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Shin Wook Kang - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous Remission of nephrotic syndrome in patients with iga nephropathy
Nephrology Dialysis Transplantation, 2011Co-Authors: Seung Hyeok Han, Ea Wha Kang, Jeong Kyung Park, Jeong Hae Kie, Dae Suk Han, Shin Wook KangAbstract:Background IgA nephropathy (IgAN) can be complicated by nephrotic syndrome. Because the Spontaneous resolution of heavy proteinuria is rare, corticosteroid therapy should be considered in such cases, particularly when IgAN is combined with minimal-change disease. Here, we report our experience of Spontaneous Remission of nephrotic syndrome in patients with IgAN and the long-term outcomes of these patients. Methods Two hundred and thirty-three patients with biopsy-proven IgAN were enrolled between January 2001 and March 2009. Demographic, clinical and laboratory data were collected retrospectively based on medical records. In addition, pathologic findings were reviewed for glomerular and tubulointerstitial lesions. Outcome data for complete or partial Remission, Spontaneous Remission, relapse, deterioration of renal function, and end-stage renal disease were recorded. Results Twenty-four patients (10.3%) presented nephrotic syndrome. Among them, five patients underwent Spontaneous Remission within 6 months after the presentation of nephrotic syndrome. Interestingly, Spontaneous Remission occurred even in two patients who had elevated serum creatinine levels and advanced renal damage. During follow-up, neither recurrence nor relapse occurred, and no patients showed progressive deterioration of kidney function. Conclusions. This study suggests that Spontaneous Remission of nephrotic syndrome may occur in any stage of IgAN and carries a favourable long-term outcome without relapse. Given the possibility of under-reported cases, large-scale studies are required, and careful attention should be paid to such complicated cases.
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Spontaneous Remission of iga nephropathy associated with resolution of hepatitis a
American Journal of Kidney Diseases, 2010Co-Authors: Seung Hyeok Han, Ea Wha Kang, Jeong Hae Kie, Dae Suk Han, Tae Hyun Yoo, Kyu Hun Choi, Shin Wook KangAbstract:Although most cases of immunoglobulin A (IgA) nephropathy are idiopathic, several diseases are associated with IgA nephropathy. Of these, chronic liver disease resulting from hepatitis B or C virus infection has been reported as a secondary cause of IgA nephropathy. Recently, hepatitis A virus (HAV)-associated kidney disease has received attention because acute kidney injury can occur as a complication of HAV infection, generally caused by acute tubular necrosis or interstitial nephritis. However, unlike IgA nephropathy related to hepatitis B or C, HAV-associated IgA nephropathy is extremely rare and long-term outcomes have not been reported yet. We describe a case of Spontaneous Remission of IgA nephropathy associated with serologically documented HAV infection. The patient presented with microhematuria and moderate proteinuria, but acute kidney injury did not occur during active hepatic injury. Kidney biopsy specimens clearly showed mesangial IgA deposits with intact tubules and interstitium. Serum liver enzyme levels returned to reference values 1 month after the onset of acute hepatitis, but urinary protein excretion remained increased. Approximately 1 year later, urinary abnormalities were resolved and a second biopsy showed no mesangial IgA deposits. These findings suggest that IgA nephropathy can transiently accompany HAV infection, but may not progress to chronic glomerulonephritis after recovery from HAV.
Zhanzheng Zhao - One of the best experts on this subject based on the ideXlab platform.
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The prognostic value of phospholipase A2 receptor autoantibodies on Spontaneous Remission for patients with idiopathic membranous nephropathy: A meta-analysis.
Medicine, 2018Co-Authors: Wenli Wu, Xiaoru Hu, Shiyi Zhang, Jin Shang, Shuai Wang, Zhanzheng ZhaoAbstract:AbstractBackground:The presence of antibodies against phospholipase A2 receptor (PLA2R-Abs) in serum at diagnosis is reported to be related to the rate of Spontaneous Remission in patients with idiopathic membranous nephropathy (IMN); however, there is still lack of enough samples to illustrate this
Natalia Polanco - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous Remission of nephrotic syndrome in membranous nephropathy with chronic renal impairment
Nephrology Dialysis Transplantation, 2012Co-Authors: Natalia Polanco, Elena Gutierrez, J Baltar, Francisco Rivera, Ines Castellanos, Dolores Lorenzo, Manuel PragaAbstract:Background Spontaneous Remission (SR) of nephrotic syndrome, in the absence of immunosuppressive treatment, is relatively common among patients with idiopathic membranous nephropathy (IMN) and normal renal function. However, it has not been reported in patients with chronic renal impairment. Methods All patients with IMN who had developed SR in the presence of chronic renal insufficiency were identified among the nephrology departments that belong to the Spanish Group for the Study of Glomerular Diseases (GLOSEN). Their characteristics and outcome after SR were studied. Results Eleven patients were identified. All of them showed renal insufficiency and nephrotic syndrome at the time of renal biopsy. Serum creatinine (Scr) continued to increase in the following months, reaching a peak value of 2.6 ± 1.5 mg/dL (range 1.7-6.5). Angiotensin converting enzyme inhibitors or spironolactone were prescribed in 10/11 patients at renal biopsy or shortly after it. Nephrotic proteinuria persisted during the first months of follow-up, but it started to Spontaneously decrease 12 ± 7 months (2-30 months) after renal biopsy. Finally, complete (nine patients) or partial (two patients) Remission of nephrotic syndrome was observed. Coinciding with proteinuria Remission, renal function tended to improve. Nephrotic syndrome relapsed in two patients, accompanied by a rapid deterioration of renal function. In the remaining nine patients, Remission persisted throughout a follow-up of 146 ± 64 months. Mean Scr at the last visit was 1.9 ± 0.9 mg/dL and proteinuria 0.2 g/24 h. Conclusion SR of nephrotic syndrome can also be observed in membranous nephropathy patients exhibiting chronic renal impairment.
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Spontaneous Remission of nephrotic syndrome in idiopathic membranous nephropathy
Journal of The American Society of Nephrology, 2010Co-Authors: Natalia Polanco, Elena Gutierrez, Adelardo Covarsi, Francisco Ariza, A Carreno, Ana Vigil, J Baltar, Gema Fernandezfresnedo, Carmen Martin, Salvador PonsAbstract:Spontaneous Remission is a well known characteristic of idiopathic membranous nephropathy, but contemporary studies describing predictors of Remission and long-term outcomes are lacking. We conducted a retrospective, multicenter cohort study of 328 patients with nephrotic syndrome resulting from idiopathic membranous nephropathy that initially received conservative therapy. Spontaneous Remission occurred in 104 (32%) patients: proteinuria progressively declined after diagnosis until Remission of disease at 14.7 ± 11.4 months. Although Spontaneous Remission was more frequent with lower levels of baseline proteinuria, it also frequently occurred in patients with massive proteinuria: 26% among those with baseline proteinuria 8 to 12 g/24 h and 22% among those with proteinuria >12 g/24 h. Baseline serum creatinine and proteinuria, treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists, and a >50% decline of proteinuria from baseline during the first year of follow-up were significant independent predictors for Spontaneous Remission. Only six patients (5.7%) experienced a relapse of nephrotic syndrome. The incidence of death and ESRD were significantly lower among patients with Spontaneous Remission. In conclusion, Spontaneous Remission is common among patients with nephrotic syndrome resulting from membranous nephropathy and carries a favorable long-term outcome with a low incidence of relapse. A decrease in proteinuria >50% from baseline during the first year predicts Spontaneous Remission.
Seung Hyeok Han - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous Remission of nephrotic syndrome in patients with iga nephropathy
Nephrology Dialysis Transplantation, 2011Co-Authors: Seung Hyeok Han, Ea Wha Kang, Jeong Kyung Park, Jeong Hae Kie, Dae Suk Han, Shin Wook KangAbstract:Background IgA nephropathy (IgAN) can be complicated by nephrotic syndrome. Because the Spontaneous resolution of heavy proteinuria is rare, corticosteroid therapy should be considered in such cases, particularly when IgAN is combined with minimal-change disease. Here, we report our experience of Spontaneous Remission of nephrotic syndrome in patients with IgAN and the long-term outcomes of these patients. Methods Two hundred and thirty-three patients with biopsy-proven IgAN were enrolled between January 2001 and March 2009. Demographic, clinical and laboratory data were collected retrospectively based on medical records. In addition, pathologic findings were reviewed for glomerular and tubulointerstitial lesions. Outcome data for complete or partial Remission, Spontaneous Remission, relapse, deterioration of renal function, and end-stage renal disease were recorded. Results Twenty-four patients (10.3%) presented nephrotic syndrome. Among them, five patients underwent Spontaneous Remission within 6 months after the presentation of nephrotic syndrome. Interestingly, Spontaneous Remission occurred even in two patients who had elevated serum creatinine levels and advanced renal damage. During follow-up, neither recurrence nor relapse occurred, and no patients showed progressive deterioration of kidney function. Conclusions. This study suggests that Spontaneous Remission of nephrotic syndrome may occur in any stage of IgAN and carries a favourable long-term outcome without relapse. Given the possibility of under-reported cases, large-scale studies are required, and careful attention should be paid to such complicated cases.
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Spontaneous Remission of iga nephropathy associated with resolution of hepatitis a
American Journal of Kidney Diseases, 2010Co-Authors: Seung Hyeok Han, Ea Wha Kang, Jeong Hae Kie, Dae Suk Han, Tae Hyun Yoo, Kyu Hun Choi, Shin Wook KangAbstract:Although most cases of immunoglobulin A (IgA) nephropathy are idiopathic, several diseases are associated with IgA nephropathy. Of these, chronic liver disease resulting from hepatitis B or C virus infection has been reported as a secondary cause of IgA nephropathy. Recently, hepatitis A virus (HAV)-associated kidney disease has received attention because acute kidney injury can occur as a complication of HAV infection, generally caused by acute tubular necrosis or interstitial nephritis. However, unlike IgA nephropathy related to hepatitis B or C, HAV-associated IgA nephropathy is extremely rare and long-term outcomes have not been reported yet. We describe a case of Spontaneous Remission of IgA nephropathy associated with serologically documented HAV infection. The patient presented with microhematuria and moderate proteinuria, but acute kidney injury did not occur during active hepatic injury. Kidney biopsy specimens clearly showed mesangial IgA deposits with intact tubules and interstitium. Serum liver enzyme levels returned to reference values 1 month after the onset of acute hepatitis, but urinary protein excretion remained increased. Approximately 1 year later, urinary abnormalities were resolved and a second biopsy showed no mesangial IgA deposits. These findings suggest that IgA nephropathy can transiently accompany HAV infection, but may not progress to chronic glomerulonephritis after recovery from HAV.
Leonidas C Platanias - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous Remission in congenital leukemia
Leukemia & Lymphoma, 2018Co-Authors: Jenna Rossoff, Imo Akpan, Leonidas C PlataniasAbstract:Congenital leukemia (CL) is a very rare disease and represents less than 1% of all pediatric leukemia diagnoses [1]. CL is diagnosed within the first month of life and, in contrast to pediatric leu...
