The Experts below are selected from a list of 11460 Experts worldwide ranked by ideXlab platform
Timothy P. Carr - One of the best experts on this subject based on the ideXlab platform.
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phytosterol Stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male syrian hamsters
Nutrition Research, 2011Co-Authors: Jiliang Hang, Patrick H. Dussault, Timothy P. CarrAbstract:Abstract The dietary impact of specific phytosterols incorporated into phytosterol fatty acid esters has not been elucidated. Therefore, we tested the hypothesis that phytosterol esters containing different sterol moieties (sitosterol, sitostanol, or stigmasterol) but the same fatty acid moiety (stearic acid) produce different effects on cholesterol metabolism. Male Syrian hamsters were fed sitosterol, sitostanol, and stigmasterol Stearate esters (25 g/kg diet) in an atherogenic diet containing cholesterol (1.2 g/kg) and coconut oil (80 g/kg). The phytosterol Stearates produced no decrease in cholesterol absorption or plasma non–high-density lipoprotein cholesterol despite a reduction in liver free cholesterol in hamsters fed both sitosterol and sitostanol Stearate diets. In addition, sitosterol Stearate significantly increased fecal esterified and total neutral sterol excretion. Stigmasterol Stearate did not differ from control in neutral sterol excretion, plasma lipids, or hepatic lipid concentration. Sitosterol Stearate demonstrated the highest level of net intestinal hydrolysis, whereas sitostanol and stigmasterol Stearate equivalently demonstrated the lowest. The cholesterol-lowering effect in liver—but not plasma—and the limited presence of fecal free sterols indicate that intact (unhydrolyzed) phytosterol Stearates may impact cholesterol metabolism by mechanisms unrelated to the role of free phytosterols. The consumption of phytosterol esters at 2.5% of the diet elicited only modest impacts on cholesterol metabolism, although sitosterol Stearate had a slightly greater therapeutic impact by lowering liver free cholesterol and increasing esterified and total neutral sterol fecal excretion, possibly due to a greater level of intestinal hydrolysis.
Xiuzhi Susan Sun - One of the best experts on this subject based on the ideXlab platform.
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solvent free acid catalyzed ring opening of epoxidized oleochemicals using Stearates stearic acid and its applications
Journal of Agricultural and Food Chemistry, 2012Co-Authors: Byungjun Kollbe Ahn, Stefan Kraft, Xiuzhi Susan SunAbstract:Toxic solvent and strong acid catalysts causing environmental issues have been mainly used for ring-opening of epoxidized oleochemicals. Here, we demonstrated that magnesium Stearate (Mg-Stearate) was a high efficient catalyst for solvent-free ring-opening of epoxidized methyl oleate, a model compound of midchain epoxide. Mg-Stearate resulted in the highest yield (95%) and conversion rate (99%) toward midchain alkoxyesters under the same conditions (160 °C, 12 h) superior to other fatty acid derivatives such as a Lewis acid (lithium and sodium Stearate) and Bronsted acid (stearic acid). Based on this chemical study, we synthesized biogrease and thermoplastic using epoxidized soybean oil (ESO) and Mg-Stearate via one-pot, solvent-free, and purification-free process. Mg-Stearate played a significant role as a reactant for epoxide ring-opening and as a thickener when excess loading rate was used; viscosity increased from 1800 to 4500 Pa·s at 25 °C when ESO:Mg-Stearate increased from 1:1 equiv to 1:2, then behaved like thermoplastics (T(g) = -27 °C, T(m) = 90 °C) with 1:4.
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Solvent-Free Acid-Catalyzed Ring-Opening of Epoxidized Oleochemicals Using Stearates/Stearic Acid, and Its Applications
2012Co-Authors: Byung-jun Kollbe Ahn, Stefan Kraft, Xiuzhi Susan SunAbstract:Toxic solvent and strong acid catalysts causing environmental issues have been mainly used for ring-opening of epoxidized oleochemicals. Here, we demonstrated that magnesium Stearate (Mg-Stearate) was a high efficient catalyst for solvent-free ring-opening of epoxidized methyl oleate, a model compound of midchain epoxide. Mg-Stearate resulted in the highest yield (95%) and conversion rate (99%) toward midchain alkoxyesters under the same conditions (160 °C, 12 h) superior to other fatty acid derivatives such as a Lewis acid (lithium and sodium Stearate) and Brønsted acid (stearic acid). Based on this chemical study, we synthesized biogrease and thermoplastic using epoxidized soybean oil (ESO) and Mg-Stearate via one-pot, solvent-free, and purification-free process. Mg-Stearate played a significant role as a reactant for epoxide ring-opening and as a thickener when excess loading rate was used; viscosity increased from 1800 to 4500 Pa·s at 25 °C when ESO:Mg-Stearate increased from 1:1 equiv to 1:2, then behaved like thermoplastics (Tg = −27 °C, Tm = 90 °C) with 1:4
Jiliang Hang - One of the best experts on this subject based on the ideXlab platform.
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phytosterol Stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male syrian hamsters
Nutrition Research, 2011Co-Authors: Jiliang Hang, Patrick H. Dussault, Timothy P. CarrAbstract:Abstract The dietary impact of specific phytosterols incorporated into phytosterol fatty acid esters has not been elucidated. Therefore, we tested the hypothesis that phytosterol esters containing different sterol moieties (sitosterol, sitostanol, or stigmasterol) but the same fatty acid moiety (stearic acid) produce different effects on cholesterol metabolism. Male Syrian hamsters were fed sitosterol, sitostanol, and stigmasterol Stearate esters (25 g/kg diet) in an atherogenic diet containing cholesterol (1.2 g/kg) and coconut oil (80 g/kg). The phytosterol Stearates produced no decrease in cholesterol absorption or plasma non–high-density lipoprotein cholesterol despite a reduction in liver free cholesterol in hamsters fed both sitosterol and sitostanol Stearate diets. In addition, sitosterol Stearate significantly increased fecal esterified and total neutral sterol excretion. Stigmasterol Stearate did not differ from control in neutral sterol excretion, plasma lipids, or hepatic lipid concentration. Sitosterol Stearate demonstrated the highest level of net intestinal hydrolysis, whereas sitostanol and stigmasterol Stearate equivalently demonstrated the lowest. The cholesterol-lowering effect in liver—but not plasma—and the limited presence of fecal free sterols indicate that intact (unhydrolyzed) phytosterol Stearates may impact cholesterol metabolism by mechanisms unrelated to the role of free phytosterols. The consumption of phytosterol esters at 2.5% of the diet elicited only modest impacts on cholesterol metabolism, although sitosterol Stearate had a slightly greater therapeutic impact by lowering liver free cholesterol and increasing esterified and total neutral sterol fecal excretion, possibly due to a greater level of intestinal hydrolysis.
Patrick H. Dussault - One of the best experts on this subject based on the ideXlab platform.
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phytosterol Stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male syrian hamsters
Nutrition Research, 2011Co-Authors: Jiliang Hang, Patrick H. Dussault, Timothy P. CarrAbstract:Abstract The dietary impact of specific phytosterols incorporated into phytosterol fatty acid esters has not been elucidated. Therefore, we tested the hypothesis that phytosterol esters containing different sterol moieties (sitosterol, sitostanol, or stigmasterol) but the same fatty acid moiety (stearic acid) produce different effects on cholesterol metabolism. Male Syrian hamsters were fed sitosterol, sitostanol, and stigmasterol Stearate esters (25 g/kg diet) in an atherogenic diet containing cholesterol (1.2 g/kg) and coconut oil (80 g/kg). The phytosterol Stearates produced no decrease in cholesterol absorption or plasma non–high-density lipoprotein cholesterol despite a reduction in liver free cholesterol in hamsters fed both sitosterol and sitostanol Stearate diets. In addition, sitosterol Stearate significantly increased fecal esterified and total neutral sterol excretion. Stigmasterol Stearate did not differ from control in neutral sterol excretion, plasma lipids, or hepatic lipid concentration. Sitosterol Stearate demonstrated the highest level of net intestinal hydrolysis, whereas sitostanol and stigmasterol Stearate equivalently demonstrated the lowest. The cholesterol-lowering effect in liver—but not plasma—and the limited presence of fecal free sterols indicate that intact (unhydrolyzed) phytosterol Stearates may impact cholesterol metabolism by mechanisms unrelated to the role of free phytosterols. The consumption of phytosterol esters at 2.5% of the diet elicited only modest impacts on cholesterol metabolism, although sitosterol Stearate had a slightly greater therapeutic impact by lowering liver free cholesterol and increasing esterified and total neutral sterol fecal excretion, possibly due to a greater level of intestinal hydrolysis.
Byungjun Kollbe Ahn - One of the best experts on this subject based on the ideXlab platform.
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solvent free acid catalyzed ring opening of epoxidized oleochemicals using Stearates stearic acid and its applications
Journal of Agricultural and Food Chemistry, 2012Co-Authors: Byungjun Kollbe Ahn, Stefan Kraft, Xiuzhi Susan SunAbstract:Toxic solvent and strong acid catalysts causing environmental issues have been mainly used for ring-opening of epoxidized oleochemicals. Here, we demonstrated that magnesium Stearate (Mg-Stearate) was a high efficient catalyst for solvent-free ring-opening of epoxidized methyl oleate, a model compound of midchain epoxide. Mg-Stearate resulted in the highest yield (95%) and conversion rate (99%) toward midchain alkoxyesters under the same conditions (160 °C, 12 h) superior to other fatty acid derivatives such as a Lewis acid (lithium and sodium Stearate) and Bronsted acid (stearic acid). Based on this chemical study, we synthesized biogrease and thermoplastic using epoxidized soybean oil (ESO) and Mg-Stearate via one-pot, solvent-free, and purification-free process. Mg-Stearate played a significant role as a reactant for epoxide ring-opening and as a thickener when excess loading rate was used; viscosity increased from 1800 to 4500 Pa·s at 25 °C when ESO:Mg-Stearate increased from 1:1 equiv to 1:2, then behaved like thermoplastics (T(g) = -27 °C, T(m) = 90 °C) with 1:4.
