The Experts below are selected from a list of 11937 Experts worldwide ranked by ideXlab platform
Jhih Wei Jian - One of the best experts on this subject based on the ideXlab platform.
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predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Scientific Reports, 2015Co-Authors: Hong-sen Chen, Hung Pin Peng, Jhih Wei Jian, San Tai Shen, Shui Tsung Chen, Ming Chi Peng, Andrew H J Wang, Chung Ming Yu, Ing Chien ChenAbstract:Predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
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Predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Scientific Reports, 2015Co-Authors: Hong-sen Chen, Hung Pin Peng, Jhih Wei Jian, King Siang Goh, San Tai Shen, Jhong Jhe You, Wen Chih Kuo, Yu-ching Lee, Shin-chen Hou, Shui Tsung ChenAbstract:Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood. We used HER2 as a model immunogen and reverse-engineered murine antibody response through constructing an artificial antibody library encoded with rudimentary sequence and Structural characteristics learned from high throughput sequencing of antibody variable domains. Antibodies selected in vitro from the phage-displayed synthetic antibody library bound to the model immunogen with high affinity and specificities, which reproduced the specificities of natural antibody responses. We conclude that natural antibody Structural repertoires are shaped to allow functional antibodies to be encoded efficiently, within the complexity limit of an individual antibody repertoire, to bind to diverse protein antigens with high specificity and affinity. Phage-displayed synthetic antibody libraries, in conjunction with high-throughput sequencing, can thus be designed to replicate natural antibody responses and to generate novel antibodies against diverse antigens.
Shui Tsung Chen - One of the best experts on this subject based on the ideXlab platform.
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predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Scientific Reports, 2015Co-Authors: Hong-sen Chen, Hung Pin Peng, Jhih Wei Jian, San Tai Shen, Shui Tsung Chen, Ming Chi Peng, Andrew H J Wang, Chung Ming Yu, Ing Chien ChenAbstract:Predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
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Predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Scientific Reports, 2015Co-Authors: Hong-sen Chen, Hung Pin Peng, Jhih Wei Jian, King Siang Goh, San Tai Shen, Jhong Jhe You, Wen Chih Kuo, Yu-ching Lee, Shin-chen Hou, Shui Tsung ChenAbstract:Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood. We used HER2 as a model immunogen and reverse-engineered murine antibody response through constructing an artificial antibody library encoded with rudimentary sequence and Structural characteristics learned from high throughput sequencing of antibody variable domains. Antibodies selected in vitro from the phage-displayed synthetic antibody library bound to the model immunogen with high affinity and specificities, which reproduced the specificities of natural antibody responses. We conclude that natural antibody Structural repertoires are shaped to allow functional antibodies to be encoded efficiently, within the complexity limit of an individual antibody repertoire, to bind to diverse protein antigens with high specificity and affinity. Phage-displayed synthetic antibody libraries, in conjunction with high-throughput sequencing, can thus be designed to replicate natural antibody responses and to generate novel antibodies against diverse antigens.
Hong-sen Chen - One of the best experts on this subject based on the ideXlab platform.
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predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Scientific Reports, 2015Co-Authors: Hong-sen Chen, Hung Pin Peng, Jhih Wei Jian, San Tai Shen, Shui Tsung Chen, Ming Chi Peng, Andrew H J Wang, Chung Ming Yu, Ing Chien ChenAbstract:Predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
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Predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Scientific Reports, 2015Co-Authors: Hong-sen Chen, Hung Pin Peng, Jhih Wei Jian, King Siang Goh, San Tai Shen, Jhong Jhe You, Wen Chih Kuo, Yu-ching Lee, Shin-chen Hou, Shui Tsung ChenAbstract:Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood. We used HER2 as a model immunogen and reverse-engineered murine antibody response through constructing an artificial antibody library encoded with rudimentary sequence and Structural characteristics learned from high throughput sequencing of antibody variable domains. Antibodies selected in vitro from the phage-displayed synthetic antibody library bound to the model immunogen with high affinity and specificities, which reproduced the specificities of natural antibody responses. We conclude that natural antibody Structural repertoires are shaped to allow functional antibodies to be encoded efficiently, within the complexity limit of an individual antibody repertoire, to bind to diverse protein antigens with high specificity and affinity. Phage-displayed synthetic antibody libraries, in conjunction with high-throughput sequencing, can thus be designed to replicate natural antibody responses and to generate novel antibodies against diverse antigens.
Ing Chien Chen - One of the best experts on this subject based on the ideXlab platform.
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predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Scientific Reports, 2015Co-Authors: Hong-sen Chen, Hung Pin Peng, Jhih Wei Jian, San Tai Shen, Shui Tsung Chen, Ming Chi Peng, Andrew H J Wang, Chung Ming Yu, Ing Chien ChenAbstract:Predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Hung Pin Peng - One of the best experts on this subject based on the ideXlab platform.
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predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Scientific Reports, 2015Co-Authors: Hong-sen Chen, Hung Pin Peng, Jhih Wei Jian, San Tai Shen, Shui Tsung Chen, Ming Chi Peng, Andrew H J Wang, Chung Ming Yu, Ing Chien ChenAbstract:Predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
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Predominant Structural Configuration of natural antibody repertoires enables potent antibody responses against protein antigens
Scientific Reports, 2015Co-Authors: Hong-sen Chen, Hung Pin Peng, Jhih Wei Jian, King Siang Goh, San Tai Shen, Jhong Jhe You, Wen Chih Kuo, Yu-ching Lee, Shin-chen Hou, Shui Tsung ChenAbstract:Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood. We used HER2 as a model immunogen and reverse-engineered murine antibody response through constructing an artificial antibody library encoded with rudimentary sequence and Structural characteristics learned from high throughput sequencing of antibody variable domains. Antibodies selected in vitro from the phage-displayed synthetic antibody library bound to the model immunogen with high affinity and specificities, which reproduced the specificities of natural antibody responses. We conclude that natural antibody Structural repertoires are shaped to allow functional antibodies to be encoded efficiently, within the complexity limit of an individual antibody repertoire, to bind to diverse protein antigens with high specificity and affinity. Phage-displayed synthetic antibody libraries, in conjunction with high-throughput sequencing, can thus be designed to replicate natural antibody responses and to generate novel antibodies against diverse antigens.
