The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform
Martijn P Van Den Heuvel - One of the best experts on this subject based on the ideXlab platform.
-
biological characteristics of connection wise resting state functional connectivity strength
Cerebral Cortex, 2019Co-Authors: Rory Pijnenburg, Lianne H Scholtens, Wim Vanduffel, Dante Mantini, Lisa Feldman Barrett, Martijn P Van Den HeuvelAbstract:Functional connectivity is defined as the statistical dependency of neurophysiological activity between 2 separate brain areas. To investigate the biological characteristics of resting-state functional connectivity (rsFC)-and in particular the significance of connection-wise variation in time-series correlations-rsFC was compared with Strychnine-based connectivity measured in the macaque. Strychnine neuronography is a historical technique that induces activity in cortical areas through means of local administration of the substance Strychnine. Strychnine causes local disinhibition through GABA suppression and leads to subsequent activation of functional pathways. Multiple resting-state fMRI recordings were acquired in 4 macaques (examining in total 299 imaging runs) from which a group-averaged rsFC matrix was constructed. rsFC was observed to be higher (P < 0.0001) between region-pairs with a Strychnine-based connection as compared with region-pairs with no Strychnine-based connection present. In particular, higher resting-state connectivity was observed in connections that were relatively stronger (weak < moderate < strong; P < 0.01) and in connections that were bidirectional (P < 0.0001) instead of unidirectional in Strychnine-based connectivity. Our results imply that the level of correlation between brain areas as extracted from resting-state fMRI relates to the strength of underlying interregional functional pathways.
Lisa Feldman Barrett - One of the best experts on this subject based on the ideXlab platform.
-
biological characteristics of connection wise resting state functional connectivity strength
Cerebral Cortex, 2019Co-Authors: Rory Pijnenburg, Lianne H Scholtens, Wim Vanduffel, Dante Mantini, Lisa Feldman Barrett, Martijn P Van Den HeuvelAbstract:Functional connectivity is defined as the statistical dependency of neurophysiological activity between 2 separate brain areas. To investigate the biological characteristics of resting-state functional connectivity (rsFC)-and in particular the significance of connection-wise variation in time-series correlations-rsFC was compared with Strychnine-based connectivity measured in the macaque. Strychnine neuronography is a historical technique that induces activity in cortical areas through means of local administration of the substance Strychnine. Strychnine causes local disinhibition through GABA suppression and leads to subsequent activation of functional pathways. Multiple resting-state fMRI recordings were acquired in 4 macaques (examining in total 299 imaging runs) from which a group-averaged rsFC matrix was constructed. rsFC was observed to be higher (P < 0.0001) between region-pairs with a Strychnine-based connection as compared with region-pairs with no Strychnine-based connection present. In particular, higher resting-state connectivity was observed in connections that were relatively stronger (weak < moderate < strong; P < 0.01) and in connections that were bidirectional (P < 0.0001) instead of unidirectional in Strychnine-based connectivity. Our results imply that the level of correlation between brain areas as extracted from resting-state fMRI relates to the strength of underlying interregional functional pathways.
Wim Vanduffel - One of the best experts on this subject based on the ideXlab platform.
-
biological characteristics of connection wise resting state functional connectivity strength
Cerebral Cortex, 2019Co-Authors: Rory Pijnenburg, Lianne H Scholtens, Wim Vanduffel, Dante Mantini, Lisa Feldman Barrett, Martijn P Van Den HeuvelAbstract:Functional connectivity is defined as the statistical dependency of neurophysiological activity between 2 separate brain areas. To investigate the biological characteristics of resting-state functional connectivity (rsFC)-and in particular the significance of connection-wise variation in time-series correlations-rsFC was compared with Strychnine-based connectivity measured in the macaque. Strychnine neuronography is a historical technique that induces activity in cortical areas through means of local administration of the substance Strychnine. Strychnine causes local disinhibition through GABA suppression and leads to subsequent activation of functional pathways. Multiple resting-state fMRI recordings were acquired in 4 macaques (examining in total 299 imaging runs) from which a group-averaged rsFC matrix was constructed. rsFC was observed to be higher (P < 0.0001) between region-pairs with a Strychnine-based connection as compared with region-pairs with no Strychnine-based connection present. In particular, higher resting-state connectivity was observed in connections that were relatively stronger (weak < moderate < strong; P < 0.01) and in connections that were bidirectional (P < 0.0001) instead of unidirectional in Strychnine-based connectivity. Our results imply that the level of correlation between brain areas as extracted from resting-state fMRI relates to the strength of underlying interregional functional pathways.
Rory Pijnenburg - One of the best experts on this subject based on the ideXlab platform.
-
biological characteristics of connection wise resting state functional connectivity strength
Cerebral Cortex, 2019Co-Authors: Rory Pijnenburg, Lianne H Scholtens, Wim Vanduffel, Dante Mantini, Lisa Feldman Barrett, Martijn P Van Den HeuvelAbstract:Functional connectivity is defined as the statistical dependency of neurophysiological activity between 2 separate brain areas. To investigate the biological characteristics of resting-state functional connectivity (rsFC)-and in particular the significance of connection-wise variation in time-series correlations-rsFC was compared with Strychnine-based connectivity measured in the macaque. Strychnine neuronography is a historical technique that induces activity in cortical areas through means of local administration of the substance Strychnine. Strychnine causes local disinhibition through GABA suppression and leads to subsequent activation of functional pathways. Multiple resting-state fMRI recordings were acquired in 4 macaques (examining in total 299 imaging runs) from which a group-averaged rsFC matrix was constructed. rsFC was observed to be higher (P < 0.0001) between region-pairs with a Strychnine-based connection as compared with region-pairs with no Strychnine-based connection present. In particular, higher resting-state connectivity was observed in connections that were relatively stronger (weak < moderate < strong; P < 0.01) and in connections that were bidirectional (P < 0.0001) instead of unidirectional in Strychnine-based connectivity. Our results imply that the level of correlation between brain areas as extracted from resting-state fMRI relates to the strength of underlying interregional functional pathways.
Young Hae Choi - One of the best experts on this subject based on the ideXlab platform.
-
Analysis of Strychnine from detoxified Strychno nux-vomica seeds using liquid chromatography–electrospray mass spectrometry
Journal of Ethnopharmacology, 2004Co-Authors: Young Hae Choi, You-min Sohn, Kwan Yul OhAbstract:Abstract The content of Strychnine from Strychno nux-vomica seeds was analyzed and compared to processed seeds by the HPLC–ESI/MS method. Using this technique, levels as low as 1 ng of Strychnine were detected. In contrast to conventional UV detectors, this method also made it possible to discriminate brucine. This study resulted in finding the content of Strychnine in detoxified seeds to be one tenth of unprocessed Strychno nux-vomica seeds.
-
analysis of Strychnine from detoxified strychno nux vomica seeds using liquid chromatography electrospray mass spectrometry
Journal of Ethnopharmacology, 2004Co-Authors: Young Hae Choi, You-min Sohn, Chul Young Kim, Jinwoong KimAbstract:The content of Strychnine from Strychnos nux-vomica [corrected] seeds was analyzed and compared to processed seeds by the HPLC-ESI/MS method. Using this technique, levels as low as 1 ng of Strychnine were detected. In contrast to conventional UV detectors, this method also made it possible to discriminate brucine. This study resulted in finding the content of Strychnine in detoxified seeds to be one tenth of unprocessed Strychnos nux-vomica [corrected] seeds.
