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Stimulation

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Antoine Depaulis – One of the best experts on this subject based on the ideXlab platform.

  • Controlling seizures is not controlling epilepsy: a parametric study of deep brain Stimulation for epilepsy.
    Neurobiology of Disease, 2007
    Co-Authors: Berend Feddersen, Antoine Depaulis, Laurent Vercueil, Soheyl Noachtar, Olivier David, Colin Deransart
    Abstract:

    Pharmacological inhibition and high-frequency Stimulation (HFS) of the substantia nigra pars reticulata (SNr) suppress seizures in different animal models of epilepsy. The aim of the present study was to determine the optimal parameters of HFS to control spontaneous seizures in a genetic model of absence epilepsy in the rat. Single SNr Stimulation that was bilateral, bipolar and monophasic at 60 Hz frequency and with 60-micros pulse width was optimal. However, when used for repeated Stimulations, long-term suppression did not occur and even the number of seizures increased. A delay of at least 60 s between Stimulations was necessary to be fully effective. Although single HFS of the SNr can be used to suppress ongoing seizures, repeated HFS is ineffective and could even aggravate seizures in our model. Thus investigations of accurate Stimulation procedures are still needed.

  • high frequency Stimulation of the sub thalamic nucleus suppresses absence seizures in the rat comparison with neurotoxic lesions
    Epilepsy Research, 1998
    Co-Authors: Laurent Vercueil, Christian Marescaux, Antoine Depaulis, Colin Deransart, A Benazzouz, Karine Bressand, A L Benabid
    Abstract:

    High-frequency electrical Stimulation of deep brain structures has recently been developed for the surgical approach of neurologic disorders. Applied to the thalamus in tremors or to the subthalamic nucleus in Parkinson‘s disease, high-frequency Stimulation has been demonstrated to exert a local inhibiting influence, leading to symptoms alleviation. In the present study, bilateral high-frequency Stimulations (130 Hz) of the subthalamic nuclei suppressed ongoing spontaneous absence seizures in rats. This effect was dissociated from motor side-effects and appears specific to the subthalamic nucleus. Bilateral excitotoxic lesions of the subthalamic nuclei only partially suppressed absence-seizures. These results confirm the involvement of the basal ganglia system in the control of generalized seizures and suggest that high-frequency Stimulations could be used in the treatment of some forms of seizures.

  • Reciprocal positive transfer between kindling of audiogenic seizures and electrical kindling of inferior colliculus
    Epilepsy Research, 1993
    Co-Authors: Edouard Hirsch, B Maton, M. Vergnes, Antoine Depaulis, Christian Marescaux
    Abstract:

    Abstract The behavioral and EEC concomitants of kindling produced by daily electrical Stimulation of the inferior collcolliculus have been recorded in three series of Wistar rats: 1.(1) non epileptic controls (NE), 2.(2) rats susceptible to audiogenic seizures (AS), 3.(3) acoustically susceptible rats with prior kindling of audiogenic seizures by repeated sound exposure (KAS). Repeated collicular Stimulation produced behavioral and EEG changes which were similar in the AS and the NE rats. The tonic seizure without cortical discharges elicited by the first Stimulation progressively changed into tonic-clonic seizures with sustained cortical EEG discharges after more than 20 Stimulations. In the KAS group, the electrical collicular kindling was clearly accelerated: kindled tonic-clonic seizures and their EEG discharges already occurred after one to five electrical Stimulations. Similarly, after completion of electrical collicular kindling in AS, sound Stimulations immediately induced characteristic kindled audiogenic seizures. The immediate reciprocal positive transfer observed between kindling of audiogenic seizures and kindling of seizures induced by electrical Stimulation of the inferior collcolliculus suggests that kindling of these two brain-stem seizures involves similar structures and mechanisms.

Christian Marescaux – One of the best experts on this subject based on the ideXlab platform.

  • high frequency Stimulation of the sub thalamic nucleus suppresses absence seizures in the rat comparison with neurotoxic lesions
    Epilepsy Research, 1998
    Co-Authors: Laurent Vercueil, Christian Marescaux, Antoine Depaulis, Colin Deransart, A Benazzouz, Karine Bressand, A L Benabid
    Abstract:

    High-frequency electrical Stimulation of deep brain structures has recently been developed for the surgical approach of neurologic disorders. Applied to the thalamus in tremors or to the subthalamic nucleus in Parkinson’s disease, high-frequency Stimulation has been demonstrated to exert a local inhibiting influence, leading to symptoms alleviation. In the present study, bilateral high-frequency Stimulations (130 Hz) of the subthalamic nuclei suppressed ongoing spontaneous absence seizures in rats. This effect was dissociated from motor side-effects and appears specific to the subthalamic nucleus. Bilateral excitotoxic lesions of the subthalamic nuclei only partially suppressed absence-seizures. These results confirm the involvement of the basal ganglia system in the control of generalized seizures and suggest that high-frequency Stimulations could be used in the treatment of some forms of seizures.

  • Reciprocal positive transfer between kindling of audiogenic seizures and electrical kindling of inferior colliculus
    Epilepsy Research, 1993
    Co-Authors: Edouard Hirsch, B Maton, M. Vergnes, Antoine Depaulis, Christian Marescaux
    Abstract:

    Abstract The behavioral and EEC concomitants of kindling produced by daily electrical Stimulation of the inferior colliculus have been recorded in three series of Wistar rats: 1.(1) non epileptic controls (NE), 2.(2) rats susceptible to audiogenic seizures (AS), 3.(3) acoustically susceptible rats with prior kindling of audiogenic seizures by repeated sound exposure (KAS). Repeated collicular Stimulation produced behavioral and EEG changes which were similar in the AS and the NE rats. The tonic seizure without cortical discharges elicited by the first Stimulation progressively changed into tonic-clonic seizures with sustained cortical EEG discharges after more than 20 Stimulations. In the KAS group, the electrical collicular kindling was clearly accelerated: kindled tonic-clonic seizures and their EEG discharges already occurred after one to five electrical Stimulations. Similarly, after completion of electrical collicular kindling in AS, sound Stimulations immediately induced characteristic kindled audiogenic seizures. The immediate reciprocal positive transfer observed between kindling of audiogenic seizures and kindling of seizures induced by electrical Stimulation of the inferior colliculus suggests that kindling of these two brain-stem seizures involves similar structures and mechanisms.

Colin Deransart – One of the best experts on this subject based on the ideXlab platform.

  • Controlling seizures is not controlling epilepsy: a parametric study of deep brain Stimulation for epilepsy.
    Neurobiology of Disease, 2007
    Co-Authors: Berend Feddersen, Antoine Depaulis, Laurent Vercueil, Soheyl Noachtar, Olivier David, Colin Deransart
    Abstract:

    Pharmacological inhibition and high-frequency Stimulation (HFS) of the substantia nigra pars reticulata (SNr) suppress seizures in different animal models of epilepsy. The aim of the present study was to determine the optimal parameters of HFS to control spontaneous seizures in a genetic model of absence epilepsy in the rat. Single SNr Stimulation that was bilateral, bipolar and monophasic at 60 Hz frequency and with 60-micros pulse width was optimal. However, when used for repeated Stimulations, long-term suppression did not occur and even the number of seizures increased. A delay of at least 60 s between Stimulations was necessary to be fully effective. Although single HFS of the SNr can be used to suppress ongoing seizures, repeated HFS is ineffective and could even aggravate seizures in our model. Thus investigations of accurate Stimulation procedures are still needed.

  • high frequency Stimulation of the sub thalamic nucleus suppresses absence seizures in the rat comparison with neurotoxic lesions
    Epilepsy Research, 1998
    Co-Authors: Laurent Vercueil, Christian Marescaux, Antoine Depaulis, Colin Deransart, A Benazzouz, Karine Bressand, A L Benabid
    Abstract:

    High-frequency electrical Stimulation of deep brain structures has recently been developed for the surgical approach of neurologic disorders. Applied to the thalamus in tremors or to the subthalamic nucleus in Parkinson’s disease, high-frequency Stimulation has been demonstrated to exert a local inhibiting influence, leading to symptoms alleviation. In the present study, bilateral high-frequency Stimulations (130 Hz) of the subthalamic nuclei suppressed ongoing spontaneous absence seizures in rats. This effect was dissociated from motor side-effects and appears specific to the subthalamic nucleus. Bilateral excitotoxic lesions of the subthalamic nuclei only partially suppressed absence-seizures. These results confirm the involvement of the basal ganglia system in the control of generalized seizures and suggest that high-frequency Stimulations could be used in the treatment of some forms of seizures.