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Jin Mo Chung - One of the best experts on this subject based on the ideXlab platform.

  • Responses of spinal dorsal horn neurons to foot movements in rats with a Sprained Ankle
    Journal of neurophysiology, 2011
    Co-Authors: Jae Hyo Kim, Hee Young Kim, Kyungsoon Chung, Jin Mo Chung
    Abstract:

    Acute Ankle injuries are common problems and often lead to persistent pain. To investigate the underlying mechanism of Ankle sprain pain, the response properties of spinal dorsal horn neurons were examined after Ankle sprain. Acute Ankle sprain was induced manually by overextending the Ankle of a rat hindlimb in a direction of plantarflexion and inversion. The weight-bearing ratio (WBR) of the affected foot was used as an indicator of pain. Single unit activities of dorsal horn neurons in response to plantarflexion and inversion of the foot or Ankle compression were recorded from the medial part of the deep dorsal horn, laminae IV-VI, in normal and Ankle-Sprained rats. One day after Ankle sprain, rats showed significantly reduced WBRs on the affected foot, and this reduction was partially restored by systemic morphine. The majority of deep dorsal horn neurons responded to a single Ankle stimulus modality. After Ankle sprain, the mean evoked response rates were significantly increased, and afterdischarges were developed in recorded dorsal horn neurons. The Ankle sprain-induced enhanced evoked responses were significantly reduced by morphine, which was reversed by naltrexone. The data indicate that movement-specific dorsal horn neuron responses were enhanced after Ankle sprain in a morphine-dependent manner, thus suggesting that hyperactivity of dorsal horn neurons is an underlying mechanism of pain after Ankle sprain.

  • Electroacupuncture reduces the evoked responses of the spinal dorsal horn neurons in Ankle-Sprained rats
    Journal of neurophysiology, 2011
    Co-Authors: Jae Hyo Kim, Hee Young Kim, Kyungsoon Chung, Jin Mo Chung
    Abstract:

    Acupuncture is shown to be effective in producing analgesia in Ankle sprain pain in humans and animals. To examine the underlying mechanisms of the acupuncture-induced analgesia, the effects of electroacupuncture (EA) on weight-bearing forces (WBR) of the affected foot and dorsal horn neuron activities were examined in a rat model of Ankle sprain. Ankle sprain was induced manually by overextending ligaments of the left Ankle in the rat. Dorsal horn neuron responses to Ankle movements or compression were recorded from the lumbar spinal cord using an in vivo extracellular single unit recording setup 1 day after Ankle sprain. EA was applied to the SI-6 acupoint on the right forelimb (contralateral to the Sprained Ankle) by trains of electrical pulses (10 Hz, 1-ms pulse width, 2-mA intensity) for 30 min. After EA, WBR of the Sprained foot significantly recovered and dorsal horn neuron activities were significantly suppressed in Ankle-Sprained rats. However, EA produced no effect in normal rats. The inhibitory effect of EA on hyperactivities of dorsal horn neurons of Ankle-Sprained rats was blocked by the α-adrenoceptor antagonist phentolamine (5 mg/kg ip) but not by the opioid receptor antagonist naltrexone (10 mg/kg ip). These data suggest that EA-induced analgesia in Ankle sprain pain is mediated mainly by suppressing dorsal horn neuron activities through α-adrenergic descending inhibitory systems at the spinal level.

Jae Hyo Kim - One of the best experts on this subject based on the ideXlab platform.

  • Responses of spinal dorsal horn neurons to foot movements in rats with a Sprained Ankle
    Journal of neurophysiology, 2011
    Co-Authors: Jae Hyo Kim, Hee Young Kim, Kyungsoon Chung, Jin Mo Chung
    Abstract:

    Acute Ankle injuries are common problems and often lead to persistent pain. To investigate the underlying mechanism of Ankle sprain pain, the response properties of spinal dorsal horn neurons were examined after Ankle sprain. Acute Ankle sprain was induced manually by overextending the Ankle of a rat hindlimb in a direction of plantarflexion and inversion. The weight-bearing ratio (WBR) of the affected foot was used as an indicator of pain. Single unit activities of dorsal horn neurons in response to plantarflexion and inversion of the foot or Ankle compression were recorded from the medial part of the deep dorsal horn, laminae IV-VI, in normal and Ankle-Sprained rats. One day after Ankle sprain, rats showed significantly reduced WBRs on the affected foot, and this reduction was partially restored by systemic morphine. The majority of deep dorsal horn neurons responded to a single Ankle stimulus modality. After Ankle sprain, the mean evoked response rates were significantly increased, and afterdischarges were developed in recorded dorsal horn neurons. The Ankle sprain-induced enhanced evoked responses were significantly reduced by morphine, which was reversed by naltrexone. The data indicate that movement-specific dorsal horn neuron responses were enhanced after Ankle sprain in a morphine-dependent manner, thus suggesting that hyperactivity of dorsal horn neurons is an underlying mechanism of pain after Ankle sprain.

  • Electroacupuncture reduces the evoked responses of the spinal dorsal horn neurons in Ankle-Sprained rats
    Journal of neurophysiology, 2011
    Co-Authors: Jae Hyo Kim, Hee Young Kim, Kyungsoon Chung, Jin Mo Chung
    Abstract:

    Acupuncture is shown to be effective in producing analgesia in Ankle sprain pain in humans and animals. To examine the underlying mechanisms of the acupuncture-induced analgesia, the effects of electroacupuncture (EA) on weight-bearing forces (WBR) of the affected foot and dorsal horn neuron activities were examined in a rat model of Ankle sprain. Ankle sprain was induced manually by overextending ligaments of the left Ankle in the rat. Dorsal horn neuron responses to Ankle movements or compression were recorded from the lumbar spinal cord using an in vivo extracellular single unit recording setup 1 day after Ankle sprain. EA was applied to the SI-6 acupoint on the right forelimb (contralateral to the Sprained Ankle) by trains of electrical pulses (10 Hz, 1-ms pulse width, 2-mA intensity) for 30 min. After EA, WBR of the Sprained foot significantly recovered and dorsal horn neuron activities were significantly suppressed in Ankle-Sprained rats. However, EA produced no effect in normal rats. The inhibitory effect of EA on hyperactivities of dorsal horn neurons of Ankle-Sprained rats was blocked by the α-adrenoceptor antagonist phentolamine (5 mg/kg ip) but not by the opioid receptor antagonist naltrexone (10 mg/kg ip). These data suggest that EA-induced analgesia in Ankle sprain pain is mediated mainly by suppressing dorsal horn neuron activities through α-adrenergic descending inhibitory systems at the spinal level.

Hee Young Kim - One of the best experts on this subject based on the ideXlab platform.

  • Responses of spinal dorsal horn neurons to foot movements in rats with a Sprained Ankle
    Journal of neurophysiology, 2011
    Co-Authors: Jae Hyo Kim, Hee Young Kim, Kyungsoon Chung, Jin Mo Chung
    Abstract:

    Acute Ankle injuries are common problems and often lead to persistent pain. To investigate the underlying mechanism of Ankle sprain pain, the response properties of spinal dorsal horn neurons were examined after Ankle sprain. Acute Ankle sprain was induced manually by overextending the Ankle of a rat hindlimb in a direction of plantarflexion and inversion. The weight-bearing ratio (WBR) of the affected foot was used as an indicator of pain. Single unit activities of dorsal horn neurons in response to plantarflexion and inversion of the foot or Ankle compression were recorded from the medial part of the deep dorsal horn, laminae IV-VI, in normal and Ankle-Sprained rats. One day after Ankle sprain, rats showed significantly reduced WBRs on the affected foot, and this reduction was partially restored by systemic morphine. The majority of deep dorsal horn neurons responded to a single Ankle stimulus modality. After Ankle sprain, the mean evoked response rates were significantly increased, and afterdischarges were developed in recorded dorsal horn neurons. The Ankle sprain-induced enhanced evoked responses were significantly reduced by morphine, which was reversed by naltrexone. The data indicate that movement-specific dorsal horn neuron responses were enhanced after Ankle sprain in a morphine-dependent manner, thus suggesting that hyperactivity of dorsal horn neurons is an underlying mechanism of pain after Ankle sprain.

  • Electroacupuncture reduces the evoked responses of the spinal dorsal horn neurons in Ankle-Sprained rats
    Journal of neurophysiology, 2011
    Co-Authors: Jae Hyo Kim, Hee Young Kim, Kyungsoon Chung, Jin Mo Chung
    Abstract:

    Acupuncture is shown to be effective in producing analgesia in Ankle sprain pain in humans and animals. To examine the underlying mechanisms of the acupuncture-induced analgesia, the effects of electroacupuncture (EA) on weight-bearing forces (WBR) of the affected foot and dorsal horn neuron activities were examined in a rat model of Ankle sprain. Ankle sprain was induced manually by overextending ligaments of the left Ankle in the rat. Dorsal horn neuron responses to Ankle movements or compression were recorded from the lumbar spinal cord using an in vivo extracellular single unit recording setup 1 day after Ankle sprain. EA was applied to the SI-6 acupoint on the right forelimb (contralateral to the Sprained Ankle) by trains of electrical pulses (10 Hz, 1-ms pulse width, 2-mA intensity) for 30 min. After EA, WBR of the Sprained foot significantly recovered and dorsal horn neuron activities were significantly suppressed in Ankle-Sprained rats. However, EA produced no effect in normal rats. The inhibitory effect of EA on hyperactivities of dorsal horn neurons of Ankle-Sprained rats was blocked by the α-adrenoceptor antagonist phentolamine (5 mg/kg ip) but not by the opioid receptor antagonist naltrexone (10 mg/kg ip). These data suggest that EA-induced analgesia in Ankle sprain pain is mediated mainly by suppressing dorsal horn neuron activities through α-adrenergic descending inhibitory systems at the spinal level.

Kyungsoon Chung - One of the best experts on this subject based on the ideXlab platform.

  • Responses of spinal dorsal horn neurons to foot movements in rats with a Sprained Ankle
    Journal of neurophysiology, 2011
    Co-Authors: Jae Hyo Kim, Hee Young Kim, Kyungsoon Chung, Jin Mo Chung
    Abstract:

    Acute Ankle injuries are common problems and often lead to persistent pain. To investigate the underlying mechanism of Ankle sprain pain, the response properties of spinal dorsal horn neurons were examined after Ankle sprain. Acute Ankle sprain was induced manually by overextending the Ankle of a rat hindlimb in a direction of plantarflexion and inversion. The weight-bearing ratio (WBR) of the affected foot was used as an indicator of pain. Single unit activities of dorsal horn neurons in response to plantarflexion and inversion of the foot or Ankle compression were recorded from the medial part of the deep dorsal horn, laminae IV-VI, in normal and Ankle-Sprained rats. One day after Ankle sprain, rats showed significantly reduced WBRs on the affected foot, and this reduction was partially restored by systemic morphine. The majority of deep dorsal horn neurons responded to a single Ankle stimulus modality. After Ankle sprain, the mean evoked response rates were significantly increased, and afterdischarges were developed in recorded dorsal horn neurons. The Ankle sprain-induced enhanced evoked responses were significantly reduced by morphine, which was reversed by naltrexone. The data indicate that movement-specific dorsal horn neuron responses were enhanced after Ankle sprain in a morphine-dependent manner, thus suggesting that hyperactivity of dorsal horn neurons is an underlying mechanism of pain after Ankle sprain.

  • Electroacupuncture reduces the evoked responses of the spinal dorsal horn neurons in Ankle-Sprained rats
    Journal of neurophysiology, 2011
    Co-Authors: Jae Hyo Kim, Hee Young Kim, Kyungsoon Chung, Jin Mo Chung
    Abstract:

    Acupuncture is shown to be effective in producing analgesia in Ankle sprain pain in humans and animals. To examine the underlying mechanisms of the acupuncture-induced analgesia, the effects of electroacupuncture (EA) on weight-bearing forces (WBR) of the affected foot and dorsal horn neuron activities were examined in a rat model of Ankle sprain. Ankle sprain was induced manually by overextending ligaments of the left Ankle in the rat. Dorsal horn neuron responses to Ankle movements or compression were recorded from the lumbar spinal cord using an in vivo extracellular single unit recording setup 1 day after Ankle sprain. EA was applied to the SI-6 acupoint on the right forelimb (contralateral to the Sprained Ankle) by trains of electrical pulses (10 Hz, 1-ms pulse width, 2-mA intensity) for 30 min. After EA, WBR of the Sprained foot significantly recovered and dorsal horn neuron activities were significantly suppressed in Ankle-Sprained rats. However, EA produced no effect in normal rats. The inhibitory effect of EA on hyperactivities of dorsal horn neurons of Ankle-Sprained rats was blocked by the α-adrenoceptor antagonist phentolamine (5 mg/kg ip) but not by the opioid receptor antagonist naltrexone (10 mg/kg ip). These data suggest that EA-induced analgesia in Ankle sprain pain is mediated mainly by suppressing dorsal horn neuron activities through α-adrenergic descending inhibitory systems at the spinal level.

Christopher Nester - One of the best experts on this subject based on the ideXlab platform.

  • Sprained Ankle Physiotherapy Based Mechanism Synthesis and Stiffness Analysis of a Robotic Rehabilitation Device
    Autonomous Robots, 2004
    Co-Authors: Jian S. Dai, Tieshi Zhao, Christopher Nester
    Abstract:

    Rehabilitation robotics is a growing field where the study of human movement is one of the key topics. Mechanisms development in terms of analysis and synthesis in the field is relatively new, particularly in the case of parallel robotic mechanisms. This paper presents the background and details of current research into the use of parallel robotic mechanisms for rehabilitation of Sprained Ankles, and proposes a new device based on a parallel mechanism with a central strut. The paper investigates a new technique in motion analysis of Ankle movement which is presented in an orientation image space and in that of a rehabilitation therapy, presents an approach of mechanism synthesis based on this analysis, and develops several parallel mechanisms with a central strut for Ankle rehabilitation. This is then related to the analysis of the stiffness effect of the central strut in the platform-type mechanism and the stiffness matrix is decomposed with the part resulting from the central strut which supports Ankle rehabilitation. In presenting this new research, the paper relates the study of mechanisms to that of rehabilitation robotics and presents a strong case in the new application of parallel robotic mechanisms.