The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform
Christian Wenger - One of the best experts on this subject based on the ideXlab platform.
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Design and Fabrication of a BiCMOS Dielectric Sensor for Viscosity Measurements: A Possible Solution for Early Detection of COPD.
Biosensors, 2018Co-Authors: Pouya Soltani Zarrin, Farabi Ibne Jamal, Subhajit Guha, Jan Wessel, Dietmar Kissinger, Christian WengerAbstract:The Viscosity variation of Sputum is a common symptom of the progression of Chronic Obstructive Pulmonary Disease (COPD). Since the hydration of the Sputum defines its Viscosity level, dielectric sensors could be used for the characterization of Sputum samples collected from patients for early diagnosis of COPD. In this work, a CMOS-based dielectric sensor for the real-time monitoring of Sputum Viscosity was designed and fabricated. A proper packaging for the ESD-protection and short-circuit prevention of the sensor was developed. The performance evaluation results show that the radio frequency sensor is capable of measuring dielectric constant of biofluids with an accuracy of 4.17%. Integration of this sensor into a portable system will result in a hand-held device capable of measuring Viscosity of Sputum samples of COPD-patients for diagnostic purposes.
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A CMOS radio frequency biosensor for rapid detection and screening of Sputum-mucin Viscosity
2017 IEEE SENSORS, 2017Co-Authors: Subhajit Guha, Katrin Ramaker, Thorsten Krause, Christian WengerAbstract:This paper presents a CMOS radio frequency dielectric sensor platform for the detection of relative Viscosity changes in Sputum-mucin. The operating frequency of the sensor is 12 GHz. The sensor chip has been fabricated in 250 nm SiGe:C BiCMOS technology of IHP. The work shows that the sensor can distinguish between a highly viscous clot of Sputum-mucin and dilute Sputum-mucin. The Viscosity of Sputum is often regarded as a distinguishing feature of lung diseases and therefore, the sensor's capability of rapid detection of Sputum Viscosity makes it suitable for fast screening of lung diseases. A change of 200 MHz in the resonant frequency is shown for a change of 60% in the Sputum-mucin Viscosity. The sensor shown in this work is first of its kind to be used for detecting Viscosity changes in a biological sample and is proposed to be used for future medical diagnostic tool for rapid screening of infectious lung diseases.
Pasquale Del Gaudio - One of the best experts on this subject based on the ideXlab platform.
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Rheological Properties of Cystic Fibrosis Bronchial Secretion and in Vitro Drug Permeation Study: The Effect of Sodium Bicarbonate
Journal of aerosol medicine and pulmonary drug delivery, 2016Co-Authors: Mariateresa Stigliani, Michele Dario Manniello, Olga Zegarra-moran, Luis J. V. Galietta, Laura Minicucci, Rosaria Casciaro, Emilia Garofalo, Loredana Incarnato, Rita Patrizia Aquino, Pasquale Del GaudioAbstract:Abstract Background: Cystic fibrosis (CF) is characterized by a thick, sticky mucus responsible for both airway obstruction and resistance to drug diffusion, reducing the effectiveness of drug delivery to the lung. Studies of drug–mucus interaction may be a crucial step in therapeutic management of CF. In the present research, the effect of a saline solution of sodium bicarbonate (100 mM) on Sputum Viscosity and the permeation properties of ketoprofen lysinate (Klys) from a previously developed dry powder inhaler were evaluated. Methods: Rheological measurements were performed using an ARES rotational rheometer (Rheometrics, Inc.) with a parallel plate geometry. The gel fraction, separated from the liquid phase of various Sputum samples from CF patients was loaded onto the plate. The elastic (G’) and the viscous (G”) moduli, tan δ (ratio of G” to G’) and η* (complex Viscosity) were evaluated as frequency-dependent parameters. Drug permeation across CF Sputum from dry powders was studied by means of Franz-...
Zhezi Chen - One of the best experts on this subject based on the ideXlab platform.
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Influence of Sputum Viscosity on vital signs of patients with craniocerebral injury and mechanical ventilation before and after the Sputum aspiration
2017Co-Authors: Zhezi ChenAbstract:Objectives To discuss and analyze the influence of closed Sputum aspiration at different airway humidification states on vital signs of patients with craniocerebral injury and mechanical ventilation, and to provide effective references for optimizing the humidified Sputum aspiration scheme for patients with mechanical ventilation. Methods The patients with craniocerebral injury and mechanical ventilation hospitalized in our hospital from January 2014 to June 2015 were selected as study objects and were divided into group A (Grade Ⅰ), group B (Grade Ⅱ), and group C (Grade Ⅲ) according to Sputum Viscosity in the process of Sputum aspiration, 20 patients in each group. The changes of vital signs and airway stimulus responses of three groups before and after the Sputum aspiration were collected and compared. Results The changes of three groups at different time points in the process of Sputum aspiration were of statistic significance (P
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influence of Sputum Viscosity on vital signs of patients with craniocerebral injury and mechanical ventilation before and after the Sputum aspiration
国际医药卫生导报, 2017Co-Authors: Zhezi ChenAbstract:Objectives To discuss and analyze the influence of closed Sputum aspiration at different airway humidification states on vital signs of patients with craniocerebral injury and mechanical ventilation, and to provide effective references for optimizing the humidified Sputum aspiration scheme for patients with mechanical ventilation. Methods The patients with craniocerebral injury and mechanical ventilation hospitalized in our hospital from January 2014 to June 2015 were selected as study objects and were divided into group A (Grade Ⅰ), group B (Grade Ⅱ), and group C (Grade Ⅲ) according to Sputum Viscosity in the process of Sputum aspiration, 20 patients in each group. The changes of vital signs and airway stimulus responses of three groups before and after the Sputum aspiration were collected and compared. Results The changes of three groups at different time points in the process of Sputum aspiration were of statistic significance (P<0.001). The inter-group differences of vital signs were of statistic significance (P<0.001). The intervention effect and time effect were of interaction effect (P<0.05). The occurrence rates of bucking, dyspnea, lacrimation, and airway hemorrhage of group A and group B were evidently lower than those of group C (P<0.05). Conclusions When airway humidification increases Sputum Viscosity to GradeⅡ, the influence of Sputum aspiration on vital signs of patients can be reduced and adverse airway stimulus response can be alleviated. It is necessary to enhance supervision and control over humidification degree in the process of airway humidification in clinics. Key words: Craniocerebral injury; Mechanical ventilation; Sputum Viscosity; Sputum aspiration; Vital signs
Subhajit Guha - One of the best experts on this subject based on the ideXlab platform.
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Design and Fabrication of a BiCMOS Dielectric Sensor for Viscosity Measurements: A Possible Solution for Early Detection of COPD.
Biosensors, 2018Co-Authors: Pouya Soltani Zarrin, Farabi Ibne Jamal, Subhajit Guha, Jan Wessel, Dietmar Kissinger, Christian WengerAbstract:The Viscosity variation of Sputum is a common symptom of the progression of Chronic Obstructive Pulmonary Disease (COPD). Since the hydration of the Sputum defines its Viscosity level, dielectric sensors could be used for the characterization of Sputum samples collected from patients for early diagnosis of COPD. In this work, a CMOS-based dielectric sensor for the real-time monitoring of Sputum Viscosity was designed and fabricated. A proper packaging for the ESD-protection and short-circuit prevention of the sensor was developed. The performance evaluation results show that the radio frequency sensor is capable of measuring dielectric constant of biofluids with an accuracy of 4.17%. Integration of this sensor into a portable system will result in a hand-held device capable of measuring Viscosity of Sputum samples of COPD-patients for diagnostic purposes.
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A CMOS radio frequency biosensor for rapid detection and screening of Sputum-mucin Viscosity
2017 IEEE SENSORS, 2017Co-Authors: Subhajit Guha, Katrin Ramaker, Thorsten Krause, Christian WengerAbstract:This paper presents a CMOS radio frequency dielectric sensor platform for the detection of relative Viscosity changes in Sputum-mucin. The operating frequency of the sensor is 12 GHz. The sensor chip has been fabricated in 250 nm SiGe:C BiCMOS technology of IHP. The work shows that the sensor can distinguish between a highly viscous clot of Sputum-mucin and dilute Sputum-mucin. The Viscosity of Sputum is often regarded as a distinguishing feature of lung diseases and therefore, the sensor's capability of rapid detection of Sputum Viscosity makes it suitable for fast screening of lung diseases. A change of 200 MHz in the resonant frequency is shown for a change of 60% in the Sputum-mucin Viscosity. The sensor shown in this work is first of its kind to be used for detecting Viscosity changes in a biological sample and is proposed to be used for future medical diagnostic tool for rapid screening of infectious lung diseases.
A M Gallon - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of nebulised acetylcysteine and normal saline in the treatment of Sputum retention following thoracotomy.
Thorax, 1996Co-Authors: A M GallonAbstract:BACKGROUND: The use of acetylcysteine as a mucolytic agent is controversial. In 1962 it was claimed to be "the most effective agent ... for the liquefaction of ... secretions" but was subsequently taken off the market as a respirator solution. Normal saline, on the other hand, is becoming increasingly popular. A study was undertaken to determine which solution is more effective at clearing retained secretions following thoracotomy. METHODS: The study included 10 patients and was of single blind, two-way crossover design. Measurements taken before and after each treatment included Sputum Viscosity, difficulty of expectoration, weight of Sputum expectorated, and oxygen saturation. RESULTS: Following nebulisation of acetylcysteine, Sputum Viscosity was reduced, difficulty of expectoration was reduced, the weight of Sputum expectorated was increased, and oxygen saturation was increased. There were no changes after nebulisation of normal saline. CONCLUSIONS: This study shows that, following thoracotomy, nebulised acetylcysteine reduces Sputum Viscosity, making expectoration easier and improving oxygenation. Nebulised normal saline has no effect.