The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Colombo Lorenzo - One of the best experts on this subject based on the ideXlab platform.
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Extraglandular hormonal Steroidogenesis in aged rats.
'Elsevier BV', 1992Co-Authors: Dalla Valle Luisa, Belvedere Paola, Simontacchi Claudia, Colombo LorenzoAbstract:We have examined the metabolisM in Vitro of [4-C-14]pregnenolone by the following organs of 2.4-year-old rats: submandibular gland, stomach, duodenum, liver, lung, heart, spleen, kidney, skin, prostate, testis and adrenal. All tissues converted pregnenolone to progesterone, the highest yields being observed with adrenal, testis and skin. Androgen formation was intense in the testis and absent in the adrenal. Moreover, 17alpha-hydroxylation of pregnenolone occurred moderately in kidney, skin and submandibular gland and markedly in duodenum and stomach, which also produced high amounts of dehydroepiandrosterone and/or 5-androstene-3beta,17beta-diol. Extratesticular synthesis of androstenedione and testosterone was very low. A significant formation of 20alpha-dihydropregnenolone was observed in all tissues but stomach, duodenum and Steroidogenic endocrines. CorticoSteroids were not synthesized extraadrenally, except a small amount of 11-deoxycorticosterone in the testis. These results indicate that key Steroid-biosynthetic enzymes, such as 3beta-hydroxySteroid dehydrogenase/DELTA5-DELTA4 isomerase, 17beta- and 20alpha-hydroxySteroid dehydrogenases and Steroid 17alpha-Monooxygenase/17,20-lyase are also expressed extraglandularly in the rat
Dalla Valle Luisa - One of the best experts on this subject based on the ideXlab platform.
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Extraglandular hormonal Steroidogenesis in aged rats.
'Elsevier BV', 1992Co-Authors: Dalla Valle Luisa, Belvedere Paola, Simontacchi Claudia, Colombo LorenzoAbstract:We have examined the metabolisM in Vitro of [4-C-14]pregnenolone by the following organs of 2.4-year-old rats: submandibular gland, stomach, duodenum, liver, lung, heart, spleen, kidney, skin, prostate, testis and adrenal. All tissues converted pregnenolone to progesterone, the highest yields being observed with adrenal, testis and skin. Androgen formation was intense in the testis and absent in the adrenal. Moreover, 17alpha-hydroxylation of pregnenolone occurred moderately in kidney, skin and submandibular gland and markedly in duodenum and stomach, which also produced high amounts of dehydroepiandrosterone and/or 5-androstene-3beta,17beta-diol. Extratesticular synthesis of androstenedione and testosterone was very low. A significant formation of 20alpha-dihydropregnenolone was observed in all tissues but stomach, duodenum and Steroidogenic endocrines. CorticoSteroids were not synthesized extraadrenally, except a small amount of 11-deoxycorticosterone in the testis. These results indicate that key Steroid-biosynthetic enzymes, such as 3beta-hydroxySteroid dehydrogenase/DELTA5-DELTA4 isomerase, 17beta- and 20alpha-hydroxySteroid dehydrogenases and Steroid 17alpha-Monooxygenase/17,20-lyase are also expressed extraglandularly in the rat
Belvedere Paola - One of the best experts on this subject based on the ideXlab platform.
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Extraglandular hormonal Steroidogenesis in aged rats.
'Elsevier BV', 1992Co-Authors: Dalla Valle Luisa, Belvedere Paola, Simontacchi Claudia, Colombo LorenzoAbstract:We have examined the metabolisM in Vitro of [4-C-14]pregnenolone by the following organs of 2.4-year-old rats: submandibular gland, stomach, duodenum, liver, lung, heart, spleen, kidney, skin, prostate, testis and adrenal. All tissues converted pregnenolone to progesterone, the highest yields being observed with adrenal, testis and skin. Androgen formation was intense in the testis and absent in the adrenal. Moreover, 17alpha-hydroxylation of pregnenolone occurred moderately in kidney, skin and submandibular gland and markedly in duodenum and stomach, which also produced high amounts of dehydroepiandrosterone and/or 5-androstene-3beta,17beta-diol. Extratesticular synthesis of androstenedione and testosterone was very low. A significant formation of 20alpha-dihydropregnenolone was observed in all tissues but stomach, duodenum and Steroidogenic endocrines. CorticoSteroids were not synthesized extraadrenally, except a small amount of 11-deoxycorticosterone in the testis. These results indicate that key Steroid-biosynthetic enzymes, such as 3beta-hydroxySteroid dehydrogenase/DELTA5-DELTA4 isomerase, 17beta- and 20alpha-hydroxySteroid dehydrogenases and Steroid 17alpha-Monooxygenase/17,20-lyase are also expressed extraglandularly in the rat
Simontacchi Claudia - One of the best experts on this subject based on the ideXlab platform.
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Extraglandular hormonal Steroidogenesis in aged rats.
'Elsevier BV', 1992Co-Authors: Dalla Valle Luisa, Belvedere Paola, Simontacchi Claudia, Colombo LorenzoAbstract:We have examined the metabolisM in Vitro of [4-C-14]pregnenolone by the following organs of 2.4-year-old rats: submandibular gland, stomach, duodenum, liver, lung, heart, spleen, kidney, skin, prostate, testis and adrenal. All tissues converted pregnenolone to progesterone, the highest yields being observed with adrenal, testis and skin. Androgen formation was intense in the testis and absent in the adrenal. Moreover, 17alpha-hydroxylation of pregnenolone occurred moderately in kidney, skin and submandibular gland and markedly in duodenum and stomach, which also produced high amounts of dehydroepiandrosterone and/or 5-androstene-3beta,17beta-diol. Extratesticular synthesis of androstenedione and testosterone was very low. A significant formation of 20alpha-dihydropregnenolone was observed in all tissues but stomach, duodenum and Steroidogenic endocrines. CorticoSteroids were not synthesized extraadrenally, except a small amount of 11-deoxycorticosterone in the testis. These results indicate that key Steroid-biosynthetic enzymes, such as 3beta-hydroxySteroid dehydrogenase/DELTA5-DELTA4 isomerase, 17beta- and 20alpha-hydroxySteroid dehydrogenases and Steroid 17alpha-Monooxygenase/17,20-lyase are also expressed extraglandularly in the rat