infectious Spondylodiscitis cases observed between 2000 and 2015. The 26 cases of CoNS-Spondylodiscitis (15 confirmed) were compared with 30 cases of SA-Spondylodiscitis. CoNS infection was considered confirmed if the same CoNS was isolated in at least two samples at two different times. Patients with CoNS-Spondylodiscitis were older (70 vs. 61 years of age; p = 0.01), had associated cancer more often (15% vs. 0%; p = 0.04) and had a longer diagnostic delay (>15 days in 88% vs. 60%; p = 0.01); experienced fever less often (19% vs. 50%; p = 0.01), and had lower white blood cell (7.6 vs. 9.9G/L; p = 0.01) and polymorphonuclear leucocyte counts (5.6 vs. 7.5G/L; p = 0.04). Patients with CoNS Spondylodiscitis had less pronounced inflammatory syndrome (erythrocyte sedimentation rate [ESR]: 62 vs. 81 mm at 1 h; p = 0.03; CRP: 60 vs. 147 mg/L; p = 0.0003) and less common (ESR
