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L Y Ho - One of the best experts on this subject based on the ideXlab platform.
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fri0393 Standardized Incidence Ratio sir time trend and risk factors of avascular bone necrosis avn in patients with systemic lupus erythematosus sle
Annals of the Rheumatic Diseases, 2015Co-Authors: L Y HoAbstract:Objectives To study the Standardized Incidence Ratio (SIR), time trend and risk factors of AVN in patients with SLE. Methods The records of all patients who fulfilled ≥4 ACR criteria for SLE in our unit between 1999 and 2014 were reviewed. Patients who developed AVN at any sites ever since the diagnosis of SLE were identified. A group of SLE controls who did not have evidence of AVN were randomly selected from our cohort database in a 4:1 (control/case) Ratio, matched for age, sex and SLE duRation. The SIR of AVN in SLE and its time trend was calculated by data retrieved from our hospital clinical information registry and the Census data from our Government. Risk factors for AVN in SLE were studied by multivariate logistic regression. The following factors were considered to be covariates in the regression model: hypertension, diabetes mellitus, lipid level, previous septic arthritis, maximum daily dose and cumulative dose of prednisolone ever used, cushingoid body habitus, cutaneous vasculitis, Raynaud9s phenomenon, antiphospholipid antibodies, and a propensity score derived from a separate logistic regression model for the probability of use of high-dose prednisolone (>0.8mg/kg/day) for different SLE manifestations. Results 55 patients with symptomatic AVN (87%women;age 33.4±12.4 years; SLE duRation 61.2±62.2 months) and 220 matched SLE controls (87% women, age 34.3±10.6 years; SLE duRation 71.7±50.1 months) were studied. The point prevalence of AVN in our SLE cohort (N=743) was 7.4%. All the patients with AVN had been treated with glucocorticoids (GCs). Compared to controls, AVN patients had used a significantly higher cumulative doses of prednisolone (16.5±14.6 vs 10.7±11.3 grams; p=0.003). A total of 104 sites of AVN were diagnosed in 55 patients (69%≥2 sites). The hip was most commonly affected (82%), followed by the femoral condyle (9%) and the humeral head (5%). Bilateral involvement was present in 67% of the patients. Surgical treatment (core decompression, vascularized bone graft or joint replacement) was performed for 41% of the AVN lesions. The age and sex stratified SIRs of AVN in our SLE patients was 131 (86.6-199; p Conclusions AVN is prevalent in SLE patients, particularly in younger patients. GC use, Cushingoid body habitus, serum LDL-cholesterol level and previous septic arthritis are independently associated with AVN. There is a trend of reduction in the SIR of AVN in our SLE patients over the past 2 decades, which is probably attributed by the judicious use of GCs and the early administRation of GC-sparing agents. Disclosure of Interest None declared
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annual Incidence and Standardized Incidence Ratio of cerebrovascular accidents in patients with systemic lupus erythematosus
Scandinavian Journal of Rheumatology, 2009Co-Authors: L Y Ho, C H ToAbstract:Objectives: To study the annual Incidence and Standardized Incidence Ratio (SIR) of cerebrovascular accident (CVA) in patients with systemic lupus erythematosus (SLE).Subjects and methods: The annual Incidence of CVA from 1999 to 2007 in a longitudinal cohort of SLE patients was calculated each year and compared with that of the regional population within the same study period. Age-specific SIRs and outcome of CVA in SLE patients were also studied.Results: In 2007, there were 490 SLE patients in our cohort. The mean annual Incidence of CVA between 1999 and 2007 was 6.45/1000 patients and no obvious trend over time was observed. Of the 20 CVAs in patients with SLE, 18 (90%) were ischaemic stroke whereas two (10%) were haemorrhagic stroke. The mean SIR of all types of CVA in SLE patients was 2.02 [95% confidence interval (CI) 1.30–3.81; p = 0.002]. The SIR of ischaemic stroke decreased with age and the stroke Incidence was no longer significantly higher than that of the population in patients aged ≥ 60 year...
C H To - One of the best experts on this subject based on the ideXlab platform.
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annual Incidence and Standardized Incidence Ratio of cerebrovascular accidents in patients with systemic lupus erythematosus
Scandinavian Journal of Rheumatology, 2009Co-Authors: L Y Ho, C H ToAbstract:Objectives: To study the annual Incidence and Standardized Incidence Ratio (SIR) of cerebrovascular accident (CVA) in patients with systemic lupus erythematosus (SLE).Subjects and methods: The annual Incidence of CVA from 1999 to 2007 in a longitudinal cohort of SLE patients was calculated each year and compared with that of the regional population within the same study period. Age-specific SIRs and outcome of CVA in SLE patients were also studied.Results: In 2007, there were 490 SLE patients in our cohort. The mean annual Incidence of CVA between 1999 and 2007 was 6.45/1000 patients and no obvious trend over time was observed. Of the 20 CVAs in patients with SLE, 18 (90%) were ischaemic stroke whereas two (10%) were haemorrhagic stroke. The mean SIR of all types of CVA in SLE patients was 2.02 [95% confidence interval (CI) 1.30–3.81; p = 0.002]. The SIR of ischaemic stroke decreased with age and the stroke Incidence was no longer significantly higher than that of the population in patients aged ≥ 60 year...
Barry I Graubard - One of the best experts on this subject based on the ideXlab platform.
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an application of a weighting method to adjust for nonresponse in Standardized Incidence Ratio analysis of cohort studies
Annals of Epidemiology, 2005Co-Authors: Alice J Sigurdson, Michele M Doody, Barry I GraubardAbstract:Purpose Cohort studies often conduct periodic follow-up interviews (or waves) to determine disease Incidence since the previous follow-up and to update measures of exposure and confounders. The common practice of excluding nonrespondents from Standardized Incidence Ratio (SIR) analyses of these cohorts can bias the estimates of interest if nonrespondents and respondents differ on important characteristics related to outcomes of interest. We propose an analytic approach to reduce the impact of nonresponse in the analyses of SIRs. Methods Logistic regression models controlling baseline information are used to estimate the propensity, or the probability of response; the reciprocals of these propensities are used as weights in the analysis of risk. This is illustrated in the analysis of 15 years of follow-up of a cohort of US radiologic technologists after an initial interview to assess the risk at several cancer sites from occupational radiation exposure. We use information from the baseline survey and certification records to compute the propensity of responding to the second survey. SIRs are computed using Surveillance, Epidemiology, and End Results (SEER) cancer Incidence rates. Variances of the SIRs are estimated by a jackknife method that accounts for additional variability resulting from estimation of the weights. Results We find that, in this application, weighting alters point estimates and confidence limits only to a small degree, thus providing reassurance that the results are robust to nonresponse. This indicates that results from the analyses excluding the missing data may be slightly biased and weighting helps in reducing the nonresponse bias. Conclusion This method is flexible, practical, easy to use with existing software, and is applicable to missing data from cohorts with baseline information on all subjects.
Lydia B Zablotska - One of the best experts on this subject based on the ideXlab platform.
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non thyroid cancer Incidence in belarusian residents exposed to chernobyl fallout in childhood and adolescence Standardized Incidence Ratio analysis 1997 2011
Environmental Research, 2016Co-Authors: Evgenia Ostroumova, Maureen Hatch, Alina V Brenner, Eldar Nadyrov, Ilya Veyalkin, Olga Polyanskaya, Vasilina Yauseyenka, Semion Polyakov, Leonid Levin, Lydia B ZablotskaAbstract:Background While an increased risk of thyroid cancer from post-Chernobyl exposure to Iodine-131 (I-131) in children and adolescents has been well-documented, risks of other cancers or leukemia as a result of residence in radioactively contaminated areas remain uncertain.
Naoyuki Yoshizawa - One of the best experts on this subject based on the ideXlab platform.
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cancer risk in japanese crohn s disease patients investigation of the Standardized Incidence Ratio
Journal of Gastroenterology and Hepatology, 2013Co-Authors: Yutaka Yano, Toshiyuki Matsui, Fumihito Hirai, Yuki Okado, Yuho Sato, Kozue Tsurumi, Satoshi Ishikawa, Tsuyoshi Beppu, Akihiro Koga, Naoyuki YoshizawaAbstract:Background and Aim There have been very few reported investigations on the Standardized Incidence Ratio (SIR) of intestinal cancer and all cancers other than intestinal cancer with Crohn's disease (CD) by organ in Japan. This study examined the risk of developing cancer (i.e. SIR) that occurs in association with CD. Methods The subjects were 770 CD patients managed at our hospital department, which specializes in inflammatory bowel disease, during the approximately 25 years from July 1985 to August 2010. The number of expected cancer patients in a healthy population matched for sex and age with the CD patients in our hospital was then calculated. The relative risk, or SIR, was also calculated. Results The total observation period was 10 552 person-years, during which 19 cases (2.5%) of cancer were discovered in 770 subjects. The cancer cases included nine cases of colorectal cancer (CRC), one case of small bowel cancer, one case of stomach cancer, three cases of acute myeloid leukemia, two cases of endometrial cancer, one case of lung cancer, one case of skin cancer, and one case of thyroid cancer. The SIR for cancers in Japan in 2003 was 0.87 (95% confidence interval [CI] 0.52–1.35) for all cancers, 2.79 (95% CI 1.28–5.29) for CRC, and 6.94 (95% CI 1.43–20.3) for leukemia. Conclusions Among the cancers in CD patients in our hospital, no significant difference was seen in the risk for all cancers in comparison with the standard population. However, the risks for CRC and leukemia were significantly higher than in the standard population.
