The Experts below are selected from a list of 11472 Experts worldwide ranked by ideXlab platform
Peter C.k. Cheung - One of the best experts on this subject based on the ideXlab platform.
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Production of bioactive metabolites by Submerged Fermentation of the medicinal mushroom Antrodia cinnamomea: recent advances and future development
Critical reviews in biotechnology, 2019Co-Authors: Bo-bo Zhang, Yu-yan Guan, Lei Chen, Liming Liu, Peter C.k. CheungAbstract:Edible and medicinal mushrooms have usually been considered as a sustainable source of unique bioactive metabolites, which are valued as promising provisions for human health. Antrodia cinnamomea is a unique edible and medicinal fungus widespread in Taiwan, which has attracted much attention in recent years for its high value in both scientific research and commercial applications owing to its potent therapeutic effects, especially for its hepatic protection and anticancer activity. Due to the scarcity of the fruiting bodies, the cultivation of A. cinnamomea by Submerged Fermentation appears to be a promising substitute which possesses some unique advantages, such as short culture time period and its high feasibility for scale-up production. However, the amount of fungal bioactive metabolites derived from the cultured mycelia of A. cinnamomea grown by Submerged Fermentation is much less than those obtained from the wild fruiting bodies. Hence, there is an urgent need to bridge such a discrepancy on bioactive metabolites between the wild fruiting bodies and the cultured mycelia. The objective of this article is to review recent advances and the future development of the mycelial Submerged Fermentation of A. cinnamomea in terms of enhancement for the production of fungal bioactive components by the optimization of culture conditions and the regulation of fungal metabolism. This review provides valuable information for further biotechnological applications of A. cinnamomea as well as other mushrooms being the source of bioactive ingredients by Submerged Fermentation.
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use of stimulatory agents to enhance the production of bioactive exopolysaccharide from pleurotus tuber regium by Submerged Fermentation
Journal of Agricultural and Food Chemistry, 2011Co-Authors: Bo-bo Zhang, Peter C.k. CheungAbstract:Fatty acids, organic solvents and surfactants were investigated for their stimulatory effects on the growth of fungal mycelium and production of exopolysaccharide (EPS) by Submerged Fermentation of...
Sek-man Wong - One of the best experts on this subject based on the ideXlab platform.
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Production of fungal chitosan by solid state and Submerged Fermentation
Carbohydrate Polymers, 2002Co-Authors: Nitar Nwe, Suwalee Chandrkrachang, Willem F. Stevens, Theingi Maw, T. K. Tan, Eugene Khor, Sek-man WongAbstract:The growth of the fungus Gongronella butleri USDB 0201 was compared in solid state Fermentation (SSF) and Submerged Fermentation (SMF) using various nitrogen sources. The optimal production of biomass and chitosan by SMF was around 1.5–2.5 times higher than SSF. Urea is the best nitrogen source tested. SSF is to be preferred for the production of lower MW chitosan.
Hongli Yuan - One of the best experts on this subject based on the ideXlab platform.
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Comparative characterization of extracellular enzymes secreted by Phanerochaete chrysosporium during solid-state and Submerged Fermentation.
International journal of biological macromolecules, 2020Co-Authors: Jiawen Liu, Jinshui Yang, Ruonan Wang, Liang Liu, Yu Zhang, Huifang Bao, Jin Myong Jang, En Tao Wang, Hongli YuanAbstract:Influence of water content on the expression of lignocellulolytic enzymes by Phanerochaete chrysosporium remains unclear. This work compares the enzyme production profiles of P. chrysosporium during solid-state and Submerged Fermentation. There were 110 and 64 extracellular carbohydrate-active enzymes identified in solid-state and Submerged Fermentation respectively, among which 57 enzymes were common to both of the secretomes. P. chrysosporium secreted more cellulases (especially lytic polysaccharide monooxygenase) and hemicellulases during solid-state Fermentation while the proportion of enzyme containing carbohydrate-binding module was higher for Submerged Fermentation. Although its activities were weaker, the enzyme cocktail from Submerged Fermentation was surprisingly more effective in hydrolysis at low substrate loading. This advantage of enzymes from Submerged Fermentation was mainly attributed to carbohydrate-binding module because more xylanases bound with substrate at the beginning of hydrolysis. These results reveal the influence of Fermentation conditions on enzyme produced by P. chrysosporium for the first time and show the importance of carbohydrate-binding module in the hydrolysis process of lignocellulose.
Bo-bo Zhang - One of the best experts on this subject based on the ideXlab platform.
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Production of bioactive metabolites by Submerged Fermentation of the medicinal mushroom Antrodia cinnamomea: recent advances and future development
Critical reviews in biotechnology, 2019Co-Authors: Bo-bo Zhang, Yu-yan Guan, Lei Chen, Liming Liu, Peter C.k. CheungAbstract:Edible and medicinal mushrooms have usually been considered as a sustainable source of unique bioactive metabolites, which are valued as promising provisions for human health. Antrodia cinnamomea is a unique edible and medicinal fungus widespread in Taiwan, which has attracted much attention in recent years for its high value in both scientific research and commercial applications owing to its potent therapeutic effects, especially for its hepatic protection and anticancer activity. Due to the scarcity of the fruiting bodies, the cultivation of A. cinnamomea by Submerged Fermentation appears to be a promising substitute which possesses some unique advantages, such as short culture time period and its high feasibility for scale-up production. However, the amount of fungal bioactive metabolites derived from the cultured mycelia of A. cinnamomea grown by Submerged Fermentation is much less than those obtained from the wild fruiting bodies. Hence, there is an urgent need to bridge such a discrepancy on bioactive metabolites between the wild fruiting bodies and the cultured mycelia. The objective of this article is to review recent advances and the future development of the mycelial Submerged Fermentation of A. cinnamomea in terms of enhancement for the production of fungal bioactive components by the optimization of culture conditions and the regulation of fungal metabolism. This review provides valuable information for further biotechnological applications of A. cinnamomea as well as other mushrooms being the source of bioactive ingredients by Submerged Fermentation.
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Enabling the biosynthesis of Antroquinonol in Submerged Fermentation of Antrodia camphorata
Biochemical Engineering Journal, 2014Co-Authors: Huan Zhang, Xiang-ru Liao, Bo-bo ZhangAbstract:Abstract In recent years, Antroquinonol has been considered as one of the most potent bioactive components in the medicinal mushroom Antrodia camphorata. However, Antroquinonol could not be produced via conventional Submerged Fermentation of A. camphorata. In this study, the biosynthesis of Antroquinonol was successfully enabled and stimulated in the Submerged Fermentation by the addition of its precursors including p-hydroxybenzoic acid, geraniol and coenzyme Q0. Referred to their structures, they involve in the biosynthesis of the quinonoid nucleus and polyprenyl side chain of Antroquinonol, respectively. Moreover, the appropriate concentration and addition time of these precursors were systematically studied. The maximum production of Antroquinonol could be achieved at 82.22 ± 0.49 mg/L with the multiple additions of coenzyme Q0 and p-hydroxybenzoic acid. This study demonstrated the bioprocess regulation of Antroquinonol production, which will be of great significance for the scientific study of A. camphorata.
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use of stimulatory agents to enhance the production of bioactive exopolysaccharide from pleurotus tuber regium by Submerged Fermentation
Journal of Agricultural and Food Chemistry, 2011Co-Authors: Bo-bo Zhang, Peter C.k. CheungAbstract:Fatty acids, organic solvents and surfactants were investigated for their stimulatory effects on the growth of fungal mycelium and production of exopolysaccharide (EPS) by Submerged Fermentation of...
Nitar Nwe - One of the best experts on this subject based on the ideXlab platform.
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Production of fungal chitosan by solid state and Submerged Fermentation
Carbohydrate Polymers, 2002Co-Authors: Nitar Nwe, Suwalee Chandrkrachang, Willem F. Stevens, Theingi Maw, T. K. Tan, Eugene Khor, Sek-man WongAbstract:The growth of the fungus Gongronella butleri USDB 0201 was compared in solid state Fermentation (SSF) and Submerged Fermentation (SMF) using various nitrogen sources. The optimal production of biomass and chitosan by SMF was around 1.5–2.5 times higher than SSF. Urea is the best nitrogen source tested. SSF is to be preferred for the production of lower MW chitosan.
