The Experts below are selected from a list of 27516 Experts worldwide ranked by ideXlab platform

Marc G. Jeschke - One of the best experts on this subject based on the ideXlab platform.

  • Stem Cell Therapy: A New Treatment for Burns?
    Pharmaceuticals, 2011
    Co-Authors: Anna Arno, Gerd G. Gauglitz, Alexandra H. Smith, Patrick H. Blit, Mohammed Al Shehab, Marc G. Jeschke
    Abstract:

    Stem Cell Therapy has emerged as a promising new approach in almost every medicine specialty. This vast, heterogeneous family of Cells are now both naturally (embryonic and adult Stem Cells) or artificially obtained (induced pluripotent Stem Cells or iPSCs) and their fates have become increasingly controllable, thanks to ongoing research in this passionate new field. We are at the beginning of a new era in medicine, with multiple applications for Stem Cell Therapy, not only as a monoTherapy, but also as an adjunct to other strategies, such as organ transplantation or standard drug treatment. Regrettably, serious preclinical concerns remain and differentiation, Cell fusion, senescence and signalling crosstalk with growth factors and biomaterials are still challenges for this promising multidisciplinary therapeutic modality. Severe burns have several indications for Stem Cell Therapy, including enhancement of wound healing, replacement of damaged skin and perfect skin regeneration – incorporating skin appendages and reduced fibrosis –, as well as syStemic effects, such as inflammation, hypermetabolism and immunosuppression. The aim of this review is to describe well established characteristics of Stem Cells and to delineate new advances in the Stem Cell field, in the context of burn injury and wound healing.

  • a review of gene and Stem Cell Therapy in cutaneous wound healing
    Burns, 2009
    Co-Authors: Ludwik K. Branski, Gerd G. Gauglitz, David N Herndon, Marc G. Jeschke
    Abstract:

    Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and Stem Cell Therapy in wound healing. Gene Therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery syStems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult Stem Cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate Stem Cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and Stem Cell Therapy has emerged as a promising approach for treatment of chronic and acute wounds.

  • A review of gene and Stem Cell Therapy in cutaneous wound healing
    Burns, 2009
    Co-Authors: Ludwik K. Branski, Gerd G. Gauglitz, David N Herndon, Marc G. Jeschke
    Abstract:

    Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and Stem Cell Therapy in wound healing. Gene Therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery syStems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult Stem Cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate Stem Cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and Stem Cell Therapy has emerged as a promising approach for treatment of chronic and acute wounds. © 2008 Elsevier Ltd and ISBI.

Ludwik K. Branski - One of the best experts on this subject based on the ideXlab platform.

  • a review of gene and Stem Cell Therapy in cutaneous wound healing
    Burns, 2009
    Co-Authors: Ludwik K. Branski, Gerd G. Gauglitz, David N Herndon, Marc G. Jeschke
    Abstract:

    Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and Stem Cell Therapy in wound healing. Gene Therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery syStems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult Stem Cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate Stem Cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and Stem Cell Therapy has emerged as a promising approach for treatment of chronic and acute wounds.

  • A review of gene and Stem Cell Therapy in cutaneous wound healing
    Burns, 2009
    Co-Authors: Ludwik K. Branski, Gerd G. Gauglitz, David N Herndon, Marc G. Jeschke
    Abstract:

    Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and Stem Cell Therapy in wound healing. Gene Therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery syStems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult Stem Cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate Stem Cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and Stem Cell Therapy has emerged as a promising approach for treatment of chronic and acute wounds. © 2008 Elsevier Ltd and ISBI.

Mathias Vrolix - One of the best experts on this subject based on the ideXlab platform.

Gerd G. Gauglitz - One of the best experts on this subject based on the ideXlab platform.

  • Stem Cell Therapy: A New Treatment for Burns?
    Pharmaceuticals, 2011
    Co-Authors: Anna Arno, Gerd G. Gauglitz, Alexandra H. Smith, Patrick H. Blit, Mohammed Al Shehab, Marc G. Jeschke
    Abstract:

    Stem Cell Therapy has emerged as a promising new approach in almost every medicine specialty. This vast, heterogeneous family of Cells are now both naturally (embryonic and adult Stem Cells) or artificially obtained (induced pluripotent Stem Cells or iPSCs) and their fates have become increasingly controllable, thanks to ongoing research in this passionate new field. We are at the beginning of a new era in medicine, with multiple applications for Stem Cell Therapy, not only as a monoTherapy, but also as an adjunct to other strategies, such as organ transplantation or standard drug treatment. Regrettably, serious preclinical concerns remain and differentiation, Cell fusion, senescence and signalling crosstalk with growth factors and biomaterials are still challenges for this promising multidisciplinary therapeutic modality. Severe burns have several indications for Stem Cell Therapy, including enhancement of wound healing, replacement of damaged skin and perfect skin regeneration – incorporating skin appendages and reduced fibrosis –, as well as syStemic effects, such as inflammation, hypermetabolism and immunosuppression. The aim of this review is to describe well established characteristics of Stem Cells and to delineate new advances in the Stem Cell field, in the context of burn injury and wound healing.

  • a review of gene and Stem Cell Therapy in cutaneous wound healing
    Burns, 2009
    Co-Authors: Ludwik K. Branski, Gerd G. Gauglitz, David N Herndon, Marc G. Jeschke
    Abstract:

    Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and Stem Cell Therapy in wound healing. Gene Therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery syStems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult Stem Cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate Stem Cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and Stem Cell Therapy has emerged as a promising approach for treatment of chronic and acute wounds.

  • A review of gene and Stem Cell Therapy in cutaneous wound healing
    Burns, 2009
    Co-Authors: Ludwik K. Branski, Gerd G. Gauglitz, David N Herndon, Marc G. Jeschke
    Abstract:

    Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and Stem Cell Therapy in wound healing. Gene Therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery syStems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult Stem Cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate Stem Cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and Stem Cell Therapy has emerged as a promising approach for treatment of chronic and acute wounds. © 2008 Elsevier Ltd and ISBI.

David N Herndon - One of the best experts on this subject based on the ideXlab platform.

  • a review of gene and Stem Cell Therapy in cutaneous wound healing
    Burns, 2009
    Co-Authors: Ludwik K. Branski, Gerd G. Gauglitz, David N Herndon, Marc G. Jeschke
    Abstract:

    Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and Stem Cell Therapy in wound healing. Gene Therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery syStems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult Stem Cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate Stem Cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and Stem Cell Therapy has emerged as a promising approach for treatment of chronic and acute wounds.

  • A review of gene and Stem Cell Therapy in cutaneous wound healing
    Burns, 2009
    Co-Authors: Ludwik K. Branski, Gerd G. Gauglitz, David N Herndon, Marc G. Jeschke
    Abstract:

    Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and Stem Cell Therapy in wound healing. Gene Therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery syStems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult Stem Cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate Stem Cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and Stem Cell Therapy has emerged as a promising approach for treatment of chronic and acute wounds. © 2008 Elsevier Ltd and ISBI.