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Abbas Shafiee - One of the best experts on this subject based on the ideXlab platform.
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Chemical composition of the essential oils of Stachys schtschegleevii Sosn. and Stachys balansae Boiss & Kotschy from Iran
Flavour and Fragrance Journal, 2020Co-Authors: Shamsali Rezazadeh, Morteza Pirali Hamedani, Reza Dowlatabadi, Darab Yazdani, Abbas ShafieeAbstract:The essential oil samples obtained by hydrodistillation from aerial parts of Stachys schtschegleevii Sosn. and Stachys balansae Boiss & Kotschy (family Lamiaceae), were analysed by GC and GC–MS and 57 compounds, representing 99.5% and 86.5% of the total oils, respectively, were identified. Both essential oils were rich in sesquiterpenes (54.2% and 37.2%, respectively) with germacrene D (25.8% and 16.4%, respectively) as the major component. Copyright © 2005 John Wiley & Sons, Ltd.
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chemical composition of the essential oils of Stachys schtschegleevii sosn and Stachys balansae boiss kotschy from iran
Flavour and Fragrance Journal, 2006Co-Authors: Shamsali Rezazadeh, Morteza Pirali Hamedani, Reza Dowlatabadi, Darab Yazdani, Abbas ShafieeAbstract:The essential oil samples obtained by hydrodistillation from aerial parts of Stachys schtschegleevii Sosn. and Stachys balansae Boiss & Kotschy (family Lamiaceae), were analysed by GC and GC–MS and 57 compounds, representing 99.5% and 86.5% of the total oils, respectively, were identified. Both essential oils were rich in sesquiterpenes (54.2% and 37.2%, respectively) with germacrene D (25.8% and 16.4%, respectively) as the major component. Copyright © 2005 John Wiley & Sons, Ltd.
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phytochemical investigation and anti inflammatory activity of aerial parts of Stachys byzanthina c koch
Journal of Ethnopharmacology, 2005Co-Authors: Mahnaz Khanavi, Mohammad Sharifzadeh, Abbas Hadjiakhoondi, Abbas ShafieeAbstract:Abstract From the aerial parts of Stachys byzanthina C. Koch., an acyclic diterpene ester, phytyl nonadecanoate, was isolated for the first time. In addition, two normal alkanes, one fatty acid and two sterols were also identified. Stuctures were established by conventional methods of analysis and confirmed by 1 H, 13 C NMR and mass spectral analysis. Anti-inflammatory effects of acetone and methanolic extracts of aerial parts of Stachys byzanthina C. Koch. were investigated in this study. For assessment of anti-inflammatory properties, two well-characterized inflammatory models, formalin test and carrageenan-induced paw edema were used. Intraperitoneal injections of either acetone or methanolic extract of Stachys byzanthina C. Koch. (50, 100 and 200 mg/kg), 30 min before formalin injection, had no effects against the first phase of the formalin-induced pain, but all three doses caused a significant blockade on the second phase ( p Stachys byzanthina C. Koch. in the inhibition of pain and inflammatory processes.
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comparison of the volatile composition of Stachys persica gmel and Stachys byzantina c koch oils obtained by hydrodistillation and steam distillation
Zeitschrift für Naturforschung C, 2004Co-Authors: Mahnaz Khanavi, Abbas Hadjiakhoondi, Abdolhossein Rustaiyan, Gholamreza Amin, Yaghoob Amanzadeh, Abbas ShafieeAbstract:: The oils obtained by hydrodistillation and steam distillation of the aerial parts of Stachys persica Gmel. and Stachys byzantina C. Koch grown in Iran were analyzed by GC/MS. The essential oil obtained by hydrodistillation of the aerial parts of S. persica was characterized by a high amount of non-terpenoid components of which methyllinoleate (27.7%), hexadecanoic acid (9.8%) and 6,10,14-trimethyl-2-pentadecanone (9.2%) were the major constituents, whereas the steam distilled oil of the plant contained hexadecanoic acid (27.2%), carvacrol (9.4%) and eugenol (5.2%). Both hydrodistilled and steam distilled essential oils of the aerial parts of S. byzantina were rich in sesquiterpenes such as a-copaene (16.6% and 10.4%), spathulenol (16.1% and 18.5%) and beta-caryophyllene (14.3% and 13.5%), respectively.
Imre Máthé - One of the best experts on this subject based on the ideXlab platform.
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Essential oils in some Stachys species growing in Hungary
Acta Horticulturae, 2020Co-Authors: E. Radnai, Imre Máthé, Ágnes Dobos, Katalin Veres, László Tóth, G. Janisak, G. BlundenAbstract:The volatile oil compositions of five Stachys species (Stachys officinalis L., St. grandiflora Host., St. byzantina Koch., St. germanica L. and St. sylvatica L.) have been studied using a GC/MS technique. All species gave low yields of oil. From St. officinalis 38 compounds were separated and partly identified, from St. grandiflora 24, St. byzantina 30, St. germanica 29 and St. sylvatica 43. All the samples contained o-ocymene, β-phellandrene, γ-terpinene, linalool, transand cis-pinocamphone, βcaryophyllene, δ-cadinene and α-cadinol. The steam distilled oils were poor in monobut rich in sesquiterpenes. Some of the sesquiterpenes, like germacrene D, epi-cubebol, and αand γ-muurolene are reported in Stachys species for the first time. The iridoids, harpagide and 8-O-acetyl-harpagide, were identified by TLC in the MeOH extracts of St. sylvatica, St. byzantina, St. officinalis (Betonica officinalis) and Betonica serotina. Taking other chemical constituents also into account Stachys species seem to be similar to those of the subfam. Lamioideae (according to Erdtman’s classification). INTRODUCTION In the course of our systematic chemotaxonomic investigation of the family Lamiaceae (Mathe et al., 1993), we have found the genus Stachys especially interesting for detailed study not only as it is the second largest genus of the family, but also as its chemistry is little known. There exist some uncertainties both in the place of the genus in the family and in the distinction between the genera Stachys and Betonica. The family Lamiaceae has been classified in different ways by Briquet, Bentham, Erdtman, and Cantino and Sanders (Cantino and Sanders, 1986) and, more recently by Cantino, Harley and Wagstaff (1992). Unlike Erdtman’s system, Bentham and Briquet, in their eight subfamilial (Bentham named ‘tribes’) system, regard the genus Stachys as a member of the subfam. Stachyoideae (tribe Stachydeae in Bentham’s system), which has morphological features characteristic of the subfam. Lamioideae in Erdtman's two subfamilial system. On the basis of literature, Stachys species contain iridoids and caffeic acid, lack rosmarinic acid, but yield essential oils. So, from chemical viewpoints, this genus may be a member of Erdtman's subfam. Lamioideae (Cantino and Sanders, 1986, Mathe, et al., 1993, Hegnauer, 1996,1990). The genus also shows some characteristics with regard to flavonoid contents (Kotsos, 2000; Skaltsa, 2000; Barberan, 1988; Skaltsa et al., 1999; Adams 1995). To verify some of these points, five Stachys species, either native to or easily cultivated in Hungary, have been studied. These are Stachys officinalis (L.) Trevis. (Betonica officinalis L.), St. grandiflora Host., St. byzantina Koch., St. germanica L. and St. sylvatica L. The rightness of the segregation of Stachys officinalis, as Betonica officinalis, from the genus Stachys is also discussed. MATERIALS AND METHODS Plants were cultivated in the experimental field of the Research Institute of Ecology and Botany of the Hungarian Academy of Sciences (at Vacratot, 40 km north of
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antiinflammatory activities of hungarian Stachys species and their iridoids
Phytotherapy Research, 2012Co-Authors: Erzsebet Haznagyradnai, Szilvia Czigle, Imre Máthé, Agnes Balogh, Judit Hohmann, Gabor BlazsoAbstract:The antiinflammatory activities of aqueous extracts prepared from the aerial parts of ten Hungarian Stachys species were investigated in vivo in the carrageenan-induced paw oedema test after intraperitoneal and oral administration to rats. Some of the extracts were found to display significant antiphlogistic effects when administered intraperitoneally and orally; in particular, the extracts of S. alpina, S. germanica, S. officinalis and S. recta demonstrated high activity following intraperitoneal administration. At the same dose of 5.0 mg/kg, these extracts exhibited similar or greater potency than that of the positive control diclofenac-Na. The main iridoids present in the investigated extracts, ajugoside, aucubin, acetylharpagide, harpagide and harpagoside, were also assayed in the same test, and high dose-dependent antiphlogistic effects were recorded for aucubin and harpagoside. These results led to the conclusion that most probably iridoids are responsible for the antiinflammatory effect of Stachys species, but other active constituents or their synergism must also be implicated in the antiinflammatory effect. Copyright © 2011 John Wiley & Sons, Ltd.
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cytotoxic activities of Stachys species
Fitoterapia, 2008Co-Authors: Erzsebet Haznagyradnai, Imre Máthé, Borbala Rethy, Sz Czigle, Istvan Zupko, Edit Weber, Tamas A Martinek, Gy FalkayAbstract:The cytotoxic activity of Stachys plants and of aucubin and harpagide against MCF7-breast adenocarcinoma, HeLa-cervix adenocarcinoma, A431-skin carcinoma of epithelial origin is reported in this study. Cisplatin and doxorubicin were use as reference compound.
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TLC and GC Analysis of the Essential Oils of Stachys Species
Jpc-journal of Planar Chromatography-modern Tlc, 2007Co-Authors: Erzsébet Háznagy-radnai, Szilvia Czigle, Imre MáthéAbstract:Species of the Lamioideae subfamily of the family Lamiaceae , including Stachys species, do not contain much essential oil. The first stage of studying the volatile components of Stachys species was characterization of n -hexane extracts by TLC, with sabinene, limonene, linalool, and β-caryophyllene as test materials. On the basis of these results we then studied the volatile compounds by use of GC-FID and GC-MS. By examination of the TLC plates, use of Kovats retention indices, and MS library search we identified components of essential oil fractions obtained from Stachys officinalis II. (L.) Trev., Stachys alpina L., Stachys macrantha (Koch) Stearn, Stachys palustris L., Stachys recta L. subsp. recta, and Stachys annua L. (from Vacratot) by vapor distillation in accordance with Hungarian Pharmacopoeia VII.
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Iridoids of Stachys Species Growing in Hungary
JPC – Journal of Planar Chromatography – Modern TLC, 2006Co-Authors: Erzsébet Háznagy-radnai, Szilvia Czigle, Gábor Janicsák, Imre MáthéAbstract:Stachys species contain iridoids, for example harpagide, acetylharpagide, aucubin, harpagoside, and ajugoside. The iridoid composition and content of leaves, stems, and inflorescences of ten Stachys species have been compared by use of a TLC–densitometric method. Harpagoside, harpagide, and acetylharpagide proved to be the main iridoids in Stachys officinalis L., St. sylvatica L., St. grandiflora Host., St. macrantha (C. Koch.) Jalas I., St. alpina L., St. palustris L., St. recta L., St. byzantina Koch., and St. germanica L. No iridoids were detected in St. annua L.
Shamsali Rezazadeh - One of the best experts on this subject based on the ideXlab platform.
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Chemical composition of the essential oils of Stachys schtschegleevii Sosn. and Stachys balansae Boiss & Kotschy from Iran
Flavour and Fragrance Journal, 2020Co-Authors: Shamsali Rezazadeh, Morteza Pirali Hamedani, Reza Dowlatabadi, Darab Yazdani, Abbas ShafieeAbstract:The essential oil samples obtained by hydrodistillation from aerial parts of Stachys schtschegleevii Sosn. and Stachys balansae Boiss & Kotschy (family Lamiaceae), were analysed by GC and GC–MS and 57 compounds, representing 99.5% and 86.5% of the total oils, respectively, were identified. Both essential oils were rich in sesquiterpenes (54.2% and 37.2%, respectively) with germacrene D (25.8% and 16.4%, respectively) as the major component. Copyright © 2005 John Wiley & Sons, Ltd.
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chemical composition of the essential oils of Stachys schtschegleevii sosn and Stachys balansae boiss kotschy from iran
Flavour and Fragrance Journal, 2006Co-Authors: Shamsali Rezazadeh, Morteza Pirali Hamedani, Reza Dowlatabadi, Darab Yazdani, Abbas ShafieeAbstract:The essential oil samples obtained by hydrodistillation from aerial parts of Stachys schtschegleevii Sosn. and Stachys balansae Boiss & Kotschy (family Lamiaceae), were analysed by GC and GC–MS and 57 compounds, representing 99.5% and 86.5% of the total oils, respectively, were identified. Both essential oils were rich in sesquiterpenes (54.2% and 37.2%, respectively) with germacrene D (25.8% and 16.4%, respectively) as the major component. Copyright © 2005 John Wiley & Sons, Ltd.
T Hirata - One of the best experts on this subject based on the ideXlab platform.
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the volatile constituents of Stachys recta l and Stachys balansae l from turkey
Flavour and Fragrance Journal, 1997Co-Authors: Ahmet Cakir, Mehmet Emin Duru, Mansur Harmandar, S Izumi, T HirataAbstract:The volatile constituents of the aerial parts of Stachys recta L. and Stachys balansae L. have been examined by GC, GC–MS, 1H-NMR and 13C-NMR. The oil of S. recta contains, as main components, oct-1-en-3-ol (33.8%), linalol (13.0%) and β-pinene (7.5%). The oil of S. balansae has β-caryophyllene (24.3%), β-pinene (24.1%) and α-pinene (16.0%) as main components. This study allowed the identification of 37 components in the oil of Stachys recta and 29 components in the oil of S. balansae. © 1997 John Wiley & Sons, Ltd.
Petar D Marin - One of the best experts on this subject based on the ideXlab platform.
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Anatomy and trichome micromorphology of Stachys scardica (Griseb.) Hayek (Lamiaceae)
Archives of Biological Sciences, 2020Co-Authors: Slavica Grujic, Ana Dzamic, Sonja Duletić-laušević, Petar D MarinAbstract:The anatomy and micromorphology of the vegetative organs and calyx of Stachys scardica (Griseb.) Hayek were investigated using light (LM) and scanning electron microscopy (SEM). The analysis of the anatomical structure of stem, leaf and leaf petiole showed the presence of an additional adaxial phloem in the vascular bundle of the petiole that was recorded exclusively in species belonging to the subgenus Betonica. On the surface of studied plant parts, three types of trichomes were found: simple nonglandular uniseriate multicellular, nonglandular branched elongated and glandular peltate trichomes. The present study shows that certain micromorphological and anatomical features of Stachys taxa are valuable taxonomic characters. [Projekat Ministarstva nauke Republike Srbije, br. 173029]
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essential oil composition of Stachys anisochila
Chemistry of Natural Compounds, 2011Co-Authors: Slavica Grujicjovanovic, Mihailo Ristic, Petar D MarinAbstract:Continuing our research on the composition and chemical polymorphism of the essential oil of the genus Stachys L., species from Serbia, we now report the results on the volatile oil of S. anisochila. The results of the essential oil analysis of S. anisochila are presented in Table 1. GC and GC-MS analysis showed 76 compounds. The main compounds were: -pinene (7.6%), -pinene (5.28%), -copaene (6.25%), and -caryophyllene (4.48%). S. anisochila essential oil contains monoterpenes (34.02%), sesquiterpenes (23.8%), and diterpenes (7.5%). This species, together with S. menthifolia and S. plumosa, belongs to subgenus Stachys, sectio Swainsonniana subsectio Decumbentes [25]. Their essentail oil composition showed that there are remarkable differences in the major constituents. The essential oil of S. plumosa is characterized by high contents of monoterpenes (70%), comprising both - and -pinenes as S. anisochila. On the other hand, the essential oil of S. menthifolia has a very high content of diterpenes (38%). The main components of S. menthifolia were abietatriene (12.99%), kaurene (12.35%), valeranone (5%), and -cadinol (4.2%). The main components of S. plumosa were -pinene (35.84%), -pinene (31.74%), -bourbonene (8%), limonene (3.62%), and abietatriene (3.47%). In our previous work, the essential oil compositions of ten Stachys species from Serbia were analyzed. The sesquiterpenes dominated in all the investigated samples of essential oils of Stachys species. Monoterpenes were present as well, but in variable amounts. The essential oils of species belonging to the subgenus Betonica (S. officinalis and S. scardica) contain a large proportion of sequiterpenes (70–80%), but the content of monoterpenes is exceptionally low, whereas diterpene compounds are completely lacking. These results may be useful in chemotaxonomy, but it is necessary to analyze more species of these genera and more populations of each species from different localities, including analyses of other secondary metabolites (e.g., flavonoids). The essential oils of Stachys species are a perspective source of interesting natural compounds. Investigation of the biological activity of essential oils of Stachys species showed antibacterial, antifungal, and antioxidative activity, which can be related to the essential oil composition. Plant Material and Isolation Procedure. The aerial parts of S. anisochila were collected at the flowering stage in
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Behavioural characterization of four endemic Stachys taxa.
Phytotherapy Research, 2010Co-Authors: Miroslav M. Savić, Petar D Marin, Renee J Grayer, Jelena Kukić, M.m. Milinkovic, Jovana Divljaković, Michael L. Van Linn, James M. Cook, Silvana PetrovićAbstract:We performed a basic behavioral characterization of methanol extracts of four Balkan endemic Stachys taxa: S. anisochila (SA), S. beckeana (SB), S. plumosa (SP) and S. alpina subsp. dinarica (SAD). The behavioral activity of extracts dosed intraperitoneally in the range 100–400 mg/kg was examined in adult male Wistar rats, in the elevated plus maze, spontaneous locomotor activity, and grip strength tests, mainly predictive of anxiolytic, sedative and myorelaxant actions, respectively. All investigated Stachys extracts lacked anxiolytic or myorelaxant activities, while SB at 400 mg/kg exerted an anxiogenic-like effect. The study with the selective antagonist β-CCt showed that the sedative effect of SAD was only partially mediated by GABAA receptors containing the α1-subunit. While discernible, the behavioral effects of SA and SP were not distinct. In all extracts, chlorogenic acid and verbascoside were identified. In SA, SB, and SAD the flavonoid fraction was constituted of isoscutellarein and hypolaetine glycosides, while in SP chrysoeriol and apigenin glycosides were present. The results reveal the psychotropic potential of four endemic Stachys taxa, of which SAD appeared most promising as a natural sedative. Copyright © 2010 John Wiley & Sons, Ltd.
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Composition of the essential oil of Stachys germanica from Serbia
Chemistry of Natural Compounds, 2008Co-Authors: S. Grujic Jovanovic, Petar D Marin, Ana Dzamic, Mihailo RistićAbstract:The genus Stachys L. comprises more than 270 species and is considered one of the largest genera of the Labiatae [1]. It is a subcosmopolitan genus centered in the warm temperate regions of the Mediterranean and SW Asia. Serbia is an area not very rich in Stachys representatives. In the flora of Serbia, 17 species are recognized [2]. Plants of this genus have long been used in folk medicine for the treatment of genital tumors, sclerosis of the spleen, inflammatory tumors, cough, and ulcers [3]. Teas prepared from the whole plant or leaves are used in phytotherapy. They posses sedative, antispasmodic, diuretic, and emmenagogue effects [4, 5]. In spite of the large species diversity of Stachys, the composition of essential oils is known in only a small number of species. Essential oils have been studied in different Stachys species [6–16]. As a part of a morphological, anatomical, and chemical research of genus Stachys in Serbian flora, we report the essential oil composition of S. germanica. Seventy-three compounds were identified in the essential oil of S. germanica, which represents 92.87% of the total oil, through their retention indexes and mass spectra obtained using GC/MS. The components with their percentage peak area are listed in Table 1. The main components were borneol (9.27%), bicyclogermacrene (8.97%), β-farnesene (5.70%), and spathulenol (4.60%). S. germanica oil contains monoterpene hydrocarbons (0.96%), oxygenated monoterpenes (14.07%), sesquiterpenes (34.23%), and oxygenated sesquiterpenes (24.89%). The essential oil of this species contains also aliphatic hydrocarbons (14.33%) and diterpenes (1.63%).
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glycosides of tricetin methyl ethers as chemosystematic markers in Stachys subgenus betonica
Phytochemistry, 2004Co-Authors: Petar D Marin, Slavica Grujicjovanovic, Renee J Grayer, Geoffrey C Kite, Nigel C VeitchAbstract:Abstract Nine species from the genus Stachys L. representing subgenera Stachys and Betonica were surveyed for flavonoid glycosides by means of HPLC coupled to diode-array detection and LC-APCI-MS. Those species belonging to subgenus Betonica were characterised by the presence of glycosides of tricetin methyl ethers, including a new derivative, which was isolated from S. scardica Griseb. and identified as tricetin 3 ′ ,4 ′ ,5 ′ -trimethyl ether 7- O -β-glucopyranoside by spectroscopic methods. This type of flavonoid was absent from species belonging to subgenus Stachys and can be considered as a chemosystematic marker for subgenus Betonica .
