The Experts below are selected from a list of 42843 Experts worldwide ranked by ideXlab platform
Sherifa S. Hamed - One of the best experts on this subject based on the ideXlab platform.
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the protective properties of the Strawberry fragaria ananassa against carbon tetrachloride induced hepatotoxicity in rats mediated by anti apoptotic and upregulation of antioxidant genes expression effects
Frontiers in Physiology, 2016Co-Authors: Nouf Alyhya, Ebtesam M Alolayan, Manal F Elkhadragy, Reem A Alajmi, Zeinab K. Hassan, Sherifa S. Hamed, Salwa B HassanAbstract:The Strawberry (Fragaria ananassa) has been extensively used to treat a wide range of ailments in many cultures. The present study was aimed at evaluating the hepatoprotective effect of Strawberry juice on experimentally induced liver injury in rats. To this end, rats were introperitoneally injected with carbon tetrachloride (CCl4) with or without Strawberry juice supplementation for 12 weeks and the hepatoprotective effect of Strawberry was assessed by measuring serum liver enzyme markers, hepatic tissue redox status and apoptotic markers with various techniques including biochemistry, ELISA, quantitative PCR assays and histochemistry. The hepatoprotective effect of the Strawberry was evident by preventing CCl4-induced increase in liver enzymes levels. Determination of oxidative balance showed that Strawberry treatment significantly blunted CCl4-induced increase in oxidative stress markers and decrease in enzymatic and non-enzymatic molecules in hepatic tissue. Furthermore, Strawberry supplementation enhanced the anti-apoptotic protein, Bcl-2, and restrained the pro-apoptotic proteins Bax and caspase-3 with a marked reduction in collagen areas in hepatic tissue. These findings demonstrated that Strawberry (Fragaria ananassa) juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties, probably mediated by the presence of polyphenols and flavonoids compounds.
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the protective properties of the Strawberry fragaria ananassa against carbon tetrachloride induced hepatotoxicity in rats mediated by anti apoptotic and upregulation of antioxidant genes expression effects
Frontiers in Physiology, 2016Co-Authors: Nouf Alyhya, Ebtesam M Alolayan, Manal F Elkhadragy, Reem A Alajmi, Zeinab K. Hassan, Sherifa S. Hamed, Salwa B HassanAbstract:The Strawberry (Fragaria ananassa) has been extensively used to treat a wide range of ailments in many cultures. The present study was aimed at evaluating the hepatoprotective effect of Strawberry juice on experimentally induced liver injury in rats. To this end, rats were introperitoneally injected with carbon tetrachloride (CCl4) with or without Strawberry juice supplementation for 12 weeks and the hepatoprotective effect of Strawberry was assessed by measuring serum liver enzyme markers, hepatic tissue redox status and apoptotic markers with various techniques including biochemistry, ELISA, quantitative PCR assays and histochemistry. The hepatoprotective effect of the Strawberry was evident by preventing CCl4-induced increase in liver enzymes levels. Determination of oxidative balance showed that Strawberry treatment significantly blunted CCl4-induced increase in oxidative stress markers and decrease in enzymatic and non-enzymatic molecules in hepatic tissue. Furthermore, Strawberry supplementation enhanced the anti-apoptotic protein, Bcl-2, and restrained the pro-apoptotic proteins Bax and caspase-3 with a marked reduction in collagen areas in hepatic tissue. These findings demonstrated that Strawberry (Fragaria ananassa) juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties, probably mediated by the presence of polyphenols and flavonoids compounds.
Salwa B Hassan - One of the best experts on this subject based on the ideXlab platform.
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the protective properties of the Strawberry fragaria ananassa against carbon tetrachloride induced hepatotoxicity in rats mediated by anti apoptotic and upregulation of antioxidant genes expression effects
Frontiers in Physiology, 2016Co-Authors: Nouf Alyhya, Ebtesam M Alolayan, Manal F Elkhadragy, Reem A Alajmi, Zeinab K. Hassan, Sherifa S. Hamed, Salwa B HassanAbstract:The Strawberry (Fragaria ananassa) has been extensively used to treat a wide range of ailments in many cultures. The present study was aimed at evaluating the hepatoprotective effect of Strawberry juice on experimentally induced liver injury in rats. To this end, rats were introperitoneally injected with carbon tetrachloride (CCl4) with or without Strawberry juice supplementation for 12 weeks and the hepatoprotective effect of Strawberry was assessed by measuring serum liver enzyme markers, hepatic tissue redox status and apoptotic markers with various techniques including biochemistry, ELISA, quantitative PCR assays and histochemistry. The hepatoprotective effect of the Strawberry was evident by preventing CCl4-induced increase in liver enzymes levels. Determination of oxidative balance showed that Strawberry treatment significantly blunted CCl4-induced increase in oxidative stress markers and decrease in enzymatic and non-enzymatic molecules in hepatic tissue. Furthermore, Strawberry supplementation enhanced the anti-apoptotic protein, Bcl-2, and restrained the pro-apoptotic proteins Bax and caspase-3 with a marked reduction in collagen areas in hepatic tissue. These findings demonstrated that Strawberry (Fragaria ananassa) juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties, probably mediated by the presence of polyphenols and flavonoids compounds.
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the protective properties of the Strawberry fragaria ananassa against carbon tetrachloride induced hepatotoxicity in rats mediated by anti apoptotic and upregulation of antioxidant genes expression effects
Frontiers in Physiology, 2016Co-Authors: Nouf Alyhya, Ebtesam M Alolayan, Manal F Elkhadragy, Reem A Alajmi, Zeinab K. Hassan, Sherifa S. Hamed, Salwa B HassanAbstract:The Strawberry (Fragaria ananassa) has been extensively used to treat a wide range of ailments in many cultures. The present study was aimed at evaluating the hepatoprotective effect of Strawberry juice on experimentally induced liver injury in rats. To this end, rats were introperitoneally injected with carbon tetrachloride (CCl4) with or without Strawberry juice supplementation for 12 weeks and the hepatoprotective effect of Strawberry was assessed by measuring serum liver enzyme markers, hepatic tissue redox status and apoptotic markers with various techniques including biochemistry, ELISA, quantitative PCR assays and histochemistry. The hepatoprotective effect of the Strawberry was evident by preventing CCl4-induced increase in liver enzymes levels. Determination of oxidative balance showed that Strawberry treatment significantly blunted CCl4-induced increase in oxidative stress markers and decrease in enzymatic and non-enzymatic molecules in hepatic tissue. Furthermore, Strawberry supplementation enhanced the anti-apoptotic protein, Bcl-2, and restrained the pro-apoptotic proteins Bax and caspase-3 with a marked reduction in collagen areas in hepatic tissue. These findings demonstrated that Strawberry (Fragaria ananassa) juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties, probably mediated by the presence of polyphenols and flavonoids compounds.
Zeinab K. Hassan - One of the best experts on this subject based on the ideXlab platform.
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the protective properties of the Strawberry fragaria ananassa against carbon tetrachloride induced hepatotoxicity in rats mediated by anti apoptotic and upregulation of antioxidant genes expression effects
Frontiers in Physiology, 2016Co-Authors: Nouf Alyhya, Ebtesam M Alolayan, Manal F Elkhadragy, Reem A Alajmi, Zeinab K. Hassan, Sherifa S. Hamed, Salwa B HassanAbstract:The Strawberry (Fragaria ananassa) has been extensively used to treat a wide range of ailments in many cultures. The present study was aimed at evaluating the hepatoprotective effect of Strawberry juice on experimentally induced liver injury in rats. To this end, rats were introperitoneally injected with carbon tetrachloride (CCl4) with or without Strawberry juice supplementation for 12 weeks and the hepatoprotective effect of Strawberry was assessed by measuring serum liver enzyme markers, hepatic tissue redox status and apoptotic markers with various techniques including biochemistry, ELISA, quantitative PCR assays and histochemistry. The hepatoprotective effect of the Strawberry was evident by preventing CCl4-induced increase in liver enzymes levels. Determination of oxidative balance showed that Strawberry treatment significantly blunted CCl4-induced increase in oxidative stress markers and decrease in enzymatic and non-enzymatic molecules in hepatic tissue. Furthermore, Strawberry supplementation enhanced the anti-apoptotic protein, Bcl-2, and restrained the pro-apoptotic proteins Bax and caspase-3 with a marked reduction in collagen areas in hepatic tissue. These findings demonstrated that Strawberry (Fragaria ananassa) juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties, probably mediated by the presence of polyphenols and flavonoids compounds.
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the protective properties of the Strawberry fragaria ananassa against carbon tetrachloride induced hepatotoxicity in rats mediated by anti apoptotic and upregulation of antioxidant genes expression effects
Frontiers in Physiology, 2016Co-Authors: Nouf Alyhya, Ebtesam M Alolayan, Manal F Elkhadragy, Reem A Alajmi, Zeinab K. Hassan, Sherifa S. Hamed, Salwa B HassanAbstract:The Strawberry (Fragaria ananassa) has been extensively used to treat a wide range of ailments in many cultures. The present study was aimed at evaluating the hepatoprotective effect of Strawberry juice on experimentally induced liver injury in rats. To this end, rats were introperitoneally injected with carbon tetrachloride (CCl4) with or without Strawberry juice supplementation for 12 weeks and the hepatoprotective effect of Strawberry was assessed by measuring serum liver enzyme markers, hepatic tissue redox status and apoptotic markers with various techniques including biochemistry, ELISA, quantitative PCR assays and histochemistry. The hepatoprotective effect of the Strawberry was evident by preventing CCl4-induced increase in liver enzymes levels. Determination of oxidative balance showed that Strawberry treatment significantly blunted CCl4-induced increase in oxidative stress markers and decrease in enzymatic and non-enzymatic molecules in hepatic tissue. Furthermore, Strawberry supplementation enhanced the anti-apoptotic protein, Bcl-2, and restrained the pro-apoptotic proteins Bax and caspase-3 with a marked reduction in collagen areas in hepatic tissue. These findings demonstrated that Strawberry (Fragaria ananassa) juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties, probably mediated by the presence of polyphenols and flavonoids compounds.
Manal F Elkhadragy - One of the best experts on this subject based on the ideXlab platform.
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the protective properties of the Strawberry fragaria ananassa against carbon tetrachloride induced hepatotoxicity in rats mediated by anti apoptotic and upregulation of antioxidant genes expression effects
Frontiers in Physiology, 2016Co-Authors: Nouf Alyhya, Ebtesam M Alolayan, Manal F Elkhadragy, Reem A Alajmi, Zeinab K. Hassan, Sherifa S. Hamed, Salwa B HassanAbstract:The Strawberry (Fragaria ananassa) has been extensively used to treat a wide range of ailments in many cultures. The present study was aimed at evaluating the hepatoprotective effect of Strawberry juice on experimentally induced liver injury in rats. To this end, rats were introperitoneally injected with carbon tetrachloride (CCl4) with or without Strawberry juice supplementation for 12 weeks and the hepatoprotective effect of Strawberry was assessed by measuring serum liver enzyme markers, hepatic tissue redox status and apoptotic markers with various techniques including biochemistry, ELISA, quantitative PCR assays and histochemistry. The hepatoprotective effect of the Strawberry was evident by preventing CCl4-induced increase in liver enzymes levels. Determination of oxidative balance showed that Strawberry treatment significantly blunted CCl4-induced increase in oxidative stress markers and decrease in enzymatic and non-enzymatic molecules in hepatic tissue. Furthermore, Strawberry supplementation enhanced the anti-apoptotic protein, Bcl-2, and restrained the pro-apoptotic proteins Bax and caspase-3 with a marked reduction in collagen areas in hepatic tissue. These findings demonstrated that Strawberry (Fragaria ananassa) juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties, probably mediated by the presence of polyphenols and flavonoids compounds.
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the protective properties of the Strawberry fragaria ananassa against carbon tetrachloride induced hepatotoxicity in rats mediated by anti apoptotic and upregulation of antioxidant genes expression effects
Frontiers in Physiology, 2016Co-Authors: Nouf Alyhya, Ebtesam M Alolayan, Manal F Elkhadragy, Reem A Alajmi, Zeinab K. Hassan, Sherifa S. Hamed, Salwa B HassanAbstract:The Strawberry (Fragaria ananassa) has been extensively used to treat a wide range of ailments in many cultures. The present study was aimed at evaluating the hepatoprotective effect of Strawberry juice on experimentally induced liver injury in rats. To this end, rats were introperitoneally injected with carbon tetrachloride (CCl4) with or without Strawberry juice supplementation for 12 weeks and the hepatoprotective effect of Strawberry was assessed by measuring serum liver enzyme markers, hepatic tissue redox status and apoptotic markers with various techniques including biochemistry, ELISA, quantitative PCR assays and histochemistry. The hepatoprotective effect of the Strawberry was evident by preventing CCl4-induced increase in liver enzymes levels. Determination of oxidative balance showed that Strawberry treatment significantly blunted CCl4-induced increase in oxidative stress markers and decrease in enzymatic and non-enzymatic molecules in hepatic tissue. Furthermore, Strawberry supplementation enhanced the anti-apoptotic protein, Bcl-2, and restrained the pro-apoptotic proteins Bax and caspase-3 with a marked reduction in collagen areas in hepatic tissue. These findings demonstrated that Strawberry (Fragaria ananassa) juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties, probably mediated by the presence of polyphenols and flavonoids compounds.
Natalia A Peres - One of the best experts on this subject based on the ideXlab platform.
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anthracnose fruit and root necrosis of Strawberry are caused by a dominant species within the colletotrichum acutatum species complex in the united states
Phytopathology, 2019Co-Authors: Nanyi Wang, Bruna B Forcelini, Natalia A PeresAbstract:Strawberry anthracnose fruit rot and root necrosis, caused by Colletotrichum acutatum, are primary limiting factors in fruit production fields in the United States. Recent research focusing on the phenotypic and genetic characteristics of this species has shed light on the diversity of the C. acutatum species complex. In this study, we performed multilocus sequence analysis of four genetic loci to characterize 217 C. acutatum isolates collected over a 23-year period from symptomatic plant tissues of Strawberry from six different states. The results revealed two Colletotrichum spp. (C. nymphaeae and C. fioriniae), with 97.7% of the isolate collection (212 of 217) belonging to C. nymphaeae as a dominant clonal linage, regardless of the isolation source. No correlation between species groups and geographical origins of the isolates was observed. Further sequence comparison between historical and contemporary isolates showed the same populations being widely distributed throughout the Strawberry nurseries and production fields in the United States and Canada. Subsequently, a subset of 12 isolates representing different quinone-outside inhibitor fungicide resistance profiles from root or fruit tissue of Strawberry was selected for comparison of pathogenicity on Strawberry. In this test, isolates of different resistance groups or different isolation sources exhibited a similar degree of aggressiveness and caused indistinguishable symptoms on Strawberry crowns (P = 0.9555 and 0.7873, respectively) and fruit (P = 0.1638 and 0.1141, respectively), although a significant difference among individual isolates was observed in detached-fruit assays (P = 0.0123). Separate pathogenicity tests using isolates of the two species revealed C. nymphaeae being more aggressive than C. fioriniae in infecting Strawberry roots and crowns (P = 0.0073). Therefore, given the occurrence and pathogenicity of C. nymphaeae, this species is likely the sole cause responsible for Strawberry anthracnose in the United States.
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sources of primary inoculum of botrytis cinerea and their impact on fungicide resistance development in commercial Strawberry fields
Plant Disease, 2017Co-Authors: Michelle Souza Oliveira, Achour Amiri, Adrian I Zuniga, Natalia A PeresAbstract:Strawberry transplants produced in nurseries across Canada, northern United States, and California are shipped annually to other Strawberry-growing regions, including Florida. Botrytis cinerea, the causal agent of gray mold, causes latent infections on transplants which are suggested as a potential source of primary inoculum in Strawberry fields. In this study, we investigated the survival of B. cinerea isolates over the summer in Florida, the presence of B. cinerea in transplants from 14 nurseries from Canada and the United States in 2011, 2012, and 2013, and the sensitivity of nursery population to several botryticides. Botrytis cinerea was detected on dead Strawberry plants sampled from commercial Strawberry fields between March and June but not in July and August, suggesting that the fungus does not over-summer in Strawberry fields in Florida. Nursery transplants surveyed in 2011, 2012, and 2013 showed B. cinerea incidences of 20 to 37, 20 to 83, and 2.5 to 92.5%, respectively. In total, 409 isolates ...
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the arabidopsis npr1 gene confers broad spectrum disease resistance in Strawberry
Transgenic Research, 2015Co-Authors: Katchen Julliany Pereira Silva, Natalia A Peres, Asha M Brunings, Zhonglin Mou, Kevin M FoltaAbstract:Although Strawberry is an economically important fruit crop worldwide, production of Strawberry is limited by its susceptibility to a wide range of pathogens and the lack of major commercial cultivars with high levels of resistance to multiple pathogens. The objective of this study is to ectopically express the Arabidopsis thaliana NPR1 gene (AtNPR1) in the diploid Strawberry Fragaria vesca L. and to test transgenic plants for disease resistance. AtNPR1 is a key positive regulator of the long-lasting broad-spectrum resistance known as systemic acquired resistance (SAR) and has been shown to confer resistance to a number of pathogens when overexpressed in Arabidopsis or ectopically expressed in several crop species. We show that ectopic expression of AtNPR1 in Strawberry increases resistance to anthracnose, powdery mildew, and angular leaf spot, which are caused by different fungal or bacterial pathogens. The increased resistance is related to the relative expression levels of AtNPR1 in the transgenic plants. In contrast to Arabidopsis plants overexpressing AtNPR1, which grow normally and do not constitutively express defense genes, the Strawberry transgenic plants are shorter than non-transformed controls, and most of them fail to produce runners and fruits. Consistently, most of the transgenic lines constitutively express the defense gene FvPR5, suggesting that the SAR activation mechanisms in Strawberry and Arabidopsis are different. Nevertheless, our results indicate that overexpression of AtNPR1 holds the potential for generation of broad-spectrum disease resistance in Strawberry.
