The Experts below are selected from a list of 417 Experts worldwide ranked by ideXlab platform

Lorna J Kennedy - One of the best experts on this subject based on the ideXlab platform.

  • DLA Class II Alleles and Haplotypes Are Associated with Risk for and Protection from Chronic Hepatitis in the English Springer
    2016
    Co-Authors: Nick Bexfield, David R Sargan, Laurence Tiley, Jonathan L Heeney, Penny J. Watson, Lorna J Kennedy
    Abstract:

    Chronic hepatitis (CH) is common in dogs in the United Kingdom. An increased prevalence of the disease is seen in the English Springer Spaniel (ESS), and this breed suffer from a severe form with young to middle aged female dogs being predisposed. The disease shares histological features with those of human viral hepatitis, although the specific aetiological agent has not yet been identified. The aim of the current study was to investigate whether dog leucocyte antigen (DLA) class II alleles and haplotypes are associated with susceptibility/resistance to CH in the ESS. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1,-DQA1 and-DQB1 class II loci were performed in 66 ESSs with CH and 84 healthy controls. There was a significant difference in the distribution of the protective alleles DRB1*00501 (3.0 % vs. 12.0%, odds ratio [OR] = 0.23, 95 % confidence interval [CI] = 0.06–0.74) and DQB1*00501 (3.8 % vs. 12.0%, OR = 0.29, 95 % CI = 0.09–0.85) between cases and controls. The haplotype DLA-DRB1*00501/DQA1*00301/DQB1*00501 was present in 11.9 % of controls and 3.0 % of cases and was significantly associated with protection against disease development (OR = 0.26, 95 % CI = 0.08– 0.80). There was a significant difference in the distribution of the risk alleles DRB1*00601 (14.4 % vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) and DQB1*00701 (14.4 % vs. 6.5%, OR = 2.40, 95 % CI = 1.10–5.63) between cases and controls. A risk haplotype (DLA-DRB1*00601/DQA1*005011/DQB1*00701) was present in 14.4 % of cases and 6.5 % of controls and conferred an elevated risk of developing CH with an OR of 3.13 (95 % CI = 1.20–8.26). These results demonstrate that DLA class II i

  • dla class ii alleles and haplotypes are associated with risk for and protection from chronic hepatitis in the english Springer Spaniel
    PLOS ONE, 2012
    Co-Authors: Nick Bexfield, Penny Watson, Jesus Aguirrehernandez, David R Sargan, Laurence Tiley, Jonathan L Heeney, Lorna J Kennedy
    Abstract:

    Chronic hepatitis (CH) is common in dogs in the United Kingdom. An increased prevalence of the disease is seen in the English Springer Spaniel (ESS), and this breed suffer from a severe form with young to middle aged female dogs being predisposed. The disease shares histological features with those of human viral hepatitis, although the specific aetiological agent has not yet been identified. The aim of the current study was to investigate whether dog leucocyte antigen (DLA) class II alleles and haplotypes are associated with susceptibility/resistance to CH in the ESS. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1, -DQA1 and -DQB1 class II loci were performed in 66 ESSs with CH and 84 healthy controls. There was a significant difference in the distribution of the protective alleles DRB1*00501 (3.0% vs. 12.0%, odds ratio [OR] = 0.23, 95% confidence interval [CI] = 0.06–0.74) and DQB1*00501 (3.8% vs. 12.0%, OR = 0.29, 95% CI = 0.09–0.85) between cases and controls. The haplotype DLA-DRB1*00501/DQA1*00301/DQB1*00501 was present in 11.9% of controls and 3.0% of cases and was significantly associated with protection against disease development (OR = 0.26, 95% CI = 0.08–0.80). There was a significant difference in the distribution of the risk alleles DRB1*00601 (14.4% vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) and DQB1*00701 (14.4% vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) between cases and controls. A risk haplotype (DLA-DRB1*00601/DQA1*005011/DQB1*00701) was present in 14.4% of cases and 6.5% of controls and conferred an elevated risk of developing CH with an OR of 3.13 (95% CI = 1.20–8.26). These results demonstrate that DLA class II is significantly associated with risk and protection from developing CH in ESSs.

Nick Bexfield - One of the best experts on this subject based on the ideXlab platform.

  • DLA Class II Alleles and Haplotypes Are Associated with Risk for and Protection from Chronic Hepatitis in the English Springer
    2016
    Co-Authors: Nick Bexfield, David R Sargan, Laurence Tiley, Jonathan L Heeney, Penny J. Watson, Lorna J Kennedy
    Abstract:

    Chronic hepatitis (CH) is common in dogs in the United Kingdom. An increased prevalence of the disease is seen in the English Springer Spaniel (ESS), and this breed suffer from a severe form with young to middle aged female dogs being predisposed. The disease shares histological features with those of human viral hepatitis, although the specific aetiological agent has not yet been identified. The aim of the current study was to investigate whether dog leucocyte antigen (DLA) class II alleles and haplotypes are associated with susceptibility/resistance to CH in the ESS. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1,-DQA1 and-DQB1 class II loci were performed in 66 ESSs with CH and 84 healthy controls. There was a significant difference in the distribution of the protective alleles DRB1*00501 (3.0 % vs. 12.0%, odds ratio [OR] = 0.23, 95 % confidence interval [CI] = 0.06–0.74) and DQB1*00501 (3.8 % vs. 12.0%, OR = 0.29, 95 % CI = 0.09–0.85) between cases and controls. The haplotype DLA-DRB1*00501/DQA1*00301/DQB1*00501 was present in 11.9 % of controls and 3.0 % of cases and was significantly associated with protection against disease development (OR = 0.26, 95 % CI = 0.08– 0.80). There was a significant difference in the distribution of the risk alleles DRB1*00601 (14.4 % vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) and DQB1*00701 (14.4 % vs. 6.5%, OR = 2.40, 95 % CI = 1.10–5.63) between cases and controls. A risk haplotype (DLA-DRB1*00601/DQA1*005011/DQB1*00701) was present in 14.4 % of cases and 6.5 % of controls and conferred an elevated risk of developing CH with an OR of 3.13 (95 % CI = 1.20–8.26). These results demonstrate that DLA class II i

  • dla class ii alleles and haplotypes are associated with risk for and protection from chronic hepatitis in the english Springer Spaniel
    PLOS ONE, 2012
    Co-Authors: Nick Bexfield, Penny Watson, Jesus Aguirrehernandez, David R Sargan, Laurence Tiley, Jonathan L Heeney, Lorna J Kennedy
    Abstract:

    Chronic hepatitis (CH) is common in dogs in the United Kingdom. An increased prevalence of the disease is seen in the English Springer Spaniel (ESS), and this breed suffer from a severe form with young to middle aged female dogs being predisposed. The disease shares histological features with those of human viral hepatitis, although the specific aetiological agent has not yet been identified. The aim of the current study was to investigate whether dog leucocyte antigen (DLA) class II alleles and haplotypes are associated with susceptibility/resistance to CH in the ESS. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1, -DQA1 and -DQB1 class II loci were performed in 66 ESSs with CH and 84 healthy controls. There was a significant difference in the distribution of the protective alleles DRB1*00501 (3.0% vs. 12.0%, odds ratio [OR] = 0.23, 95% confidence interval [CI] = 0.06–0.74) and DQB1*00501 (3.8% vs. 12.0%, OR = 0.29, 95% CI = 0.09–0.85) between cases and controls. The haplotype DLA-DRB1*00501/DQA1*00301/DQB1*00501 was present in 11.9% of controls and 3.0% of cases and was significantly associated with protection against disease development (OR = 0.26, 95% CI = 0.08–0.80). There was a significant difference in the distribution of the risk alleles DRB1*00601 (14.4% vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) and DQB1*00701 (14.4% vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) between cases and controls. A risk haplotype (DLA-DRB1*00601/DQA1*005011/DQB1*00701) was present in 14.4% of cases and 6.5% of controls and conferred an elevated risk of developing CH with an OR of 3.13 (95% CI = 1.20–8.26). These results demonstrate that DLA class II is significantly associated with risk and protection from developing CH in ESSs.

  • chronic hepatitis in the english Springer Spaniel clinical presentation histological description and outcome
    Veterinary Record, 2011
    Co-Authors: Nick Bexfield, C Andresabdo, T J Scase, Fernando Constantinocasas, Penny Watson
    Abstract:

    Medical records and liver histology of 68 English Springer Spaniels (ESS) with a histological diagnosis of CH were reviewed retrospectively. PCR was performed on liver tissue for canine adenovirus-1 (CAV-1), canine parvovirus, canine herpesvirus and pathogenic Leptospira species. Follow-up information was obtained to calculate survival times. Median age at presentation was three years seven months (range, seven months to eight years five months) and there were 48 female and 20 male dogs. Clinical signs were non-specific and five dogs were asymptomatic. All dogs had an increase in serum activity of one or more hepatobiliary enzymes. Histopathology demonstrated hepatocyte necrosis and apoptosis with varying amounts of fibrosis. A predominantly lymphoplasmacytic infiltrate throughout the hepatic parenchyma was found in all 68 dogs, but 45 of these dogs also had a neutrophilic component to the inflammatory infiltrate. There was no significant copper accumulation and no aetiological agent was identified by PCR. The median survival time was 189 days (range, 1 to 1211 days), 38 dogs died within three months and 12 dogs survived more than a year following diagnosis.

Jens Haggstrom - One of the best experts on this subject based on the ideXlab platform.

  • Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours
    PLOS Genetics, 2016
    Co-Authors: Malin Melin, Maja Arendt, Eva Murén, Mike Starkey, Kaja Sverdrup Borge, Patricio Rivera, Ulla Gustafson, Frode Lingaas, Ingegerd Elvers, Jens Haggstrom
    Abstract:

    Canine mammary tumours (CMT) are the most common neoplasia in unspayed female dogs. CMTs are suitable naturally occurring models for human breast cancer and share many characteristics, indicating that the genetic causes could also be shared. We have performed a genome-wide association study (GWAS) in English Springer Spaniel dogs and identified a genome-wide significant locus on chromosome 11 (praw = 5.6x10-7, pperm = 0.019). The most associated haplotype spans a 446 kb region overlapping the CDK5RAP2 gene. The CDK5RAP2 protein has a function in cell cycle regulation and could potentially have an impact on response to chemotherapy treatment. Two additional loci, both on chromosome 27, were nominally associated (praw = 1.97x10-5 and praw = 8.30x10-6). The three loci explain 28.1±10.0% of the phenotypic variation seen in the cohort, whereas the top ten associated regions account for 38.2±10.8% of the risk. Furthermore, the ten GWAS loci and regions with reduced genetic variability are significantly enriched for snoRNAs and tumour-associated antigen genes, suggesting a role for these genes in CMT development. We have identified several candidate genes associated with canine mammary tumours, including CDK5RAP2. Our findings enable further comparative studies to investigate the genes and pathways in human breast cancer patients.

David R Sargan - One of the best experts on this subject based on the ideXlab platform.

  • DLA Class II Alleles and Haplotypes Are Associated with Risk for and Protection from Chronic Hepatitis in the English Springer
    2016
    Co-Authors: Nick Bexfield, David R Sargan, Laurence Tiley, Jonathan L Heeney, Penny J. Watson, Lorna J Kennedy
    Abstract:

    Chronic hepatitis (CH) is common in dogs in the United Kingdom. An increased prevalence of the disease is seen in the English Springer Spaniel (ESS), and this breed suffer from a severe form with young to middle aged female dogs being predisposed. The disease shares histological features with those of human viral hepatitis, although the specific aetiological agent has not yet been identified. The aim of the current study was to investigate whether dog leucocyte antigen (DLA) class II alleles and haplotypes are associated with susceptibility/resistance to CH in the ESS. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1,-DQA1 and-DQB1 class II loci were performed in 66 ESSs with CH and 84 healthy controls. There was a significant difference in the distribution of the protective alleles DRB1*00501 (3.0 % vs. 12.0%, odds ratio [OR] = 0.23, 95 % confidence interval [CI] = 0.06–0.74) and DQB1*00501 (3.8 % vs. 12.0%, OR = 0.29, 95 % CI = 0.09–0.85) between cases and controls. The haplotype DLA-DRB1*00501/DQA1*00301/DQB1*00501 was present in 11.9 % of controls and 3.0 % of cases and was significantly associated with protection against disease development (OR = 0.26, 95 % CI = 0.08– 0.80). There was a significant difference in the distribution of the risk alleles DRB1*00601 (14.4 % vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) and DQB1*00701 (14.4 % vs. 6.5%, OR = 2.40, 95 % CI = 1.10–5.63) between cases and controls. A risk haplotype (DLA-DRB1*00601/DQA1*005011/DQB1*00701) was present in 14.4 % of cases and 6.5 % of controls and conferred an elevated risk of developing CH with an OR of 3.13 (95 % CI = 1.20–8.26). These results demonstrate that DLA class II i

  • Respiratory parameters measured by whole-body barometric plethysmography (WBBP).
    2015
    Co-Authors: Nai-chieh Liu, David R Sargan, Vicki J. Adams, Jane F. Ladlow
    Abstract:

    Means (m) and standard deviations of the means (sd) of RR, Te/Ti, PEF/PIF, and MV/BW were calculated for 20 breaths collected from each dog.RR = respiratory rate (breath per minute); Te/Ti = expiratory time (s) /inspiratory time(s); PEF/PIF = peak expiratory flow rate (ml/s)/ peak inspiratory flow rate (ml/s); MV/BW = minute volume (ml)/ body weight(kg); m = mean of the parameter calculated from the 20 breaths of each dog; sd = standard deviation of the parameter calculated from the 20 breaths of each dog.a Breeds: English Springer Spaniel (n = 2), Border collie (n = 1), Jack Russell terrier (n = 1), Labrador retriever (n = 3), American bullterrier (n = 1), Beagles (n = 6), Dachshund (n = 1), Cairn terrier (n = 1), West Highland white terrier (n = 1), cross breeds (n = 3).b BOAS- FB = Grade 0/I FB; BOAS+ FB = Grade II/III FB. Functional grades, refer to Table 1.π The Kolmogorov-Smironov test was significant (i.e. data were not normal distributed); p

  • Signalment (median [minimum-maximum]) and details of French bulldogs and non-brachycephalic controls.
    2015
    Co-Authors: Nai-chieh Liu, David R Sargan, Vicki J. Adams, Jane F. Ladlow
    Abstract:

    Data are presented as median (minimum-maximum). BOAS refers to Brachycephalic Obstructive Airway Syndrome; BCS, body condition score.a Functional grades, refer to Table 1.b Breeds: English Springer Spaniel (n = 2), Border collie (n = 1), Jack Russell terrier (n = 1), Labrador retriever (n = 3), American bullterrier (n = 1), Beagles (n = 6), Dachshund (n = 1), Cairn terrier (n = 1), West Highland white terrier (n = 1), cross breeds (n = 3).Signalment (median [minimum-maximum]) and details of French bulldogs and non-brachycephalic controls.

  • dla class ii alleles and haplotypes are associated with risk for and protection from chronic hepatitis in the english Springer Spaniel
    PLOS ONE, 2012
    Co-Authors: Nick Bexfield, Penny Watson, Jesus Aguirrehernandez, David R Sargan, Laurence Tiley, Jonathan L Heeney, Lorna J Kennedy
    Abstract:

    Chronic hepatitis (CH) is common in dogs in the United Kingdom. An increased prevalence of the disease is seen in the English Springer Spaniel (ESS), and this breed suffer from a severe form with young to middle aged female dogs being predisposed. The disease shares histological features with those of human viral hepatitis, although the specific aetiological agent has not yet been identified. The aim of the current study was to investigate whether dog leucocyte antigen (DLA) class II alleles and haplotypes are associated with susceptibility/resistance to CH in the ESS. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1, -DQA1 and -DQB1 class II loci were performed in 66 ESSs with CH and 84 healthy controls. There was a significant difference in the distribution of the protective alleles DRB1*00501 (3.0% vs. 12.0%, odds ratio [OR] = 0.23, 95% confidence interval [CI] = 0.06–0.74) and DQB1*00501 (3.8% vs. 12.0%, OR = 0.29, 95% CI = 0.09–0.85) between cases and controls. The haplotype DLA-DRB1*00501/DQA1*00301/DQB1*00501 was present in 11.9% of controls and 3.0% of cases and was significantly associated with protection against disease development (OR = 0.26, 95% CI = 0.08–0.80). There was a significant difference in the distribution of the risk alleles DRB1*00601 (14.4% vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) and DQB1*00701 (14.4% vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) between cases and controls. A risk haplotype (DLA-DRB1*00601/DQA1*005011/DQB1*00701) was present in 14.4% of cases and 6.5% of controls and conferred an elevated risk of developing CH with an OR of 3.13 (95% CI = 1.20–8.26). These results demonstrate that DLA class II is significantly associated with risk and protection from developing CH in ESSs.

Laurence Tiley - One of the best experts on this subject based on the ideXlab platform.

  • DLA Class II Alleles and Haplotypes Are Associated with Risk for and Protection from Chronic Hepatitis in the English Springer
    2016
    Co-Authors: Nick Bexfield, David R Sargan, Laurence Tiley, Jonathan L Heeney, Penny J. Watson, Lorna J Kennedy
    Abstract:

    Chronic hepatitis (CH) is common in dogs in the United Kingdom. An increased prevalence of the disease is seen in the English Springer Spaniel (ESS), and this breed suffer from a severe form with young to middle aged female dogs being predisposed. The disease shares histological features with those of human viral hepatitis, although the specific aetiological agent has not yet been identified. The aim of the current study was to investigate whether dog leucocyte antigen (DLA) class II alleles and haplotypes are associated with susceptibility/resistance to CH in the ESS. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1,-DQA1 and-DQB1 class II loci were performed in 66 ESSs with CH and 84 healthy controls. There was a significant difference in the distribution of the protective alleles DRB1*00501 (3.0 % vs. 12.0%, odds ratio [OR] = 0.23, 95 % confidence interval [CI] = 0.06–0.74) and DQB1*00501 (3.8 % vs. 12.0%, OR = 0.29, 95 % CI = 0.09–0.85) between cases and controls. The haplotype DLA-DRB1*00501/DQA1*00301/DQB1*00501 was present in 11.9 % of controls and 3.0 % of cases and was significantly associated with protection against disease development (OR = 0.26, 95 % CI = 0.08– 0.80). There was a significant difference in the distribution of the risk alleles DRB1*00601 (14.4 % vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) and DQB1*00701 (14.4 % vs. 6.5%, OR = 2.40, 95 % CI = 1.10–5.63) between cases and controls. A risk haplotype (DLA-DRB1*00601/DQA1*005011/DQB1*00701) was present in 14.4 % of cases and 6.5 % of controls and conferred an elevated risk of developing CH with an OR of 3.13 (95 % CI = 1.20–8.26). These results demonstrate that DLA class II i

  • dla class ii alleles and haplotypes are associated with risk for and protection from chronic hepatitis in the english Springer Spaniel
    PLOS ONE, 2012
    Co-Authors: Nick Bexfield, Penny Watson, Jesus Aguirrehernandez, David R Sargan, Laurence Tiley, Jonathan L Heeney, Lorna J Kennedy
    Abstract:

    Chronic hepatitis (CH) is common in dogs in the United Kingdom. An increased prevalence of the disease is seen in the English Springer Spaniel (ESS), and this breed suffer from a severe form with young to middle aged female dogs being predisposed. The disease shares histological features with those of human viral hepatitis, although the specific aetiological agent has not yet been identified. The aim of the current study was to investigate whether dog leucocyte antigen (DLA) class II alleles and haplotypes are associated with susceptibility/resistance to CH in the ESS. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1, -DQA1 and -DQB1 class II loci were performed in 66 ESSs with CH and 84 healthy controls. There was a significant difference in the distribution of the protective alleles DRB1*00501 (3.0% vs. 12.0%, odds ratio [OR] = 0.23, 95% confidence interval [CI] = 0.06–0.74) and DQB1*00501 (3.8% vs. 12.0%, OR = 0.29, 95% CI = 0.09–0.85) between cases and controls. The haplotype DLA-DRB1*00501/DQA1*00301/DQB1*00501 was present in 11.9% of controls and 3.0% of cases and was significantly associated with protection against disease development (OR = 0.26, 95% CI = 0.08–0.80). There was a significant difference in the distribution of the risk alleles DRB1*00601 (14.4% vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) and DQB1*00701 (14.4% vs. 6.5%, OR = 2.40, 95% CI = 1.10–5.63) between cases and controls. A risk haplotype (DLA-DRB1*00601/DQA1*005011/DQB1*00701) was present in 14.4% of cases and 6.5% of controls and conferred an elevated risk of developing CH with an OR of 3.13 (95% CI = 1.20–8.26). These results demonstrate that DLA class II is significantly associated with risk and protection from developing CH in ESSs.