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Flavio S. Schenkel - One of the best experts on this subject based on the ideXlab platform.
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Estimates of heritability of atrial fibrillation in the Standardbred raceHorse
Equine veterinary journal, 2017Co-Authors: Megan Kraus, P. W. Physick‐sheard, Luiz F. Brito, Flavio S. SchenkelAbstract:SummaryBackground The number of Standardbred raceHorses admitted to the Ontario Veterinary College Teaching Hospital (OVCTH, Guelph, Canada) for treatment of atrial fibrillation (AF) has been on the rise since the early 1990s. A small number of sires have been contributing to a large proportion of cases, indicating there may be a genetic predisposition to the arrhythmia in this breed. Objectives The objectives of this study were to determine the heritability of AF in Standardbred Horses and whether heritability of the arrhythmia differs across gaits and/or sexes. Study design Heritability study based on retrospective review of clinical records and publicly available pedigree and racing records. Methods Standardbred Horses admitted to OVCTH for treatment of AF that were born between 1978 and 2007 comprised the affected case population (n = 204). Five randomly selected racing contemporaries for each case, assumed to not suffer from the arrhythmia, comprised the control population (n = 1,017). Racing contemporaries were identified by examining the race records of affected Horses within the six months prior to their admission, and randomly selecting sex- and gait-matched Horses from these races. Heritability was estimated from the sampled Horses as a whole (n = 1,221), as well as for both sexes and gaits, using a generalised linear mixed model. Results Heritability of AF on the underlying liability scale was estimated to be (± s.e.) 0.30 ± 0.04 in the entire data set; 0.30 ± 0.06 in males; 0.24 ± 0.08 in females; and 0.32 ± 0.05 in pacers. After conversion to the observed scale, heritability estimates were 0.14, 0.15, 0.09, and 0.15, respectively. Main limitations There were insufficient data to estimate heritability of AF for trotters. Conclusions Modest heritability estimates were found for AF in the Standardbred Horse, particularly in males and pacers, which support the hypothesis that there is a genetic contribution to the arrhythmia in this breed. This article is protected by copyright. All rights reserved.
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breed predisposition and heritability of atrial fibrillation in the Standardbred Horse a retrospective case control study
Journal of Veterinary Cardiology, 2014Co-Authors: P W Physicksheard, Megan Kraus, Pari K. Basrur, Kimberly Mcgurrin, Daniel G. Kenney, Flavio S. SchenkelAbstract:Abstract Objectives To assess evidence for genetic contributions to atrial fibrillation (AF) in the Standardbred Horse. Animals Equine referrals to the Ontario Veterinary College Health Sciences Centre (OVCHSC) for 1985–2009, and age and gait matched breed registry controls. Methods Breeds presenting ≥5 times annually were tabulated (admission year and diagnosis; total 40,039; AF 396; no AF 39,643), and breed and year effects examined. Heritability and inbreeding coefficients were determined for Standardbred AF cases and racing contemporaries, and odds ratios for AF were calculated for frequently occurring sires. Results Year and breed effects on diagnosis were highly significant (Chi-Square 212.85, p p 2 u ) was estimated at 29.6 ± 3.9% and on the observed binomial scale (h 2 o ), at 9.6%. For Horses born in 1994 or later, h 2 u was 31.1 ± 4.3% and h 2 o, 10.1%. Of 22 first generation sires appearing ≥10 times in the case/control file, seven pacing and one trotting sire produced affected Horses more frequently than expected (OR 2.66–66.32). Inbreeding was not a factor. Conclusions There is genetic liability to AF in Standardbred Horses, likely due to more than single genes with simple Mendelian inheritance. Genomic studies are required.
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Breed predisposition and heritability of atrial fibrillation in the Standardbred Horse: A retrospective case–control study
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 2014Co-Authors: P. W. Physick‐sheard, Megan Kraus, Pari K. Basrur, Kimberly Mcgurrin, Daniel G. Kenney, Flavio S. SchenkelAbstract:Abstract Objectives To assess evidence for genetic contributions to atrial fibrillation (AF) in the Standardbred Horse. Animals Equine referrals to the Ontario Veterinary College Health Sciences Centre (OVCHSC) for 1985–2009, and age and gait matched breed registry controls. Methods Breeds presenting ≥5 times annually were tabulated (admission year and diagnosis; total 40,039; AF 396; no AF 39,643), and breed and year effects examined. Heritability and inbreeding coefficients were determined for Standardbred AF cases and racing contemporaries, and odds ratios for AF were calculated for frequently occurring sires. Results Year and breed effects on diagnosis were highly significant (Chi-Square 212.85, p p 2 u ) was estimated at 29.6 ± 3.9% and on the observed binomial scale (h 2 o ), at 9.6%. For Horses born in 1994 or later, h 2 u was 31.1 ± 4.3% and h 2 o, 10.1%. Of 22 first generation sires appearing ≥10 times in the case/control file, seven pacing and one trotting sire produced affected Horses more frequently than expected (OR 2.66–66.32). Inbreeding was not a factor. Conclusions There is genetic liability to AF in Standardbred Horses, likely due to more than single genes with simple Mendelian inheritance. Genomic studies are required.
Megan Kraus - One of the best experts on this subject based on the ideXlab platform.
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Estimates of heritability of atrial fibrillation in the Standardbred raceHorse
Equine veterinary journal, 2017Co-Authors: Megan Kraus, P. W. Physick‐sheard, Luiz F. Brito, Flavio S. SchenkelAbstract:SummaryBackground The number of Standardbred raceHorses admitted to the Ontario Veterinary College Teaching Hospital (OVCTH, Guelph, Canada) for treatment of atrial fibrillation (AF) has been on the rise since the early 1990s. A small number of sires have been contributing to a large proportion of cases, indicating there may be a genetic predisposition to the arrhythmia in this breed. Objectives The objectives of this study were to determine the heritability of AF in Standardbred Horses and whether heritability of the arrhythmia differs across gaits and/or sexes. Study design Heritability study based on retrospective review of clinical records and publicly available pedigree and racing records. Methods Standardbred Horses admitted to OVCTH for treatment of AF that were born between 1978 and 2007 comprised the affected case population (n = 204). Five randomly selected racing contemporaries for each case, assumed to not suffer from the arrhythmia, comprised the control population (n = 1,017). Racing contemporaries were identified by examining the race records of affected Horses within the six months prior to their admission, and randomly selecting sex- and gait-matched Horses from these races. Heritability was estimated from the sampled Horses as a whole (n = 1,221), as well as for both sexes and gaits, using a generalised linear mixed model. Results Heritability of AF on the underlying liability scale was estimated to be (± s.e.) 0.30 ± 0.04 in the entire data set; 0.30 ± 0.06 in males; 0.24 ± 0.08 in females; and 0.32 ± 0.05 in pacers. After conversion to the observed scale, heritability estimates were 0.14, 0.15, 0.09, and 0.15, respectively. Main limitations There were insufficient data to estimate heritability of AF for trotters. Conclusions Modest heritability estimates were found for AF in the Standardbred Horse, particularly in males and pacers, which support the hypothesis that there is a genetic contribution to the arrhythmia in this breed. This article is protected by copyright. All rights reserved.
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breed predisposition and heritability of atrial fibrillation in the Standardbred Horse a retrospective case control study
Journal of Veterinary Cardiology, 2014Co-Authors: P W Physicksheard, Megan Kraus, Pari K. Basrur, Kimberly Mcgurrin, Daniel G. Kenney, Flavio S. SchenkelAbstract:Abstract Objectives To assess evidence for genetic contributions to atrial fibrillation (AF) in the Standardbred Horse. Animals Equine referrals to the Ontario Veterinary College Health Sciences Centre (OVCHSC) for 1985–2009, and age and gait matched breed registry controls. Methods Breeds presenting ≥5 times annually were tabulated (admission year and diagnosis; total 40,039; AF 396; no AF 39,643), and breed and year effects examined. Heritability and inbreeding coefficients were determined for Standardbred AF cases and racing contemporaries, and odds ratios for AF were calculated for frequently occurring sires. Results Year and breed effects on diagnosis were highly significant (Chi-Square 212.85, p p 2 u ) was estimated at 29.6 ± 3.9% and on the observed binomial scale (h 2 o ), at 9.6%. For Horses born in 1994 or later, h 2 u was 31.1 ± 4.3% and h 2 o, 10.1%. Of 22 first generation sires appearing ≥10 times in the case/control file, seven pacing and one trotting sire produced affected Horses more frequently than expected (OR 2.66–66.32). Inbreeding was not a factor. Conclusions There is genetic liability to AF in Standardbred Horses, likely due to more than single genes with simple Mendelian inheritance. Genomic studies are required.
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Breed predisposition and heritability of atrial fibrillation in the Standardbred Horse: A retrospective case–control study
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 2014Co-Authors: P. W. Physick‐sheard, Megan Kraus, Pari K. Basrur, Kimberly Mcgurrin, Daniel G. Kenney, Flavio S. SchenkelAbstract:Abstract Objectives To assess evidence for genetic contributions to atrial fibrillation (AF) in the Standardbred Horse. Animals Equine referrals to the Ontario Veterinary College Health Sciences Centre (OVCHSC) for 1985–2009, and age and gait matched breed registry controls. Methods Breeds presenting ≥5 times annually were tabulated (admission year and diagnosis; total 40,039; AF 396; no AF 39,643), and breed and year effects examined. Heritability and inbreeding coefficients were determined for Standardbred AF cases and racing contemporaries, and odds ratios for AF were calculated for frequently occurring sires. Results Year and breed effects on diagnosis were highly significant (Chi-Square 212.85, p p 2 u ) was estimated at 29.6 ± 3.9% and on the observed binomial scale (h 2 o ), at 9.6%. For Horses born in 1994 or later, h 2 u was 31.1 ± 4.3% and h 2 o, 10.1%. Of 22 first generation sires appearing ≥10 times in the case/control file, seven pacing and one trotting sire produced affected Horses more frequently than expected (OR 2.66–66.32). Inbreeding was not a factor. Conclusions There is genetic liability to AF in Standardbred Horses, likely due to more than single genes with simple Mendelian inheritance. Genomic studies are required.
P. W. Physick‐sheard - One of the best experts on this subject based on the ideXlab platform.
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Estimates of heritability of atrial fibrillation in the Standardbred raceHorse
Equine veterinary journal, 2017Co-Authors: Megan Kraus, P. W. Physick‐sheard, Luiz F. Brito, Flavio S. SchenkelAbstract:SummaryBackground The number of Standardbred raceHorses admitted to the Ontario Veterinary College Teaching Hospital (OVCTH, Guelph, Canada) for treatment of atrial fibrillation (AF) has been on the rise since the early 1990s. A small number of sires have been contributing to a large proportion of cases, indicating there may be a genetic predisposition to the arrhythmia in this breed. Objectives The objectives of this study were to determine the heritability of AF in Standardbred Horses and whether heritability of the arrhythmia differs across gaits and/or sexes. Study design Heritability study based on retrospective review of clinical records and publicly available pedigree and racing records. Methods Standardbred Horses admitted to OVCTH for treatment of AF that were born between 1978 and 2007 comprised the affected case population (n = 204). Five randomly selected racing contemporaries for each case, assumed to not suffer from the arrhythmia, comprised the control population (n = 1,017). Racing contemporaries were identified by examining the race records of affected Horses within the six months prior to their admission, and randomly selecting sex- and gait-matched Horses from these races. Heritability was estimated from the sampled Horses as a whole (n = 1,221), as well as for both sexes and gaits, using a generalised linear mixed model. Results Heritability of AF on the underlying liability scale was estimated to be (± s.e.) 0.30 ± 0.04 in the entire data set; 0.30 ± 0.06 in males; 0.24 ± 0.08 in females; and 0.32 ± 0.05 in pacers. After conversion to the observed scale, heritability estimates were 0.14, 0.15, 0.09, and 0.15, respectively. Main limitations There were insufficient data to estimate heritability of AF for trotters. Conclusions Modest heritability estimates were found for AF in the Standardbred Horse, particularly in males and pacers, which support the hypothesis that there is a genetic contribution to the arrhythmia in this breed. This article is protected by copyright. All rights reserved.
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Breed predisposition and heritability of atrial fibrillation in the Standardbred Horse: A retrospective case–control study
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 2014Co-Authors: P. W. Physick‐sheard, Megan Kraus, Pari K. Basrur, Kimberly Mcgurrin, Daniel G. Kenney, Flavio S. SchenkelAbstract:Abstract Objectives To assess evidence for genetic contributions to atrial fibrillation (AF) in the Standardbred Horse. Animals Equine referrals to the Ontario Veterinary College Health Sciences Centre (OVCHSC) for 1985–2009, and age and gait matched breed registry controls. Methods Breeds presenting ≥5 times annually were tabulated (admission year and diagnosis; total 40,039; AF 396; no AF 39,643), and breed and year effects examined. Heritability and inbreeding coefficients were determined for Standardbred AF cases and racing contemporaries, and odds ratios for AF were calculated for frequently occurring sires. Results Year and breed effects on diagnosis were highly significant (Chi-Square 212.85, p p 2 u ) was estimated at 29.6 ± 3.9% and on the observed binomial scale (h 2 o ), at 9.6%. For Horses born in 1994 or later, h 2 u was 31.1 ± 4.3% and h 2 o, 10.1%. Of 22 first generation sires appearing ≥10 times in the case/control file, seven pacing and one trotting sire produced affected Horses more frequently than expected (OR 2.66–66.32). Inbreeding was not a factor. Conclusions There is genetic liability to AF in Standardbred Horses, likely due to more than single genes with simple Mendelian inheritance. Genomic studies are required.
Stephanie A. Collins - One of the best experts on this subject based on the ideXlab platform.
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The effect of exercise intensity and use of an electrolyte supplement on plasma electrolyte concentrations in the Standardbred Horse
Canadian Journal of Animal Science, 2017Co-Authors: Emily Jane Walker, Stephanie A. CollinsAbstract:Eleven Standardbred Horses were tested to assess plasma electrolyte fluctuations during different intensities of exercise (at rest, immediately following 20 min of jogging, and immediately following a 2 min race), with and without an orally administered electrolyte supplement 2 h prior to sample collection. Exercise treatments were repeated after Horses were given an oral dosage of an electrolyte supplement 2 h prior to sample collection. Data were analyzed using a repeated incomplete 6 × 6 Latin-square design with a 3 × 2 factorial arrangement of treatments (exercise × supplement). Jogging Horses had an elevated heart rate as compared with resting Horses and plasma potassium concentrations that were higher than those of the other two treatments (P
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the effect of exercise intensity and use of an electrolyte supplement on plasma electrolyte concentrations in the Standardbred Horse
Canadian Journal of Animal Science, 2017Co-Authors: Emily Jane Walker, Stephanie A. CollinsAbstract:Eleven Standardbred Horses were tested to assess plasma electrolyte fluctuations during different intensities of exercise (at rest, immediately following 20 min of jogging, and immediately following a 2 min race), with and without an orally administered electrolyte supplement 2 h prior to sample collection. Exercise treatments were repeated after Horses were given an oral dosage of an electrolyte supplement 2 h prior to sample collection. Data were analyzed using a repeated incomplete 6 × 6 Latin-square design with a 3 × 2 factorial arrangement of treatments (exercise × supplement). Jogging Horses had an elevated heart rate as compared with resting Horses and plasma potassium concentrations that were higher than those of the other two treatments (P < 0.05). Racing Horses had the highest heart rate of the three treatments and plasma sodium concentrations that were higher than those of resting and jogging Horses (P < 0.05). Provision of an electrolyte supplement significantly increased heart rate, as well a...
L. Boure - One of the best experts on this subject based on the ideXlab platform.
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The Used Electrocautery Loop in the Equine Proximal Phalanx
VCOT Archive, 1999Co-Authors: L. BoureAbstract:An electrocautery loop probe was used in the arthroscopic treatment of type I proximal plantar osteochondral fragments of the proximal hind phalanx in a Standardbred Horse. The loop electrocautery probe was used as an alternative to manual sharp instruments.
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The Used Electrocautery Loop in the Equine Proximal Phalanx
Veterinary and Comparative Orthopaedics and Traumatology, 1999Co-Authors: L. BoureAbstract:SummaryAn 18-month-old 420 kg Standardbred colt was admitted for removal of three type I proximal plantar osteochondral fragments of the proximal phalanx. An electrocautery loop probe was used for the arthroscopic removal of the osteochondral fragments. Distension of the metatarsophalangeal joints was achieved using a 1.5% glycine solution. Under arthroscopic guidance, the soft tissue attachments of the osteochondral fragments were transected with the electrocautery loop probe. Once freed of all soft tissue attachments, the fragments were removed with a Ferris-Smith intervertebral disc rongeur. The electrocautery loop probe permitted an easy, precise and smooth dissection of intra-articular soft-tissue structures. Six weeks after the operation, the colt had returned to training. After eight months, the colt remained sound and was racing. The loop electrocautery probe was used as an alternative to manual sharp instruments in the arthroscopic treatment of Type I proximal plantar osteochondral fragments of the proximal phalanx.An electrocautery loop probe was used in the arthroscopic treatment of type I proximal plantar osteochondral fragments of the proximal hind phalanx in a Standardbred Horse. The loop electrocautery probe was used as an alternative to manual sharp instruments.