The Experts below are selected from a list of 594 Experts worldwide ranked by ideXlab platform
J. Dalrymple - One of the best experts on this subject based on the ideXlab platform.
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Structural characterisation of bis(suberate) cobalt(II) 1.5 hydrate and a thermal analysis study of Suberic Acid and bis(suberate) cobalt(II) 1.5 hydrate
Thermochimica Acta, 1993Co-Authors: J.r. Allan, J. DalrympleAbstract:Abstract A metal complex of Suberic Acid with cobalt of stoichiometry Co(C 8 H 12 O 4 ) · 1.5H 2 O has been prepared. The compound has a tetrahedral structure. Thermal decomposition studies of Suberic Acid and of Co(C 8 H 12 O 4 ) · 1.5H 2 O show that the Suberic Acid melts at 143°C, while the metal complex loses water and then the organic ligand, to give CO 3 O 4 .
Brian G. Amsden - One of the best experts on this subject based on the ideXlab platform.
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immobilization of a bone and cartilage stimulating peptide to a synthetic bone graft
Journal of Materials Science: Materials in Medicine, 2008Co-Authors: Vivian Wang, Gauri Misra, Brian G. AmsdenAbstract:A synthetic peptide fragment of human collagen type I (BCSP™-1) was linked to the surface of a commercially available ceramic in an effort to improve the properties of the bone graft substitute to accelerate local healing. BCSP™-1 was covalently immobilized on the surface of the ceramic via the linkers 3-aminopropyl-triethoxysilane (APTES) and Suberic Acid bis-N-hydroxysuccinimide ester (DSS). The chosen chemistry was non-cytotoxic. A rat calvaria cell assay using alkaline phosphatase (ALP) as an osteoblast differentiation marker, showed that modifying the surface of the ceramic was enough to enhance ALP activity, although the total cell population on the surface decreased. A significant increase in ALP activity/cell was noted with serum albumin bound to the surface, however, the BCSP™-1 bound surface exhibited an even greater ALP activity that showed a surface concentration dependent trend. An optimal BCSP™-1 surface density in the range of 0.87–2.24 nmol/cm2 elicited the maximum ALP activity/cell at day 6 of culture. The peptide bound ceramic generated an ALP activity/cell that was roughly 3-fold higher than the non-modified ceramic and 2-fold higher than the APTES-grafted ceramic.
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immobilization of a bone and cartilage stimulating peptide to a synthetic bone graft
Journal of Materials Science: Materials in Medicine, 2008Co-Authors: Vivian Wang, Gauri Misra, Brian G. AmsdenAbstract:A synthetic peptide fragment of human collagen type I (BCSP™-1) was linked to the surface of a commercially available ceramic in an effort to improve the properties of the bone graft substitute to accelerate local healing. BCSP™-1 was covalently immobilized on the surface of the ceramic via the linkers 3-aminopropyl-triethoxysilane (APTES) and Suberic Acid bis-N-hydroxysuccinimide ester (DSS). The chosen chemistry was non-cytotoxic. A rat calvaria cell assay using alkaline phosphatase (ALP) as an osteoblast differentiation marker, showed that modifying the surface of the ceramic was enough to enhance ALP activity, although the total cell population on the surface decreased. A significant increase in ALP activity/cell was noted with serum albumin bound to the surface, however, the BCSP™-1 bound surface exhibited an even greater ALP activity that showed a surface concentration dependent trend. An optimal BCSP™-1 surface density in the range of 0.87–2.24 nmol/cm2 elicited the maximum ALP activity/cell at day 6 of culture. The peptide bound ceramic generated an ALP activity/cell that was roughly 3-fold higher than the non-modified ceramic and 2-fold higher than the APTES-grafted ceramic.
J.r. Allan - One of the best experts on this subject based on the ideXlab platform.
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Structural characterisation of bis(suberate) cobalt(II) 1.5 hydrate and a thermal analysis study of Suberic Acid and bis(suberate) cobalt(II) 1.5 hydrate
Thermochimica Acta, 1993Co-Authors: J.r. Allan, J. DalrympleAbstract:Abstract A metal complex of Suberic Acid with cobalt of stoichiometry Co(C 8 H 12 O 4 ) · 1.5H 2 O has been prepared. The compound has a tetrahedral structure. Thermal decomposition studies of Suberic Acid and of Co(C 8 H 12 O 4 ) · 1.5H 2 O show that the Suberic Acid melts at 143°C, while the metal complex loses water and then the organic ligand, to give CO 3 O 4 .
Vivian Wang - One of the best experts on this subject based on the ideXlab platform.
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immobilization of a bone and cartilage stimulating peptide to a synthetic bone graft
Journal of Materials Science: Materials in Medicine, 2008Co-Authors: Vivian Wang, Gauri Misra, Brian G. AmsdenAbstract:A synthetic peptide fragment of human collagen type I (BCSP™-1) was linked to the surface of a commercially available ceramic in an effort to improve the properties of the bone graft substitute to accelerate local healing. BCSP™-1 was covalently immobilized on the surface of the ceramic via the linkers 3-aminopropyl-triethoxysilane (APTES) and Suberic Acid bis-N-hydroxysuccinimide ester (DSS). The chosen chemistry was non-cytotoxic. A rat calvaria cell assay using alkaline phosphatase (ALP) as an osteoblast differentiation marker, showed that modifying the surface of the ceramic was enough to enhance ALP activity, although the total cell population on the surface decreased. A significant increase in ALP activity/cell was noted with serum albumin bound to the surface, however, the BCSP™-1 bound surface exhibited an even greater ALP activity that showed a surface concentration dependent trend. An optimal BCSP™-1 surface density in the range of 0.87–2.24 nmol/cm2 elicited the maximum ALP activity/cell at day 6 of culture. The peptide bound ceramic generated an ALP activity/cell that was roughly 3-fold higher than the non-modified ceramic and 2-fold higher than the APTES-grafted ceramic.
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immobilization of a bone and cartilage stimulating peptide to a synthetic bone graft
Journal of Materials Science: Materials in Medicine, 2008Co-Authors: Vivian Wang, Gauri Misra, Brian G. AmsdenAbstract:A synthetic peptide fragment of human collagen type I (BCSP™-1) was linked to the surface of a commercially available ceramic in an effort to improve the properties of the bone graft substitute to accelerate local healing. BCSP™-1 was covalently immobilized on the surface of the ceramic via the linkers 3-aminopropyl-triethoxysilane (APTES) and Suberic Acid bis-N-hydroxysuccinimide ester (DSS). The chosen chemistry was non-cytotoxic. A rat calvaria cell assay using alkaline phosphatase (ALP) as an osteoblast differentiation marker, showed that modifying the surface of the ceramic was enough to enhance ALP activity, although the total cell population on the surface decreased. A significant increase in ALP activity/cell was noted with serum albumin bound to the surface, however, the BCSP™-1 bound surface exhibited an even greater ALP activity that showed a surface concentration dependent trend. An optimal BCSP™-1 surface density in the range of 0.87–2.24 nmol/cm2 elicited the maximum ALP activity/cell at day 6 of culture. The peptide bound ceramic generated an ALP activity/cell that was roughly 3-fold higher than the non-modified ceramic and 2-fold higher than the APTES-grafted ceramic.
Kumaresh Ghosh - One of the best experts on this subject based on the ideXlab platform.
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molecular recognition chain length selectivity studies of dicarboxylic Acids by the cavity of a new troger s base receptor
Tetrahedron Letters, 1997Co-Authors: Shyamaprosad Goswami, Kumaresh GhoshAbstract:Abstract A new dicarboxylic Acid receptor 1 having two pyridinc amide motifs built on a Troger's base spacer has been designed and synthesised. The binding studies are performed with a series of dicarboxylic Acids and the cavity of receptor 1 was found to be selective for Suberic Acid.
