The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform
Yukiyoshi Esaki - One of the best experts on this subject based on the ideXlab platform.
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Oncocytic adenocarcinoma of the Stomach: Parietal Cell carcinoma.
The American Journal of Surgical Pathology, 2002Co-Authors: Kaiyo Takubo, Naoko Honma, Motoji Sawabe, Tomio Arai, Naotaka Izumiyama-shimomura, Makoto Kammori, Koji Sasajima, Yukiyoshi EsakiAbstract:We report 10 cases of an unusual type of gastric adenocarcinoma that occurred in elderly patients 58-81 years of age. Histologically, the tumors were well to moderately differentiated tubular adenocarcinomas with very eosinophilic, finely granular cytoplasm. Immunohistochemical stains for antimitochondrial antibody were strongly positive. Ultrastructurally, the tumor Cells had numerous mitochondria in their cytoplasm and occasional intracytoplasmic lumina with associated long microvilli. These histologic and ultrastructural features are similar to those of Parietal Cells in normal gastric fundic mucosa, but immunohistochemical staining of the tumors using four different antiParietal Cell antibodies (anti-H + -K + -adenosine triphosphatase antibodies) was negative in all cases. Therefore, we think that these tumors were not Parietal Cell carcinomas but could be termed oncocytic adenocarcinomas, or adenocarcinomas with oncocytic differentiation. Previously reported cases of Parietal Cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma.
Kaiyo Takubo - One of the best experts on this subject based on the ideXlab platform.
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Oncocytic adenocarcinoma of the Stomach: Parietal Cell carcinoma.
The American Journal of Surgical Pathology, 2002Co-Authors: Kaiyo Takubo, Naoko Honma, Motoji Sawabe, Tomio Arai, Naotaka Izumiyama-shimomura, Makoto Kammori, Koji Sasajima, Yukiyoshi EsakiAbstract:We report 10 cases of an unusual type of gastric adenocarcinoma that occurred in elderly patients 58-81 years of age. Histologically, the tumors were well to moderately differentiated tubular adenocarcinomas with very eosinophilic, finely granular cytoplasm. Immunohistochemical stains for antimitochondrial antibody were strongly positive. Ultrastructurally, the tumor Cells had numerous mitochondria in their cytoplasm and occasional intracytoplasmic lumina with associated long microvilli. These histologic and ultrastructural features are similar to those of Parietal Cells in normal gastric fundic mucosa, but immunohistochemical staining of the tumors using four different antiParietal Cell antibodies (anti-H + -K + -adenosine triphosphatase antibodies) was negative in all cases. Therefore, we think that these tumors were not Parietal Cell carcinomas but could be termed oncocytic adenocarcinomas, or adenocarcinomas with oncocytic differentiation. Previously reported cases of Parietal Cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma.
Naoko Honma - One of the best experts on this subject based on the ideXlab platform.
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Oncocytic adenocarcinoma of the Stomach: Parietal Cell carcinoma.
The American Journal of Surgical Pathology, 2002Co-Authors: Kaiyo Takubo, Naoko Honma, Motoji Sawabe, Tomio Arai, Naotaka Izumiyama-shimomura, Makoto Kammori, Koji Sasajima, Yukiyoshi EsakiAbstract:We report 10 cases of an unusual type of gastric adenocarcinoma that occurred in elderly patients 58-81 years of age. Histologically, the tumors were well to moderately differentiated tubular adenocarcinomas with very eosinophilic, finely granular cytoplasm. Immunohistochemical stains for antimitochondrial antibody were strongly positive. Ultrastructurally, the tumor Cells had numerous mitochondria in their cytoplasm and occasional intracytoplasmic lumina with associated long microvilli. These histologic and ultrastructural features are similar to those of Parietal Cells in normal gastric fundic mucosa, but immunohistochemical staining of the tumors using four different antiParietal Cell antibodies (anti-H + -K + -adenosine triphosphatase antibodies) was negative in all cases. Therefore, we think that these tumors were not Parietal Cell carcinomas but could be termed oncocytic adenocarcinomas, or adenocarcinomas with oncocytic differentiation. Previously reported cases of Parietal Cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma.
Motoji Sawabe - One of the best experts on this subject based on the ideXlab platform.
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Oncocytic adenocarcinoma of the Stomach: Parietal Cell carcinoma.
The American Journal of Surgical Pathology, 2002Co-Authors: Kaiyo Takubo, Naoko Honma, Motoji Sawabe, Tomio Arai, Naotaka Izumiyama-shimomura, Makoto Kammori, Koji Sasajima, Yukiyoshi EsakiAbstract:We report 10 cases of an unusual type of gastric adenocarcinoma that occurred in elderly patients 58-81 years of age. Histologically, the tumors were well to moderately differentiated tubular adenocarcinomas with very eosinophilic, finely granular cytoplasm. Immunohistochemical stains for antimitochondrial antibody were strongly positive. Ultrastructurally, the tumor Cells had numerous mitochondria in their cytoplasm and occasional intracytoplasmic lumina with associated long microvilli. These histologic and ultrastructural features are similar to those of Parietal Cells in normal gastric fundic mucosa, but immunohistochemical staining of the tumors using four different antiParietal Cell antibodies (anti-H + -K + -adenosine triphosphatase antibodies) was negative in all cases. Therefore, we think that these tumors were not Parietal Cell carcinomas but could be termed oncocytic adenocarcinomas, or adenocarcinomas with oncocytic differentiation. Previously reported cases of Parietal Cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma.
Tomio Arai - One of the best experts on this subject based on the ideXlab platform.
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Oncocytic adenocarcinoma of the Stomach: Parietal Cell carcinoma.
The American Journal of Surgical Pathology, 2002Co-Authors: Kaiyo Takubo, Naoko Honma, Motoji Sawabe, Tomio Arai, Naotaka Izumiyama-shimomura, Makoto Kammori, Koji Sasajima, Yukiyoshi EsakiAbstract:We report 10 cases of an unusual type of gastric adenocarcinoma that occurred in elderly patients 58-81 years of age. Histologically, the tumors were well to moderately differentiated tubular adenocarcinomas with very eosinophilic, finely granular cytoplasm. Immunohistochemical stains for antimitochondrial antibody were strongly positive. Ultrastructurally, the tumor Cells had numerous mitochondria in their cytoplasm and occasional intracytoplasmic lumina with associated long microvilli. These histologic and ultrastructural features are similar to those of Parietal Cells in normal gastric fundic mucosa, but immunohistochemical staining of the tumors using four different antiParietal Cell antibodies (anti-H + -K + -adenosine triphosphatase antibodies) was negative in all cases. Therefore, we think that these tumors were not Parietal Cell carcinomas but could be termed oncocytic adenocarcinomas, or adenocarcinomas with oncocytic differentiation. Previously reported cases of Parietal Cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma.