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Prabhanjan M - One of the best experts on this subject based on the ideXlab platform.

  • Steven Johnson Syndrome: Adverse Drug Reaction
    Journal of general practice, 2018
    Co-Authors: Chandaluri P, Prabhanjan M
    Abstract:

    The Steven-Johnson Syndrome (SJS) is a rare immune complex mediated hypersensitivity condition. Here we report the case of Steven-Johnson Syndrome due to the co-administration of aceclofenac and cefixime. NSAIDs are the rare type of medication that causes SJS and cefixime is a traditional medication that causes the condition. A 22- years-old patient was admitted in the hospital with a complaint of fever for 15 days and he was treated by giving aceclofenac, cefixime and general symptomatic treatment. On the 4th day of treatment erythromatous patches were observed throughout the body. Laboratory investigations were performed and the case was identified as Steven-Johnson Syndrome. The treatment was withdrawn and he was administered with steroids, amoxicillin, metronidazole and general symptomatic treatment. The patient has recovered after a week.

Druva Kumar B. Rangappa - One of the best experts on this subject based on the ideXlab platform.

  • Steven-Johnson Syndrome due to ayurvedic drugs
    Indian Journal of Pharmacology, 2012
    Co-Authors: Raghu Prasada M. Shivamurthy, Ravindra Kallappa, Shashikala G. H. Reddy, Druva Kumar B. Rangappa
    Abstract:

    Steven-Johnson Syndrome may be considered as a cytotoxic immune reaction to drugs, infections etc. This is a case report of Steven-Johnson Syndrome due to an ayurvedic preparation which was used in the treatment of mental retardation in a young girl.

  • Steven-Johnson Syndrome due to unknown drugs [corrected].
    Indian journal of pharmacology, 2012
    Co-Authors: Raghu Prasada M. Shivamurthy, Ravindra Kallappa, Shashikala G. H. Reddy, Druva Kumar B. Rangappa
    Abstract:

    Steven-Johnson Syndrome may be considered as a cytotoxic immune reaction to drugs, infections etc. This is a case report of Steven-Johnson Syndrome due to an ayurvedic preparation which was used in the treatment of mental retardation in a young girl.

Shailendra Verma - One of the best experts on this subject based on the ideXlab platform.

  • Tamoxifen-associated skin reactions in breast cancer patients: from case report to literature review
    Breast Cancer Research and Treatment, 2014
    Co-Authors: Peter Andrew, Sabira Valiani, Jennifer Macisaac, Hamid Mithoowani, Shailendra Verma
    Abstract:

    The purpose of this study was to firstly present the maiden case of tamoxifen-induced acute cutaneous lupus erythematosus (ACLE), and secondly, to broaden the discussion into a systematic review of the various tamoxifen-related skin changes documented in patients with breast cancer. We searched PubMed, Cochrane, Embase, CancerLit, Scopus, Web of Science, and Google Scholar databases using keywords to identify reported cases of tamoxifen-related cutaneous adverse events. Outcomes captured included type of cutaneous reaction, time to adverse event, pathologic mechanism, and possible treatment. From 17 clinical studies identified, over ten distinct types of adverse reactions of the skin were itemized. The character of these cutaneous events ranged from the relatively common hot flashes to the rare, but potentially life-threatening, Steven Johnson Syndrome. Overall, tamoxifen is generally a well-tolerated hormone therapy with decades of supporting safety data. Based on current medical literature, we present the first case of tamoxifen-induced ACLE. Our clinical experience of managing this case revealed that despite its broad use and the frequency of associated skin reactions, there is a lack of concise information detailing the cutaneous adverse events associated with tamoxifen. The absence of summarized information concerning tamoxifen-related skin changes prompted us to perform a review herein.

Chandaluri P - One of the best experts on this subject based on the ideXlab platform.

  • Steven Johnson Syndrome: Adverse Drug Reaction
    Journal of general practice, 2018
    Co-Authors: Chandaluri P, Prabhanjan M
    Abstract:

    The Steven-Johnson Syndrome (SJS) is a rare immune complex mediated hypersensitivity condition. Here we report the case of Steven-Johnson Syndrome due to the co-administration of aceclofenac and cefixime. NSAIDs are the rare type of medication that causes SJS and cefixime is a traditional medication that causes the condition. A 22- years-old patient was admitted in the hospital with a complaint of fever for 15 days and he was treated by giving aceclofenac, cefixime and general symptomatic treatment. On the 4th day of treatment erythromatous patches were observed throughout the body. Laboratory investigations were performed and the case was identified as Steven-Johnson Syndrome. The treatment was withdrawn and he was administered with steroids, amoxicillin, metronidazole and general symptomatic treatment. The patient has recovered after a week.

Philip R Cohen - One of the best experts on this subject based on the ideXlab platform.

  • fixed drug eruption to supplement containing ginkgo biloba and vinpocetine a case report and review of related cutaneous side effects
    The Journal of clinical and aesthetic dermatology, 2017
    Co-Authors: Philip R Cohen
    Abstract:

    : BACKGROUND: Fixed drug eruption is a cutaneous reaction to a systemic agent that typically presents as an annular or oval erythematous patch or blister and subsequently resolves with postinflammatory hyperpigmentation at the site. Ginkgo biloba leaf extract and vinpocetine are nutritional supplements used to enhance memory in patients with dementia and age-related memory impairment conditions such as Alzheimer's disease. PURPOSE: To describe a fixed drug eruption in a man who repeatedly developed pruritus and macular erythema on his distal penile shaft after ingesting a natural product containing Ginkgo biloba and vinpocetine. METHODS: The medical literature was retrospectively reviewed using PubMed, searching specifically for the terms cutaneous/skin adverse/side effects, fixed drug eruption, Ginkgo biloba, and vinpocetine. Patient reports and previous reviews of the subject were critically assessed, and the salient features of cutaneous adverse effects in patients receiving either Ginkgo biloba or vinpocetine are presented. RESULTS: Cutaneous adverse effects from Ginkgo biloba and vinpocetine are infrequent. Ginkgo biloba fruit can result in contact dermatitis (following topical exposure) and mucosal symptoms of the mouth and anus (following oral exposure); in addition, an erythematous maculopapular generalized eruption or possibly Steven-Johnson Syndrome can occur after oral ingestion of the Ginkgo biloba leaf extract. Facial erythema has been associated with vinpocetine ingestion. Pruritus and an annular erythema localized to the distal penile shaft developed after initial and repeat ingestion of a Ginkgo biloba/vinpocetine product. CONCLUSION:Ginkgo biloba and vinpocetine should be added to the agents that can potentially cause a fixed drug eruption.