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Chengquan Zhao - One of the best experts on this subject based on the ideXlab platform.
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conventional pap smear cervical cancer screening in 11 rural counties in hainan province china analysis of bethesda system reporting rates for 218 195 women predominantly ages 35 64 years screened in china s national cervical cancer screening program in rural areas nccspra
Journal of the American Society of Cytopathology, 2017Co-Authors: Baowen Zheng, Marshall R Austin, Xiaoman Liang, Yaoming Liang, Chengquan ZhaoAbstract:Objective Recently the Chinese government has introduced support for cervical screening in rural areas. The College of American Pathologists (CAP)-certified Guangzhou Kingmed Diagnostics laboratory supported rural screening program in Hainan Providence utilizing low-cost conventional Papanicolaou smears (CPS). Study design This was a retrospective study of CPS screening results from 2011 to 2014 in 11 rural counties in Hainan Province. Women, most previously unscreened, volunteered to attend free CPS screening. The targeted population was women aged 35-65 years. Results Among total 218,195 conventional Papanicolaou smears, the reported abnormal rate was 4.4% of all smears, with 0.5% for high-grade Squamous Intraepithelial Lesion (HSIL), 0.9% for low-grade Squamous Intraepithelial Lesion (LSIL), 2.6% for atypical Squamous cells of undetermined significance, and 0.3% for atypical Squamous cells, cannot exclude high-grade Squamous Intraepithelial Lesion. Reporting rates for different TBS categories were generally within CAP benchmark ranges, except for low reporting rates for unsatisfactory smears and for atypical glandular cells. Abnormal cytology rates varied among counties. Comparing different age groups, the LSIL rate was significantly higher in women Conclusions CPS offered a low cost method to introduce cervical screening in rural China. The international College of American Pathologists Laboratory Accreditation Program provided laboratory quality control standards not otherwise readily available. Educational training programs have been instituted to address areas identified for quality improvement.
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misinterpretation rates of high grade Squamous Intraepithelial Lesion in the college of american pathologists gynecologic pap education and pap proficiency test program
Archives of Pathology & Laboratory Medicine, 2016Co-Authors: Chengquan Zhao, Rhona J Souers, Barbara A Crothers, Mohiedean Ghofrani, Mujtaba Hussain, Fang Fan, Idris T Ocal, Diane D DaveyAbstract:Context.— Misinterpretation of high-grade Squamous Intraepithelial Lesion (HSIL) is an important problem in daily practice and in the College of American Pathologists (CAP) PAP Proficiency Test (PA...
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trends in cervical cytology screening and reporting practices results from the college of american pathologists 2011 pap education supplemental questionnaire
Archives of Pathology & Laboratory Medicine, 2016Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Christine N Booth, Ritu Nayar, Rosemary H Tambouret, Guliz A Barkan, Vijayalakshmi Padmanabhan, Laura Z Tabatabai, Rhona J SouersAbstract:Context.— The College of American Pathologists periodically surveys laboratories to determine changes in cytopathology practices. We report the results of a 2011 gynecologic cytology survey. Objective.— To provide a cross-sectional survey of gynecologic cytology practices in 2010. Design.— In 2011, a survey was sent to 1604 laboratories participating in the College of American Pathologists gynecologic cytology interlaboratory comparison education program and proficiency testing programs requesting data from 2010 on the following topics: terminology/reporting, cytotechnologist workload, quality assurance, reagents, and ancillary testing. Results.— Six hundred and twenty-five laboratories (39%) replied to the survey. The nonstandard use of “low-grade Squamous Intraepithelial Lesion cannot exclude high-grade Squamous Intraepithelial Lesion” is used by most laboratories to report the presence of low-grade Squamous Intraepithelial Lesion with possibility of high-grade Squamous Intraepithelial Lesion. Most labo...
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false positive papanicolaou pap test rates in the college of american pathologists pap education and pap proficiency test programs evaluation of false positive responses of high grade Squamous Intraepithelial Lesion or cancer to a negative reference
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Christine N Booth, Ann T MoriartyAbstract:Context.—In cytology proficiency testing (PT), participants fail for incorrectly interpreting a high-grade Squamous Intraepithelial Lesion or cancer (HSIL+) Papanicolaou test result as negative. This penalty may lead to a false-positive interpretation of negative slides as HSIL+ to avoid failure. Objective.—To investigate factors related to false-positive responses in a PT versus an educational environment. Design.—We analyzed 420 079 responses from 9414 validated negative reference slides in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) and compared them with responses from the Gynecologic Cytology Proficiency Testing Program for the percentage of false-positive (HSIL+) interpretations in each of 7 negative subcategories. We evaluated the influence of preparation type (ThinPrep, SurePath, and conventional Papanicolaou test), participant type (pathologist or cytotechnologist), and program time interval (preproficiency test or PT) on a ...
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histopathologic follow up and human papillomavirus dna test results in 290 patients with high grade Squamous Intraepithelial Lesion papanicolaou test results
Cancer Cytopathology, 2011Co-Authors: Faye F Gao, Marshall R Austin, Chengquan ZhaoAbstract:BACKGROUND: The study documents histopathologic outcomes and high-risk (hr) human papillomavirus (HPV) test results in a large cohort of patients with high-grade Squamous Intraepithelial Lesion (HSIL) liquid-based cytology (LBC) Pap test results. METHODS: A total of 352 patients with HSIL results (338 cervical and 14 vaginal) who had hrHPV testing and 290 patients with biopsy follow-up were studied. hrHPV detection rates were compared at different ages, with or without an endocervical/transformation zone sample (EC/TZS), and for cervical and vaginal HSIL Pap smears. Histopathologic follow-up findings were also compared. hrHPV-negative HSIL slides were re-evaluated in a blinded manner. RESULTS: A total of 325 of 338 (96.2%) cervical HSIL and 12 of 14 (87.5%) vaginal HSIL tested hrHPV-positive. A total of 271 of 281 (96.4%) EC/TZS-positive cervical HSIL and 54 of 57 (94.7%) EC/TZS-negative cervical HSIL tested hrHPV-positive. The percentage of hrHPV-positive HSIL declined slightly with increasing age. 197 of 273 (72.3%) hrHPV-positive cervical HSIL had histopathologic cervical Intraepithelial neoplasia (CIN) 2/3+ follow-up, including 8 Squamous carcinomas, compared with 4 of 12 (33.3%) hrHPV-negative HSIL with CIN2/3 (no carcinomas). 167 of 241 (69.2%) EC/TZS-positive HSIL had CIN2/3+ follow-up, compared with 34 of 44 (77.3%) EC/TZS-negative HSIL. Equivocal HSIL morphology characterized some HPV-negative HSIL without CIN2/3+ follow-up. CONCLUSIONS: hrHPV was detected in LBC vials from 96.2% of 338 cervical HSIL and 85.7% of 14 vaginal HSIL. CIN2/3+ was significantly more likely with hrHPV-positive cervical HSIL than with hrHPV-negative cervical HSIL. Presence or absence of an EC/TZS did not significantly impact HSIL hrHPV or CIN2/3+ rates. Some hrHPV-negative HSIL cases may represent HSIL cytologic mimics. Cancer (Cancer Cytopathol) 2011;. © 2011 American Cancer Society.
Rhona J Souers - One of the best experts on this subject based on the ideXlab platform.
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misinterpretation rates of high grade Squamous Intraepithelial Lesion in the college of american pathologists gynecologic pap education and pap proficiency test program
Archives of Pathology & Laboratory Medicine, 2016Co-Authors: Chengquan Zhao, Rhona J Souers, Barbara A Crothers, Mohiedean Ghofrani, Mujtaba Hussain, Fang Fan, Idris T Ocal, Diane D DaveyAbstract:Context.— Misinterpretation of high-grade Squamous Intraepithelial Lesion (HSIL) is an important problem in daily practice and in the College of American Pathologists (CAP) PAP Proficiency Test (PA...
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trends in cervical cytology screening and reporting practices results from the college of american pathologists 2011 pap education supplemental questionnaire
Archives of Pathology & Laboratory Medicine, 2016Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Christine N Booth, Ritu Nayar, Rosemary H Tambouret, Guliz A Barkan, Vijayalakshmi Padmanabhan, Laura Z Tabatabai, Rhona J SouersAbstract:Context.— The College of American Pathologists periodically surveys laboratories to determine changes in cytopathology practices. We report the results of a 2011 gynecologic cytology survey. Objective.— To provide a cross-sectional survey of gynecologic cytology practices in 2010. Design.— In 2011, a survey was sent to 1604 laboratories participating in the College of American Pathologists gynecologic cytology interlaboratory comparison education program and proficiency testing programs requesting data from 2010 on the following topics: terminology/reporting, cytotechnologist workload, quality assurance, reagents, and ancillary testing. Results.— Six hundred and twenty-five laboratories (39%) replied to the survey. The nonstandard use of “low-grade Squamous Intraepithelial Lesion cannot exclude high-grade Squamous Intraepithelial Lesion” is used by most laboratories to report the presence of low-grade Squamous Intraepithelial Lesion with possibility of high-grade Squamous Intraepithelial Lesion. Most labo...
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the tahoe study bias in the interpretation of papanicolaou test results when human papillomavirus status is known
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Ann T Moriarty, Nicole Thomas, Ritu Nayar, Terry Arnold, Lisa Gearries, Andrew A Renshaw, Rhona J SouersAbstract:Context.—Knowledge of human papillomavirus (HPV) status is expected to bias the morphologic evaluation of Papanicolaou (Pap) test results. Objective.—To characterize Pap test result interpretive bias when the HPV status is known at the microscopic evaluation. Design.—Forty HPV-positive liquid-based Pap test results initially interpreted as negative for Squamous Intraepithelial Lesion or malignancy were selected from a quality assurance program, separated into 2 groups of 20 slides each, and circulated in 2 groups to 22 members of the College of American Pathologists Cytopathology Committee. Each member reviewed each case and indicated whether the result was negative for Squamous Intraepithelial Lesion or malignancy or was an epithelial cell abnormality (ECA). The participants assessed the severity of ECAs using the Bethesda System. The participants were not informed of the HPV status in the initial review round. Each group of 20 slides was then distributed to the opposite group (to avoid slide recall), an...
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false positive papanicolaou pap test rates in the college of american pathologists pap education and pap proficiency test programs evaluation of false positive responses of high grade Squamous Intraepithelial Lesion or cancer to a negative reference
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Christine N Booth, Ann T MoriartyAbstract:Context.—In cytology proficiency testing (PT), participants fail for incorrectly interpreting a high-grade Squamous Intraepithelial Lesion or cancer (HSIL+) Papanicolaou test result as negative. This penalty may lead to a false-positive interpretation of negative slides as HSIL+ to avoid failure. Objective.—To investigate factors related to false-positive responses in a PT versus an educational environment. Design.—We analyzed 420 079 responses from 9414 validated negative reference slides in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) and compared them with responses from the Gynecologic Cytology Proficiency Testing Program for the percentage of false-positive (HSIL+) interpretations in each of 7 negative subcategories. We evaluated the influence of preparation type (ThinPrep, SurePath, and conventional Papanicolaou test), participant type (pathologist or cytotechnologist), and program time interval (preproficiency test or PT) on a ...
Barbara A Crothers - One of the best experts on this subject based on the ideXlab platform.
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misinterpretation rates of high grade Squamous Intraepithelial Lesion in the college of american pathologists gynecologic pap education and pap proficiency test program
Archives of Pathology & Laboratory Medicine, 2016Co-Authors: Chengquan Zhao, Rhona J Souers, Barbara A Crothers, Mohiedean Ghofrani, Mujtaba Hussain, Fang Fan, Idris T Ocal, Diane D DaveyAbstract:Context.— Misinterpretation of high-grade Squamous Intraepithelial Lesion (HSIL) is an important problem in daily practice and in the College of American Pathologists (CAP) PAP Proficiency Test (PA...
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trends in cervical cytology screening and reporting practices results from the college of american pathologists 2011 pap education supplemental questionnaire
Archives of Pathology & Laboratory Medicine, 2016Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Christine N Booth, Ritu Nayar, Rosemary H Tambouret, Guliz A Barkan, Vijayalakshmi Padmanabhan, Laura Z Tabatabai, Rhona J SouersAbstract:Context.— The College of American Pathologists periodically surveys laboratories to determine changes in cytopathology practices. We report the results of a 2011 gynecologic cytology survey. Objective.— To provide a cross-sectional survey of gynecologic cytology practices in 2010. Design.— In 2011, a survey was sent to 1604 laboratories participating in the College of American Pathologists gynecologic cytology interlaboratory comparison education program and proficiency testing programs requesting data from 2010 on the following topics: terminology/reporting, cytotechnologist workload, quality assurance, reagents, and ancillary testing. Results.— Six hundred and twenty-five laboratories (39%) replied to the survey. The nonstandard use of “low-grade Squamous Intraepithelial Lesion cannot exclude high-grade Squamous Intraepithelial Lesion” is used by most laboratories to report the presence of low-grade Squamous Intraepithelial Lesion with possibility of high-grade Squamous Intraepithelial Lesion. Most labo...
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false positive papanicolaou pap test rates in the college of american pathologists pap education and pap proficiency test programs evaluation of false positive responses of high grade Squamous Intraepithelial Lesion or cancer to a negative reference
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Christine N Booth, Ann T MoriartyAbstract:Context.—In cytology proficiency testing (PT), participants fail for incorrectly interpreting a high-grade Squamous Intraepithelial Lesion or cancer (HSIL+) Papanicolaou test result as negative. This penalty may lead to a false-positive interpretation of negative slides as HSIL+ to avoid failure. Objective.—To investigate factors related to false-positive responses in a PT versus an educational environment. Design.—We analyzed 420 079 responses from 9414 validated negative reference slides in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) and compared them with responses from the Gynecologic Cytology Proficiency Testing Program for the percentage of false-positive (HSIL+) interpretations in each of 7 negative subcategories. We evaluated the influence of preparation type (ThinPrep, SurePath, and conventional Papanicolaou test), participant type (pathologist or cytotechnologist), and program time interval (preproficiency test or PT) on a ...
Ann T Moriarty - One of the best experts on this subject based on the ideXlab platform.
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the tahoe study bias in the interpretation of papanicolaou test results when human papillomavirus status is known
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Ann T Moriarty, Nicole Thomas, Ritu Nayar, Terry Arnold, Lisa Gearries, Andrew A Renshaw, Rhona J SouersAbstract:Context.—Knowledge of human papillomavirus (HPV) status is expected to bias the morphologic evaluation of Papanicolaou (Pap) test results. Objective.—To characterize Pap test result interpretive bias when the HPV status is known at the microscopic evaluation. Design.—Forty HPV-positive liquid-based Pap test results initially interpreted as negative for Squamous Intraepithelial Lesion or malignancy were selected from a quality assurance program, separated into 2 groups of 20 slides each, and circulated in 2 groups to 22 members of the College of American Pathologists Cytopathology Committee. Each member reviewed each case and indicated whether the result was negative for Squamous Intraepithelial Lesion or malignancy or was an epithelial cell abnormality (ECA). The participants assessed the severity of ECAs using the Bethesda System. The participants were not informed of the HPV status in the initial review round. Each group of 20 slides was then distributed to the opposite group (to avoid slide recall), an...
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false positive papanicolaou pap test rates in the college of american pathologists pap education and pap proficiency test programs evaluation of false positive responses of high grade Squamous Intraepithelial Lesion or cancer to a negative reference
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Christine N Booth, Ann T MoriartyAbstract:Context.—In cytology proficiency testing (PT), participants fail for incorrectly interpreting a high-grade Squamous Intraepithelial Lesion or cancer (HSIL+) Papanicolaou test result as negative. This penalty may lead to a false-positive interpretation of negative slides as HSIL+ to avoid failure. Objective.—To investigate factors related to false-positive responses in a PT versus an educational environment. Design.—We analyzed 420 079 responses from 9414 validated negative reference slides in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) and compared them with responses from the Gynecologic Cytology Proficiency Testing Program for the percentage of false-positive (HSIL+) interpretations in each of 7 negative subcategories. We evaluated the influence of preparation type (ThinPrep, SurePath, and conventional Papanicolaou test), participant type (pathologist or cytotechnologist), and program time interval (preproficiency test or PT) on a ...
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the potential for failure in gynecologic regulatory proficiency testing with current slide validation criteria results from the college of american pathologists interlaboratory comparison in gynecologic cytology program
Archives of Pathology & Laboratory Medicine, 2009Co-Authors: Nancy A Young, Ann T Moriarty, Molly K Walsh, Edward Wang, David C WilburAbstract:Abstract Context.—Current regulatory proficiency testing scoring results in an automatic failure for identifying high-grade Squamous Intraepithelial Lesion (HSIL) as negative. Objective.—The Colleg...
Teresa M Darragh - One of the best experts on this subject based on the ideXlab platform.
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trends in cervical cytology screening and reporting practices results from the college of american pathologists 2011 pap education supplemental questionnaire
Archives of Pathology & Laboratory Medicine, 2016Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Christine N Booth, Ritu Nayar, Rosemary H Tambouret, Guliz A Barkan, Vijayalakshmi Padmanabhan, Laura Z Tabatabai, Rhona J SouersAbstract:Context.— The College of American Pathologists periodically surveys laboratories to determine changes in cytopathology practices. We report the results of a 2011 gynecologic cytology survey. Objective.— To provide a cross-sectional survey of gynecologic cytology practices in 2010. Design.— In 2011, a survey was sent to 1604 laboratories participating in the College of American Pathologists gynecologic cytology interlaboratory comparison education program and proficiency testing programs requesting data from 2010 on the following topics: terminology/reporting, cytotechnologist workload, quality assurance, reagents, and ancillary testing. Results.— Six hundred and twenty-five laboratories (39%) replied to the survey. The nonstandard use of “low-grade Squamous Intraepithelial Lesion cannot exclude high-grade Squamous Intraepithelial Lesion” is used by most laboratories to report the presence of low-grade Squamous Intraepithelial Lesion with possibility of high-grade Squamous Intraepithelial Lesion. Most labo...
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false positive papanicolaou pap test rates in the college of american pathologists pap education and pap proficiency test programs evaluation of false positive responses of high grade Squamous Intraepithelial Lesion or cancer to a negative reference
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Christine N Booth, Ann T MoriartyAbstract:Context.—In cytology proficiency testing (PT), participants fail for incorrectly interpreting a high-grade Squamous Intraepithelial Lesion or cancer (HSIL+) Papanicolaou test result as negative. This penalty may lead to a false-positive interpretation of negative slides as HSIL+ to avoid failure. Objective.—To investigate factors related to false-positive responses in a PT versus an educational environment. Design.—We analyzed 420 079 responses from 9414 validated negative reference slides in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) and compared them with responses from the Gynecologic Cytology Proficiency Testing Program for the percentage of false-positive (HSIL+) interpretations in each of 7 negative subcategories. We evaluated the influence of preparation type (ThinPrep, SurePath, and conventional Papanicolaou test), participant type (pathologist or cytotechnologist), and program time interval (preproficiency test or PT) on a ...
