The Experts below are selected from a list of 996 Experts worldwide ranked by ideXlab platform

Zhanyong Guo - One of the best experts on this subject based on the ideXlab platform.

  • design synthesis of novel Starch Derivative bearing 1 2 3 triazolium and pyridinium and evaluation of its antifungal activity
    Carbohydrate Polymers, 2017
    Co-Authors: Wenqiang Tan, Zhenpeng Gao, Shuai Qiu, Fang Dong, Zhanyong Guo
    Abstract:

    Based on cuprous-catalyzed azide-alkyne cycloaddition (CuAAC), Starch Derivative bearing 1,2,3-triazole and pyridine (II) was prepared and subsequently followed by alkylation with iodomethane to synthesize Starch Derivative bearing 1,2,3-triazolium and pyridinium (III). The antifungal activities of Starch Derivatives against Colletotrichum lagenarium, Watermelon fusarium, and Phomopsis asparagi, were then assayed by hypha measurement in vitro. Apparently, Starch Derivatives showed enhanced antifungal activity against three fungi at the tested concentrations compared with Starch. Especially, the best inhibitory index of Starch Derivative (III) against Colletotrichum lagenarium attained 97% above at 1.0mg/mL. Meanwhile, Starch Derivative (III) had stronger antifungal activity than Starch Derivative (II), which was reasonable to propose that the alkylation of 1,2,3-triazole and pyridine was significant for enhanced antifungal activity. As this novel Starch Derivative bearing 1,2,3-triazolium and pyridinium could be prepared efficiently and exhibited superduper antifungal activity, this material might provide an effective way and notion to prepare novel antifungal agents.

Dianyu Dong - One of the best experts on this subject based on the ideXlab platform.

  • zwitterionic modified Starch based stealth micelles for prolonging circulation time and reducing macrophage response
    ACS Applied Materials & Interfaces, 2016
    Co-Authors: Lei Ye, Yabin Zhang, Boguang Yang, Xin Zhou, Junjie Li, Dianyu Dong
    Abstract:

    Over the last few decades, nanoparticles have been emerging as useful means to improve the therapeutic efficacy of drug delivery and medical diagnoses. However, the heterogeneity and complexity of blood as a medium is a fundamental problem; large amounts of protein can be adsorbed onto the surface of nanoparticles and cause their rapid clearance before reaching their target sites, resulting in the failure of drug delivery. To overcome this challenge, we present a rationally designed Starch Derivative (SB-ST-OC) with both a superhydrophilic moiety of zwitterionic sulfobetaine (SB) and a hydrophobic segment of octane (OC) as functional groups, which can self-assemble into “stealth” micelles (SSO micelles). The superhydrophilic SB kept the micelles stable against aggregation in complex media and imbued them with “stealth” properties, eventually extending their circulation time in blood. In stability and hemolysis tests the SSO micelles showed excellent protein resistance properties and hemocompatibility. Mor...

  • Zwitterionic-Modified Starch-Based Stealth Micelles for Prolonging Circulation Time and Reducing Macrophage Response
    2016
    Co-Authors: Yabin Zhang, Boguang Yang, Xin Zhou, Dianyu Dong, Zhihui Qin, Yuanlu Cui, Fanglian Yao
    Abstract:

    Over the last few decades, nanoparticles have been emerging as useful means to improve the therapeutic efficacy of drug delivery and medical diagnoses. However, the heterogeneity and complexity of blood as a medium is a fundamental problem; large amounts of protein can be adsorbed onto the surface of nanoparticles and cause their rapid clearance before reaching their target sites, resulting in the failure of drug delivery. To overcome this challenge, we present a rationally designed Starch Derivative (SB-ST-OC) with both a superhydrophilic moiety of zwitterionic sulfobetaine (SB) and a hydrophobic segment of octane (OC) as functional groups, which can self-assemble into “stealth” micelles (SSO micelles). The superhydrophilic SB kept the micelles stable against aggregation in complex media and imbued them with “stealth” properties, eventually extending their circulation time in blood. In stability and hemolysis tests the SSO micelles showed excellent protein resistance properties and hemocompatibility. Moreover, a phagocytosis test and cytokine secretion assay confirmed that the SSO micelles had less potential to trigger the activation of macrophages and were more suitable as a drug delivery candidate in vivo. On the basis of these results, doxorubicin (DOX), a hydrophobic drug, was used to investigate the potential application of this novel Starch Derivative in vivo. The results of the pharmacokinetic study showed that the values of the plasma area under the concentration curve (AUC) and elimination half-life (T1/2) of the SSO micelles were higher than those of micelles without SB modifications. In conclusion, the combination of excellent protein resistance, lower macrophage activation, and longer circulation time in vivo makes this synthesized novel Starch Derivative a promising candidate as a hydrophobic drug carrier for long-term circulation in vivo.

Wenqiang Tan - One of the best experts on this subject based on the ideXlab platform.

  • design synthesis of novel Starch Derivative bearing 1 2 3 triazolium and pyridinium and evaluation of its antifungal activity
    Carbohydrate Polymers, 2017
    Co-Authors: Wenqiang Tan, Zhenpeng Gao, Shuai Qiu, Fang Dong, Zhanyong Guo
    Abstract:

    Based on cuprous-catalyzed azide-alkyne cycloaddition (CuAAC), Starch Derivative bearing 1,2,3-triazole and pyridine (II) was prepared and subsequently followed by alkylation with iodomethane to synthesize Starch Derivative bearing 1,2,3-triazolium and pyridinium (III). The antifungal activities of Starch Derivatives against Colletotrichum lagenarium, Watermelon fusarium, and Phomopsis asparagi, were then assayed by hypha measurement in vitro. Apparently, Starch Derivatives showed enhanced antifungal activity against three fungi at the tested concentrations compared with Starch. Especially, the best inhibitory index of Starch Derivative (III) against Colletotrichum lagenarium attained 97% above at 1.0mg/mL. Meanwhile, Starch Derivative (III) had stronger antifungal activity than Starch Derivative (II), which was reasonable to propose that the alkylation of 1,2,3-triazole and pyridine was significant for enhanced antifungal activity. As this novel Starch Derivative bearing 1,2,3-triazolium and pyridinium could be prepared efficiently and exhibited superduper antifungal activity, this material might provide an effective way and notion to prepare novel antifungal agents.

Muhyaddin J. H. Rawa - One of the best experts on this subject based on the ideXlab platform.

  • organosoluble Starch cellulose binary polymer blend as a quasi solid electrolyte in a dye sensitized solar cell
    Polymers, 2020
    Co-Authors: Vidhya Selvanathan, Hatem Sindi, Majid Nour, Rosiyah Yahya, Mohd Hafidz Ruslan, Kamaruzzaman Sopian, Muhyaddin J. H. Rawa
    Abstract:

    This work is a pioneer attempt to fabricate quasi-solid dye-sensitized solar cell (QSDDSC) based on organosoluble Starch Derivative. Rheological characterizations of the PhSt-HEC blend based gels exhibited viscoelastic properties favorable for electrolyte fabrication. From amplitude sweep and tack test analyses, it was evident that the inclusion of LiI improved the rigidity and tack property of the gels. On the other hand, the opposite was true for TPAI based gels, which resulted in less rigid and tacky electrolytes. The crystallinity of the gels was found to decline with increasing amount of salt in both systems. The highest photoconversion efficiency of 3.94% was recorded upon addition of 12.5 wt % TPAI and this value is one of the highest DSSC performance recorded for Starch based electrolytes. From electrochemical impedance spectroscopy (EIS), it is deduced that the steric hindrance imposed by bulky cations aids in hindering recombination between photoanode and electrolyte.

Fang Dong - One of the best experts on this subject based on the ideXlab platform.

  • design synthesis of novel Starch Derivative bearing 1 2 3 triazolium and pyridinium and evaluation of its antifungal activity
    Carbohydrate Polymers, 2017
    Co-Authors: Wenqiang Tan, Zhenpeng Gao, Shuai Qiu, Fang Dong, Zhanyong Guo
    Abstract:

    Based on cuprous-catalyzed azide-alkyne cycloaddition (CuAAC), Starch Derivative bearing 1,2,3-triazole and pyridine (II) was prepared and subsequently followed by alkylation with iodomethane to synthesize Starch Derivative bearing 1,2,3-triazolium and pyridinium (III). The antifungal activities of Starch Derivatives against Colletotrichum lagenarium, Watermelon fusarium, and Phomopsis asparagi, were then assayed by hypha measurement in vitro. Apparently, Starch Derivatives showed enhanced antifungal activity against three fungi at the tested concentrations compared with Starch. Especially, the best inhibitory index of Starch Derivative (III) against Colletotrichum lagenarium attained 97% above at 1.0mg/mL. Meanwhile, Starch Derivative (III) had stronger antifungal activity than Starch Derivative (II), which was reasonable to propose that the alkylation of 1,2,3-triazole and pyridine was significant for enhanced antifungal activity. As this novel Starch Derivative bearing 1,2,3-triazolium and pyridinium could be prepared efficiently and exhibited superduper antifungal activity, this material might provide an effective way and notion to prepare novel antifungal agents.