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Wilbert S. Aronow - One of the best experts on this subject based on the ideXlab platform.
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Increased prevalence of peripheral arterial disease in older men and women with Subclinical Hypothyroidism.
The journals of gerontology. Series A Biological sciences and medical sciences, 2003Co-Authors: Min Min Mya, Wilbert S. AronowAbstract:Background. We report the prevalence of symptomatic peripheral arterial disease (PAD) associated with Subclinical Hypothyroidism in older persons. Methods. We investigated the association of Subclinical Hypothyroidism with symptomatic PAD in 18 persons (16 women and 2 men) with Subclinical Hypothyroidism and in 231 euthyroid persons (151 women and 96 men), mean age 79 6 9 years, in an academic nursing home. Results. Symptomatic PAD was present in 14 of 18 persons (78%) with Subclinical Hypothyroidism and in 40 of 231 euthyroid persons (17%; p , .0001, comparing Subclinical Hypothyroidism with euthyroidism). Symptomatic PAD was present in 13 of 16 women (81%) and in 1 of 2 men (50%) with Subclinical Hypothyroidism ( p was not significant). Conclusions. Subclinical Hypothyroidism was associated with a high prevalence of symptomatic PAD in elderly men and women.
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Subclinical Hypothyroidism Is Associated With Coronary Artery Disease in Older Persons
The journals of gerontology. Series A Biological sciences and medical sciences, 2002Co-Authors: Min Min Mya, Wilbert S. AronowAbstract:Background. We report the prevalence of coronary artery disease (CAD) associated with Subclinical Hypothyroidism in older persons. Methods. We investigated the prevalence of Subclinical Hypothyroidism and its association with dyslipidemia and with CAD in 170 women and 110 men, mean age 75 � 9 years, in an academic nursing home. Results. Of 280 persons, 18 (6%) had Subclinical Hypothyroidism, 18 (6%) had treated clinical Hypothyroidism, 13 (5%) had Subclinical hyperthyroidism, and 231 (83%) were euthyroid. Dyslipidemia occurred in 15 of 18 persons (83%) with Subclinical Hypothyroidism, in nine of 18 persons (50%) treated for Hypothyroidism, in six of 13 persons (46%) with Subclinical hyperthyroidism, and in 128 of 231 euthyroid persons (55%) ( p � .025 comparing Subclinical Hypothyroidism with euthyroidism and p � .005 comparing Subclinical Hypothyroidism with treated Hypothyroidism and with Subclinical hyperthyroidism). CAD was present in 10 of 18 persons (56%) with Subclinical Hypothyroidism, in nine of 18 persons (50%) with treated Hypothyroidism, in 5 of 13 persons (38%) with Subclinical hyperthyroidism, and in 38 of 231 euthyroid persons (16%) ( p � .001 comparing Subclinical Hypothyroidism with euthyroidism; p � .005 comparing treated Hypothyroidism with euthyroidism; and p � .05 comparing Subclinical hyperthyroidism with euthyroidism). Conclusions. Subclinical Hypothyroidism was associated with a high prevalence of dyslipidemia and a high prevalence of CAD.
Min Min Mya - One of the best experts on this subject based on the ideXlab platform.
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Increased prevalence of peripheral arterial disease in older men and women with Subclinical Hypothyroidism.
The journals of gerontology. Series A Biological sciences and medical sciences, 2003Co-Authors: Min Min Mya, Wilbert S. AronowAbstract:Background. We report the prevalence of symptomatic peripheral arterial disease (PAD) associated with Subclinical Hypothyroidism in older persons. Methods. We investigated the association of Subclinical Hypothyroidism with symptomatic PAD in 18 persons (16 women and 2 men) with Subclinical Hypothyroidism and in 231 euthyroid persons (151 women and 96 men), mean age 79 6 9 years, in an academic nursing home. Results. Symptomatic PAD was present in 14 of 18 persons (78%) with Subclinical Hypothyroidism and in 40 of 231 euthyroid persons (17%; p , .0001, comparing Subclinical Hypothyroidism with euthyroidism). Symptomatic PAD was present in 13 of 16 women (81%) and in 1 of 2 men (50%) with Subclinical Hypothyroidism ( p was not significant). Conclusions. Subclinical Hypothyroidism was associated with a high prevalence of symptomatic PAD in elderly men and women.
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Subclinical Hypothyroidism Is Associated With Coronary Artery Disease in Older Persons
The journals of gerontology. Series A Biological sciences and medical sciences, 2002Co-Authors: Min Min Mya, Wilbert S. AronowAbstract:Background. We report the prevalence of coronary artery disease (CAD) associated with Subclinical Hypothyroidism in older persons. Methods. We investigated the prevalence of Subclinical Hypothyroidism and its association with dyslipidemia and with CAD in 170 women and 110 men, mean age 75 � 9 years, in an academic nursing home. Results. Of 280 persons, 18 (6%) had Subclinical Hypothyroidism, 18 (6%) had treated clinical Hypothyroidism, 13 (5%) had Subclinical hyperthyroidism, and 231 (83%) were euthyroid. Dyslipidemia occurred in 15 of 18 persons (83%) with Subclinical Hypothyroidism, in nine of 18 persons (50%) treated for Hypothyroidism, in six of 13 persons (46%) with Subclinical hyperthyroidism, and in 128 of 231 euthyroid persons (55%) ( p � .025 comparing Subclinical Hypothyroidism with euthyroidism and p � .005 comparing Subclinical Hypothyroidism with treated Hypothyroidism and with Subclinical hyperthyroidism). CAD was present in 10 of 18 persons (56%) with Subclinical Hypothyroidism, in nine of 18 persons (50%) with treated Hypothyroidism, in 5 of 13 persons (38%) with Subclinical hyperthyroidism, and in 38 of 231 euthyroid persons (16%) ( p � .001 comparing Subclinical Hypothyroidism with euthyroidism; p � .005 comparing treated Hypothyroidism with euthyroidism; and p � .05 comparing Subclinical hyperthyroidism with euthyroidism). Conclusions. Subclinical Hypothyroidism was associated with a high prevalence of dyslipidemia and a high prevalence of CAD.
Elizabeth N Pearce - One of the best experts on this subject based on the ideXlab platform.
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Update in Lipid Alterations in Subclinical Hypothyroidism
The Journal of clinical endocrinology and metabolism, 2011Co-Authors: Elizabeth N PearceAbstract:Thyroid hormone has multiple effects on the regulation of lipid synthesis, absorption, and metabolism. Studies consistently demonstrate elevated levels of serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B, lipoprotein(a), and possibly triglycerides in individuals with overt Hypothyroidism, all of which are reversible with levothyroxine therapy. Although it is estimated that 1 to 11% of all patients with dyslipidemia have Subclinical Hypothyroidism, the effects of Subclinical Hypothyroidism on serum lipid values are less clear. Apolipoprotein B levels may be increased in patients with Subclinical Hypothyroidism. Although some studies have demonstrated that total cholesterol and LDL-C levels are elevated in patients with Subclinical Hypothyroidism, others have not shown any effect of Subclinical Hypothyroidism on these lipid measurements. Serum triglycerides, lipid subparticle size, and LDL-C oxidizability may be altered in Subclinical Hypothyroidism, but these studies h...
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Subclinical Hypothyroidism.
Current opinion in endocrinology diabetes and obesity, 2007Co-Authors: Giampaolo Papi, Ettore Degli Uberti, Corrado Betterle, Cesare Carani, Elizabeth N Pearce, Lewis E Braverman, Elio RotiAbstract:Mild or Subclinical Hypothyroidism is characterized by normal serum free thyroxine concentrations with elevated serum thyroid-stimulating hormone concentrations. Subclinical Hypothyroidism is relatively prevalent in the general population, especially among women and the elderly. The main cause of Subclinical Hypothyroidism is autoimmune chronic thyroiditis. The present report reviews the most important and recent studies on Subclinical Hypothyroidism, and discusses the most controversial aspects of this topic. Several studies have demonstrated that Subclinical Hypothyroidism may affect both diastolic and systolic cardiac function. It may also worsen many risk factors for cardiovascular disease, including hypertension, abnormal endothelial function, and elevated low-density lipoprotein cholesterol concentrations. Furthermore, a growing body of evidence suggests that Subclinical Hypothyroidism may cause symptoms or progress to symptomatic overt Hypothyroidism. Prompt treatment of Subclinical Hypothyroidism in pregnant women is mandatory to decrease risks for pregnancy complications and impaired cognitive development in offspring. Children with Subclinical Hypothyroidism should be treated to prevent growth retardation. Whether nonpregnant adult patients with Subclinical Hypothyroidism should be treated, and at what thyroid-stimulating hormone values, is debatable.
Onyebuchi E Okosieme - One of the best experts on this subject based on the ideXlab platform.
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myxedema coma in a patient with Subclinical Hypothyroidism
Thyroid, 2011Co-Authors: Akhila Mallipedhi, Hamza Vali, Onyebuchi E OkosiemeAbstract:Background: Myxedema coma is the extreme manifestation of Hypothyroidism, typically seen in patients with severe biochemical Hypothyroidism. Its occurrence in association with Subclinical Hypothyroidism is extremely unusual. We describe a patient with Subclinical Hypothyroidism who developed clinical manifestations of myxedema coma. Summary: A 47-year-old woman presented to our endocrine clinic with complaints of fatigue and biochemical findings of Subclinical Hypothyroidism. She was started on treatment with thyroxine (T4) but remained unwell and was later admitted to hospital with hormone profile showing persisting Subclinical Hypothyroidism (elevated thyrotropin and normal free T4 [FT4] and free triiodothyronine [FT3]): FT4 10.7 pmol/L (reference range 10.3–24.5), FT3 2.7 pmol/L (reference range 2.67–7.03), and thyrotropin 6.09 mU/L (reference range 0.4–4.0). She subsequently developed hypothermia (temperature 33.2°C), circulatory collapse, and coma. Biochemical profile showed hyponatremia, elevated cr...
Shinichiro Ichimaru - One of the best experts on this subject based on the ideXlab platform.
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Metabolic cardiovascular disease risk factors and their clustering in Subclinical Hypothyroidism
Clinical endocrinology, 2010Co-Authors: Kiyoto Ashizawa, Misa Imaizumi, Toshiro Usa, Tan Tominaga, Nobuko Sera, Ayumi Hida, Eri Ejima, Kazuo Neriishi, Midori Soda, Shinichiro IchimaruAbstract:Summary Objective A possible association between Subclinical Hypothyroidism and cardiovascular disease (CVD) has been reported. Monitoring of atomic-bomb survivors for late effects of radiation exposure at the Radiation Effects Research Foundation has provided the opportunity to examine associations between Subclinical Hypothyroidism and metabolic CVD risk factors. The objective of the study was to evaluate associations between Subclinical Hypothyroidism and metabolic CVD risk factors, and a cluster of these factors. Design and participants This was a cross-sectional study of 3549 subjects (mean age 70 years; 1221 men and 2328 women) between 2000 and 2003 comprising 306 subjects with Subclinical Hypothyroidism and 3243 control euthyroid subjects in Japan. Measurements We investigated associations between Subclinical Hypothyroidism and metabolic CVD risk factors such as hypertension, diabetes mellitus, dyslipidaemia and hyperuricaemia, and a cluster of these factors. Results Subclinical Hypothyroidism was not significantly associated with either hypertension, diabetes mellitus or hyperuricaemia defined by taking into account the use of medications in both men and women, but in men it was associated with dyslipidaemia (P = 0·02). We observed a significantly increased odds ratio (OR) for the presence of three or more metabolic CVD risk factors in men with Subclinical Hypothyroidism after adjusting for age, body mass index (BMI), and smoking status [OR: 1·83, 95% confidence interval (CI): 1·13–2·94, P = 0·01]. The significant associations remained after an additional adjustment for atomic-bomb radiation dose. Conclusions There appears to be a significant increase in a cluster of metabolic CVD risk factors among people with Subclinical Hypothyroidism.
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risk for ischemic heart disease and all cause mortality in Subclinical Hypothyroidism
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Misa Imaizumi, Kiyoto Ashizawa, Toshiro Usa, Ayumi Hida, Midori Soda, Shinichiro Ichimaru, Masazumi Akahoshi, Eiji Nakashima, Naokata Yokoyama, Renju MaedaAbstract:We investigated possible associations between Subclinical Hypothyroidism and atherosclerotic diseases (ischemic heart disease and cerebrovascular disease) and mortality. Of 2856 participants (mean age 58.5 yr) in a thyroid disease screening between 1984 and 1987, 257 subjects with Subclinical Hypothyroidism (TSH > 5.0 mU/liter) and 2293 control subjects (TSH range 0.6-5.0 mU/liter) were analyzed. In the baseline cross-sectional analysis, Subclinical Hypothyroidism was associated with ischemic heart disease independent of age, systolic blood pressure, body mass index, cholesterol, smoking, erythrocyte sedimentation rate, or presence of diabetes mellitus [odds ratio (OR), 2.5; 95% confidence interval (95% CI), 1.1-5.4 in total subjects and OR, 4.0; 95% CI, 1.4-11.5 in men] but not in women. However, there was no association with cerebrovascular disease (OR, 0.9; 95% CI, 0.4-2.4). We were unable to detect an influence of thyroid antibody presence on the association between Subclinical Hypothyroidism and ischemic heart disease. In a 10-yr follow-up study until 1998, increased mortalities from all causes in yr 3-6 after baseline measurement were apparent in men with Subclinical Hypothyroidism (hazard ratio, 1.9-2.1) but not in women, although specific causes of death were not determined. Our results indicate that Subclinical Hypothyroidism is associated with ischemic heart disease and might affect all-cause mortality in men.
