The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform
Michael Otto - One of the best experts on this subject based on the ideXlab platform.
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understanding the significance of Staphylococcus Epidermidis bacteremia in babies and children
Current Opinion in Infectious Diseases, 2010Co-Authors: Gordon Y C Cheung, Michael OttoAbstract:Purpose of reviewThis article provides an overview of Staphylococcus Epidermidis bacteremia/sepsis and coagulase-negative staphylococci (CoNS) infections in neonates and children.Recent findingsThe incidence of S. Epidermidis and CoNS sepsis in neonates is still very high and preventing and treating
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Staphylococcus Epidermidis — the 'accidental' pathogen
Nature Reviews Microbiology, 2009Co-Authors: Michael OttoAbstract:The commensal bacterium Staphylococcus Epidermidis is a colonizer of the human skin. Despite lacking recognized virulence factors, S. Epidermidis can cause infection, often on the surface of indwelling medical devices. In this Review, Michael Otto highlights how normally benign bacterial factors take on more virulent roles during host infection with this 'accidental' pathogen.
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Staphylococcus Epidermidis--the 'accidental' pathogen.
Nature Reviews Microbiology, 2009Co-Authors: Michael OttoAbstract:The commensal bacterium Staphylococcus Epidermidis is a colonizer of the human skin. Despite lacking recognized virulence factors, S. Epidermidis can cause infection, often on the surface of indwelling medical devices. In this Review, Michael Otto highlights how normally benign bacterial factors take on more virulent roles during host infection with this 'accidental' pathogen.
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Staphylococcus Epidermidis infections
Microbes and Infection, 2002Co-Authors: Cuong Vuong, Michael OttoAbstract:The opportunistic human pathogen Staphylococcus Epidermidis has become the most important cause of nosocomial infections in recent years. Its pathogenicity is mainly due to the ability to form biofilms on indwelling medical devices. In a biofilm, S. Epidermidis is protected against attacks from the immune system and against antibiotic treatment, making S. Epidermidis infections difficult to eradicate.
Eric Bonnet - One of the best experts on this subject based on the ideXlab platform.
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Successful treatment of Staphylococcus Epidermidis hip prosthesis infection with oral linezolid
Annals of Pharmacotherapy, 2004Co-Authors: Ingrid Mogenet, Sabine Raetz-dillon, Jean Marie Canonge, Maryse Archambaud, Eric BonnetAbstract:To report a case of Staphylococcus Epidermidis infection of a hip prosthesis successfully treated with oral linezolid.
Philip S Stewart - One of the best experts on this subject based on the ideXlab platform.
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daptomycin rapidly penetrates a Staphylococcus Epidermidis biofilm
Antimicrobial Agents and Chemotherapy, 2009Co-Authors: Philip S Stewart, William M Davison, Judith N SteenbergenAbstract:Fluorescently tagged daptomycin accessed the interior of Staphylococcus Epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.
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penetration of rifampin through Staphylococcus Epidermidis biofilms
Antimicrobial Agents and Chemotherapy, 2002Co-Authors: Zhilan Zheng, Philip S StewartAbstract:Rifampin penetrated biofilms formed by Staphylococcus Epidermidis but failed to effectively kill the bacteria. Penetration was demonstrated by a simple diffusion cell bioassay and by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm.
Xiaoli Zhang - One of the best experts on this subject based on the ideXlab platform.
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Staphylococcus Epidermidis bacteremia induces brain injury in neonatal mice via toll like receptor 2 dependent and independent pathways
The Journal of Infectious Diseases, 2015Co-Authors: Dan Bi, Lili Qiao, Ilana Bergelson, Joakim C Ek, Luqi Duan, Xiaoli ZhangAbstract:Background. Staphylococcus Epidermidis causes late-onset sepsis in preterm infants. Staphylococcus Epidermidis activates host responses in part via Toll-like receptor 2 (TLR2). Epidemiologic studies link bacteremia and neonatal brain injury, but direct evidence is lacking. Methods. Wild-type and TLR2-deficient (TLR2−/−) mice were injected intravenously with S. Epidermidis at postnatal day 1 prior to measuring plasma and brain cytokine and chemokine levels, bacterial clearance, brain caspase-3 activation, white/gray matter volume, and innate transcriptome. Results. Staphylococcus Epidermidis bacteremia spontaneously resolved over 24 hours without detectable bacteria in the cerebrospinal fluid (CSF). TLR2−/− mice demonstrated delayed S. Epidermidis clearance from blood, spleen, and liver. Staphylococcus Epidermidis increased the white blood cell count in the CSF, increased interleukin 6, interleukin 12p40, CCL2, and CXCL1 concentrations in plasma; increased the CCL2 concentration in the brain; and caused rapid (within 6 hours) TLR2-dependent brain activation of caspase-3 and TLR2-independent white matter injury. Conclusions. Staphylococcus Epidermidis bacteremia, in the absence of bacterial entry into the CSF, impairs neonatal brain development. Staphylococcus Epidermidis bacteremia induced both TLR2-dependent and –independent brain injury, with the latter occurring in the absence of TLR2, a condition associated with an increased bacterial burden. Our study indicates that the consequences of transient bacteremia in early life may be more severe than commonly appreciated, and our findings may inform novel approaches to reduce bacteremia-associated brain injury.
Mark C Enright - One of the best experts on this subject based on the ideXlab platform.
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improved multilocus sequence typing scheme for Staphylococcus Epidermidis
Journal of Clinical Microbiology, 2007Co-Authors: Jonathan C. Thomas, Miguel R Vargas, Maria Miragaia, Sharon J Peacock, Gordon L Archer, Mark C EnrightAbstract:We evaluated three multilocus sequence typing (MLST) schemes for Staphylococcus Epidermidis and selected the seven most discriminatory loci for the formation of a new, more powerful MLST scheme. This improved scheme gave 31 sequence types (STs) and 5 clonal complexes (CCs), whereas the other schemes delineate 16 to 24 STs and 1 to 3 CCs.