The Experts below are selected from a list of 2859 Experts worldwide ranked by ideXlab platform
Chengyu Zheng - One of the best experts on this subject based on the ideXlab platform.
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nanometer photocatalytic plasma biological deodorization method and full automatic peculiar smell control deodorization system
2010Co-Authors: Chengyu ZhengAbstract:The invention relates to a nanometer photocatalytic plasma biological deodorization method. The method comprises the following steps of: a, pre-charged dust collection; b, plasma purification; c, plant extract purification, namely atomizing plant extract to form liquid drops with a diameter of less than 1 mu m and performing purification on the liquid drops; and d, nanometer photocatalytic purification. A nanometer photocatalytic plasma biological deodorization method comprises a primary purification room and a secondary purification room, wherein an outlet of the primary purification room is connected with an inlet of the secondary purification room; the primary purification room is provided with coarse filtering equipment, static dust collecting equipment, a photocatalyst, a plasma purification system and a negative ion generator in sequence from the inlet to the outlet; the secondary purification room is provided with a Spray Atomizer which atomizes the plant extract stored in the system to form the liquid drops with the diameter of less than 1 mu m; and an outlet of the secondary purification room is connected with an exhaust system. The system has the characteristic of good deodorization effect.
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deodorizing system by nano photocatalytic plasma biological method
2010Co-Authors: Chengyu ZhengAbstract:The utility model relates to a deodorizing system by the nano-photocatalytic plasma biological method, which comprises a first-stage purifying chamber and a second-stage purifying chamber, wherein theoutlet of the first-stage purifying chamber is connected with the inlet of the second-stage purifying chamber, and a coarse filter device, an electrostatic dust collection device, a photocatalyst, aplasma purifying system and a negative-ion generator are sequentially in the first-stage purifying chamber along a direction from the inlet to the outlet, and a Spray Atomizer is arranged in the second-stage purifying chamber; and the plant extract in a storage system is atomized to form liquid drops with the diameter of less than 1 mum by the Spray Atomizer, and the outlet of the second-stage purifying chamber is connected with an exhaust system. The utility model has the characteristic of good deodorizing effect.
James J. Sloan - One of the best experts on this subject based on the ideXlab platform.
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Low Pressure Aerosol Flow Reactor
Aerosol Science and Technology, 2005Co-Authors: R. G. Remorov, A. Yu. Zasetsky, James J. SloanAbstract:In this work we report the development of a novel low pressure aerosol flow reactor for the determination of the kinetic parameters of fast heterogeneous processes. The experimental apparatus consists of a Spray Atomizer to introduce aerosols into a low pressure zone; a fast flow reactor for kinetic measurements and an IR spectrometer and mass spectrometer for concentration measurements. The surface area distribution and number density of the aerosol particles are determined from their infrared spectra and the decay kinetics are determined by monitoring the disappearance rates of the gas phase species (with a mass spectrometer) as a function of the aerosol properties. We report the application of this apparatus to the investigation of the uptake of acetone by liquid water aerosols (0.1–20 μ m diameter) at room temperature and a pressure of 35 Torr. These measurements yielded a value of the mass accommodation coefficient, α, of 3.6 − 2 + 3.1 × 10 − 3 .
Calmet Hadrien - One of the best experts on this subject based on the ideXlab platform.
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Large-scale CFD and micro-particles simulations in a large human airways under sniff condition and drug delivery application
Universitat Politècnica de Catalunya, 2020Co-Authors: Calmet HadrienAbstract:As we inhale, the air drawn through our nose undergoes successive accelerations and decelerations as it is turned, split, and recombined before splitting again at the end of the trachea as it enters the bronchi. Fully describing the dynamic behaviour of the airflow and how it transports inhaled particles poses a severe challenge to computational simulations. The dynamics of unsteady flow in the human large airways during a rapid and short inhalation (a so-called sniff) is a perfect example of perhaps the most complex and violent human inhalation inflow. Combining the flow solution with a Lagrangian computation reveals the effects of flow behaviour and airway geometry on the deposition of inhaled microparticles. Highly detailed large-scale computational fluid dynamics allow resolving all the spatial and temporal scales of the flow, thanks to the use of massive computational resources. A highly parallel finite element code running on supercomputers can solve the transient incompressible Navier-Stokes equations on unstructured meshes. Given that the finest mesh contained 350 million elements, the study sets a precedent for large-scale simulations of the respiratory system, proposing an analysis strategy for mean flow, fluctuations, wall shear stresses, energy spectral and particle deposition on a rapid and short inhalation. Then in a second time, we will propose a drug delivery study of nasal Sprayed particle from commercial product in a human nasal cavity under different inhalation conditions; sniffing, constant flow rate and breath-hold. Particles were introduced into the flow field with initial Spray conditions, including Spray cone angle, insertion angle, and initial velocity. Since nasal Spray Atomizer design determines the particle conditions, fifteen particle size distributions were used,each defined by a log-normal distribution with a different volume mean diameter. This thesis indicates the potential of large-scale simulations to further understanding of airway physiological mechanics, which is essential to guide clinical diagnosis; better understanding of the flow and delivery of therapeutic aerosols, which could be applied to improve diagnosis and treatment.En una inhalación, el aire que atraviesa nuestra cavidad nasal es sometido a una serie de aceleraciones y deceleraciones al producirse un giros, bifurcaciones y recombinarse de nuevo antes de volver a dividirse de nuevo a la altura de la tráquea en la entrada a los bronquios principales. La descripción precisa y acurada del comportamiento dinámico de este fluido así como el transporte de partículas inhalada que entran con el mismo a través de una simulación computacional supone un gran desafío. La dinámica del fluido en las vías respiratorias durante una inhalación rápida y corta (también llamado sniff) es un ejemplo perfecto de lo que sería probablemente la inhalación en el ser humano más compleja y violenta. Combinando la solución del fluido con un modelo lagrangiano revela el comportamiento del flujo y el effecto de la geometría de las vías respiratorias sobre la deposición de micropartículas inhaladas. La dinámica de fluidos computacional a gran escala de alta precisión permite resolver todas las escalas espaciales y temporales gracias al uso de recursos computacionales masivos. Un código de elementos finitos paralelos que se ejecuta en supercomputadoras puede resolver las ecuaciones transitorias e incompresibles de Navier-Stokes. Considerando que la malla más fina contiene 350 millones de elementos, cabe señalar que el presente estudio establece un precedente para simulaciones a gran escala de las vías respiratorias, proponiendo una estrategia de análisis para flujo medio, fluctuaciones, tensiones de corte de pared, espectro de energía y deposición de partículas en el contexto de una inhalación rápida y corta. Una vez realizado el analisis anterior, propondremos un estudio de administración de fármacos con un Spray nasal en una cavidad nasal humana bajo diferentes condiciones de inhalación; sniff, caudal constante y respiración sostenida. Las partículas se introdujeron en el fluido con condiciones iniciales de pulverización, incluido el ángulo del cono de pulverización, el ángulo de inserción y la velocidad inicial. El diseño del atomizador del Spray nasal determina las condiciones de partículas, entonces se utilizaron quince distribuciones de tamaño de partícula, cada uno definido por una distribución logarítmica normal con una media de volumen diferente. Esta tesis demuestra el potencial de las simulaciones a gran escala para una mejor comprensión de los mecanismos fisiológicos de las vías respiratorias. Gracias a estas herramientas se podrá mejorar el diagnóstico y sus respectivos tratamientos ya que con ellas se profundizará en la comprensión del flujo que recorre las vías aereas así como el transporte de aerosoles terapéuticos
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Nasal Sprayed particle deposition in a human nasal cavity under different inhalation conditions
'Public Library of Science (PLoS)', 2019Co-Authors: Calmet Hadrien, Inthavong Kiao, Eguzkitza Beatriz, Lehmkuhl Oriol, Houzeaux GuillaumeAbstract:Deposition of polydisperse particles representing nasal Spray application in a human nasal cavity was performed under transient breathing profiles of sniffing, constant flow, and breath hold. The LES turbulence model was used to describe the fluid phase. Particles were introduced into the flow field with initial Spray conditions, including Spray cone angle, insertion angle, and initial velocity. Since nasal Spray Atomizer design determines the particle conditions, fifteen particle size distributions were used, each defined by a log-normal distribution with a different volume mean diameter (Dv50). Particle deposition in the anterior region was approximately 80% when Dv50 > 50μm, and this decreased to 45% as Dv50 decreased to 10μ m for constant and sniff breathing conditions. The decrease in anterior deposition was countered with increased deposition in the middle and posterior regions. The significance of increased deposition in the middle region for drug delivery shows there is potential for nasal delivered drugs to reach the highly vascularised mucosal walls in the main nasal passages. For multiple targeted deposition sites, an optimisation equation was introduced where deposition results of any two targeted sites could be combined and a weighting between 0 to 1 was applied to each targeted site, representing the relative importance of each deposition site.This work was financially supported by CompBiomed (Grant agreement ID: 675451) under European Commission (H2020) and by the Spanish Ministry of Economy and competitiveness (Project INSPIRE (FIS2017-89535-C2-1-R).Peer Reviewe
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Nasal Sprayed particle deposition in a human nasal cavity under different inhalation conditions
'Public Library of Science (PLoS)', 2019Co-Authors: Calmet Hadrien, Inthavong Kiao, Eguzkitza Beatriz, Lehmkuhl Oriol, Houzeaux GuillaumeAbstract:Deposition of polydisperse particles representing nasal Spray application in a human nasal cavity was performed under transient breathing profiles of sniffing, constant flow, and breath hold. The LES turbulence model was used to describe the fluid phase. Particles were introduced into the flow field with initial Spray conditions, including Spray cone angle, insertion angle, and initial velocity. Since nasal Spray Atomizer design determines the particle conditions, fifteen particle size distributions were used, each defined by a log-normal distribution with a different volume mean diameter (Dv50). Particle deposition in the anterior region was approximately 80% when Dv50 > 50μm, and this decreased to 45% as Dv50 decreased to 10μ m for constant and sniff breathing conditions. The decrease in anterior deposition was countered with increased deposition in the middle and posterior regions. The significance of increased deposition in the middle region for drug delivery shows there is potential for nasal delivered drugs to reach the highly vascularised mucosal walls in the main nasal passages. For multiple targeted deposition sites, an optimisation equation was introduced where deposition results of any two targeted sites could be combined and a weighting between 0 to 1 was applied to each targeted site, representing the relative importance of each deposition site.This work was financially supported by CompBiomed (Grant agreement ID: 675451) under European Commission (H2020) and by the Spanish Ministry of Economy and competitiveness (Project INSPIRE (FIS2017-89535-C2-1-R).Peer ReviewedPostprint (published version
Houzeaux Guillaume - One of the best experts on this subject based on the ideXlab platform.
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Nasal Sprayed particle deposition in a human nasal cavity under different inhalation conditions
'Public Library of Science (PLoS)', 2019Co-Authors: Calmet Hadrien, Inthavong Kiao, Eguzkitza Beatriz, Lehmkuhl Oriol, Houzeaux GuillaumeAbstract:Deposition of polydisperse particles representing nasal Spray application in a human nasal cavity was performed under transient breathing profiles of sniffing, constant flow, and breath hold. The LES turbulence model was used to describe the fluid phase. Particles were introduced into the flow field with initial Spray conditions, including Spray cone angle, insertion angle, and initial velocity. Since nasal Spray Atomizer design determines the particle conditions, fifteen particle size distributions were used, each defined by a log-normal distribution with a different volume mean diameter (Dv50). Particle deposition in the anterior region was approximately 80% when Dv50 > 50μm, and this decreased to 45% as Dv50 decreased to 10μ m for constant and sniff breathing conditions. The decrease in anterior deposition was countered with increased deposition in the middle and posterior regions. The significance of increased deposition in the middle region for drug delivery shows there is potential for nasal delivered drugs to reach the highly vascularised mucosal walls in the main nasal passages. For multiple targeted deposition sites, an optimisation equation was introduced where deposition results of any two targeted sites could be combined and a weighting between 0 to 1 was applied to each targeted site, representing the relative importance of each deposition site.This work was financially supported by CompBiomed (Grant agreement ID: 675451) under European Commission (H2020) and by the Spanish Ministry of Economy and competitiveness (Project INSPIRE (FIS2017-89535-C2-1-R).Peer Reviewe
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Nasal Sprayed particle deposition in a human nasal cavity under different inhalation conditions
'Public Library of Science (PLoS)', 2019Co-Authors: Calmet Hadrien, Inthavong Kiao, Eguzkitza Beatriz, Lehmkuhl Oriol, Houzeaux GuillaumeAbstract:Deposition of polydisperse particles representing nasal Spray application in a human nasal cavity was performed under transient breathing profiles of sniffing, constant flow, and breath hold. The LES turbulence model was used to describe the fluid phase. Particles were introduced into the flow field with initial Spray conditions, including Spray cone angle, insertion angle, and initial velocity. Since nasal Spray Atomizer design determines the particle conditions, fifteen particle size distributions were used, each defined by a log-normal distribution with a different volume mean diameter (Dv50). Particle deposition in the anterior region was approximately 80% when Dv50 > 50μm, and this decreased to 45% as Dv50 decreased to 10μ m for constant and sniff breathing conditions. The decrease in anterior deposition was countered with increased deposition in the middle and posterior regions. The significance of increased deposition in the middle region for drug delivery shows there is potential for nasal delivered drugs to reach the highly vascularised mucosal walls in the main nasal passages. For multiple targeted deposition sites, an optimisation equation was introduced where deposition results of any two targeted sites could be combined and a weighting between 0 to 1 was applied to each targeted site, representing the relative importance of each deposition site.This work was financially supported by CompBiomed (Grant agreement ID: 675451) under European Commission (H2020) and by the Spanish Ministry of Economy and competitiveness (Project INSPIRE (FIS2017-89535-C2-1-R).Peer ReviewedPostprint (published version
R. G. Remorov - One of the best experts on this subject based on the ideXlab platform.
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Low Pressure Aerosol Flow Reactor
Aerosol Science and Technology, 2005Co-Authors: R. G. Remorov, A. Yu. Zasetsky, James J. SloanAbstract:In this work we report the development of a novel low pressure aerosol flow reactor for the determination of the kinetic parameters of fast heterogeneous processes. The experimental apparatus consists of a Spray Atomizer to introduce aerosols into a low pressure zone; a fast flow reactor for kinetic measurements and an IR spectrometer and mass spectrometer for concentration measurements. The surface area distribution and number density of the aerosol particles are determined from their infrared spectra and the decay kinetics are determined by monitoring the disappearance rates of the gas phase species (with a mass spectrometer) as a function of the aerosol properties. We report the application of this apparatus to the investigation of the uptake of acetone by liquid water aerosols (0.1–20 μ m diameter) at room temperature and a pressure of 35 Torr. These measurements yielded a value of the mass accommodation coefficient, α, of 3.6 − 2 + 3.1 × 10 − 3 .