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Patricia Munoz - One of the best experts on this subject based on the ideXlab platform.

  • two weeks of postsurgical therapy may be enough for high risk cases of endocarditis caused by Streptococcus viridans or Streptococcus bovis
    Clinical Microbiology and Infection, 2012
    Co-Authors: Patricia Munoz, Maddalena Giannella, F Scoti, M Predomingo, D Puga, Angel Gonzalez Pinto, J Roda
    Abstract:

    Abstract The duration of antimicrobial therapy after surgery for infective endocarditis (IE) is controversial. A short course of postsurgical therapy is currently accepted only for patients with negative valve culture. We performed a retrospective (1994–2008) analysis of patients who underwent surgery for IE in our hospital and had a high risk of complications (one of more of the following: Streptococcus viridans or Streptococcus bovis was independently associated with SAT. Postsurgical SAT is safe, especially when IE is caused by Streptococcus viridans or Streptococcus bovis , even in patients at high risk of complications.

  • two weeks of postsurgical therapy may be enough for high risk cases of endocarditis caused by Streptococcus viridans or Streptococcus bovis
    Clinical Microbiology and Infection, 2012
    Co-Authors: Patricia Munoz, Maddalena Giannella, F Scoti, M Predomingo, D Puga, Angel Gonzalez Pinto, J Roda, Mercedes Marin
    Abstract:

    The duration of antimicrobial therapy after surgery for infective endocarditis (IE) is controversial. A short course of postsurgical therapy is currently accepted only for patients with negative valve culture. We performed a retrospective (1994-2008) analysis of patients who underwent surgery for IE in our hospital and had a high risk of complications ( one of more of the following: <2 weeks of antibiotic treatment before surgery; embolism; perivalvular extension; and positive valve culture) to compare outcomes of patients who received short-course antimicrobial therapy (SAT) (median 15 days) or long-course antimicrobial therapy (LAT) (median 32 days), irrespective of the results of valve culture. Our endpoints included length of hospital stay, renal and hepatic failure, relapse, re-infection, and mortality rates 1 year after surgery. During the study period, 140 patients underwent surgery for IE (valve replacement, 87.9%). Of these, 133 fulfilled the high-risk group criteria and 92 completed the antimicrobial schedule. Comparison of patients receiving SAT (37) and LAT (55) showed that the SAT group had a shorter length of hospital stay (29 vs. 40 days, p 0.01), and a trend towards lower frequency of renal failure (5.4% vs. 18.2%, p 0.11) and hepatic failure (5.4% vs. 9.1%, p 0.69), whereas mortality (5.4% vs. 3.6%, p 1), relapse (0% vs. 1.8%, p 1) and re-infection (5.4% vs. 3.6%, p 1) rates were similar between both groups. Multivariate analysis showed that IE caused by Streptococcus viridans or Streptococcus bovis was independently associated with SAT. Postsurgical SAT is safe, especially when IE is caused by Streptococcus viridans or Streptococcus bovis, even in patients at high risk of complications.

Guoliang Zhao - One of the best experts on this subject based on the ideXlab platform.

  • synthesis crystal structure and biological activity of a nickel ii complex constructed by 2 phenyl 4 selenazole carboxylic acid and 1 10 phenanthroline
    Journal of Coordination Chemistry, 2013
    Co-Authors: Pei Shi, Xia Shi, Quanyin Guan, Guoliang Zhao
    Abstract:

    A nickel(II) complex, [NiL(phen)2]L·5H2O (HL = 2-phenyl-4-selenazole carboxylic acid, C10H7O2NSe, phen = 1,10-phenanthroline), was synthesized and characterized by elemental analysis and IR. The single crystal structure was determined by single-crystal X-ray diffraction. C88H78N12Ni2O19Se4 crystallized in the triclinic system, space group Pī. The interaction between the complex and the calf thymus DNA was studied by an ethidium bromide fluorescent probe. The antibacterial activities of the complex and ligand against five species of bacteria, Escherichia coli, Staphylococcus epidermidis, Streptococcus viridans, Staphylococcus aureus and Acinetobacter baumanii, were tested. The anticancer activities of the complex against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied by employing an MTT assay.

Pei Shi - One of the best experts on this subject based on the ideXlab platform.

  • synthesis crystal structure and biological activity of a nickel ii complex constructed by 2 phenyl 4 selenazole carboxylic acid and 1 10 phenanthroline
    Journal of Coordination Chemistry, 2013
    Co-Authors: Pei Shi, Xia Shi, Quanyin Guan, Guoliang Zhao
    Abstract:

    A nickel(II) complex, [NiL(phen)2]L·5H2O (HL = 2-phenyl-4-selenazole carboxylic acid, C10H7O2NSe, phen = 1,10-phenanthroline), was synthesized and characterized by elemental analysis and IR. The single crystal structure was determined by single-crystal X-ray diffraction. C88H78N12Ni2O19Se4 crystallized in the triclinic system, space group Pī. The interaction between the complex and the calf thymus DNA was studied by an ethidium bromide fluorescent probe. The antibacterial activities of the complex and ligand against five species of bacteria, Escherichia coli, Staphylococcus epidermidis, Streptococcus viridans, Staphylococcus aureus and Acinetobacter baumanii, were tested. The anticancer activities of the complex against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied by employing an MTT assay.

Maddalena Giannella - One of the best experts on this subject based on the ideXlab platform.

  • two weeks of postsurgical therapy may be enough for high risk cases of endocarditis caused by Streptococcus viridans or Streptococcus bovis
    Clinical Microbiology and Infection, 2012
    Co-Authors: Patricia Munoz, Maddalena Giannella, F Scoti, M Predomingo, D Puga, Angel Gonzalez Pinto, J Roda
    Abstract:

    Abstract The duration of antimicrobial therapy after surgery for infective endocarditis (IE) is controversial. A short course of postsurgical therapy is currently accepted only for patients with negative valve culture. We performed a retrospective (1994–2008) analysis of patients who underwent surgery for IE in our hospital and had a high risk of complications (one of more of the following: Streptococcus viridans or Streptococcus bovis was independently associated with SAT. Postsurgical SAT is safe, especially when IE is caused by Streptococcus viridans or Streptococcus bovis , even in patients at high risk of complications.

  • two weeks of postsurgical therapy may be enough for high risk cases of endocarditis caused by Streptococcus viridans or Streptococcus bovis
    Clinical Microbiology and Infection, 2012
    Co-Authors: Patricia Munoz, Maddalena Giannella, F Scoti, M Predomingo, D Puga, Angel Gonzalez Pinto, J Roda, Mercedes Marin
    Abstract:

    The duration of antimicrobial therapy after surgery for infective endocarditis (IE) is controversial. A short course of postsurgical therapy is currently accepted only for patients with negative valve culture. We performed a retrospective (1994-2008) analysis of patients who underwent surgery for IE in our hospital and had a high risk of complications ( one of more of the following: <2 weeks of antibiotic treatment before surgery; embolism; perivalvular extension; and positive valve culture) to compare outcomes of patients who received short-course antimicrobial therapy (SAT) (median 15 days) or long-course antimicrobial therapy (LAT) (median 32 days), irrespective of the results of valve culture. Our endpoints included length of hospital stay, renal and hepatic failure, relapse, re-infection, and mortality rates 1 year after surgery. During the study period, 140 patients underwent surgery for IE (valve replacement, 87.9%). Of these, 133 fulfilled the high-risk group criteria and 92 completed the antimicrobial schedule. Comparison of patients receiving SAT (37) and LAT (55) showed that the SAT group had a shorter length of hospital stay (29 vs. 40 days, p 0.01), and a trend towards lower frequency of renal failure (5.4% vs. 18.2%, p 0.11) and hepatic failure (5.4% vs. 9.1%, p 0.69), whereas mortality (5.4% vs. 3.6%, p 1), relapse (0% vs. 1.8%, p 1) and re-infection (5.4% vs. 3.6%, p 1) rates were similar between both groups. Multivariate analysis showed that IE caused by Streptococcus viridans or Streptococcus bovis was independently associated with SAT. Postsurgical SAT is safe, especially when IE is caused by Streptococcus viridans or Streptococcus bovis, even in patients at high risk of complications.

J Roda - One of the best experts on this subject based on the ideXlab platform.

  • two weeks of postsurgical therapy may be enough for high risk cases of endocarditis caused by Streptococcus viridans or Streptococcus bovis
    Clinical Microbiology and Infection, 2012
    Co-Authors: Patricia Munoz, Maddalena Giannella, F Scoti, M Predomingo, D Puga, Angel Gonzalez Pinto, J Roda
    Abstract:

    Abstract The duration of antimicrobial therapy after surgery for infective endocarditis (IE) is controversial. A short course of postsurgical therapy is currently accepted only for patients with negative valve culture. We performed a retrospective (1994–2008) analysis of patients who underwent surgery for IE in our hospital and had a high risk of complications (one of more of the following: Streptococcus viridans or Streptococcus bovis was independently associated with SAT. Postsurgical SAT is safe, especially when IE is caused by Streptococcus viridans or Streptococcus bovis , even in patients at high risk of complications.

  • two weeks of postsurgical therapy may be enough for high risk cases of endocarditis caused by Streptococcus viridans or Streptococcus bovis
    Clinical Microbiology and Infection, 2012
    Co-Authors: Patricia Munoz, Maddalena Giannella, F Scoti, M Predomingo, D Puga, Angel Gonzalez Pinto, J Roda, Mercedes Marin
    Abstract:

    The duration of antimicrobial therapy after surgery for infective endocarditis (IE) is controversial. A short course of postsurgical therapy is currently accepted only for patients with negative valve culture. We performed a retrospective (1994-2008) analysis of patients who underwent surgery for IE in our hospital and had a high risk of complications ( one of more of the following: <2 weeks of antibiotic treatment before surgery; embolism; perivalvular extension; and positive valve culture) to compare outcomes of patients who received short-course antimicrobial therapy (SAT) (median 15 days) or long-course antimicrobial therapy (LAT) (median 32 days), irrespective of the results of valve culture. Our endpoints included length of hospital stay, renal and hepatic failure, relapse, re-infection, and mortality rates 1 year after surgery. During the study period, 140 patients underwent surgery for IE (valve replacement, 87.9%). Of these, 133 fulfilled the high-risk group criteria and 92 completed the antimicrobial schedule. Comparison of patients receiving SAT (37) and LAT (55) showed that the SAT group had a shorter length of hospital stay (29 vs. 40 days, p 0.01), and a trend towards lower frequency of renal failure (5.4% vs. 18.2%, p 0.11) and hepatic failure (5.4% vs. 9.1%, p 0.69), whereas mortality (5.4% vs. 3.6%, p 1), relapse (0% vs. 1.8%, p 1) and re-infection (5.4% vs. 3.6%, p 1) rates were similar between both groups. Multivariate analysis showed that IE caused by Streptococcus viridans or Streptococcus bovis was independently associated with SAT. Postsurgical SAT is safe, especially when IE is caused by Streptococcus viridans or Streptococcus bovis, even in patients at high risk of complications.