The Experts below are selected from a list of 59799 Experts worldwide ranked by ideXlab platform
Sara Cadecco - One of the best experts on this subject based on the ideXlab platform.
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a specific ptprc cd45 phosphorylation event governed by Stem Cell chemokine cxcl12 regulates primitive hematopoietic Cell motility
Molecular & Cellular Proteomics, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Mark Aspinallodea, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.
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A Specific PTPRC/CD45 Phosphorylation Event Governed by Stem Cell Chemokine CXCL12 Regulates Primitive Hematopoietic Cell Motility
Molecular & cellular proteomics : MCP, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Mark Aspinall-o'dea, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.
Andrew J. K. Williamson - One of the best experts on this subject based on the ideXlab platform.
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a specific ptprc cd45 phosphorylation event governed by Stem Cell chemokine cxcl12 regulates primitive hematopoietic Cell motility
Molecular & Cellular Proteomics, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Mark Aspinallodea, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.
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A Specific PTPRC/CD45 Phosphorylation Event Governed by Stem Cell Chemokine CXCL12 Regulates Primitive Hematopoietic Cell Motility
Molecular & cellular proteomics : MCP, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Mark Aspinall-o'dea, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.
Ewa Jaworska - One of the best experts on this subject based on the ideXlab platform.
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a specific ptprc cd45 phosphorylation event governed by Stem Cell chemokine cxcl12 regulates primitive hematopoietic Cell motility
Molecular & Cellular Proteomics, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Mark Aspinallodea, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.
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A Specific PTPRC/CD45 Phosphorylation Event Governed by Stem Cell Chemokine CXCL12 Regulates Primitive Hematopoietic Cell Motility
Molecular & cellular proteomics : MCP, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Mark Aspinall-o'dea, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.
Cong Zhou - One of the best experts on this subject based on the ideXlab platform.
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a specific ptprc cd45 phosphorylation event governed by Stem Cell chemokine cxcl12 regulates primitive hematopoietic Cell motility
Molecular & Cellular Proteomics, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Mark Aspinallodea, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.
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A Specific PTPRC/CD45 Phosphorylation Event Governed by Stem Cell Chemokine CXCL12 Regulates Primitive Hematopoietic Cell Motility
Molecular & cellular proteomics : MCP, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Mark Aspinall-o'dea, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.
Lee Lancashire - One of the best experts on this subject based on the ideXlab platform.
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a specific ptprc cd45 phosphorylation event governed by Stem Cell chemokine cxcl12 regulates primitive hematopoietic Cell motility
Molecular & Cellular Proteomics, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Mark Aspinallodea, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.
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A Specific PTPRC/CD45 Phosphorylation Event Governed by Stem Cell Chemokine CXCL12 Regulates Primitive Hematopoietic Cell Motility
Molecular & cellular proteomics : MCP, 2013Co-Authors: Andrew J. K. Williamson, Andrew Pierce, Ewa Jaworska, Cong Zhou, Mark Aspinall-o'dea, Lee Lancashire, Richard D. Unwin, Sheela A. Abraham, Michael J. Walker, Sara CadeccoAbstract:CXCL12 governs Cellular motility, a process deregulated by hematopoietic Stem Cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor Cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for Regulation of Stem Cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of Stem Cell Regulation. We also identified a novel phosphorylation event in hematopoietic progenitor Cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor Cell and lymphoid Cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing Cells. The use of discovery proteomics has enabled further understanding of the Regulation of PTPRC/CD45 and its important role in Cellular motility in progenitor Cells.