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Dietmar R Kammerer - One of the best experts on this subject based on the ideXlab platform.
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Simultaneous determination of bufadienolides and phenolic compounds in sea Squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MS^n as a means to differentiate individual plant parts and developmental stages
Analytical and Bioanalytical Chemistry, 2014Co-Authors: Diana N Knittel, Florian C Stintzing, Dietmar R KammererAbstract:Mediterranean sea Squill ( Drimia maritima (L.) Stearn) is used in the production of medicinal products. Current HPLC methods comprise tedious sample clean-up and have been merely focused on the analysis of cardiac glycosides, whereas a thorough characterization of D. maritima considering both the latter compound class and more hydrophilic secondary metabolites in one HPLC run has not been performed so far. Consequently, a novel HPLC-DAD-MS^n method has been developed allowing the simultaneous determination of both cardiac glycosides and phenolic compounds, which is characterized by simplified sample preparation. This method was applied to characterize sea Squill, revealing a complex profile of its extractive compounds derived from the two classes. Furthermore, the potential of the method reported here to quantitate the predominant compounds, i.e., dihydroquercetin derivatives and bufadienolides, was demonstrated. The occurrence of phenolic compounds, not described for sea Squill so far, and of characteristic compounds specific to individual plant parts or vegetation stages was further addressed. The data revealed that classification of various vegetation phases based on quantitative evaluation of bufadienolides and dihydroquercetin derivatives applying principal component analysis (PCA) appears possible. Thus, the methodology presented here forms the basis for future routine application in quality control of raw materials and pharmaceutical preparations derived from sea Squill. This will allow systematic comparison of different plant parts, vegetation stages and origins based on an extended sample set. Figure Red sea Squill with inflorescence and cross-section of a fresh bulb
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Simultaneous determination of bufadienolides and phenolic compounds in sea Squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MSn as a means to differentiate individual plant parts and developmental stages.
Analytical and Bioanalytical Chemistry, 2014Co-Authors: Diana N Knittel, Florian C Stintzing, Dietmar R KammererAbstract:Mediterranean sea Squill (Drimia maritima (L.) Stearn) is used in the production of medicinal products. Current HPLC methods comprise tedious sample clean-up and have been merely focused on the analysis of cardiac glycosides, whereas a thorough characterization of D. maritima considering both the latter compound class and more hydrophilic secondary metabolites in one HPLC run has not been performed so far. Consequently, a novel HPLC-DAD-MSn method has been developed allowing the simultaneous determination of both cardiac glycosides and phenolic compounds, which is characterized by simplified sample preparation. This method was applied to characterize sea Squill, revealing a complex profile of its extractive compounds derived from the two classes. Furthermore, the potential of the method reported here to quantitate the predominant compounds, i.e., dihydroquercetin derivatives and bufadienolides, was demonstrated. The occurrence of phenolic compounds, not described for sea Squill so far, and of characteristic compounds specific to individual plant parts or vegetation stages was further addressed. The data revealed that classification of various vegetation phases based on quantitative evaluation of bufadienolides and dihydroquercetin derivatives applying principal component analysis (PCA) appears possible. Thus, the methodology presented here forms the basis for future routine application in quality control of raw materials and pharmaceutical preparations derived from sea Squill. This will allow systematic comparison of different plant parts, vegetation stages and origins based on an extended sample set.
Diana N Knittel - One of the best experts on this subject based on the ideXlab platform.
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Simultaneous determination of bufadienolides and phenolic compounds in sea Squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MS^n as a means to differentiate individual plant parts and developmental stages
Analytical and Bioanalytical Chemistry, 2014Co-Authors: Diana N Knittel, Florian C Stintzing, Dietmar R KammererAbstract:Mediterranean sea Squill ( Drimia maritima (L.) Stearn) is used in the production of medicinal products. Current HPLC methods comprise tedious sample clean-up and have been merely focused on the analysis of cardiac glycosides, whereas a thorough characterization of D. maritima considering both the latter compound class and more hydrophilic secondary metabolites in one HPLC run has not been performed so far. Consequently, a novel HPLC-DAD-MS^n method has been developed allowing the simultaneous determination of both cardiac glycosides and phenolic compounds, which is characterized by simplified sample preparation. This method was applied to characterize sea Squill, revealing a complex profile of its extractive compounds derived from the two classes. Furthermore, the potential of the method reported here to quantitate the predominant compounds, i.e., dihydroquercetin derivatives and bufadienolides, was demonstrated. The occurrence of phenolic compounds, not described for sea Squill so far, and of characteristic compounds specific to individual plant parts or vegetation stages was further addressed. The data revealed that classification of various vegetation phases based on quantitative evaluation of bufadienolides and dihydroquercetin derivatives applying principal component analysis (PCA) appears possible. Thus, the methodology presented here forms the basis for future routine application in quality control of raw materials and pharmaceutical preparations derived from sea Squill. This will allow systematic comparison of different plant parts, vegetation stages and origins based on an extended sample set. Figure Red sea Squill with inflorescence and cross-section of a fresh bulb
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Simultaneous determination of bufadienolides and phenolic compounds in sea Squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MSn as a means to differentiate individual plant parts and developmental stages.
Analytical and Bioanalytical Chemistry, 2014Co-Authors: Diana N Knittel, Florian C Stintzing, Dietmar R KammererAbstract:Mediterranean sea Squill (Drimia maritima (L.) Stearn) is used in the production of medicinal products. Current HPLC methods comprise tedious sample clean-up and have been merely focused on the analysis of cardiac glycosides, whereas a thorough characterization of D. maritima considering both the latter compound class and more hydrophilic secondary metabolites in one HPLC run has not been performed so far. Consequently, a novel HPLC-DAD-MSn method has been developed allowing the simultaneous determination of both cardiac glycosides and phenolic compounds, which is characterized by simplified sample preparation. This method was applied to characterize sea Squill, revealing a complex profile of its extractive compounds derived from the two classes. Furthermore, the potential of the method reported here to quantitate the predominant compounds, i.e., dihydroquercetin derivatives and bufadienolides, was demonstrated. The occurrence of phenolic compounds, not described for sea Squill so far, and of characteristic compounds specific to individual plant parts or vegetation stages was further addressed. The data revealed that classification of various vegetation phases based on quantitative evaluation of bufadienolides and dihydroquercetin derivatives applying principal component analysis (PCA) appears possible. Thus, the methodology presented here forms the basis for future routine application in quality control of raw materials and pharmaceutical preparations derived from sea Squill. This will allow systematic comparison of different plant parts, vegetation stages and origins based on an extended sample set.
Florian C Stintzing - One of the best experts on this subject based on the ideXlab platform.
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Simultaneous determination of bufadienolides and phenolic compounds in sea Squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MS^n as a means to differentiate individual plant parts and developmental stages
Analytical and Bioanalytical Chemistry, 2014Co-Authors: Diana N Knittel, Florian C Stintzing, Dietmar R KammererAbstract:Mediterranean sea Squill ( Drimia maritima (L.) Stearn) is used in the production of medicinal products. Current HPLC methods comprise tedious sample clean-up and have been merely focused on the analysis of cardiac glycosides, whereas a thorough characterization of D. maritima considering both the latter compound class and more hydrophilic secondary metabolites in one HPLC run has not been performed so far. Consequently, a novel HPLC-DAD-MS^n method has been developed allowing the simultaneous determination of both cardiac glycosides and phenolic compounds, which is characterized by simplified sample preparation. This method was applied to characterize sea Squill, revealing a complex profile of its extractive compounds derived from the two classes. Furthermore, the potential of the method reported here to quantitate the predominant compounds, i.e., dihydroquercetin derivatives and bufadienolides, was demonstrated. The occurrence of phenolic compounds, not described for sea Squill so far, and of characteristic compounds specific to individual plant parts or vegetation stages was further addressed. The data revealed that classification of various vegetation phases based on quantitative evaluation of bufadienolides and dihydroquercetin derivatives applying principal component analysis (PCA) appears possible. Thus, the methodology presented here forms the basis for future routine application in quality control of raw materials and pharmaceutical preparations derived from sea Squill. This will allow systematic comparison of different plant parts, vegetation stages and origins based on an extended sample set. Figure Red sea Squill with inflorescence and cross-section of a fresh bulb
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Simultaneous determination of bufadienolides and phenolic compounds in sea Squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MSn as a means to differentiate individual plant parts and developmental stages.
Analytical and Bioanalytical Chemistry, 2014Co-Authors: Diana N Knittel, Florian C Stintzing, Dietmar R KammererAbstract:Mediterranean sea Squill (Drimia maritima (L.) Stearn) is used in the production of medicinal products. Current HPLC methods comprise tedious sample clean-up and have been merely focused on the analysis of cardiac glycosides, whereas a thorough characterization of D. maritima considering both the latter compound class and more hydrophilic secondary metabolites in one HPLC run has not been performed so far. Consequently, a novel HPLC-DAD-MSn method has been developed allowing the simultaneous determination of both cardiac glycosides and phenolic compounds, which is characterized by simplified sample preparation. This method was applied to characterize sea Squill, revealing a complex profile of its extractive compounds derived from the two classes. Furthermore, the potential of the method reported here to quantitate the predominant compounds, i.e., dihydroquercetin derivatives and bufadienolides, was demonstrated. The occurrence of phenolic compounds, not described for sea Squill so far, and of characteristic compounds specific to individual plant parts or vegetation stages was further addressed. The data revealed that classification of various vegetation phases based on quantitative evaluation of bufadienolides and dihydroquercetin derivatives applying principal component analysis (PCA) appears possible. Thus, the methodology presented here forms the basis for future routine application in quality control of raw materials and pharmaceutical preparations derived from sea Squill. This will allow systematic comparison of different plant parts, vegetation stages and origins based on an extended sample set.
Reinhold Wutka - One of the best experts on this subject based on the ideXlab platform.
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The structure of the fructan sinistrin from Urginea maritima
Carbohydrate research, 1992Co-Authors: Thomas Spies, Werner Praznik, Andreas Hofinger, Friedrich Altmann, Ernst Nitsch, Reinhold WutkaAbstract:Abstract The structure of sinistrin from red Squill (Urginea maritima) was determined by methylation analysis and 13C NMR spectroscopy, using the fructa
Mehrnaz Asadi Gharabaghi - One of the best experts on this subject based on the ideXlab platform.
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Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial.
Journal of Ethnopharmacology, 2017Co-Authors: Fatemeh Nejatbakhsh, Mahbubeh Bozorgi, Hossein Karegar-borzi, Gholamreza Amin, Alireza Eslaminejad, Mostafa Hosseini, Mehrnaz Asadi GharabaghiAbstract:Abstract Ethnopharmacological relevance In Traditional Iranian Medicine (TIM), Squill (Drimia maritima (L.) Stearn) Oxymel was utilized in the treatment of asthma. Squill has been reported to exert anti-inflammatory, anti-oxidant, anti-cholinergic, and mucus secretion modulating effects. Objective This study aimed to make a preliminary evaluation of the efficacy and safety of an add-on Squill Oxymel treatment in patients with moderate to severe persistent asthma. Methods In a 6-week, triple-blind, randomized, placebo-controlled trial, 60 patients with stable moderate to severe persistent asthma were randomly allocated to receive either 10 ml syrup of Squill Oxymel, simple oxymel, or a placebo 2 times a day, as an add-on to their routine treatment (inhaled corticosteroids and β2 agonists). Spirometry and plethysmography were performed on patients to evaluate the effect of the treatment at baseline and end of intervention. Forced Expiratory Volume in first second (FEV1) was considered the primary outcome. St. George's respiratory questionnaire (SGRQ) was also used for the subjective evaluation of patients' responses. Results Fifty-four patients completed the study. The results showed significant improvement in spirometry parameters, especially FEV1 (1.54±.38 vs. 2.11±.49 l), in the Squill Oxymel group compared with the other groups. The increases in FEV1 liter, FEV1%, FEV1/FVC%, and MEF 25–75% during the intervention were significantly higher in the Squill Oxymel group than in the other groups (p .05). The SGRQ scores (symptoms, activity, and total score) were significantly improved after intervention in both the Squill Oxymel and the simple honey oxymel groups (p Conclusions The results of the current study show preliminary evidence for the efficacy and safety of the add-on treatment of Squill Oxymel in patients with moderate to severe persistent asthma.