The Experts below are selected from a list of 1863 Experts worldwide ranked by ideXlab platform
Fuqiang Jin - One of the best experts on this subject based on the ideXlab platform.
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Facile conversion of trifluoroacetyltriphenylsilane 2,4,6-triisepropylbenzenesulfonylhydrazone to 2,2,2-trifluorodiazoethane. An unusual example of the bamford-Stevens Reaction
1992Co-Authors: Fuqiang JinAbstract:Abstract Trifluoroacetyltriphenylsilane 2,4,6-triisepropylbenzenesulfonylhydrazone( 1 ) reacted with dipolarophiles in the presence of Et 3 N to produce trifluorcmethylated pyrazoles or pyrazolines in good yields. The Reaction was found to proceed through the intermediacy of 2,2,2-trifluorodiazoethane, and this unusual co)nversion of 1 to 2,2,2-trifluorodiazoethane was studied from the mechanistic viewpoint.
Tohru Fukuyama - One of the best experts on this subject based on the ideXlab platform.
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modified mcfadyen Stevens Reaction for a versatile synthesis of aliphatic aromatic aldehydes design optimization and mechanistic investigations
2013Co-Authors: Yuri Iwai, Takashi J Ozaki, Ryo Takita, Masanobu Uchiyama, Jun Shimokawa, Tohru FukuyamaAbstract:The traditional McFadyen–Stevens Reaction requires harsh alkaline Reaction conditions, thus precluding application to the synthesis of aliphatic aldehydes. Our modified McFadyen–Stevens Reaction enables the transformation from the N,N-acylsulfonyl hydrazine to the corresponding aldehyde upon treatment with an imidazole–TMS imidazole combination without relying on oxidative or reductive reagents. The reduced basicity and in situ protection of the resulting aldehyde widens the substrate scope to include aliphatic aldehydes, even ones bearing an α-hydrogen atom. Close examination of the side Reactions for particular substrates in combination with theoretical considerations via DFT calculations led to a mechanistic understanding of the McFadyen–Stevens Reaction involving an acyl diazene and a hydroxy carbene as reasonable intermediates.
Yuri Iwai - One of the best experts on this subject based on the ideXlab platform.
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modified mcfadyen Stevens Reaction for a versatile synthesis of aliphatic aromatic aldehydes design optimization and mechanistic investigations
2013Co-Authors: Yuri Iwai, Takashi J Ozaki, Ryo Takita, Masanobu Uchiyama, Jun Shimokawa, Tohru FukuyamaAbstract:The traditional McFadyen–Stevens Reaction requires harsh alkaline Reaction conditions, thus precluding application to the synthesis of aliphatic aldehydes. Our modified McFadyen–Stevens Reaction enables the transformation from the N,N-acylsulfonyl hydrazine to the corresponding aldehyde upon treatment with an imidazole–TMS imidazole combination without relying on oxidative or reductive reagents. The reduced basicity and in situ protection of the resulting aldehyde widens the substrate scope to include aliphatic aldehydes, even ones bearing an α-hydrogen atom. Close examination of the side Reactions for particular substrates in combination with theoretical considerations via DFT calculations led to a mechanistic understanding of the McFadyen–Stevens Reaction involving an acyl diazene and a hydroxy carbene as reasonable intermediates.
Takashi J Ozaki - One of the best experts on this subject based on the ideXlab platform.
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modified mcfadyen Stevens Reaction for a versatile synthesis of aliphatic aromatic aldehydes design optimization and mechanistic investigations
2013Co-Authors: Yuri Iwai, Takashi J Ozaki, Ryo Takita, Masanobu Uchiyama, Jun Shimokawa, Tohru FukuyamaAbstract:The traditional McFadyen–Stevens Reaction requires harsh alkaline Reaction conditions, thus precluding application to the synthesis of aliphatic aldehydes. Our modified McFadyen–Stevens Reaction enables the transformation from the N,N-acylsulfonyl hydrazine to the corresponding aldehyde upon treatment with an imidazole–TMS imidazole combination without relying on oxidative or reductive reagents. The reduced basicity and in situ protection of the resulting aldehyde widens the substrate scope to include aliphatic aldehydes, even ones bearing an α-hydrogen atom. Close examination of the side Reactions for particular substrates in combination with theoretical considerations via DFT calculations led to a mechanistic understanding of the McFadyen–Stevens Reaction involving an acyl diazene and a hydroxy carbene as reasonable intermediates.
Jun Shimokawa - One of the best experts on this subject based on the ideXlab platform.
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modified mcfadyen Stevens Reaction for a versatile synthesis of aliphatic aromatic aldehydes design optimization and mechanistic investigations
2013Co-Authors: Yuri Iwai, Takashi J Ozaki, Ryo Takita, Masanobu Uchiyama, Jun Shimokawa, Tohru FukuyamaAbstract:The traditional McFadyen–Stevens Reaction requires harsh alkaline Reaction conditions, thus precluding application to the synthesis of aliphatic aldehydes. Our modified McFadyen–Stevens Reaction enables the transformation from the N,N-acylsulfonyl hydrazine to the corresponding aldehyde upon treatment with an imidazole–TMS imidazole combination without relying on oxidative or reductive reagents. The reduced basicity and in situ protection of the resulting aldehyde widens the substrate scope to include aliphatic aldehydes, even ones bearing an α-hydrogen atom. Close examination of the side Reactions for particular substrates in combination with theoretical considerations via DFT calculations led to a mechanistic understanding of the McFadyen–Stevens Reaction involving an acyl diazene and a hydroxy carbene as reasonable intermediates.