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Antoine Depaulis - One of the best experts on this subject based on the ideXlab platform.
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Controlling seizures is not controlling epilepsy: a parametric study of deep brain Stimulation for epilepsy.
Neurobiology of Disease, 2007Co-Authors: Berend Feddersen, Antoine Depaulis, Laurent Vercueil, Soheyl Noachtar, Olivier David, Colin DeransartAbstract:Pharmacological inhibition and high-frequency Stimulation (HFS) of the substantia nigra pars reticulata (SNr) suppress seizures in different animal models of epilepsy. The aim of the present study was to determine the optimal parameters of HFS to control spontaneous seizures in a genetic model of absence epilepsy in the rat. Single SNr Stimulation that was bilateral, bipolar and monophasic at 60 Hz frequency and with 60-micros pulse width was optimal. However, when used for repeated Stimulations, long-term suppression did not occur and even the number of seizures increased. A delay of at least 60 s between Stimulations was necessary to be fully effective. Although single HFS of the SNr can be used to suppress ongoing seizures, repeated HFS is ineffective and could even aggravate seizures in our model. Thus investigations of accurate Stimulation procedures are still needed.
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high frequency Stimulation of the sub thalamic nucleus suppresses absence seizures in the rat comparison with neurotoxic lesions
Epilepsy Research, 1998Co-Authors: Laurent Vercueil, Antoine Depaulis, Christian Marescaux, Colin Deransart, A Benazzouz, Karine Bressand, A L BenabidAbstract:High-frequency electrical Stimulation of deep brain structures has recently been developed for the surgical approach of neurologic disorders. Applied to the thalamus in tremors or to the subthalamic nucleus in Parkinson's disease, high-frequency Stimulation has been demonstrated to exert a local inhibiting influence, leading to symptoms alleviation. In the present study, bilateral high-frequency Stimulations (130 Hz) of the subthalamic nuclei suppressed ongoing spontaneous absence seizures in rats. This effect was dissociated from motor side-effects and appears specific to the subthalamic nucleus. Bilateral excitotoxic lesions of the subthalamic nuclei only partially suppressed absence-seizures. These results confirm the involvement of the basal ganglia system in the control of generalized seizures and suggest that high-frequency Stimulations could be used in the treatment of some forms of seizures.
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Reciprocal positive transfer between kindling of audiogenic seizures and electrical kindling of inferior colliculus
Epilepsy Research, 1993Co-Authors: Edouard Hirsch, B Maton, M. Vergnes, Antoine Depaulis, Christian MarescauxAbstract:Abstract The behavioral and EEC concomitants of kindling produced by daily electrical Stimulation of the inferior colliculus have been recorded in three series of Wistar rats: 1.(1) non epileptic controls (NE), 2.(2) rats susceptible to audiogenic seizures (AS), 3.(3) acoustically susceptible rats with prior kindling of audiogenic seizures by repeated sound exposure (KAS). Repeated collicular Stimulation produced behavioral and EEG changes which were similar in the AS and the NE rats. The tonic seizure without cortical discharges elicited by the first Stimulation progressively changed into tonic-clonic seizures with sustained cortical EEG discharges after more than 20 Stimulations. In the KAS group, the electrical collicular kindling was clearly accelerated: kindled tonic-clonic seizures and their EEG discharges already occurred after one to five electrical Stimulations. Similarly, after completion of electrical collicular kindling in AS, sound Stimulations immediately induced characteristic kindled audiogenic seizures. The immediate reciprocal positive transfer observed between kindling of audiogenic seizures and kindling of seizures induced by electrical Stimulation of the inferior colliculus suggests that kindling of these two brain-stem seizures involves similar structures and mechanisms.
Christian Marescaux - One of the best experts on this subject based on the ideXlab platform.
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high frequency Stimulation of the sub thalamic nucleus suppresses absence seizures in the rat comparison with neurotoxic lesions
Epilepsy Research, 1998Co-Authors: Laurent Vercueil, Antoine Depaulis, Christian Marescaux, Colin Deransart, A Benazzouz, Karine Bressand, A L BenabidAbstract:High-frequency electrical Stimulation of deep brain structures has recently been developed for the surgical approach of neurologic disorders. Applied to the thalamus in tremors or to the subthalamic nucleus in Parkinson's disease, high-frequency Stimulation has been demonstrated to exert a local inhibiting influence, leading to symptoms alleviation. In the present study, bilateral high-frequency Stimulations (130 Hz) of the subthalamic nuclei suppressed ongoing spontaneous absence seizures in rats. This effect was dissociated from motor side-effects and appears specific to the subthalamic nucleus. Bilateral excitotoxic lesions of the subthalamic nuclei only partially suppressed absence-seizures. These results confirm the involvement of the basal ganglia system in the control of generalized seizures and suggest that high-frequency Stimulations could be used in the treatment of some forms of seizures.
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Reciprocal positive transfer between kindling of audiogenic seizures and electrical kindling of inferior colliculus
Epilepsy Research, 1993Co-Authors: Edouard Hirsch, B Maton, M. Vergnes, Antoine Depaulis, Christian MarescauxAbstract:Abstract The behavioral and EEC concomitants of kindling produced by daily electrical Stimulation of the inferior colliculus have been recorded in three series of Wistar rats: 1.(1) non epileptic controls (NE), 2.(2) rats susceptible to audiogenic seizures (AS), 3.(3) acoustically susceptible rats with prior kindling of audiogenic seizures by repeated sound exposure (KAS). Repeated collicular Stimulation produced behavioral and EEG changes which were similar in the AS and the NE rats. The tonic seizure without cortical discharges elicited by the first Stimulation progressively changed into tonic-clonic seizures with sustained cortical EEG discharges after more than 20 Stimulations. In the KAS group, the electrical collicular kindling was clearly accelerated: kindled tonic-clonic seizures and their EEG discharges already occurred after one to five electrical Stimulations. Similarly, after completion of electrical collicular kindling in AS, sound Stimulations immediately induced characteristic kindled audiogenic seizures. The immediate reciprocal positive transfer observed between kindling of audiogenic seizures and kindling of seizures induced by electrical Stimulation of the inferior colliculus suggests that kindling of these two brain-stem seizures involves similar structures and mechanisms.
Colin Deransart - One of the best experts on this subject based on the ideXlab platform.
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Controlling seizures is not controlling epilepsy: a parametric study of deep brain Stimulation for epilepsy.
Neurobiology of Disease, 2007Co-Authors: Berend Feddersen, Antoine Depaulis, Laurent Vercueil, Soheyl Noachtar, Olivier David, Colin DeransartAbstract:Pharmacological inhibition and high-frequency Stimulation (HFS) of the substantia nigra pars reticulata (SNr) suppress seizures in different animal models of epilepsy. The aim of the present study was to determine the optimal parameters of HFS to control spontaneous seizures in a genetic model of absence epilepsy in the rat. Single SNr Stimulation that was bilateral, bipolar and monophasic at 60 Hz frequency and with 60-micros pulse width was optimal. However, when used for repeated Stimulations, long-term suppression did not occur and even the number of seizures increased. A delay of at least 60 s between Stimulations was necessary to be fully effective. Although single HFS of the SNr can be used to suppress ongoing seizures, repeated HFS is ineffective and could even aggravate seizures in our model. Thus investigations of accurate Stimulation procedures are still needed.
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high frequency Stimulation of the sub thalamic nucleus suppresses absence seizures in the rat comparison with neurotoxic lesions
Epilepsy Research, 1998Co-Authors: Laurent Vercueil, Antoine Depaulis, Christian Marescaux, Colin Deransart, A Benazzouz, Karine Bressand, A L BenabidAbstract:High-frequency electrical Stimulation of deep brain structures has recently been developed for the surgical approach of neurologic disorders. Applied to the thalamus in tremors or to the subthalamic nucleus in Parkinson's disease, high-frequency Stimulation has been demonstrated to exert a local inhibiting influence, leading to symptoms alleviation. In the present study, bilateral high-frequency Stimulations (130 Hz) of the subthalamic nuclei suppressed ongoing spontaneous absence seizures in rats. This effect was dissociated from motor side-effects and appears specific to the subthalamic nucleus. Bilateral excitotoxic lesions of the subthalamic nuclei only partially suppressed absence-seizures. These results confirm the involvement of the basal ganglia system in the control of generalized seizures and suggest that high-frequency Stimulations could be used in the treatment of some forms of seizures.
Gary K Steinberg - One of the best experts on this subject based on the ideXlab platform.
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abstract 69 cerebellar dentate nucleus is an effective brain Stimulation target for post stroke recovery
Stroke, 2016Co-Authors: Shunsuke Ishizaka, Michelle Y Cheng, Aatman Shah, Eric H Wang, Alex R Bautista, Gary K SteinbergAbstract:Objective: Functional recovery after stroke has been observed in both human and animal studies. Post-stroke brain Stimulations are promising neurorestorative techniques as they allow direct manipulation of the target area’s excitability. Previously we have demonstrated that optogenetic neuronal Stimulation of the ipsilesional primary motor cortex (iM1) promotes functional recovery. To determine an optimal brain Stimulation target, we test whether optogenetic neuronal Stimulation of the contralesional cerebellar dentate nucleus (cLCN) can promote recovery. We hypothesize that Stimulation of cLCN may be more effective, as it sends excitatory outputs to multiple motor and premotor areas. Methods: Thy-1-ChR2-YFP line-18 transgenic male mice were used. Mice underwent stereotaxic surgery to implant an optical fiber in cLCN or iM1, followed by an intraluminal middle cerebral artery suture occlusion. Three groups of mice were used: control non-stimulated stroke mice, short stimulated stroke mice (short-stim, day5-14 post-stroke) and long stimulated stroke mice (long-stim, day5-28 post-stroke). Sensorimotor behavior tests were used to assess their recovery. Results: Our data showed that cLCN-stimulated stroke mice recovered quickly, with significant improvement in distance traveled as early as day7 (p Conclusion: Our data suggest that cLCN Stimulations post-stroke can promote persistent functional recovery. Furthermore, cLCN-stimulated mice recovered faster than iM1-stimulated mice, indicate that cLCN may be a more effective brain Stimulation target. Current studies examine the brain activation patterns of cLCN-stimulated mice, as well as the mechanisms of cLCN-induced recovery.
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abstract t mp19 optogenetic Stimulation of cerebellar dentate nucleus promotes persistent functional recovery after stroke
Stroke, 2015Co-Authors: Michelle Y Cheng, Aatman Shah, Eric H Wang, Shunsuke Ishizaka, Alex R Bautista, Gary K SteinbergAbstract:Objective: Functional recovery after stroke has been observed in both human and animal studies. Post-stroke brain Stimulations are promising neurorestorative techniques as they allow direct manipulation of the target area’s excitability. Previously we have demonstrated that optogenetic neuronal Stimulation of the ipsilesional primary motor cortex promotes functional recovery. To determine an optimal brain Stimulation target, we test whether optogenetic neuronal Stimulation of the contralesional cerebellar dentate nucleus (cLCN) can promote recovery. We hypothesize that Stimulation of cLCN may be more effective, as it sends excitatory outputs to multiple motor and premotor areas. Methods: Thy-1-ChR2-YFP line-18 transgenic male mice were used. Mice underwent stereotaxic surgery to implant a fiber cannula in cLCN, followed by an intraluminal middle cerebral artery suture occlusion. Three groups of mice were used: control non-stimulated stroke mice, short stim stimulated stroke mice (day5-14 post-stroke) and long stim stimulated stroke mice (day5-28 post-stroke). Sensorimotor behavior tests (rotating beam tests) were used to assess their recovery at day 0, 4, 7, 10, 14, 21 and 28 post-stroke. Results: Our data showed that stimulated stroke mice recovered quickly, with significant improvement in distance traveled as early as day7 (p<0.05), and faster speed at day14 post-stroke (p<0.001). To evaluate whether the effect of cLCN Stimulation was persistent, we tested the effects of short stim (day5-14) and long stim (day5-28) on recovery. Interestingly, the short stim group continued to recover after day14 without further Stimulations and the long stim group did not further enhance recovery, indicating that functional outcome of cLCN Stimulation is persistent, and prolonged Stimulations may not be necessary to achieve permanent recovery. Analysis of pCREB activation showed that cLCN Stimulation activates the dentatothalamocortical pathway. Conclusion: Our data suggest that cLCN Stimulations post-stroke can promote functional recovery, and this pro-recovery effect is persistent. Current studies examine the mechanisms of cLCN-induced recovery, including cortical excitability and synaptic/plasticity markers.
Laurent Vercueil - One of the best experts on this subject based on the ideXlab platform.
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Controlling seizures is not controlling epilepsy: a parametric study of deep brain Stimulation for epilepsy.
Neurobiology of Disease, 2007Co-Authors: Berend Feddersen, Antoine Depaulis, Laurent Vercueil, Soheyl Noachtar, Olivier David, Colin DeransartAbstract:Pharmacological inhibition and high-frequency Stimulation (HFS) of the substantia nigra pars reticulata (SNr) suppress seizures in different animal models of epilepsy. The aim of the present study was to determine the optimal parameters of HFS to control spontaneous seizures in a genetic model of absence epilepsy in the rat. Single SNr Stimulation that was bilateral, bipolar and monophasic at 60 Hz frequency and with 60-micros pulse width was optimal. However, when used for repeated Stimulations, long-term suppression did not occur and even the number of seizures increased. A delay of at least 60 s between Stimulations was necessary to be fully effective. Although single HFS of the SNr can be used to suppress ongoing seizures, repeated HFS is ineffective and could even aggravate seizures in our model. Thus investigations of accurate Stimulation procedures are still needed.
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high frequency Stimulation of the sub thalamic nucleus suppresses absence seizures in the rat comparison with neurotoxic lesions
Epilepsy Research, 1998Co-Authors: Laurent Vercueil, Antoine Depaulis, Christian Marescaux, Colin Deransart, A Benazzouz, Karine Bressand, A L BenabidAbstract:High-frequency electrical Stimulation of deep brain structures has recently been developed for the surgical approach of neurologic disorders. Applied to the thalamus in tremors or to the subthalamic nucleus in Parkinson's disease, high-frequency Stimulation has been demonstrated to exert a local inhibiting influence, leading to symptoms alleviation. In the present study, bilateral high-frequency Stimulations (130 Hz) of the subthalamic nuclei suppressed ongoing spontaneous absence seizures in rats. This effect was dissociated from motor side-effects and appears specific to the subthalamic nucleus. Bilateral excitotoxic lesions of the subthalamic nuclei only partially suppressed absence-seizures. These results confirm the involvement of the basal ganglia system in the control of generalized seizures and suggest that high-frequency Stimulations could be used in the treatment of some forms of seizures.
