The Experts below are selected from a list of 22068 Experts worldwide ranked by ideXlab platform
Gerhard Sengle - One of the best experts on this subject based on the ideXlab platform.
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fibrillin microfibrils and proteases key integrators of fibrotic pathways
Advanced Drug Delivery Reviews, 2019Co-Authors: Paola Zigrino, Gerhard SengleAbstract:Abstract Supramolecular networks composed of multi-domain ECM proteins represent intricate cellular microenvironments which are required to balance tissue homeostasis and direct remodeling. Structural Deficiency in ECM proteins results in imbalances in ECM-cell communication resulting often times in fibrotic reactions. To understand how individual components of the ECM integrate communication with the cell surface by presenting growth factors or providing fine-tuned biomechanical properties is mandatory for gaining a better understanding of disease mechanisms in the quest for new therapeutic approaches. Here we provide an overview about what we can learn from inherited connective tissue disorders caused primarily by mutations in fibrillin-1 and binding partners as well as by altered ECM processing leading to defined Structural changes and similar functional knock-in mouse models. We will utilize this knowledge to propose new molecular hypotheses which should be tested in future studies.
Daniel N Farhey - One of the best experts on this subject based on the ideXlab platform.
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Structural Performances of Bridge Types in the U.S. National Bridge Inventory
MDPI AG, 2018Co-Authors: Daniel N FarheyAbstract:This paper demonstrates a comprehensive national network-level analysis to determine the relative deteriorations and operational Structural performances of the various types of bridge Structural design and/or construction. The study analyzes the entire database of the U.S. National Bridge Inventory for the year 2013 and considers bridge counts along with bridge deck areas that provide more significant results. Analysis of the proportional distribution of Structural Deficiency reveals issues of deterioration. Considering the Structural Deficiency, service life cycle and deterioration trends of bridge types over time, the multi-criteria equivalent Structural performances incorporate the condition, durability, longevity, rate and pattern performances. The results provide support for more sustainable engineering and management decisions. Stringer/multi beam or girder (type 02) bridges are the most common bridge type, 40.75% by counts and 61.88% by areas. The Structural performance of type 02 bridges seems comparable to the average of all bridges, yet they have lower durability and longevity performances, revealing a relative service life cycle vulnerability. The lowest Structural performances are orthotropic (type 08) and segmental box girder (type 21) bridges; while their condition performances are rather high, their durability, longevity, rate and pattern performances are essentially low. The slight improvement of Structural performance from 2006 to 2013 for most bridge types is not significant over seven years. Also, certain bridge types worsened
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operational Structural performances of bridge materials by deterioration trends
Journal of Performance of Constructed Facilities, 2014Co-Authors: Daniel N FarheyAbstract:This paper demonstrates the analysis of the deterioration trends of bridges to evaluate the operational Structural performances of the various kinds of bridge construction materials and/or Structural designs. The goal of this study is to improve the performance of Structural materials used to construct bridges, based on rigorous population-based analysis of the performance of those materials in service. The analysis uses the raw database of the entire National Bridge Inventory in the United States and derives material deterioration aspects at the serviceability limit states. The study develops measures of deterioration to consider the trends in the accumulation of Structural Deficiency versus service life cycle by material. The approach defines the criteria of rate and pattern performances to analyze the comparative deterioration trends. A multiple-criteria diagnostic approach determines the overall equivalent Structural performances integrating the rate and pattern performances with the measures of condition, durability, and longevity. The national network-level operational experience by categorical deterioration trends produces the most comprehensive comparative basis of Structural performance of bridge materials. Overall for all bridges, the average increase of Structural Deficiency is 0.51%/year, adding to the already existing 12.35% and consisting of an average annual increase of Structurally deficient bridges by 4.10%. The accumulation of Structurally deficient bridges begins only after 10 years for most materials. The rate and pattern performances of almost all of the materials are quite poor. Thus, the equivalent performances integrating the deterioration trends are lower. The results provide a more objective indication and comparison of Structural performances under the actual circumstances and help predict future performance. The approach supports the development of improvements necessary to increase the relative performances of distinct bridge materials for more sustainable service.
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performance of bridge materials by Structural Deficiency analysis
Journal of Performance of Constructed Facilities, 2010Co-Authors: Daniel N FarheyAbstract:The diagnostic concept of the Structural Deficiency of bridges is an essential engineering and management consideration with implications of performance. The Structural Deficiency analysis reflects the constructed system performance at the serviceability limit states. This paper analyzes trends in the Structural Deficiency of bridge inventory on the basis of material kind. A multiple-criteria diagnostic approach defines measures for condition, durability, and longevity performances and determines the overall equivalent performance. Thus, the Structural performance levels reflect the Structural reliability and vulnerability indices for bridge serviceability. The application of the approach analyzes the raw database of the entire bridge inventory in the United States. This comprehensive operational experience provides a national network-level comparative basis. The comparison suggests a relative need for improvements in one or more areas, such as design details or maintenance level, to increase the desirability of bridge construction materials. The results support more objective bridge management and decision making on distribution of funds, updating of policies, perfection of practices, and trade-off analyses for design, construction, maintenance, and replacement.
Keli Daniell - One of the best experts on this subject based on the ideXlab platform.
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development of user friendly software application for extracting information from national bridge inventory source files
Transportation Research Record, 2010Co-Authors: Scott Mcclure, Keli DaniellAbstract:The nation is facing enormous repair, maintenance, and replacement costs for its aging bridge infrastructure, and this issue is of concern to a broad cross section of public and private interests. A simple-to-use bridge information system is needed by technical and nontechnical users who would like to review detailed information on the condition of the nation's public bridges without recourse to access-restricted and cost-prohibitive proprietary software. The annual National Bridge Inventory (NBI) text files collected from the states over consecutive years and maintained by FHWA constitute a wealth of information on approximately 600,000 public bridges throughout the United States, including information on condition and load ratings, geometry, sufficiency, age, location, functional classification, average daily traffic, improvement costs, inspection frequency, material and design types, historical significance, Structural Deficiency, and functional obsolescence. This information is of potential significan...
Paola Zigrino - One of the best experts on this subject based on the ideXlab platform.
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fibrillin microfibrils and proteases key integrators of fibrotic pathways
Advanced Drug Delivery Reviews, 2019Co-Authors: Paola Zigrino, Gerhard SengleAbstract:Abstract Supramolecular networks composed of multi-domain ECM proteins represent intricate cellular microenvironments which are required to balance tissue homeostasis and direct remodeling. Structural Deficiency in ECM proteins results in imbalances in ECM-cell communication resulting often times in fibrotic reactions. To understand how individual components of the ECM integrate communication with the cell surface by presenting growth factors or providing fine-tuned biomechanical properties is mandatory for gaining a better understanding of disease mechanisms in the quest for new therapeutic approaches. Here we provide an overview about what we can learn from inherited connective tissue disorders caused primarily by mutations in fibrillin-1 and binding partners as well as by altered ECM processing leading to defined Structural changes and similar functional knock-in mouse models. We will utilize this knowledge to propose new molecular hypotheses which should be tested in future studies.
Scott Mcclure - One of the best experts on this subject based on the ideXlab platform.
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development of user friendly software application for extracting information from national bridge inventory source files
Transportation Research Record, 2010Co-Authors: Scott Mcclure, Keli DaniellAbstract:The nation is facing enormous repair, maintenance, and replacement costs for its aging bridge infrastructure, and this issue is of concern to a broad cross section of public and private interests. A simple-to-use bridge information system is needed by technical and nontechnical users who would like to review detailed information on the condition of the nation's public bridges without recourse to access-restricted and cost-prohibitive proprietary software. The annual National Bridge Inventory (NBI) text files collected from the states over consecutive years and maintained by FHWA constitute a wealth of information on approximately 600,000 public bridges throughout the United States, including information on condition and load ratings, geometry, sufficiency, age, location, functional classification, average daily traffic, improvement costs, inspection frequency, material and design types, historical significance, Structural Deficiency, and functional obsolescence. This information is of potential significan...
