The Experts below are selected from a list of 1416 Experts worldwide ranked by ideXlab platform

Richard J. O'callaghan - One of the best experts on this subject based on the ideXlab platform.

  • Staphylococcus Alpha-Toxin Action on the Rabbit Iris: Toxic Effects and Their Inhibition
    Current eye research, 2014
    Co-Authors: Angela M. Arana, Michael A. Bierdeman, Charles L. Balzli, Aihua Tang, Armando R. Caballero, Rupesh Patel, Richard J. O'callaghan
    Abstract:

    AbstractPurpose: Staphylococcus aureus infection of the anterior chamber can occur after cataract surgery, causing inflammation and extensive damage to the iris. Alpha-Toxin, the most potent S. aureus corneal Toxin, was tested as a possible mediator of damage to the iris, and Alpha-Toxin anti-serum and a chemical Toxin inhibitor were tested as potential pathology-reducing agents.Methods: The hemolytic activity of Alpha-Toxin and its inhibition by a chemical inhibitor or anti-serum were quantified in vitro. Purified Alpha-Toxin, heat-inactivated Toxin, or Alpha-Toxin plus normal serum, Alpha-Toxin anti-serum, or the chemical inhibitor, methyl-β-cyclodextrin-cholesterol (CD-cholesterol), was injected into the rabbit anterior chamber. Pathological changes were photographed, quantified by slit-lamp examination (SLE) scoring, and further documented by histopathological analysis.Results: At five hours post-injection, eyes injected with Alpha-Toxin or heat-inactivated Toxin had a mean SLE score of 7.3 ± 0.59 or ...

Angela M. Arana - One of the best experts on this subject based on the ideXlab platform.

  • Staphylococcus Alpha-Toxin Action on the Rabbit Iris: Toxic Effects and Their Inhibition
    Current eye research, 2014
    Co-Authors: Angela M. Arana, Michael A. Bierdeman, Charles L. Balzli, Aihua Tang, Armando R. Caballero, Rupesh Patel, Richard J. O'callaghan
    Abstract:

    AbstractPurpose: Staphylococcus aureus infection of the anterior chamber can occur after cataract surgery, causing inflammation and extensive damage to the iris. Alpha-Toxin, the most potent S. aureus corneal Toxin, was tested as a possible mediator of damage to the iris, and Alpha-Toxin anti-serum and a chemical Toxin inhibitor were tested as potential pathology-reducing agents.Methods: The hemolytic activity of Alpha-Toxin and its inhibition by a chemical inhibitor or anti-serum were quantified in vitro. Purified Alpha-Toxin, heat-inactivated Toxin, or Alpha-Toxin plus normal serum, Alpha-Toxin anti-serum, or the chemical inhibitor, methyl-β-cyclodextrin-cholesterol (CD-cholesterol), was injected into the rabbit anterior chamber. Pathological changes were photographed, quantified by slit-lamp examination (SLE) scoring, and further documented by histopathological analysis.Results: At five hours post-injection, eyes injected with Alpha-Toxin or heat-inactivated Toxin had a mean SLE score of 7.3 ± 0.59 or ...

Michael A. Bierdeman - One of the best experts on this subject based on the ideXlab platform.

  • Staphylococcus Alpha-Toxin Action on the Rabbit Iris: Toxic Effects and Their Inhibition
    Current eye research, 2014
    Co-Authors: Angela M. Arana, Michael A. Bierdeman, Charles L. Balzli, Aihua Tang, Armando R. Caballero, Rupesh Patel, Richard J. O'callaghan
    Abstract:

    AbstractPurpose: Staphylococcus aureus infection of the anterior chamber can occur after cataract surgery, causing inflammation and extensive damage to the iris. Alpha-Toxin, the most potent S. aureus corneal Toxin, was tested as a possible mediator of damage to the iris, and Alpha-Toxin anti-serum and a chemical Toxin inhibitor were tested as potential pathology-reducing agents.Methods: The hemolytic activity of Alpha-Toxin and its inhibition by a chemical inhibitor or anti-serum were quantified in vitro. Purified Alpha-Toxin, heat-inactivated Toxin, or Alpha-Toxin plus normal serum, Alpha-Toxin anti-serum, or the chemical inhibitor, methyl-β-cyclodextrin-cholesterol (CD-cholesterol), was injected into the rabbit anterior chamber. Pathological changes were photographed, quantified by slit-lamp examination (SLE) scoring, and further documented by histopathological analysis.Results: At five hours post-injection, eyes injected with Alpha-Toxin or heat-inactivated Toxin had a mean SLE score of 7.3 ± 0.59 or ...

Charles L. Balzli - One of the best experts on this subject based on the ideXlab platform.

  • Staphylococcus Alpha-Toxin Action on the Rabbit Iris: Toxic Effects and Their Inhibition
    Current eye research, 2014
    Co-Authors: Angela M. Arana, Michael A. Bierdeman, Charles L. Balzli, Aihua Tang, Armando R. Caballero, Rupesh Patel, Richard J. O'callaghan
    Abstract:

    AbstractPurpose: Staphylococcus aureus infection of the anterior chamber can occur after cataract surgery, causing inflammation and extensive damage to the iris. Alpha-Toxin, the most potent S. aureus corneal Toxin, was tested as a possible mediator of damage to the iris, and Alpha-Toxin anti-serum and a chemical Toxin inhibitor were tested as potential pathology-reducing agents.Methods: The hemolytic activity of Alpha-Toxin and its inhibition by a chemical inhibitor or anti-serum were quantified in vitro. Purified Alpha-Toxin, heat-inactivated Toxin, or Alpha-Toxin plus normal serum, Alpha-Toxin anti-serum, or the chemical inhibitor, methyl-β-cyclodextrin-cholesterol (CD-cholesterol), was injected into the rabbit anterior chamber. Pathological changes were photographed, quantified by slit-lamp examination (SLE) scoring, and further documented by histopathological analysis.Results: At five hours post-injection, eyes injected with Alpha-Toxin or heat-inactivated Toxin had a mean SLE score of 7.3 ± 0.59 or ...

Aihua Tang - One of the best experts on this subject based on the ideXlab platform.

  • Staphylococcus Alpha-Toxin Action on the Rabbit Iris: Toxic Effects and Their Inhibition
    Current eye research, 2014
    Co-Authors: Angela M. Arana, Michael A. Bierdeman, Charles L. Balzli, Aihua Tang, Armando R. Caballero, Rupesh Patel, Richard J. O'callaghan
    Abstract:

    AbstractPurpose: Staphylococcus aureus infection of the anterior chamber can occur after cataract surgery, causing inflammation and extensive damage to the iris. Alpha-Toxin, the most potent S. aureus corneal Toxin, was tested as a possible mediator of damage to the iris, and Alpha-Toxin anti-serum and a chemical Toxin inhibitor were tested as potential pathology-reducing agents.Methods: The hemolytic activity of Alpha-Toxin and its inhibition by a chemical inhibitor or anti-serum were quantified in vitro. Purified Alpha-Toxin, heat-inactivated Toxin, or Alpha-Toxin plus normal serum, Alpha-Toxin anti-serum, or the chemical inhibitor, methyl-β-cyclodextrin-cholesterol (CD-cholesterol), was injected into the rabbit anterior chamber. Pathological changes were photographed, quantified by slit-lamp examination (SLE) scoring, and further documented by histopathological analysis.Results: At five hours post-injection, eyes injected with Alpha-Toxin or heat-inactivated Toxin had a mean SLE score of 7.3 ± 0.59 or ...