The Experts below are selected from a list of 2331 Experts worldwide ranked by ideXlab platform

Yan Hong - One of the best experts on this subject based on the ideXlab platform.

  • comparison of fresh dried and Stir Frying gingers in decoction with blood stasis syndrome in rats based on a gc tof ms metabolomics approach
    Journal of Pharmaceutical and Biomedical Analysis, 2016
    Co-Authors: Yanquan Han, Jia-rong Gao, Yongzhong Wang, Lunzhu Xia, Yan Hong
    Abstract:

    In China, ginger (Zingiberofficinale Rosc.) and its processed products, such as dried ginger and Stir-Frying ginger are commonly applied in traditional Chinese medicine (TCM). The paper presents the research on the effects of fresh ginger, dried ginger and Stir-Frying ginger extracts in blood stasis syndrome. First, a blood stasis syndrome rats model was established and then the hemorheological and blood coagulation activities were analyzed. Third, a sensitive, simple, and valid gas chromatography combined with time-of-flight mass spectrometry (GC-TOF/MS) method was established to compare the metabolic fingerprint coupled with multivariate analysis. The total 27 metabolites (16 in serum and 11 in urine) were identified and contributed to the blood stasis progress. These metabolites mainly involve six metabolism pathways in different impact-value. The altered efficacy index and metabolites can be regulated to normal levels by fresh ginger (FG), dried ginger (DG) and Stir-Frying ginger (SG). FG is the most effective as shown by the efficacy index, similarity analysis and peak intensity. The result presented here shows that metabolomics equipped with efficacy index makes it possible to study the blood stasis syndrome and to compare the effect and metabolites in fresh, dried and Stir-Frying gingers. The metabolomics approach can be recommended to study the pharmacological effect and mechanism of herbal drugs.

  • Comparison of fresh, dried and Stir-Frying gingers in decoction with blood stasis syndrome in rats based on a GC-TOF/MS metabolomics approach.
    Journal of pharmaceutical and biomedical analysis, 2016
    Co-Authors: Yanquan Han, Wang Yongzhong, Xia Lunzhu, Jia-rong Gao, Yan Hong
    Abstract:

    In China, ginger (Zingiberofficinale Rosc.) and its processed products, such as dried ginger and Stir-Frying ginger are commonly applied in traditional Chinese medicine (TCM). The paper presents the research on the effects of fresh ginger, dried ginger and Stir-Frying ginger extracts in blood stasis syndrome. First, a blood stasis syndrome rats model was established and then the hemorheological and blood coagulation activities were analyzed. Third, a sensitive, simple, and valid gas chromatography combined with time-of-flight mass spectrometry (GC-TOF/MS) method was established to compare the metabolic fingerprint coupled with multivariate analysis. The total 27 metabolites (16 in serum and 11 in urine) were identified and contributed to the blood stasis progress. These metabolites mainly involve six metabolism pathways in different impact-value. The altered efficacy index and metabolites can be regulated to normal levels by fresh ginger (FG), dried ginger (DG) and Stir-Frying ginger (SG). FG is the most effective as shown by the efficacy index, similarity analysis and peak intensity. The result presented here shows that metabolomics equipped with efficacy index makes it possible to study the blood stasis syndrome and to compare the effect and metabolites in fresh, dried and Stir-Frying gingers. The metabolomics approach can be recommended to study the pharmacological effect and mechanism of herbal drugs.

  • Chemical characterization and antioxidant activities comparison in fresh, dried, Stir-Frying and carbonized ginger.
    Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2016
    Co-Authors: Yan Hong, Yanquan Han, Wang Yongzhong, Xia Lunzhu
    Abstract:

    Ginger (Zingiber officinale Rosc.) is a common dietary adjunct that contributes to the taste and flavor of foods, and is also an important Traditional Chinese medicine (TCM). Different processing methods can produce different processed gingers with dissimilar chemical constituents and pharmacological activities. In this study, an ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF-MS) was applied to identify the complicated components from fresh, dried, Stir-Frying and carbonized ginger extracts. All of the 27 compounds were identified from four kinds of ginger samples (fresh, dried, Stir-Frying and carbonized ginger). Five main constituents (zingerone, 6-gingerol, 8-gingerol, 6-shogaol and 10-gingerol) in these four kinds of ginger sample extracts were simultaneously determined by UPLC-PDA. Meanwhile, the antioxidant effect of fresh, dried, Stir-Frying and carbonized gingers were evaluated by three assays (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt (ABTS), and ferric reducing antioxidant power (FRAP)). The results demonstrated that antioxidant activity of dried ginger was the highest, for its phenolic contents are 5.2-, 1.1- and 2.4-fold higher than that of fresh, Stir-Frying and carbonized ginger, respectively, the antioxidant activities' results indicated a similar tendency with phenolic contents: dried ginger>Stir-Frying ginger>fresh ginger>carbonized ginger. The processing contributed to the decreased concentration of gingerols and the increased levels of shogaols, which reducing the antioxidant effects in pace with processing. This study elucidated the relationship of the heating process with the constituents and antioxidant activity, and provided a guide for choosing different kinds of ginger samples on clinical application.

Yanquan Han - One of the best experts on this subject based on the ideXlab platform.

  • comparison of fresh dried and Stir Frying gingers in decoction with blood stasis syndrome in rats based on a gc tof ms metabolomics approach
    Journal of Pharmaceutical and Biomedical Analysis, 2016
    Co-Authors: Yanquan Han, Jia-rong Gao, Yongzhong Wang, Lunzhu Xia, Yan Hong
    Abstract:

    In China, ginger (Zingiberofficinale Rosc.) and its processed products, such as dried ginger and Stir-Frying ginger are commonly applied in traditional Chinese medicine (TCM). The paper presents the research on the effects of fresh ginger, dried ginger and Stir-Frying ginger extracts in blood stasis syndrome. First, a blood stasis syndrome rats model was established and then the hemorheological and blood coagulation activities were analyzed. Third, a sensitive, simple, and valid gas chromatography combined with time-of-flight mass spectrometry (GC-TOF/MS) method was established to compare the metabolic fingerprint coupled with multivariate analysis. The total 27 metabolites (16 in serum and 11 in urine) were identified and contributed to the blood stasis progress. These metabolites mainly involve six metabolism pathways in different impact-value. The altered efficacy index and metabolites can be regulated to normal levels by fresh ginger (FG), dried ginger (DG) and Stir-Frying ginger (SG). FG is the most effective as shown by the efficacy index, similarity analysis and peak intensity. The result presented here shows that metabolomics equipped with efficacy index makes it possible to study the blood stasis syndrome and to compare the effect and metabolites in fresh, dried and Stir-Frying gingers. The metabolomics approach can be recommended to study the pharmacological effect and mechanism of herbal drugs.

  • Comparison of fresh, dried and Stir-Frying gingers in decoction with blood stasis syndrome in rats based on a GC-TOF/MS metabolomics approach.
    Journal of pharmaceutical and biomedical analysis, 2016
    Co-Authors: Yanquan Han, Wang Yongzhong, Xia Lunzhu, Jia-rong Gao, Yan Hong
    Abstract:

    In China, ginger (Zingiberofficinale Rosc.) and its processed products, such as dried ginger and Stir-Frying ginger are commonly applied in traditional Chinese medicine (TCM). The paper presents the research on the effects of fresh ginger, dried ginger and Stir-Frying ginger extracts in blood stasis syndrome. First, a blood stasis syndrome rats model was established and then the hemorheological and blood coagulation activities were analyzed. Third, a sensitive, simple, and valid gas chromatography combined with time-of-flight mass spectrometry (GC-TOF/MS) method was established to compare the metabolic fingerprint coupled with multivariate analysis. The total 27 metabolites (16 in serum and 11 in urine) were identified and contributed to the blood stasis progress. These metabolites mainly involve six metabolism pathways in different impact-value. The altered efficacy index and metabolites can be regulated to normal levels by fresh ginger (FG), dried ginger (DG) and Stir-Frying ginger (SG). FG is the most effective as shown by the efficacy index, similarity analysis and peak intensity. The result presented here shows that metabolomics equipped with efficacy index makes it possible to study the blood stasis syndrome and to compare the effect and metabolites in fresh, dried and Stir-Frying gingers. The metabolomics approach can be recommended to study the pharmacological effect and mechanism of herbal drugs.

  • Chemical characterization and antioxidant activities comparison in fresh, dried, Stir-Frying and carbonized ginger.
    Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2016
    Co-Authors: Yan Hong, Yanquan Han, Wang Yongzhong, Xia Lunzhu
    Abstract:

    Ginger (Zingiber officinale Rosc.) is a common dietary adjunct that contributes to the taste and flavor of foods, and is also an important Traditional Chinese medicine (TCM). Different processing methods can produce different processed gingers with dissimilar chemical constituents and pharmacological activities. In this study, an ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF-MS) was applied to identify the complicated components from fresh, dried, Stir-Frying and carbonized ginger extracts. All of the 27 compounds were identified from four kinds of ginger samples (fresh, dried, Stir-Frying and carbonized ginger). Five main constituents (zingerone, 6-gingerol, 8-gingerol, 6-shogaol and 10-gingerol) in these four kinds of ginger sample extracts were simultaneously determined by UPLC-PDA. Meanwhile, the antioxidant effect of fresh, dried, Stir-Frying and carbonized gingers were evaluated by three assays (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt (ABTS), and ferric reducing antioxidant power (FRAP)). The results demonstrated that antioxidant activity of dried ginger was the highest, for its phenolic contents are 5.2-, 1.1- and 2.4-fold higher than that of fresh, Stir-Frying and carbonized ginger, respectively, the antioxidant activities' results indicated a similar tendency with phenolic contents: dried ginger>Stir-Frying ginger>fresh ginger>carbonized ginger. The processing contributed to the decreased concentration of gingerols and the increased levels of shogaols, which reducing the antioxidant effects in pace with processing. This study elucidated the relationship of the heating process with the constituents and antioxidant activity, and provided a guide for choosing different kinds of ginger samples on clinical application.

Jia-rong Gao - One of the best experts on this subject based on the ideXlab platform.

  • comparison of fresh dried and Stir Frying gingers in decoction with blood stasis syndrome in rats based on a gc tof ms metabolomics approach
    Journal of Pharmaceutical and Biomedical Analysis, 2016
    Co-Authors: Yanquan Han, Jia-rong Gao, Yongzhong Wang, Lunzhu Xia, Yan Hong
    Abstract:

    In China, ginger (Zingiberofficinale Rosc.) and its processed products, such as dried ginger and Stir-Frying ginger are commonly applied in traditional Chinese medicine (TCM). The paper presents the research on the effects of fresh ginger, dried ginger and Stir-Frying ginger extracts in blood stasis syndrome. First, a blood stasis syndrome rats model was established and then the hemorheological and blood coagulation activities were analyzed. Third, a sensitive, simple, and valid gas chromatography combined with time-of-flight mass spectrometry (GC-TOF/MS) method was established to compare the metabolic fingerprint coupled with multivariate analysis. The total 27 metabolites (16 in serum and 11 in urine) were identified and contributed to the blood stasis progress. These metabolites mainly involve six metabolism pathways in different impact-value. The altered efficacy index and metabolites can be regulated to normal levels by fresh ginger (FG), dried ginger (DG) and Stir-Frying ginger (SG). FG is the most effective as shown by the efficacy index, similarity analysis and peak intensity. The result presented here shows that metabolomics equipped with efficacy index makes it possible to study the blood stasis syndrome and to compare the effect and metabolites in fresh, dried and Stir-Frying gingers. The metabolomics approach can be recommended to study the pharmacological effect and mechanism of herbal drugs.

  • Comparison of fresh, dried and Stir-Frying gingers in decoction with blood stasis syndrome in rats based on a GC-TOF/MS metabolomics approach.
    Journal of pharmaceutical and biomedical analysis, 2016
    Co-Authors: Yanquan Han, Wang Yongzhong, Xia Lunzhu, Jia-rong Gao, Yan Hong
    Abstract:

    In China, ginger (Zingiberofficinale Rosc.) and its processed products, such as dried ginger and Stir-Frying ginger are commonly applied in traditional Chinese medicine (TCM). The paper presents the research on the effects of fresh ginger, dried ginger and Stir-Frying ginger extracts in blood stasis syndrome. First, a blood stasis syndrome rats model was established and then the hemorheological and blood coagulation activities were analyzed. Third, a sensitive, simple, and valid gas chromatography combined with time-of-flight mass spectrometry (GC-TOF/MS) method was established to compare the metabolic fingerprint coupled with multivariate analysis. The total 27 metabolites (16 in serum and 11 in urine) were identified and contributed to the blood stasis progress. These metabolites mainly involve six metabolism pathways in different impact-value. The altered efficacy index and metabolites can be regulated to normal levels by fresh ginger (FG), dried ginger (DG) and Stir-Frying ginger (SG). FG is the most effective as shown by the efficacy index, similarity analysis and peak intensity. The result presented here shows that metabolomics equipped with efficacy index makes it possible to study the blood stasis syndrome and to compare the effect and metabolites in fresh, dried and Stir-Frying gingers. The metabolomics approach can be recommended to study the pharmacological effect and mechanism of herbal drugs.

Xia Lunzhu - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of fresh, dried and Stir-Frying gingers in decoction with blood stasis syndrome in rats based on a GC-TOF/MS metabolomics approach.
    Journal of pharmaceutical and biomedical analysis, 2016
    Co-Authors: Yanquan Han, Wang Yongzhong, Xia Lunzhu, Jia-rong Gao, Yan Hong
    Abstract:

    In China, ginger (Zingiberofficinale Rosc.) and its processed products, such as dried ginger and Stir-Frying ginger are commonly applied in traditional Chinese medicine (TCM). The paper presents the research on the effects of fresh ginger, dried ginger and Stir-Frying ginger extracts in blood stasis syndrome. First, a blood stasis syndrome rats model was established and then the hemorheological and blood coagulation activities were analyzed. Third, a sensitive, simple, and valid gas chromatography combined with time-of-flight mass spectrometry (GC-TOF/MS) method was established to compare the metabolic fingerprint coupled with multivariate analysis. The total 27 metabolites (16 in serum and 11 in urine) were identified and contributed to the blood stasis progress. These metabolites mainly involve six metabolism pathways in different impact-value. The altered efficacy index and metabolites can be regulated to normal levels by fresh ginger (FG), dried ginger (DG) and Stir-Frying ginger (SG). FG is the most effective as shown by the efficacy index, similarity analysis and peak intensity. The result presented here shows that metabolomics equipped with efficacy index makes it possible to study the blood stasis syndrome and to compare the effect and metabolites in fresh, dried and Stir-Frying gingers. The metabolomics approach can be recommended to study the pharmacological effect and mechanism of herbal drugs.

  • Chemical characterization and antioxidant activities comparison in fresh, dried, Stir-Frying and carbonized ginger.
    Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2016
    Co-Authors: Yan Hong, Yanquan Han, Wang Yongzhong, Xia Lunzhu
    Abstract:

    Ginger (Zingiber officinale Rosc.) is a common dietary adjunct that contributes to the taste and flavor of foods, and is also an important Traditional Chinese medicine (TCM). Different processing methods can produce different processed gingers with dissimilar chemical constituents and pharmacological activities. In this study, an ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF-MS) was applied to identify the complicated components from fresh, dried, Stir-Frying and carbonized ginger extracts. All of the 27 compounds were identified from four kinds of ginger samples (fresh, dried, Stir-Frying and carbonized ginger). Five main constituents (zingerone, 6-gingerol, 8-gingerol, 6-shogaol and 10-gingerol) in these four kinds of ginger sample extracts were simultaneously determined by UPLC-PDA. Meanwhile, the antioxidant effect of fresh, dried, Stir-Frying and carbonized gingers were evaluated by three assays (2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt (ABTS), and ferric reducing antioxidant power (FRAP)). The results demonstrated that antioxidant activity of dried ginger was the highest, for its phenolic contents are 5.2-, 1.1- and 2.4-fold higher than that of fresh, Stir-Frying and carbonized ginger, respectively, the antioxidant activities' results indicated a similar tendency with phenolic contents: dried ginger>Stir-Frying ginger>fresh ginger>carbonized ginger. The processing contributed to the decreased concentration of gingerols and the increased levels of shogaols, which reducing the antioxidant effects in pace with processing. This study elucidated the relationship of the heating process with the constituents and antioxidant activity, and provided a guide for choosing different kinds of ginger samples on clinical application.

Yongsheng Chen - One of the best experts on this subject based on the ideXlab platform.

  • Stir Frying treatments affect the phenolics profiles and cellular antioxidant activity of adinandra nitida tea shiyacha in daily tea model
    International Journal of Food Science and Technology, 2017
    Co-Authors: Yongsheng Chen, Yingbin Shen, Arshad Mehmood Abbasi, Rian Yan
    Abstract:

    Summary Adinandra nitida tea (Shiyacha) is a well-known resource of functional foods with many healthful features. Effect of Stir Frying on phenolics, aromatic compounds, cellular antioxidant and antiproliferative activities in A. nitida tea was investigated. Stir-fried samples depicted a significant increase in total water-soluble solid, phenolics and flavonoids contents, respectively. In Stir-fried treated samples, main compounds were higher than in corresponding untreated samples. Similar trend was observed in aromatic compounds. Hydrophilic peroxyl radical scavenging capacity and oxygen radical absorbance capacity were enhanced immensely in the treated samples. Furthermore, cellular antioxidant activities of treated samples were higher than those of untreated samples. Stir-fried samples exhibited higher antiproliferative activity on HepG2 cells, whereas an lack in untreated samples. These findings suggest that Stir Frying could be an effective technique to improve A. nitida tea quality, and support that A. nitida tea could act as a potential functional food against intracellular oxidative stress and inhibitor of liver cancer.

  • Stir‐Frying treatments affect the phenolics profiles and cellular antioxidant activity of Adinandra nitida tea (Shiyacha) in daily tea model
    International Journal of Food Science & Technology, 2017
    Co-Authors: Yongsheng Chen, Yingbin Shen, Arshad Mehmood Abbasi, Rian Yan
    Abstract:

    Summary Adinandra nitida tea (Shiyacha) is a well-known resource of functional foods with many healthful features. Effect of Stir Frying on phenolics, aromatic compounds, cellular antioxidant and antiproliferative activities in A. nitida tea was investigated. Stir-fried samples depicted a significant increase in total water-soluble solid, phenolics and flavonoids contents, respectively. In Stir-fried treated samples, main compounds were higher than in corresponding untreated samples. Similar trend was observed in aromatic compounds. Hydrophilic peroxyl radical scavenging capacity and oxygen radical absorbance capacity were enhanced immensely in the treated samples. Furthermore, cellular antioxidant activities of treated samples were higher than those of untreated samples. Stir-fried samples exhibited higher antiproliferative activity on HepG2 cells, whereas an lack in untreated samples. These findings suggest that Stir Frying could be an effective technique to improve A. nitida tea quality, and support that A. nitida tea could act as a potential functional food against intracellular oxidative stress and inhibitor of liver cancer.