The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform
Lynn L C Jeffers - One of the best experts on this subject based on the ideXlab platform.
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lymphangiosarcoma stewart treves Syndrome in postmastectomy patients
Journal of Hand Surgery (European Volume), 2000Co-Authors: Kevin C. Chung, Lynn L C JeffersAbstract:Abstract Stewart-Treves Syndrome (STS) is a rare but aggressive upper extremity lymphangiosarcoma in postmastectomy patients. Unfamiliarity with this disease and the innocuous appearance of the tumor often lead to delayed diagnosis. A comprehensive search of the databases at a single tertiary-care academic institution revealed only 3 cases of STS in the last 63 years. The latency time between breast cancer treatment and diagnosis of STS was 11 to 21 years. Survival after diagnosis of STS ranged from 8 to 15 months. One patient underwent radical surgery. The extensive lymphangiosarcoma in the other 2 patients precluded surgical resection and they underwent chemotherapy. All patients had adjuvant radiation therapy at the time of the original breast cancer resection. This report includes a discussion of the epidemiology, etiology, presentation, treatment, and prognosis of STS. (J Hand Surg 2000;25A:1163-1168. Copyright © 2000 by the American Society for Surgery of the Hand.)
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Lymphangiosarcoma (Stewart-Treves Syndrome) in postmastectomy patients
The Journal of hand surgery, 2000Co-Authors: Kevin C. Chung, Huyi Jin Elizabeth Kim, Lynn L C JeffersAbstract:Stewart-Treves Syndrome (STS) is a rare but aggressive upper extremity lymphangiosarcoma in postmastectomy patients. Unfamiliarity with this disease and the innocuous appearance of the tumor often lead to delayed diagnosis. A comprehensive search of the databases at a single tertiary-care academic institution revealed only 3 cases of STS in the last 63 years. The latency time between breast cancer treatment and diagnosis of STS was 11 to 21 years. Survival after diagnosis of STS ranged from 8 to 15 months. One patient underwent radical surgery. The extensive lymphangiosarcoma in the other 2 patients precluded surgical resection and they underwent chemotherapy. All patients had adjuvant radiation therapy at the time of the original breast cancer resection. This report includes a discussion of the epidemiology, etiology, presentation, treatment, and prognosis of STS.
Kevin C. Chung - One of the best experts on this subject based on the ideXlab platform.
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lymphangiosarcoma stewart treves Syndrome in postmastectomy patients
Journal of Hand Surgery (European Volume), 2000Co-Authors: Kevin C. Chung, Lynn L C JeffersAbstract:Abstract Stewart-Treves Syndrome (STS) is a rare but aggressive upper extremity lymphangiosarcoma in postmastectomy patients. Unfamiliarity with this disease and the innocuous appearance of the tumor often lead to delayed diagnosis. A comprehensive search of the databases at a single tertiary-care academic institution revealed only 3 cases of STS in the last 63 years. The latency time between breast cancer treatment and diagnosis of STS was 11 to 21 years. Survival after diagnosis of STS ranged from 8 to 15 months. One patient underwent radical surgery. The extensive lymphangiosarcoma in the other 2 patients precluded surgical resection and they underwent chemotherapy. All patients had adjuvant radiation therapy at the time of the original breast cancer resection. This report includes a discussion of the epidemiology, etiology, presentation, treatment, and prognosis of STS. (J Hand Surg 2000;25A:1163-1168. Copyright © 2000 by the American Society for Surgery of the Hand.)
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Lymphangiosarcoma (Stewart-Treves Syndrome) in postmastectomy patients
The Journal of hand surgery, 2000Co-Authors: Kevin C. Chung, Huyi Jin Elizabeth Kim, Lynn L C JeffersAbstract:Stewart-Treves Syndrome (STS) is a rare but aggressive upper extremity lymphangiosarcoma in postmastectomy patients. Unfamiliarity with this disease and the innocuous appearance of the tumor often lead to delayed diagnosis. A comprehensive search of the databases at a single tertiary-care academic institution revealed only 3 cases of STS in the last 63 years. The latency time between breast cancer treatment and diagnosis of STS was 11 to 21 years. Survival after diagnosis of STS ranged from 8 to 15 months. One patient underwent radical surgery. The extensive lymphangiosarcoma in the other 2 patients precluded surgical resection and they underwent chemotherapy. All patients had adjuvant radiation therapy at the time of the original breast cancer resection. This report includes a discussion of the epidemiology, etiology, presentation, treatment, and prognosis of STS.
Zhong Dingrong - One of the best experts on this subject based on the ideXlab platform.
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Angiosarcoma (Stewart-Treves Syndrome) in postmastectomy patients: report of 10 cases and review of literature
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015Co-Authors: Cui Lifang, Zhang Jixin, Zhang Xinmin, Chang Hong, Qu Congling, Zhang Jiangying, Zhong DingrongAbstract:Aims: To study the clinicopathologic features of Stewart-Treves Syndrome (STS) in postmastectomy patients including the epidemiology, presentation, morphology, differentiation, pathogenesis and therapeutic options. Methods and results: Ten cases of STS in postmastectomy patients were retrospectively identified in our archives, and immunohistochemistry for CD34, CD31, D2-40, HHV-8, CK, EMA and Ki-67 was performed. All ten patients presented with lymphedema after mastectomy as the first sign. Physical examination revealed multiple raised, pinkish-red papulo-vesicular lesions or ulceration as the early evidence of tumor in the field where radiation therapy was introduced. Microscopic examination revealed infiltrative proliferation of vessels and the heteromorphic tumor cells expressed CD34, CD31 and D2-40. Despite the various treatment modalities, 5 patients died in an average of 19 months, 4 patients survived to the last follow-up (9-31 months), and 1 patient got lost. Conclusions: STS is a fatal complication of postmastectomy lymphedema. Patients with STS have very poor prognosis. The key to improve patient's survival is the early diagnosis through a high alert of this disease by primary care physicians and comprehensive physical examination of patients with pertinent history and suspicious clinical presentations followed by prompt biopsy for definitive diagnosis.SCI(E)PubMedREVIEWzhongdingrong@sina.com911108-11115
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lymphangiosarcoma stewart treves Syndrome in postmastectomy patients
Chinese Journal of Diagnostic Pathology, 2011Co-Authors: Zhong DingrongAbstract:Objective To study the clinical pathologic characteristics of Stewart-Treves Syndrome in postmastectomy patients.Methods Three cases of Stewart-Treves Syndrome in postmastectomy patient were collected,immunohistochemical study for CD34,CD31,FⅧ,D2-40,CK,EMA,vimentin,Ki-67 was performed.Results All the 3 patients presented with lymphedema after mastectomy as the first sign,physical examination revealed multiple raised,pinkish-red papulo-vesicular or ulcer on the field that received radiation therapy.Microscopic examination revealed irregular vessel infiltratively grew,the expression of CD34,CD31,FⅧ,D2-40 and vimentin were detected in the heteromorphic tumor cells.Conclusion Stewart-Treves Syndrome in postmastectomy patients is rare.It is related with lymphedema.Heteromorphic tumor cells and immunohistochemical expression are the key points to the diagnosis.
Toshikatsu Okumura - One of the best experts on this subject based on the ideXlab platform.
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Pancreatic metastasis of angiosarcoma (Stewart-Treves Syndrome) diagnosed using endoscopic ultrasound-guided fine needle aspiration: A case report.
Medicine, 2016Co-Authors: Junpei Sasajima, Jiro Uehara, Takuma Goto, Shugo Fujibayashi, Kazuya Koizumi, Yusuke Mizukami, Akemi Ishida-yamamoto, Mikihiro Fujiya, Toshikatsu OkumuraAbstract:BACKGROUND Pancreatic involvement of angiosarcoma is extremely rare. METHODS We herein report a rare case of angiosarcoma associated with chronic lymphedema (Stewart-Treves Syndrome) with pancreatic metastasis that was diagnosed using endoscopic ultrasound (EUS)/fine needle aspiration (FNA). RESULTS A 43-year-old woman with a history of radical hysterectomy with bilateral inguinal lymphadenectomy and chemoradiotherapy for cervical cancer 15 years prior noticed the presence of erythematous indurative plaques on her right femoral region, where chronic lymphedema had developed. Contrast-enhanced computed tomography (CT) revealed not only multiple nodules in the subcutaneous tissue of the right femoral region but also a 25 mm × 20 mm solid mass in the region of the pancreatic tail. A histological analysis of the specimens obtained using EUS/FNA revealed angiosarcoma that was immunohistochemically positive for platelet/endothelial cell adhesion molecule-1 but negative for cytokeratin. The patient was diagnosed as Stewart-Treves Syndrome that had metastasized to the pancreas. Chemotherapy was performed, but the patient died 14 months after her diagnosis. CONCLUSION Unfortunately, this patient was not followed up, even though she had chronic lymphedema of the right femoral region due to the repeated occurrence of phlegmon. To improve the survival rate of this fatal secondary malignant complication of radical lymphadenectomy, an early diagnosis with consecutive and long-term clinical follow-up and close monitoring for Stewart-Treves Syndrome is therefore important.
Junpei Sasajima - One of the best experts on this subject based on the ideXlab platform.
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Pancreatic metastasis of angiosarcoma (Stewart-Treves Syndrome) diagnosed using endoscopic ultrasound-guided fine needle aspiration: A case report.
Medicine, 2016Co-Authors: Junpei Sasajima, Jiro Uehara, Takuma Goto, Shugo Fujibayashi, Kazuya Koizumi, Yusuke Mizukami, Akemi Ishida-yamamoto, Mikihiro Fujiya, Toshikatsu OkumuraAbstract:BACKGROUND Pancreatic involvement of angiosarcoma is extremely rare. METHODS We herein report a rare case of angiosarcoma associated with chronic lymphedema (Stewart-Treves Syndrome) with pancreatic metastasis that was diagnosed using endoscopic ultrasound (EUS)/fine needle aspiration (FNA). RESULTS A 43-year-old woman with a history of radical hysterectomy with bilateral inguinal lymphadenectomy and chemoradiotherapy for cervical cancer 15 years prior noticed the presence of erythematous indurative plaques on her right femoral region, where chronic lymphedema had developed. Contrast-enhanced computed tomography (CT) revealed not only multiple nodules in the subcutaneous tissue of the right femoral region but also a 25 mm × 20 mm solid mass in the region of the pancreatic tail. A histological analysis of the specimens obtained using EUS/FNA revealed angiosarcoma that was immunohistochemically positive for platelet/endothelial cell adhesion molecule-1 but negative for cytokeratin. The patient was diagnosed as Stewart-Treves Syndrome that had metastasized to the pancreas. Chemotherapy was performed, but the patient died 14 months after her diagnosis. CONCLUSION Unfortunately, this patient was not followed up, even though she had chronic lymphedema of the right femoral region due to the repeated occurrence of phlegmon. To improve the survival rate of this fatal secondary malignant complication of radical lymphadenectomy, an early diagnosis with consecutive and long-term clinical follow-up and close monitoring for Stewart-Treves Syndrome is therefore important.